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8183007 |
ADP detection based methods using adenylate cyclase and bioluminescence
The disclosure provides compositions and methods to determine or detect ADP or the activity of enzymes, including phosphotransferases such as kinases (e.g., protein, lipid, and sugar kinases) and...
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8183350 |
Compositions and methods for promoting neuronal outgrowth
Neural outgrowth in the central nervous system is achieved by administering chondroitinase AC and/or chondroitinase B to degrade chondroitin sulfate proteoglycans that inhibit or contribute to the...
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8168177 |
Method of regulating mammalian target-of-rapamycin activity by interaction between phospholipase D and Rheb
The present invention relates to method of regulating mammalian target-of-rapamycin (mTOR) based on a novel finding of a regulating mechanism of mTOR by a phospholipase D (PLD), and Ras homolog...
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8143046 |
Variant Buttiauxella sp. phytases having altered properties
The present invention relates to variant phytase enzymes having altered properties.
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8128925 |
Manufacture of active highly phosphorylated human lysosomal sulfatase enzymes and uses thereof
This invention provides compositions of active highly phosphorylated lysosomal sulfatase enzymes, their pharmaceutical compositions, methods of producing and purifying such lysosomal sulfatase...
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8114398 |
EGLN2 variants and use thereof in preventing or treating thromboembolic disorders and coronary heart disease
The present invention refers to human EGLN2 variants having at position 58 of the amino acid sequence a serine or a leucine and their use in the prevention or treatment of thromboembolic or...
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8110386 |
Lipase powder, methods for producing the same and use thereof
A lipase powder which is a granulated substance containing a lipase and a solid content of animal milk, a lipase composition wherein said lipase powder is immersed or impregnated in fatty oil, and...
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8105585 |
Ply-GBS mutant lysins
Methods, compositions and articles of manufacture useful for the treatment of various Group B streptococci (GBS) bacteria using various lysins, including certain PlyGBS mutant lysins, are provided.
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8093031 |
Heparanases and splice variants thereof, polynucleotides encoding them and uses thereof
The invention relates to novel heparanases, heparanase splice variants, and to polynucleotides encoding them. Particularly, the invention relates to Spalax heparanases, and to Spalax and human...
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8088372 |
Thrombin mutant
A thrombin mutant in which at least serine at position 205 among amino acids in the active center of the thrombin B chain has been replaced with another amino acid, and further at least one of the...
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8084025 |
Method for the treatment of the symptoms of drug and alcohol addiction
A therapeutic agent for the treatment of the symptoms of addiction and the method for preparing the therapeutic agent is disclosed. The therapeutic agent is a stable pharmaceutical preparation...
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8075902 |
Diagnosis and treatment of cancer related to human dormancy
New devices and methods for diagnosis and compositions and methods for treatment of cancers use combinations of antimicrobial agents and agents that can reverse dormancy and hibernation pathways....
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8071089 |
Composition with a fungal (yeast) lipase and method for treating lipid malabsorption in cystic fibrosis as well as people suffering from pancreatic lipase insufficiency
The invention provides compositions and methods for treating pancreatic enzyme insufficiency, such as the pancreatic enzyme insufficiency associated with cystic fibrosis. The invention also...
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8066990 |
Lysin protein having broad antibacterial activity specific to bacteria
The present invention relates to a lysin protein originated from bacteriophage, more precisely a lysin protein comprising the amino acid sequence represented by SEQ. ID. NO: 2 which has no harm to...
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8052970 |
Lysosomal phospholipase A2 (LPLA2) activity as a diagnostic and therapeutic target for identifying and treating systemic lupus erythematosis
The present invention is directed to methods for diagnosis and treatment of systemic lupus erythematosus and drug-induced systemic lupus erythematosus. More specifically, the specification...
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8053221 |
Enzymes
The present invention relates to enzymes and processes. In particular, there is described a host cell transformed or transfected with a nucleic acid encoding a bacterial phytase enzyme and variants...
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8048412 |
Enzyme with microbial lysis activity from Trichoderma reesei
The invention provides fungal polypeptides from Trichoderma reesei that possess anti-microbial activity, polynucleotides encoding the polypeptides, compositions comprising the polypeptides and...
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8048413 |
Site-specific intestinal delivery of adsorbents, alone or in combination with degrading molecules
Compositions which deliver adsorbents, alone or in combination with active drug “degrading molecules,” in a site-specific manner to the intestine, and which eliminate or at least lower the con...
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8039240 |
Recombinant human T2 RNase and uses thereof
The cloning and heterologous expression of human T2 RNase6PL are disclosed. Further disclosed are methods for preventing, inhibiting and/or reversing cell motility, actin filament assembly or...
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8038990 |
Compositions and methods for the prevention and removal of biofilms on inert and biological surfaces
Organisms, compositions, and methods for at least partially reducing the formation of a biofilm and/or at least partially removing a biofilm are provided. The organisms, compositions, and methods...
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8034385 |
Anti-ageing skin cosmetic
The invention relates to a cosmetic based on various natural raw materials, which can be used to counter ageing processes of the human skin. The inventive cosmetic contains 0.1-5% by weight of an...
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8029782 |
Therapeutic ribonucleases
The present invention relates to the use of ribonucleases (RNases) in the treatment or prevention of disease.
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8021866 |
Therapeutic use of ADPase enhanced apyrases
The present invention provides for design and therapeutic use of ADPase enhanced polypeptides, pharmaceutical compositions, and methods useful for preventing and reversing platelet aggregation and...
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7989192 |
Modified beta-lactamase and method for its preparation
The invention relates to targeted post translational modification of metallo-beta-lactamase by truncation and insertion of a dipeptide at the amino terminal end to reduce amino terminal...
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7972593 |
Delivery of therapeutic agents to the bone
This invention relates to compositions and methods of delivering therapeutic agents to bone. More specifically, the invention relates to endowing a large molecule vectors i.e., adeno virus,...
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7968691 |
Pullulanase variants with increased productivity
The invention relates to novel variants of the enzymatic peptide pullulanase, the gene sequences encoding said novel peptides, expression vectors comprising those gene sequences as well as...
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7960137 |
Selection and use of lactic acid bacteria for reducing inflammation caused by Helicobacter
Strains of Lactobacillus which have been selected for their capability of reducing gastrointestinal inflammation, such as that due to Helicobacter pylori, and products derived from these strains,...
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7951366 |
Pharmaceutical preparation and method of treatment of human malignancies with arginine deprivation
The present invention provides an isolated and substantially purified recombinant human arginase having sufficiently high enzymatic activity and stability to maintain Adequate Arginine Depletion in...
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7947306 |
Modifications of solid 3-sn-phosphoglycerides
Methods for hydrolyzing solid ungranulated lysophosphatidylcholine with phospholipase A2 are provided. Also disclosed are methods for making a lipid matrix of lysophosphatidylcholine, monoglyceride...
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7943127 |
Defense and counter-defense compositions and methods
Contemplated compositions and methods are directed to the use of a proteinase to reduce capsaicin-induced pain sensation in a mammal. Preferably, the proteinase comprises a bromelain preparation in...
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7939064 |
Phospholipase(s) and use(s) thereof
The invention relates to phospholipase(s), isoforms, derivatives, mutants and/or fragments thereof, for the preparation of a medicament for the treatment and/or prevention of ischemia. Preferred is...
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7927587 |
MAPC administration for the treatment of lysosomal storage disorders
The present invention relates to methods for providing lysosomal enzymes to a subject by administering stem cells, preferably Multipotent Adult Progenitor Cells (MAPCs). The invention further...
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7919082 |
High-activity mutants of butyrylcholinesterase for cocaine hydrolysis and method of generating the same
A novel computational method and generation of mutant butyrylcholinesterase for cocaine hydrolysis is provided. The method includes molecular modeling a possible BChE mutant and conducting...
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7914783 |
Pharmacological vitreolysis
Methods of treating or preventing a disorder, or a complication of a disorder, of an eye of a subject, comprising contacting a vitreous and/or aqueous humor with a composition comprising a...
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7892537 |
High activity mutants of butyrylcholinesterase for cocaine hydrolysis
Butyrylcholinesterase (BChE) polypeptide variants of the presently-disclosed subject matter have enhanced catalytic efficiency for (−)-cocaine, as compared to wild-type BChE. Pharmaceutical c...
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7871609 |
Supplements for pain management
Dietary supplements, compositions and methods of administering the supplements to reduce pain, inflammation and stiffness in said mammal within a few hours. The supplements and compositions can...
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7867489 |
Pharmacological vitreolysis
A method of treating or preventing a disorder, or a complication of a disorder, of an eye of a subject comprising contacting a vitreous and/or aqueous humor with a composition comprising a...
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7867743 |
Polypeptides having phytase activity and polynucleotides encoding same
The invention relates to a phytase derived from Citrobacter braakii and related phytases. The phytases belong to the acid histidine phosphatase family, are acid-stable, of an excellent performance...
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7863031 |
Phytases and methods of making and using them
The invention provides a purified, isolated, synthetic or recombinant phytase enzyme (e.g., SEQ ID NO:2) initially derived from Escherichia coli B. The enzyme has a molecular weight of about 47.1...
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7858085 |
Alkaline phosphatase to control diabetes
The present invention provides methods for using human placental alkaline phosphatase or an active derivative to reduce blood glucose level in a mammal. Treatment regimens provided by the invention...
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7846430 |
Composition and method for treating bovine papilloma virus in equine
A composition of lysozyme and a pharmaceutically acceptable carrier is active against the papilloma virus in both humans and animals. The composition can be used to treat women suffering from...
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7838275 |
Anti-HIV and anti-tumor peptides and fragments of lysozyme
A fragment of lysozyme which contains a minimum nine amino acid sequence with antiviral, anti-tumor and bactericidal activities but lacking muramidase activity is provided. The invention also...
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7838561 |
Method for preventing or treating cardiac hypertrophy
A method for treating or preventing cardiac hypertrophy in a mammal, comprising manipulating levels of RBP, retinoids, or an affiliated signaling and regulatory pathway in the mammal. Preferably,...
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7833742 |
Treatment of α-galactosidase A deficiency
The invention provides methods of treating α-galactosidase A deficiency. Dosage forms, methods of administration, and methods of analyzing human α-galactosidase A are also included.
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7833523 |
Compositions and methods for enzymatic detachment of bacterial and fungal biofilms
Isolated nucleic acid sequences and amino acid sequences for soluble, β-N-acetylglucosaminidase or active fragments or variants thereof which promote detachment of bacterial cells from a biofilm ...
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7833765 |
Galenic formulation for colon-targeted delivery of active ingredients
The invention concerns multiparticulate galenic formulations for oral administration and designed for colon targeted delivery of active principles selected from the group comprising enzymes capable...
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7803368 |
Pharmacological vitreolysis
Methods of treating or preventing a disorder, or a complication of a disorder, of an eye of a subject, comprising contacting a vitreous and/or aqueous humor with a composition comprising a...
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7794709 |
Apparatus and methods for enzymatic escharotomy in burn induced compartment syndrome
Apparatus suitable for use in the prevention and treatment of burn induced compartment syndrome facilitates the rapid and efficient deployment of enzymatic compositions to the affected limb or...
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7790685 |
Combinations of human proteins to enhance viability of transplanted stem cells and progenitor cells
Embodiments of the present invention include the use of placental alkaline phosphatase alone or in combination with human transferrin and, optionally, human α1-antitrypsin to enhance the ...
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7790430 |
Cellulase resistant to surfactants
Disclosed is a novel cellulose having an amino acid sequence in which the 162nd and/or 166th amino acid residues in the amino acid sequence of cellulose NCE5 are substituted. Further, a...
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