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7390784 |
Administering bifunctional molecules containing a drug moiety and presenter protein ligand for therapy
Bifunctional molecules and methods for their use in the production of binary complexes in a host are provided. The bifunctional molecule is a conjugate of a drug moiety and a presenter protein...
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7378090 |
Alleviation of the memory deficits and memory components of psychiatric dysfunctions by altering atypical PKM activity
Methods have been developed for alleviating memory problems or psychiatric dysfunctions that have a memory formation component. These methods are based on the finding that a truncated form of an...
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7368108 |
Glycopeptide remodeling using amidases
This invention provides methods for modifying glycosylation patterns of glycopeptides, including recombinantly produced glycopeptides. Also provided are glycopeptide compositions in which the...
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7364887 |
Use of PAK inhibitor for the treatment of a joint disease
The invention refers to the use of a p21-activated kinase (PAK) inhibitor for the treatment of a joint disease such as osteoarthritis or rheumatoid arthritis or for the treatment of a joint pain...
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7344870 |
3-phosphoinositide-dependent protein kinase
The present invention provides for a substantially pure human or rabbit 3-phosphoinositide-dependent protein kinase.
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7309484 |
Compositions and methods for screening antibacterial compounds
The present invention pertains to compositions and methods used to ascertain if putative antibiotics trigger a cell envelope stress response in bacterial organisms. In one aspect of the invention,...
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7264819 |
Lyase treatment for P. carinii
Infection by P. carinii can be treated by administering methioninase optionally in combination with additional therapeutic agents, such as antibiotics.
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7264799 |
Use of heparinases to decrease inflammatory response
Heparinase enzymes can be used as a medical treatment to reduce localized inflammatory responses. Treatment of activated endothelium with heparinase inhibits leukocyte rolling, adhesion and...
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7251525 |
Treatment of arrhythmias via inhibition of a multifunctional calcium/calmodulin-dependent protein kinase
This invention provides a method for treating or preventing arrhythmias in a human subject comprising the administration of an effective amount of a calcium/calmodulin-dependent protein kinase...
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7220583 |
Pseudomonas avr and hop proteins, their encoding nucleic acids, and use thereof
One aspect of the present invention relates to isolated nucleic acid molecules encoding avirulence proteins or polypeptides of Pseudomonas syringae pv. syringae DC 3000, or nucleic acid...
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7205135 |
Regulation of human adenylate cyclase
Reagents which regulate human adenylate cyclase and reagents which bind to human adenylate cyclase gene products can play a role in preventing, ameliorating, or correcting dysfunctions or diseases...
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7198931 |
Phosphorylated glyoxalase I and its use
The present invention relates to a phosphorylated form of mammalian glyoxalase I. The present invention relates further to the use of phosphorylated mammalian glyoxalase I to modulate...
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7182954 |
Prebiotic oligosaccharides via alternansucrase acceptor reactions
Oligosaccharides produced by an alternansucrase enzyme catalyzed reaction of sucrose with an acceptor oligosaccharide are effective as prebiotics for controlling enteric bacterial pathogens....
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7172879 |
Detection of sphingosine kinase activity and sphingosine kinase agonist or antagonist activity
The invention relates to detection of sphingosine kinase activity and sphingosine kinase agonist or antagonist activity.
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7166700 |
PRO703 Polypeptides
The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid...
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7112427 |
Sphingosine kinase enzyme
The present invention relates generally to novel protein molecules and to derivatives, analogues, chemical equivalents and mimetics thereof capable of modulating cellular activity and, in...
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7091021 |
Inactive variants of the human telomerase catalytic subunit
The invention provides compositions and methods related to human telomerase reverse transcriptase (hTRT), the catalytic protein subunit of human telomerase. Catalytically active and inactive human...
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7091020 |
Human Jak2 kinase
The present invention provides a polynucleotide (hjak2) which identifies and encodes a novel human Jak2 kinase (HJAK2) which was expressed in the placenta. The present invention also provides for...
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7083783 |
Method for treating glaucoma
A method for increasing outflow facility and reducing intraocular pressure from an eye of a subject having glaucoma includes the step of administering to the eye an amount of an ADP...
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7070968 |
DNA damaging agents in combination with tyrosine kinase inhibitors
The present invention relates to the signalling pathways connecting DNA damage, such as that induced by ionizing radiation or alkylating agents, and phosphorylation by tyrosine kinases.
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7056900 |
Disaccharide derivatives for treating hyperglycaemia
The invention relates to the use of the disaccharide derivatives 3′-aminosucrose, sucrose-C6-acid and palatinose-C6′-acid and/or of an amide or alkyl ester thereof for the prevention or...
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7056899 |
Disaccharide derivatives for treating hyperglycaemia
The invention relates to the use of the disaccharide derivatives 3′-aminosucrose, sucrose-C6-acid and palatinose-C6′-acid and/or of an amide or alkyl ester thereof for the prevention or...
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7056513 |
Telomerase
The present invention is directed to novel telomerase nucleic acids and amino acids. In particular, the present invention is directed to nucleic acid and amino acid sequences encoding various...
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7056504 |
Rationally designed heparinases derived from heparinase I and II
Modified heparinases having altered binding specificity and activity are provided. Isolated nucleic acids encoding the same as well as vectors and host cells are provided. Methods for using the...
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7049124 |
Hyaluronidase from the Hirudinaria manillensis isolation, purification and recombinant method of production
The present invention relates to the isolation, purification and characterization of a hyaluronidase which derives from the tropical leech Hirudinaria manillensis . Therefore, according to this...
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7049117 |
Mutant possessing uracil phosphoribosyl transferase activity
The invention concerns a polypeptide having a uracil phosphoribosyl transferase (UPRTase) by mutation of one or several residues of the UPRTase. The invention also concerns a nucleotide sequence...
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7029892 |
Serine threonine kinase member, h2520-59
The present invention relates to a serine threonine kinase. The invention also relates to nucleic acids encoding the kinase, vectors, host cells, antibodies and recombinant methods for producing...
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7014851 |
Process for inhibiting platelet aggregation
An object of the present invention is to provide a platelet aggregation inhibitor without side effects and a supplement food effective for inhibiting platelet aggregation. The platelet aggregation...
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6982083 |
Starch granules containing a recombinant polypeptide of interest, method for obtaining them, and their uses
The present invention relates to starch granules containing a fusion polypeptide between a starch synthase and a recombinant polypeptide of interest, the nucleotide sequences used for obtaining...
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6979445 |
Method for treating von willebrand's disease
Use of factor XIII for treating von Willebrand's disease. A patient having von Willebrand's disease is treated by administering factor XIII generally in conjunction with factor VIII concentrate,...
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6962699 |
Rationally designed polysaccharide lyases derived from chondroitinase B
The invention relates to rationally designed polysaccharide lyases and uses thereof. In particular, the invention relates to modified chondroitinase B. The modified chondroitinase B enzymes of the...
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6958148 |
Linkage of agents to body tissue using microparticles and transglutaminase
Methods, products and kits are provided for attaching agents to a body tissue surface via microparticles using endogenous or exogenous transglutaminase. The microparticles have surface available...
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6946273 |
Compositions and methods utilizing DNA polymerases
The invention features a novel isolated Family B DNA polymerase, a Thermococcus polymerase JDF-3, and mutant recombinant forms thereof. Mutant polymerases of the invention are deficient in 3′...
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6939541 |
Cloning, overexpression and therapeutic use of bioactive histidine ammonia lyase
Histidine ammonia lyase (HAL) isolated from Corynebacteriaceae can decrease serum histidine levels, induce accumulation of urocanic acid, and is not inhibited by L-histidinol. As a result,...
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6936452 |
Inhibitors of the inositol polyphosphate 5-phosphate SHIP2 molecule
The present invention is related to an inhibitor of the inositol polyphosphate 5-phosphatase SHIP2 protein or its encoding nucleotide sequence identified by SEQ ID NO. 1 or of SHIP2 mRNA...
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6936245 |
Mediators of signal transduction
Polypeptides capable of regulating signal transduction, which preferably exhibit kinase activity, or antibodies against such polypeptides that inhibit the interaction of these polypeptides with...
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6919076 |
Conjugates of agents and transglutaminase substrate linking molecules
Methods, products, compositions and kits are provided for attaching agents to tissue with a linking molecule in the presence of transglutaminase. The linking molecule and/or agent is a substrate of...
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6887842 |
Modulating a pharmacokinetic property of a drug by administering a bifunctional molecule containing the drug
Bifunctional molecules and methods for their use are provided. The subject bifunctional molecules are conjugates of a drug moiety and a pharmacokinetic modulating moiety, where these two moieties...
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6852686 |
Methods for ameliorating icthyosiform skin diseases
The present invention relates to the discovery of a method to provide stabilized transglutaminase 1 enzyme, involucrin, and other molecules necessary for the assembly of the cell envelope to skin...
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6849599 |
Combination drug therapy
The invention provides antineoplastic composition containing an inhibitor of angiogenesis and an inhibitor of DNA topoisomerase type I enzyme activity.
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6833258 |
Process for producing transglutaminase
The present invention relates to a high-yield process for producing high-activity, high-purity transglutaminase by refolding denatured microorganism-derived transglutaminase by reacting denatured...
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6821763 |
Process for producing microbial transglutaminase
Disclosed are a protein having a transglutaminase activity, which comprises a sequence ranging from serine residue at the second position to proline residue at the 331st position in an amino acid...
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6800283 |
Isolated human casein kinase proteins, nucleic acid molecules encoding human casein kinase proteins, and uses thereof
The present invention provides amino acid sequences of peptides that are encoded by genes within the human genome, the kinase peptides of the present invention. The present invention specifically...
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6787133 |
Using purified telomerase to identify telomerase activators and inhibitors
This invention provides purified telomerase and methods of purifying it. The methods involve the use of several sequential steps, including the use of matrices that bind molecules bearing negative...
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6776991 |
Methods for treating priapism
A method for treating priapism in a mammal by administration of a botulinum toxin.
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6773897 |
Method of predicting the clinical response to chemotherapeutic treatment with alkylating agents
The present invention provides methods relating to chemotherapeutic treatment of a cell proliferative disorder. In particular, a method is provided for predicting the clinical response to certain...
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6753158 |
Assays, agents, therapy and diagnosis relating to modulation of cellular DNA repair activity
A yeast homologue of mammalian DNA ligase IV is provided and a role for DNA ligase IV established in the Ku-associated DNA repair pathway. Additionally interactions between DNA ligase IV and XRCC4,...
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6743424 |
Method for treating hyperthyroidism
A method for treating hypothyroidism by local administration of a neurotoxin, such as a botulinum toxin, to a thyroid, thereby reducing an inhibitory effect upon thyroid hormone secretion. A method...
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6740321 |
Method for treating thyroid disorders with a botulinum toxin
A method for treating hypothyroidism by local administration of a neurotoxin, such as a botulinum toxin, to a thyroid, thereby reducing an inhibitory effect upon thyroid hormone secretion. A method...
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6719986 |
Hyaluronate lyase used for promoting penetration in topical agents
The invention relates to an agent for treating skin diseases and/or functional disorders of the skin on the basis of different medicaments and/or auxiliary substances through promotion of...
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