|
Match
|
Document |
Document Title |
|
|
7341720 |
Targeting of glycoprotein therapeutics
Methods of making ligand-decorated polymer conjugates of therapeutic glycoproteins are described. Improved targeting of glycoproteins to specific tissues is achieved by masking the natural...
|
|
|
7329516 |
Methods for increasing protein polyethylene glycol (PEG) conjugation
The present invention relates to highly conjugated proteins and methods for making such proteins. In particular, the present invention relates to methods for linking additional sites to a protein...
|
|
|
7323452 |
Method for the accelerated in vivo removal of ethanol
A method for accelerating the process of removing ethanol from the blood through the use of certain additives that accelerate the metabolic oxidation of ethanol, and others which in addition act as...
|
|
|
7211281 |
Method for improving the activity of enzymes
A method for improving the performance of enzymes used in animal feeds by the use of surfactants. Lecithin and/or lysolecithin is added to an animal feed including an exogenous enzyme to boost the...
|
|
|
RE39497 |
Storage of materials
A material or mixture of materials which is not itself storage stable is rendered storage stable by incorporation into a water-soluble or swellable glassy or rubbery composition which can then be...
|
|
|
7172760 |
Compositions and methods for prevention and treatment of uncontrolled formation of intravascular fibrin clots
Compositions and methods for prevention and treatment of uncontrolled formation of intravascular fibrin clots are provided wherein fibrinolytic or anticoagulant drugs are biocompatibly coupled to...
|
|
|
7169590 |
Method of stabilizing reduced coenzyme Q10 and method of acidic crystallization
The present invention relates to a method of efficiently producing reduced coenzyme Q 10 having excellent qualities which is useful as an ingredient in foods, functional nutritive foods, specific...
|
|
|
7169589 |
Silicatein-mediated synthesis of amorphous silicates and siloxanes and use thereof
Silicatein is an enzyme of silicate-forming organisms used for the synthesis of their silicate scaffold. The present invention relates to the use of highly-expressed and highly active recombinant...
|
|
|
7157556 |
Deglycosylated kringle 1-3 region fragments of plasminogen and methods of use
Disclosed are deglycosylated fragments of a kringle 1-3 region of plasminogen, nucleotides encoding deglycosylated kringle 1-3 region proteins and antibodies specific for deglycosylated kringle 1-3...
|
|
|
7157416 |
Stabilization of enzymes
Enzyme-containing formulations having improved stability and enzymatic activity in liquid medium, comprising one or more protease enzymes produced from any Bacillus bacteria, at least about 5%...
|
|
|
7150870 |
Anti-tumor agent
The invention prevents or treats a tumor, inhibiting tumor growth and malignant progression by providing an antitumor agent containing a treated SOD as the active ingredient, especially a melon SOD...
|
|
|
7087399 |
β-secretase and modulation of β-secretase activity
The invention concerns a novel β-secretase, a method of partially purifying this novel β-secretase, and its use in assays to screen for potential drug candidates against Alzheimer's disease and...
|
|
|
7041287 |
Compositions and methods for selective dissolution of nascent intravascular blood clots
Compositions and methods for prevention and treatment of uncontrolled formation of intravascular fibrin clots, which are capable of selective dissolution of pathological nascent clots formed...
|
|
|
7037894 |
Stabilized proteins
Isolated polypeptides or polypeptide chains are modified by di-tyrosine cross-linking such that the retain at least one functional activity. In one embodiment, the isolated polypeptide or...
|
|
|
7005282 |
Enzymes coated with ionic liquid
Disclosed is an ionic liquid-coated enzyme, wherein the ionic liquid is an organic salt which presents as a liquid phase at a temperature of about 150° C. or below. The ionic liquid-coated enzyme...
|
|
|
6906106 |
Compositions for the skin comprising fibers and ubiquinones and methods of using the same
The present invention relates to a composition for topical application on the skin, comprising fibers and at least one or two or more compounds selected from the group of the ubiquinones and...
|
|
|
6894025 |
Biologically active molecules having thiol moiety conjugated to polymers containing ethyl sulfone moiety
A poly(ethylene glycol) derivative is disclosed that is activated with a sulfone moiety for selective attachment to thiol moieties on molecules and surfaces. The activated PEG is water soluble,...
|
|
|
6884416 |
Stable PQQ-dependent glucose dehydrogenase composition
The present invention provides a stable lyophilized PQQ-dependent glucose dehydrogenase composition comprising a PQQ-dependent glucose dehydrogenase together with (i) at least one compound selected...
|
|
|
6833362 |
Method and composition for the accelerated in vivo removal of ethanol
A composition for accelerating the disposal of ethanol from bodily fluid. Certain additives can accelerate the metabolic oxidation of ethanol, and others in addition act as catalysts or...
|
|
|
6808706 |
Method for keeping the quality of aqueous parenteral solution of thrombomodulin in storage and distribution
A method for keeping the quality of an aqueous parenteral solution of thrombomodulin which is not in a frozen or freeze-dried state but in a liquid form in storage and distribution, characterized...
|
|
|
6783968 |
Methods for sterilizing preparations of glycosidases
Methods are disclosed for sterilizing preparations of glycosidases to reduce the level therein of one or more active biological contaminants or pathogens, such as viruses, bacteria (including...
|
|
|
6726925 |
Temperature-sensitive liposomal formulation
A liposome contains an active agent and has a gel-phase lipid bilayer membrane comprising phospholipid and a surface active agent. The phospholipids are the primary lipid source for the lipid...
|
|
|
6709650 |
Spray-dried microparticles and their use as therapeutic vehicles
Microparticles of a water-soluble material, which are smooth and spherical, and at least 90% of which have a mass median particle size of 1 to 10 μm, and which carry a therapeutic or diagnostic...
|
|
|
6689755 |
Method of stabilizing biologically active substances
The present invention relates to a rapid and readily reproducible process for stabilizing biologically active substances by combining the biologically active substance witha a stabilizingmixture...
|
|
|
6676963 |
Ligand-targeted emulsions carrying bioactive agents
A composition for use in delivering a bioactive agent to targeted tissues or cells comprises: (a) a site-specific targeting ligand; (b) a lipid encapsulated oil in water emulsion; and (c) a...
|
|
|
6613322 |
Method for treating a subject suffering from conditions associated with an extracellular zinc sphingomyelinase
The present invention provides for a method for treating a subject suffering from a condition associated with an extracellular zinc sphingomyelinase activity which comprises administering to the...
|
|
|
6586524 |
Cellular targeting poly(ethylene glycol)-grafted polymeric gene carrier
The present invention relates to cationic polymeric conjugates and methods of preparing and using them as gene carriers. The cationic polymeric conjugates comprise a poly(ethylene glycol) (PEG)...
|
|
|
6579707 |
Stabilization of enzymes during freezing
A method for stabilizing an enzyme during freezing, wherein the enzyme is in a zwitterionic buffer solution. The zwitterionic buffer is able to maintain the activity of the enzyme during freezing...
|
|
|
6565842 |
Crosslinkable polypeptide compositions
In accordance with the present invention, there are provided rapidly crosslinkable polypeptides which are obtained upon introduction of unsaturated group(s) into the polypeptide via linkage to...
|
|
|
6552170 |
PEGylation reagents and compounds formed therewith
Compounds are disclosed having the general formula R 1 -X-R 2 , wherein R 1 and R 2 are biologically active groups, at least one of which is polypeptidic. X is a non-peptidic polymeric group. R 1...
|
|
|
6548556 |
Stable enzymatic wound debrider
This invention relates to an enzymatic anhydrous hydrophilic wound debrider that uses in combination a proteolytic enzyme and an anhydrous hydrophilic poloxamer carrier.
|
|
|
6534282 |
Detection of hypertension using immunoreactive metabolic products
A method to assess hypertension by measuring the amount of free and conjugated hydroxyeicosatrienoic acids (DHETs) and metabolites of DHETs, which are metabolites of arachidonic acid (AA)...
|
|
|
6531125 |
Antiviral ricin-like proteins
The present invention provides a protein having an A chain of a ricin-like toxin, a B chain of a ricin-like toxin and a heterologous linker amino acid sequence, linking the A and B chains. The...
|
|
|
6503506 |
Nutrient therapy for immuno-compromised patients
A nutritional supplement is taught for treating chronic debilitating diseases such as HIV/AIDS to overcome conditions of oxidative stress, decreased lean muscle mass, decreased energy production...
|
|
|
6500426 |
Carbohydrate-based enzyme-containing granules for use in animal feed
Enzyme-containing granules for manufacturing animal feed compositions are prepared using a carrier containing at least about 15% (w/w) carbohydrate such as starch and less than 5% (w/w) protein. A...
|
|
|
6436652 |
Method of detecting a pathogen using a virus
A bacteriophage linked to an enzyme can replace an antibody in a system for detecting the presence of a bacteria in a sample. Specifically Brucella abortus (a pathogen which causes brucellosis in...
|
|
|
6426086 |
pH-sensitive, serum-stable liposomes
This invention relates to the field of liposomes. In particular, this invention provides novel liposomes that are pH-sensitive, yet are also stable in serum. The liposomes are complexed with a...
|
|
|
6410017 |
Personal care compositions containing active proteins tethered to a water insoluble substrate
The present invention relates to personal care compositions comprising a water insoluble substrate, a plurality of active proteins, and a binding means, comprising a polymeric tether, permanently...
|
|
|
6406897 |
Modified protein, method for preparation thereof and compositions for external application containing the modified protein
A protein modified to improve its stability, said modified protein being coupled to a β-1,3-glucan branched with β-1,6-linkage is provided. A method for the production thereof and a cosmetic or...
|
|
|
6403117 |
Archaesomes, archaeosomes containing coenzyme Q10 and other types of liposomes containing coenzyme Q10 adjuvants and as delivery vehicles
Novel archaeosome compositions and their use in vaccine formulations as adjuvants and/or delivery systems, to enhance the immune response to immunogens in an animal such as a human, are described....
|
|
|
6399059 |
Thermally stable enzyme composition and method of preparing the same
A thermally stable enzyme composition contains an enzyme, and a heat stabilizer including a phospholipid and an oil-soluble vitamin. The enzyme composition can be prepared in the form of a powder...
|
|
|
6368619 |
Hydrophobic preparations of hydrophilic species and process for their preparation
Single phase preparations of hydrophilic species, in particular macromolecular compounds such as proteins or glycoproteins in a hydrophobic solvent such as an oil can be obtained by preparing a...
|
|
|
6355267 |
Liposome preparation and material encapsulation method
The present invention relates to a method of producing liposomes useful for encapsulating and delivering a wide variety of biologically active materials. The invention provides liposomes and a...
|
|
|
6348042 |
Bioactive shunt
The present invention relates to a shunt, and a method for treating catheters, more particularly shunts, wherein the catheter is made of a biocompatible material and adapted at least for insertion...
|
|
|
6322810 |
Materials and methods for making improved micelle compositions
Provided are methods for preparing improved biologically active micelle and crystalline products comprising a biologically active amphipathic compound in association with a micelle or crystalline...
|
|
|
6319498 |
Modulators of amyloid aggregation
Compounds that modulate the aggregation of amyloidogenic proteins or peptides are disclosed. The modulators of the invention can promote amyloid aggregation or, more preferably, can inhibit natural...
|
|
|
6312687 |
Stabilized lactoperoxidase and glucose oxidase concentrate
A stabilized aqueous enzyme concentrate composition which comprises: a) 1000 to 1800 units/ml of lactoperoxidase; b) 1500 to 2750 units/ml of glucose oxidase; c) 10 to 20% w/v of an alkali...
|
|
|
6309633 |
Amphiphilic drug-oligomer conjugates with hydroyzable lipophile components and methods for making and using the same
The invention provides a drug-oligomer conjugate having the following general formula: ##STR1## wherein D is a therapeutic drug moiety; H and H' are each a hydrophilic moiety, independently...
|
|
|
6303119 |
Personal care compositions containing subtilisin enzymes bound to water insoluble substrates
The present invention relates to personal care compositions comprising a water insoluble substrate, a plurality of Protease G enzymes, and a binding means, permanently attaching each of the enzymes...
|
|
|
6296870 |
Liposomes containing active agents
Liposomes formulations are designed to maximize the amount of poorly water-soluble active agent that can be carried by the liposome. Liposomes containing active agent in the lipid bilayer of the...
|