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6423312 |
Compositions including glycosaminoglycans degrading enzymes and use of same against surface protected bacteria
A method of rendering a surface protected bacteria more susceptible to an anti-bacterial agent effected by subjecting the bacteria to a glycosaminoglycans degrading enzyme.
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6416755 |
Human beta-alanine-pyruvate aminotransferase
The invention provides a human beta-alanine-pyruvate aminotransferase (HAPA) and polynucleotides which identify and encode HAPA. The invention also provides expression vectors, host cells,...
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6410688 |
Def1
The invention provides Def1 polypeptides and DNA (RNA) encoding Def1 polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing Def1...
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6406875 |
Mammalian putative phosphatidylinositol-4-phosphate-5-kinase
A novel mammalian phosphatidylinositol-4-phosphate-5-kinase (PIP5K) referred to herein as p235 and novel polynucleotides encoding p235, are provided. p235 is specifically expressed in adipocytes...
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6399319 |
Protein kinase assay as a method for identification of fungicides
Protein kinase inhibition assays are utilized for identifying new fungicides. An assay for detecting substances having fungicidal activity comprises a protein kinase as enzyme in a buffer system,...
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6379722 |
Human S-adenosyl-L-methionine methyltransferase
The invention provides a human S-adenosyl-L-methionine methyltransferase (SAM-MT) and polynucleotides which identify and encode SAM-MT. The invention also provides expression vectors, host cells,...
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6379664 |
Composition and method for the prevention and treatment of oxidative damage in ocular tissues
Thioltransferase and derivatives thereof are provided. Methods of treating or preventing cataract formation comprising administering thioltransferase or a derivative thereof are also provided....
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6372211 |
Methods and compositions for controlling insects
Compositions and methods for controlling insects by co-expressing an amino acid oxidase and a second enzyme that provides insecticidal activity when present in a mixture with the amino acid oxidase...
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6372712 |
Synthetic bifunctional molecules containing a drug moiety and presenter protein ligand
Bifunctional molecules and methods for their use in the production of binary complexes in a host are provided. The bifunctional molecule is a conjugate of a drug moiety and a presenter protein...
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6358738 |
Polo box therapeutic compositions, methods, and uses therefor
The amino acid sequence of a polo box is provided based on residue-by-residue mutation and analysis of phenotype. Additional polo boxes in the polo kinase protein located between the first polo box...
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6350601 |
Enzyme composition for use as a clinical diagnostic reagent
Disclosed is a stabilized enzyme composition for use in clinical examination, comprising: (a) an enzyme component comprising at least two enzymes selected from the group consisting of alkaline...
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6350598 |
MurD
The invention provides MurD polypeptides and DNA (RNA) encoding MurD polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing MurD...
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6348578 |
Apt
The invention provides apt polypeptides and DNA (RNA) encoding apt polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing apt...
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6346244 |
Fungal protein disulfide isomerase
The present invention relates to protein disulfide isomerases which are encoded by a nucleic acid sequence which hybridizes with (i) the DNA sequence of SEQ ID NO:1 or (ii) the DNA sequence of SEQ...
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6312688 |
Tyrosine-phosphatase-related protein
The present invention relates to a tyrosine-phosphatase-related protein, a DNA which codes for such a protein and a process for producing such a protein. In addition, the invention concerns the use...
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6290953 |
Modulation of cellular proliferation with thymidine phosphorylase
A method of modulating cellular proliferation by the application of a thymidine phosphorylase to an organism. In a further aspect of the subject method, the thymidine phosphorylase is a conjugate...
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6290952 |
Method of dephosphorylating an endotoxin in vivo with alkaline phosphatase
The invention relates to pharmaceutical compositions suitable for treating or curing clinical complications mediated by endotoxin, including sepsis. The compositions contain components suitable for...
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6274139 |
Topoisomerase I
Topoisomerase I polypeptides and DNA and RNA encoding such Topoisomerase I polypeptides and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are...
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6267957 |
Attaching agents to tissue with transglutaminase and a transglutaminase substrate
Methods, products and kits are provided for attaching agents to tissue with a linking molecule in the presence of transglutaminase. The linking molecule and/or agent is a substrate of...
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6264947 |
Protein kinase homologs
The invention provides human protein kinase homologs (PKH) and polynucleotides which identify and encode PKH. The invention also provides expression vectors, host cells, antibodies, agonists, and...
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6261556 |
Purified telomerose
This invention provides purified human telomerase and methods of purifying it. The methods involve the use of several sequential steps, including the use of a first matrix that binds molecules...
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6255468 |
MPROT12 polynucleotides and methods thereof
MPROT12 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing MPROT12 polypeptides and...
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6248325 |
Glutathione s-transferase
The present invention provides a human glutathione s-transferase (HGST) and polynucleotides which identify and encode HGST. The invention also provides genetically engineered expression vectors and...
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6231854 |
Methioninase formulations and use in diagnostic methods
The present invention discloses the cloning of a methioninase-encoding nucleic acid molecule from Pseudomonas putida and the construction of high-level expression modules containing the...
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6217863 |
Rationally designed polysaccharide lyases derived from heparinase I
Modified heparinases having altered binding specificity and activity are provided. Isolated nucleic acids encoding the same as as vectors and host cells are provided. Methods for using the modified...
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6217864 |
Method for targeted degradation of intracellular proteins in vivo or ex vivo
A method for in vivo selective targeted degradation of intracellular proteins in situ by inducing in vivo or ex vivo in cells a production of dual-function protein comprising N-terminal domain as...
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6207150 |
Variants of thymidine kinase, nucleic acids encoding them, and methods of using them
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6204036 |
Stable transglutaminase preparations and processes for their production
The present invention relates to stable preparation forms of a transglutaminase, for example factor XIII, which, after lyophilization, are readily soluble without turbidity. The preparation froms...
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6200562 |
Method for reducing absorption of dietary oxalate using enzymes and microbes
This invention provides materials and procedures for the delivery of selected strains of bacteria and/or oxalate-degrading enzymes to the intestinal tracts of persons who are at increased risk for...
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6194187 |
Apoptosis-inducing protein and gene encoding the same
An object of the present invention is to provide a protein which induces apoptosis, a base sequence encoding the protein, and an agent for use in the treatment of malignant tumors. The present...
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6190894 |
Method and compositions for disrupting the epithelial barrier function
A method for disrupting epithelial barrier function in a host in need of the topical administration of a physiologically active substance which comprises applying to the epithelium of the host,...
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6184023 |
Chondroitinase, process for preparing the same, and pharmaceutical composition comprising the same
A crystallizable, purified chondroitinase ABC having a molecular weight of about 100,000 dalton by the measurement of the SDS-polyacrylamide gel electrophoresis (SDS-PAGE) and the measurement by...
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6165738 |
Expression in yeast of antigenically active, recombinant hybrid glutamic acid decarboxylase
An antigenically active hybrid glutamic acid decarboxylase (GAD) comprising an amino-terminal moiety derived from the GAD67 isoform linked directly or indirectly with a middle and carboxy-terminal...
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6165462 |
Sugar kinase
The invention provides sugar kinase polypeptides and DNA (RNA) encoding sugar kunase polypepties and methods for producing such polypeptides by recombinant techniques. Also provided are methods or...
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6162431 |
Serine/threonine protein kinase
The present invention provides a human growth factor receptor binding protein (HSTPK) and polynucleotides which encode HSTPK. The invention also provides expression vectors, host cells, agonists,...
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6153187 |
Use of glycosaminoglycans degrading enzymes for management of airway associated diseases
A method of managing a patient having an accumulation of mucoid, mucopurulent or purulent material containing glycosaminoglycans, the method comprising the step of administering at least one...
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6132714 |
Human growth-associated methyltransferases
The invention provides a human growth-associated methyltransferase (GAMT) and polynucleotides which identify and encode GAMT. The invention also provides expression vectors, host cells, antibodies,...
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6124123 |
UBCH7-like ubiquitin-conjugating enzyme
The present invention provides a human ubiquitin-conjugating enzyme (UBCPB) and polynucleotides which identify and encode UBCPB. The invention also provides genetically engineered expression...
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6117433 |
Use of compositions comprising stabilized biologically effective compounds
A dual chambered dispensing system allows for application of an aqueous composition containing a biologically effective compound which is adequately stabilized. The system separately contains the...
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6110722 |
F.sub.0 ATP synthase subunit
The present invention provides a human ATP synthase subunit (ASYS) and polynucleotides which encode ASYS. The invention also provides expression vectors, host cells, agonists, antisense molecules,...
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6099834 |
Method for modulating eicosanoid mediated immune responses in arthropods
The invention is directed to compositions which alter the health of invertebrate organisms by affecting eicosanoid-mediated immune responses, and methods of using the compositions. The invention...
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6099835 |
Method of using antiviral composition
A composition having antiviral and antibacterial effects is disclosed which comprises the dimeric forms of enzymes selected from lysozyme and ribonuclease and a pharmaceutically acceptable carrier....
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6093563 |
Chondroitin lyase enzymes
The present invention describes a method for the production of two highly purified enzymes capable of degrading chondroitin sulfate polysaccharides. A multi-step purification method incorporating...
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6090605 |
Purified porcine kidney L-fucose kinase
The present invention provides an enzyme L-fucokinase isolated from porcine kidney and in homogeneously purified form. The enzyme has a native molecular weight of 440 kDa based on gel filtration, a...
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6066465 |
Process for the diagnostic assessment and monitoring, as well as medicaments for the therapy of states of shock in humans
A method is provided for detecting shock by measuring the concentration of cyclophilins in a patient's blood and comparing the measured concentration against a control. The severity of shock is...
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6063376 |
Human deoxycytidine kinase 2
A human deoxycytidine kinase 2 polypeptide and DNA (RNA) encoding such polypeptide and a procedure for producing such polypeptide by recombinant techniques is disclosed. Also disclosed are methods...
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6045792 |
Human proteins kinases
The present invention provides novel human protein kinases (HPK) and polynucleotides which identify and encode HPK. The invention provides for genetically engineered expression vectors and host...
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6042823 |
Enzyme composition and use thereof
Oligosaccharides having physiological activities are synthesized in vivo in order to, for example, improve intestinal bacterial flora. An enzyme composition comprising an enzyme capable of forming...
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6042824 |
Methods using cross linked protein crystal formulations as catalysts in organic solvents
The present invention relates to the application of biocatalysis technology for performing selective chemical reactions. In one embodiment, this invention relates to crosslinked protein crystal...
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6040149 |
Assay for identifying agents which act on the ceramide-activated protein kinase, kinase suppressor of ras, and methods of using said agents
The subject invention provides a purified membrane-bound ceramide-activated protein kinase having an apparent molecular weight of about 110 kD as determined by SDS polyacrylamide gel...
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