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7390485 |
Design and therapeutic use of adpase enhanced apyrases
The present invention provides for design and therapeutic use of ADPase enhanced polypeptides, pharmaceutical compositions, and methods useful for preventing and reversing platelet aggregation and...
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7371375 |
Protein
A nucleic acid comprising a nucleotide sequence encoding a lysin, which nucleotide sequence comprises the sequence shown in SEQ ID No. 1 or a variant, homologue or derivative thereof. A novel lysin...
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7351410 |
Treatment of Pompe's disease
The invention provides methods of treating Pompe's disease using human acid alpha glucosidase. A preferred treatment regime comprises administering greater than 10 mg/kg body weight per week to a...
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7323167 |
Method of treatment with modified arginine deiminase
The present invention is directed to arginine deiminase modified with polyethylene glycol, to methods of treating cancer, and to methods of treating and/or inhibiting metastasis.
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7320788 |
Enzyme treatment of foodstuffs for Celiac Sprue
Administering an effective dose of glutenase to a Celiac or dermatitis herpetiformis patient reduces levels of toxic gluten oligopeptides, thereby attenuating or eliminating the damaging effects of...
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7319015 |
Methods and compositions for using alveolar macrophage phospholipase A2
The present invention is directed to methods and compositions for improving pulmonary surfactant catabolism. More specifically, the specification describes methods and compositions for making and...
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7312198 |
Protein compositions for promoting wound healing and skin regeneration
Methods for stimulating proliferation and inhibiting death of cells in the epidermis and dermis of wounded and non-wounded as well as transplanted mammalian skin and transplanted skin cell...
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7294497 |
Compositions and methods for enzymatic detachment of bacterial and fungal biofilms
Isolated nucleic acid sequences and amino acid sequences for soluble, β-N-acetylglucosaminidase or active fragments or variants thereof which promote detachment of bacterial cells from a biofilm...
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7273607 |
Health enhancement method
A health enhancement system establishing a health enhancement program through which may be provided a group of natural products, vitamins and minerals, amino acids, herbs and essential oils that...
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7270815 |
2-O sulfatase compositions and related methods
The invention relates to 2-O sulfatase and uses thereof. In particular, the invention relates to recombinantly produced 2-O sulfatase, functional variants and nucleic acid molecules that encode...
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7264800 |
Method and composition for inhibiting cancer cell growth
Improvements in methods of treating cancer with weakly basic anti-cancer compounds are provided. In one aspect, the invention provides an improvement in a method of treating cancer cells whose...
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7261888 |
Combined use of triglycerides containing medium chain fatty acids and exogenous lipolytic enzymes as feed supplements
The present invention relates to the use of triglycerides (TG) containing medium chain fatty acids (C4 to C12), combined with exogenous lipolytic enzymes (esterases or lipases) as a feed supplement...
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7258855 |
Polypeptides having phospholipase A2 activity
The present invention relates to a novel phospholipase A 2 polypeptide, DNA encoding the polypeptide, a vector comprising the DNA, a transformant transformed with the vector, and a process for...
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7252799 |
Methods for sterilizing preparations containing albumin
Methods are disclosed for sterilizing preparations containing albumin to reduce the level of one or more active biological contaminants or pathogens therein, such as viruses, bacteria (including...
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7247300 |
Therapeutic use of soluble CD39L3
The present invention provides soluble forms of CD39L3 polypeptides and compositions, and methods useful inhibiting platelet activation and recruitment for the treatment and prevention of...
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7241442 |
Method for producing proteins suitable for treating lysosomal storage disorders
The present invention is based on the discovery that proteins produced in insect cell cultures are glycosylated in a unique manner that causes them to be selectively imported by cells that express...
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7238350 |
Phytase polypeptides
The present invention relates to isolated polypeptides having phytase activity, the corresponding cloned DNA sequences, a process for preparing such polypeptides, and the use thereof for a number...
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7223386 |
Preparations for topical skin use and treatment
Topical preparations for release of an active agent and to methods of making and using the topical preparations are provided. The preparations may have an internal phase dispersed within an...
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7217547 |
Aspartoacylase gene, protein, and methods of screening for mutations associated with Canavan disease
Canavan disease, an autosomal recessive leukodystrophy, is caused by deficiency of aspartoacylase and accumulation of N-acetylaspartic acid in brain. Human aspartoacylase (ASP) cDNA spanning 1,435...
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7211281 |
Method for improving the activity of enzymes
A method for improving the performance of enzymes used in animal feeds by the use of surfactants. Lecithin and/or lysolecithin is added to an animal feed including an exogenous enzyme to boost the...
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7198785 |
Systems and methods related to degradation of uremic toxins
The present invention generally relates to the treatment of uremic toxins in vivo using uremic toxin-treating enzymes, and/or cells capable of producing uremic toxin-treating enzymes or otherwise...
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7176010 |
Isolated human protein having esterase activity and DNA encoding the same
The present invention provides novel esterase proteins, Specifically, the present invention provides proteins having the same or substantially the same amino acid sequence as the amino acid...
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7172773 |
Food supplement formulation
An improved food supplement formulation comprises fish oil, peppermint oil, and lipase.
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7172650 |
Deproteinized natural rubber latex, method of preparing the same, rubber product using the same, and proteolytic agent for deproteinized natural rubber latex
The present invention provides a deproteinized natural rubber latex wherein coagulation of a rubber component does not occur when the concentration of calcium ions (Ca 2+ ) is 0.01 mol/L or less...
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7160540 |
Methods for detecting activity of clottings factors
Whole blood assays and kits are described for evaluating dosage of factor VIIa or activated protein C, as well as for monitoring responsiveness to factor VIIa or activated protein C.
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7150985 |
Bacteriolytic complex, method for producing said complex and strain for carrying out said method
The inventions relate to the field of medicine, veterinary and biotechnology and may be used for production of a drug for medical and veterinary purposes. A bacteriolytic complex, produced by the...
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7147847 |
Use of bacteria endowed with arginine deiminase to induce apoptosis and/or reduce an inflammatory reaction and pharmaceutical or dietetic compositions containing such bacteria
Disclosed is the use of bacteria endowed with arginine deiminase to induce apoptosis and/or reduce an inflammatory reaction, and pharmaceutical or dietetic compositions containing such bacteria....
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7141404 |
Candida kefyr cytosine deaminase
A new cytosine deaminase gene and protein from Candida kefyr are provided. This protein has increased ability to convert the 5-fluorocytosine prodrug to its toxic form when compared against the ...
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7138114 |
Pharmaceutical compositions of fibrinolytic agent
Frozen and lyophilized compositions for a metalloproteinase fibrinolytic agent (fibrolase or NAT), a method for preparing the lyophilized composition, and a kit and method for reconstituting the...
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7125683 |
Preparations for diagnosis extrapancreatic secretory function
A preparation for the diagnosis of pancreatic exocrine function by determining the amount in which a substance administered to a subject or a degradation product or metabolite thereof migrates into...
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7122516 |
Stabilized bioactive peptides and methods of identification, synthesis and use
An intracellular selection system allows concurrent screening for peptide bioactivity and stability. Randomized recombinant peptides are screened for bioactivity in a tightly regulated expression...
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7109161 |
Preserved pharmaceutical formulations
The present invention is directed to the use of benzethonium chloride, alone or in combination with phenoxyethanol or phenyl ethyl alcohol, to provide anti-microbial activity in pharmaceutical...
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7083964 |
Method for purifying enzymes from clostridium histolyticum using multi-stage chromatography
The invention relates to a method for purifying at least one enzyme obtained in an excess fermentation of Clostridium histolyticum. It is provided for that the enzymes of the excess...
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7078050 |
Composition for topical treatment
A white cream bacteriostat and fungicide capable of serving as a vehicle for additional medicaments. Also disclosed is a method for blending the ingredients, some of which are not readily...
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7070973 |
Butyrylcholinesterase variants and methods of use
The invention provides four butyrylcholinesterase variants having increased cocaine hydrolysis activity as well as the corresponding encoding nucleic acids. The invention also provides libraries...
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7070773 |
Chemical and/or biological decontamination system
The present invention provides compositions effective in decontaminating either biological pathogens or both chemical and biological pathogens. These compositions are particularly suitable for the...
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7067483 |
Pharmaceutical compositions containing a gycopeptide antibiotic and a cyclodextrin
Disclosed are pharmaceutical composition containing a cyclodextrin and a therapeutically effective amount of a glycopeptide antibiotic or a salt thereof. Also disclosed are methods of treating a...
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7067124 |
Protease composition and method for treating a digestive disorder
There is provided methods, kits, combinations, and compositions comprising a Aspergillus oryzae protease enzyme, a Bacillus subtilis protease enzyme, and a Aspergillus niger lipase enzyme for...
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7060265 |
Cloning and recombinant production of polistinae venom enzymes, such as phospholipase and hyaluronidase, and immunological therapies based thereon
A unique clone of a Polistinae venom enzyme, recombinantly produced Polistinae venom enzymes, and methods of using the recombinant enzymes are provided. In a specific example, both phospholipase...
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7060264 |
Insect inhibitory lipid acyl hydrolases
The present invention discloses DNA sequences encoding plant and novel lipid acyl hydrolase proteins having coleopteran specific insect inhibitory activity, as well as variants and permuteins...
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7056720 |
LLG polypeptides of the triacylglycerol lipase family, and compositions and methods for their use in enzymatic hydrolysis, and protein and gene therapies
The present invention relates to LLG polypeptides, which are polypeptides of the triacylglycerol lipase family, and fragments thereof, antibodies against such polypeptides, nucleic acids encoding...
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RE39118 |
Sphingomyelinase compositions and use thereof
The use of sphingomyelinase to increase the levels of skin and mucosal ceramides, as well as dermatolgical and cosmetic compositions containing game which are suitable for topical application are...
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7053042 |
Activation of peptide prodrugs by hK2
The invention provides novel peptide prodrugs that contain cleavage sites specifically cleaved by human kallikrein 2 (hK2). These prodrugs are useful for substantially inhibiting the non-specific...
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7052894 |
Isolated human phosphatase proteins, nucleic acid molecules encoding human phosphatase proteins, and uses thereof
The present invention provides amino acid sequences of peptides that are encoded by genes within the human genome, the phosphatase peptides of the present invention. The present invention...
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7052689 |
Method for producing therapeutically suitable glutaminase
DNA encoding a therapeutically suitable glutaminase has been molecularly cloned. This allows one to obtain a polypeptide which is a therapeutically suitable glutaminase free of contaminating...
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7049120 |
Regulation of human mrp5-like protein
Reagents that regulate human MRP5-like protein and reagents which bind to human MRP5-like protein gene products can play a role in preventing, ameliorating, or correcting dysfunctions or diseases...
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7048931 |
Compositions and methods for the therapy and diagnosis of prostate cancer
Compositions and methods for the therapy and diagnosis of cancer, such as prostate cancer, are disclosed. Compositions may comprise one or more prostate-specific proteins, immunogenic portions...
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7048914 |
Placental alkaline phosphatase to control diabetes
The present invention provides methods for using human placental alkaline phosphatase or an active derivative to reduce blood glucose level in a mammal. Treatment regimens provided by the invention...
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7045126 |
Histone deacetylase-8 proteins, nucleic acids, and methods for use
The present invention is directed to novel nucleic acids that encode novel HDAC proteins, which have an affect on chromatin structure and transcription. Also provided herein are vectors and host...
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7037534 |
Inactivation of viral infections agents by chemiluminescence activated light-sensitive compounds
Described herein is an invention that relates to chemiluminescence-directed antiviral activities of natural and synthesized light-sensitive compounds. Methods are described herein for inactivating...
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