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6946273 |
Compositions and methods utilizing DNA polymerases
The invention features a novel isolated Family B DNA polymerase, a Thermococcus polymerase JDF-3, and mutant recombinant forms thereof. Mutant polymerases of the invention are deficient in 3′...
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6939541 |
Cloning, overexpression and therapeutic use of bioactive histidine ammonia lyase
Histidine ammonia lyase (HAL) isolated from Corynebacteriaceae can decrease serum histidine levels, induce accumulation of urocanic acid, and is not inhibited by L-histidinol. As a result,...
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6936452 |
Inhibitors of the inositol polyphosphate 5-phosphate SHIP2 molecule
The present invention is related to an inhibitor of the inositol polyphosphate 5-phosphatase SHIP2 protein or its encoding nucleotide sequence identified by SEQ ID NO. 1 or of SHIP2 mRNA...
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6936245 |
Mediators of signal transduction
Polypeptides capable of regulating signal transduction, which preferably exhibit kinase activity, or antibodies against such polypeptides that inhibit the interaction of these polypeptides with...
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6919076 |
Conjugates of agents and transglutaminase substrate linking molecules
Methods, products, compositions and kits are provided for attaching agents to tissue with a linking molecule in the presence of transglutaminase. The linking molecule and/or agent is a substrate of...
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6887842 |
Modulating a pharmacokinetic property of a drug by administering a bifunctional molecule containing the drug
Bifunctional molecules and methods for their use are provided. The subject bifunctional molecules are conjugates of a drug moiety and a pharmacokinetic modulating moiety, where these two moieties...
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6852686 |
Methods for ameliorating icthyosiform skin diseases
The present invention relates to the discovery of a method to provide stabilized transglutaminase 1 enzyme, involucrin, and other molecules necessary for the assembly of the cell envelope to skin...
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6849599 |
Combination drug therapy
The invention provides antineoplastic composition containing an inhibitor of angiogenesis and an inhibitor of DNA topoisomerase type I enzyme activity.
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6833258 |
Process for producing transglutaminase
The present invention relates to a high-yield process for producing high-activity, high-purity transglutaminase by refolding denatured microorganism-derived transglutaminase by reacting denatured...
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6821763 |
Process for producing microbial transglutaminase
Disclosed are a protein having a transglutaminase activity, which comprises a sequence ranging from serine residue at the second position to proline residue at the 331st position in an amino acid...
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6800283 |
Isolated human casein kinase proteins, nucleic acid molecules encoding human casein kinase proteins, and uses thereof
The present invention provides amino acid sequences of peptides that are encoded by genes within the human genome, the kinase peptides of the present invention. The present invention specifically...
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6787133 |
Using purified telomerase to identify telomerase activators and inhibitors
This invention provides purified telomerase and methods of purifying it. The methods involve the use of several sequential steps, including the use of matrices that bind molecules bearing negative...
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6776991 |
Methods for treating priapism
A method for treating priapism in a mammal by administration of a botulinum toxin.
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6773897 |
Method of predicting the clinical response to chemotherapeutic treatment with alkylating agents
The present invention provides methods relating to chemotherapeutic treatment of a cell proliferative disorder. In particular, a method is provided for predicting the clinical response to certain...
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6753158 |
Assays, agents, therapy and diagnosis relating to modulation of cellular DNA repair activity
A yeast homologue of mammalian DNA ligase IV is provided and a role for DNA ligase IV established in the Ku-associated DNA repair pathway. Additionally interactions between DNA ligase IV and XRCC4,...
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6743424 |
Method for treating hyperthyroidism
A method for treating hypothyroidism by local administration of a neurotoxin, such as a botulinum toxin, to a thyroid, thereby reducing an inhibitory effect upon thyroid hormone secretion. A method...
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6740321 |
Method for treating thyroid disorders with a botulinum toxin
A method for treating hypothyroidism by local administration of a neurotoxin, such as a botulinum toxin, to a thyroid, thereby reducing an inhibitory effect upon thyroid hormone secretion. A method...
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6719986 |
Hyaluronate lyase used for promoting penetration in topical agents
The invention relates to an agent for treating skin diseases and/or functional disorders of the skin on the basis of different medicaments and/or auxiliary substances through promotion of...
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6716427 |
Method for treating hypocalcemia
A method for treating hypothyroidism by local administration of a neurotoxin, such as a botulinum toxin, to a thyroid, thereby reducing an inhibitory effect upon thyroid hormone secretion. A method...
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6706508 |
Ornithine carbamoyltransferase
The invention provides ornithine carbamoyltransferase polypeptides and DNA (RNA) encoding ornithine carbamoyltransferase polypeptides and methods for producing such polypeptides by recombinant...
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6699469 |
Materials and methods for treating or preventing oxalate-related disease
This invention provides materials and procedures for the delivery of selected strains of bacteria and/or oxalate-degrading enzymes to the intestinal tracts of persons and/or domestic or zoological...
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6685938 |
Methods and compositions useful for modulation of angiogenesis and vascular permeability using SRC or Yes tyrosine kinases
The present invention describes methods for modulating vascular permeability (VP) in tissues using Src or modified Src protein, Yes protein or modified Yes protein, or mixtures thereof, and nucleic...
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6673586 |
Steroid hormone receptor interacting protein kinase
The present invention features a novel p21-activated kinase that interacts with steroid hormone receptors, the steroid hormone receptor interacting p21-activated kinase (PAK SI ). In general, the...
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6664085 |
Isolated human calcium/calmodulin (CaMk) dependent kinase proteins
The present invention provides amino acid sequences of peptides that are encoded by genes within the human genome, the kinase peptides of the present invention. The present invention specifically...
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6649362 |
Screening method for an agent having an effect on a sphingosine kinase signaling pathway
A screening method for identifying a therapeutic candidate for a coronary heart disease or an inflammatory condition is disclosed. The screening method tests for the presence or absence of an...
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6638526 |
Polypeptides conjugated to copolymers of ethylene oxide and propylene oxide to reduce allergenicity
A polypeptide-polymer conjugate is prepared having one or more polymers covalently bound to a polypeptide. The polymer has the general formula; EO X PO Y wherein EO is ethylene oxide, PO is...
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6635247 |
Hypoparathyroid therapy
A method for treating hypoparathyroidism and/or hypocalcemia by local administration of a neurotoxin, such as a botulinum toxin, to a parathyroid gland, thereby reducing an inhibitory effect upon...
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6632430 |
Modulators of methylation for control of bacterial virulence
Compositions and methods which ameliorate the virulence of bacterial infection are described wherein the active ingredient modulates transmethylation reactions in bacterial cells. Particularly...
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6630319 |
Thermostable DNA polymerase
The present invention relates to an enzyme which has the properties of thermostability, DNA polymerase activity and proof-reading, said properties being derived from at least two different sources,...
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6620608 |
Isolated human synthase proteins
The present invention provides amino acid sequences of peptides that are encoded by genes within the human genome, the enzyme peptides of the present invention. The present invention specifically...
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6602526 |
Oral compositions containing lotus
Oral compositions of extract of the Lotus (Nelumbo) as an active anti-aging agent in a suitable carrier or vehicle, along with methods of treatment to reduce signs of aging such loss of elasticity,...
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6585970 |
Method for treating hypothyroidism
A method for treating hypothyroidism by local administration of a neurotoxin, such as a botulinum toxin, to a thyroid, thereby reducing an inhibitory effect upon thyroid hormone secretion. A method...
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6562606 |
Methods and compositions for disrupting the epithelial barrier function
A method for disrupting epithelial barrier function in a host in need of the topical administration of a physiologically active substance which comprises applying to the epithelium of the host,...
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6548060 |
Anti-apoptotic use of human glutaminyl-tRNA synthetase with two consecutive pro-apoptotic mediators
Aminoacyl-tRNA synthetases are the enzymes catalyzing ligation of their cognate amino acids and tRNAs. Human glutaminyl-tRNA synthetase (QRS) consists of the unique N-terminal extension (236 aa)...
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6544515 |
Acceleration of the rate of digestion of a protein
The invention thus relates to a method for accelerating the rate of digestion of a protein matter, in which a protein matter is treated with transglutaminase, and it is mixed with anionic...
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6541606 |
Stabilized protein crystals formulations containing them and methods of making them
This invention relates to methods for the stabilization, storage and delivery of biologically active macromolecules, such as proteins, peptides and nucleic acids. In particular, this invention...
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6539309 |
Crystallizable farnesyl protein transferase compositions, crystals thereby obtained, and methods for use
The present invention relates to compositions and crystals of farnesyl protein transferase and farnesyl protein transferase in complex with substrates and inhibitors. Also disclosed are...
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6535820 |
Crystalline farnesyl protein transferase compositions and methods for use
The present invention relates to crystalline compositions comprising farnesyl protein transferase-like polypeptides in complex with substrates and inhibitors. Also disclosed are crystallization...
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6528637 |
Fatty acid synthase mRNA binding protein
Disclosed is a 178 kDa glucose-inducible human fatty acid synthase (FAS) mRNA binding protein which has been purified to homogeneity and its binding element characterized. This large phosphoprotein...
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6524832 |
DNA damaging agents in combination with tyrosine kinase inhibitors
The present invention relates to the signalling pathways connecting DNA damage, such as that induced by ionizing radiation or alkylating agents, and phosphorylation by tyrosine kinases.
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6524580 |
Method for treating thyroid disorders
A method for treating hypothyroidism by local administration of a neurotoxin, such as a botulinum toxin, to a thyroid, thereby reducing an inhibitory effect upon thyroid hormone secretion. A method...
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6524579 |
Human RNA binding process
The invention provides human RNA binding proteins (RNABP) and polynucleotides which identify and encode RNABP. The invention also provides expression vectors, host cells, antibodies, agonists, and...
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6524838 |
Human peptidyl-prolyl isomerases
The invention provides human peptidyl-prolyl isomerases (HPPIP) and polynucleotides which identify and encode HPPIP. The invention also provides expression vectors, host cells, antibodies,...
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6517834 |
Purified telomerase
This invention provides purified telomerase and methods of purifying it. The methods involve the use of several sequential steps, including the use of matrices that bind molecules bearing negative...
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6485941 |
Inhibition of the carboxyltransferase component of acetyl-CoA carboxylase, and the use of such inhibition in anti-cancer and anti-lipogenic therapies
A method is disclosed for inhibiting carboxyltransferase with bisubstrate analogs. One such analog has been shown to inhibit the carboxyltransferase component of E. coli acetyl-CoA carboxylase....
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6475767 |
Process for producing L-methionine &ggr -lyase crystals
A process for production of L-methionine γ-lyase crystals by using polyethylene glycol, characterized by comprising the first step of warming a solution containing L-methionine γ-lyase before or...
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6471959 |
Human transferase
The invention provides three human transferases (HUTRAN) and polynucleotides which identify and encode HUTRAN. The invention also provides expression vectors, host cells, antibodies, agonists, and...
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6458572 |
Phosphatidylglycerophosphate synthase from Staphylococcus aureus
The invention provides Phosphatidylglycerophosphate Synthase polypeptides from Staphylococcus aureus (“pgsA polypeptides”). Also provided are methods for utilizing pgsA polypeptides to screen...
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6451579 |
Regulated expression of recombinant proteins using RNA viruses
The present invention describes cells and constructs for a regulated viral (e.g. alphavirus) expression system, where gene expression is controlled by controlling expression of replicases or...
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6440417 |
Antibodies to argatroban derivatives and their use in therapeutic and diagnostic treatments
Antibodies to a therapeutic agent and its derivatives and conjugates are disclosed, including antibodies to argatroban and its derivatives and conjugates. The antibodies are useful as reagents in...
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