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9034318 Chemically modified cystathionine beta-synthase enzyme for treatment of homocystinuria  
The invention provides reagents and methods for enzyme replacement therapy using chemically modified species of human cystathionine β-synthase (CBS) to treat homocystinuria and other related...
9011845 Methods for treatment of inflammatory and infectious viral diseases  
Methods and therapeutic treatments of diseases such as viral infections are provided including applying peg-Arginase I. Methods are provided that treat inflammation mediated diseases with...
8999320 Nanoscale bound bilayers, methods of use and production  
Methods for rapidly obtaining a nanoscale apolipoprotein bound phospholipid bilayer (NABB) associated with at least one membrane protein are provided. Also disclosed are methods for rapidly...
8992996 Cosmetic  
A composition is provided that includes a fish spawn protein isolate. A natural product extract is also present that includes unsaturated fatty acids and sterols. An emulsifier is provided to form...
8961958 High concentration self-microemulsifying coenzyme Q10 preparations for nutritional use  
A method and composition are presented for enhancing the dissolution and bioavailable properties of CoQ10 nutritional supplements and/or therapeutic agents for a human being and other mammals. The...
8945625 Regulated delivery systems for inner ear drug application and uses thereof  
The invention relates to a controlled release delivery compositions and methods of using them for pathologies associated with Otorhinolaryngology and Head and Neck. Specifically, the invention...
8940687 Antimicrobial angiogenin complexes (ANGex) and uses thereof  
Antimicrobial compositions based upon stabilized angiogenin compositions also contain osteopontin and antimicrobial proteins such as lactoperoxidase (LPO), myeloperoxidase (MPO), salivary...
8920807 Vault complexes for cytokine delivery  
The invention relates to compositions of vault complexes containing recombinant cytokine fusion proteins that include a cytokine and a vault targeting domain, and methods of using the vault...
8920801 Methods and compositions for increasing arylsulfatase A activity in the CNS  
Provided herein are methods and compositions for treating a subject suffering from a deficiency in arylsulfatase A in the CNS. The methods include systemic administration of a bifunctional fusion...
8906379 Targeting of glycoprotein therapeutics  
Methods of making ligand-decorated polymer conjugates of therapeutic glycoproteins are described. Improved targeting of glycoproteins to specific tissues is achieved by masking the natural...
8894993 Mitochondria-targeted antioxidants  
The present invention relates to a pharmaceutical or veterinary or nutritional or personal care composition comprising coenzyme Q10 (CoQ10), reduced CoQ10, or mixtures thereof and oxygenated...
8889398 Composition for inactivating an enveloped virus  
The present invention relates generally to the field of prevention of diseases caused by enveloped viruses. More particularly, this invention concerns a composition for inactivating an enveloped...
8883140 Stabilized liquid tenside preparation comprising enzymes  
A hydrolytic enzyme is stabilized in a liquid surfactant preparation using a component that stabilizes the hydrolytic enzyme and encompasses an oligoaminobiphenyl oligocarboxylic acid.
8883141 Stabilized liquid tenside preparation comprising enzymes  
A hydrolytic enzyme is stabilized in a liquid surfactant preparation using a component that stabilizes the hydrolytic enzyme and includes a phenylalkyldicarboxylic acid.
8877183 Methods for treatment of ocular diseases  
Methods and therapeutic treatments of ocular diseases are provided including applying peg-Arginase I to affected eyes. Methods are provided that simultaneously treat inflammation and...
8846603 NPP1 fusion proteins  
The present invention provides a novel fusion polypeptide containing a catalytic portion of NPP1 fused to a targeting moiety, nucleic acids encoding the fusion polypeptide, a vector containing the...
8834865 Delivery system for co-formulated enzyme and substrate  
The invention provides methods, compositions, systems, and kits that include an enzyme/substrate co-delivery system. The liquid delivery system includes at least one enzyme encapsulated in a...
8834866 Methods and compositions for treatment of myotubular myopathy using chimeric polypeptides comprising myotubularin 1(MTM1) polypeptides  
The present invention provides chimeric polypeptides comprising myotubularin 1 (MTMI) polypeptides and an internalising moiety, wherein, the moiety can be an antibody, and is preferably monoclonal...
8802087 Pharmaceutical compositions of lipase-containing products, in particular of pancreation  
Orally administrable pharmaceutical compositions of lipase-containing products, particularly pancreatin and pancreatin-containing products, or of enzyme products which contain at least one lipase...
8795734 Hydrophobic nanotubes and nanoparticles as transporters for the delivery of drugs into cells  
Methods and materials for delivering biologically active molecules to cells in vitro or in vivo are provided. The methods and materials use carbon nanotubes or other hydrophobic particles, tubes...
8790639 Enhanced antimicrobial lytic activity of a chimeric Ply187 endolysin  
Peptidoglycan hydrolases are an effective new source of antimicrobials. A chimeric fusion protein of the Ply187 endopeptidase domain and LysK SH3b cell wall binding domain is a potent agent...
8785595 Functionalising reagents and their uses  
Reagents and methods for functionalizing polypeptides with moieties poly (alkylene glycol) molecules and glycan groups are disclosed that are based on a functionalizing reagent which comprises a...
8778336 Stabilized proteases that have been immobilized and further crosslinked for use in skin care  
Disclosed is an invention which relates to synthesizing immobilized and crosslinked proteases derived from plants for use as skin care agents. The resulting stabilized protease will minimally...
8729022 Stabilised solid compositions of factor VII polypeptides  
The invention relates to chemically as well as physically stable compositions comprising Factor VII or a Factor VII-related polypeptide such that these compositions can be stored, handled and used...
8715661 Methods and compositions for increasing arylsulfatase A activity in the CNS  
Provided herein are methods and compositions for treating a subject suffering from a deficiency in arylsulfatase A in the CNS. The methods include systemic administration of a bifunctional fusion...
8697844 Method of purifying pegylated proteins  
The invention relates to a method of purifying PEGylated proteins by removing impurities from samples containing PEGylated proteins, in particular, but not exclusively vitamin K-dependent blood...
8647620 Chimeric factor VII molecules  
The present invention relates to chimeric Factor VII polypeptides and methods of using the same.
8637007 Factor VIIa-polysialic acid conjugate having prolonged in vivo half-life  
The present invention relates to a proteinaceous construct comprising plasmatic or recombinant factor VIIa (FVIIa) or biologically active derivatives thereof, which are bound to a carbohydrate...
8632770 Glycopegylated factor IX  
The present invention provides conjugates between Factor IX and PEG moieties. The conjugates are linked via an intact glycosyl linking group interposed between and covalently attached to the...
8597641 Instant enzyme formulations for animal nutrition  
The invention relates to a process for preparing an instant enzyme formulation; instant enzyme formulations obtainable by this process and feedstuff compositions prepared using instant enzyme...
8580250 Botulinum toxin compositions  
A high potency botulinum toxin pharmaceutical composition comprising two excipients (such as albumin and sodium chloride) in a weight to weight ratio of between about 1 and about 100.
8574569 Stabilized protease composition  
A composition is provided, which comprises a serine protease; a reversible inhibitor of said serine protease; and a stabilizing agent M having the formula I: Also provided are uses of the...
8568708 Tumor-specific delivery of therapeutic agents via liposomase  
Clostridium novyi is an obligate anaerobe that can infect hypoxic regions within experimental tumors. We found that mice bearing large, established tumors were often cured when treated with C....
8545837 Methods and compositions for CNS delivery of iduronate-2-sulfatase  
The present invention provides, among other things, compositions and methods for CNS delivery of lysosomal enzymes for effective treatment of lysosomal storage diseases. In some embodiments, the...
8518409 System for selective cell treatment using ideotypically modulated pharmacoeffectors  
In a method embodiment, a method includes introducing a plurality of Ideotypically Modulated Pharmacoeffectors (IMP) into a population of cells. Each IMP may include a detection domain and an...
8486399 Methods and compositions for increasing arylsulfatase A activity in the CNS  
Provided herein are methods and compositions for treating a subject suffering from a deficiency in arylsulfatase A in the CNS. The methods include systemic administration of a bifunctional fusion...
8486388 Protein formulation  
An aqueous composition which comprises a protein or other biological molecule and also (i) optionally comprises one or more metal ions at a concentration of 0.01 to 20 mM; (ii) comprises...
8481040 Carrier for targeting nerve cells  
The present invention relates to a transport protein which can be obtained by modifying the heavy chain of the neurotoxin formed by Clostridium botulinum wherein (i) the protein binds specifically...
8465734 Methods for increasing protein polyethylene glycol (PEG) conjugation  
The present invention relates to highly conjugated proteins and methods for making such proteins. In particular, the present invention relates to methods for linking additional sites to a protein...
8449880 Chemical modification of proteins for their more accurate molecular-weight determination by electrophoresis  
Disclosed herein is a composition and method for sample preparation of proteins for their size separation by electrophoresis, suitable for molecular-weight determination of proteins in the range...
8449979 Molecular aggregate capable of undergoing phase transition by dehydrating condensation and method of phase transition thereof  
Provided is a bilayer membrane vesicle capable of undergoing a phase transition. The bilayer membrane vesicle includes: (a) a fatty acid salt having 6 to 20 carbon atoms; (b) an alcohol or an...
8444963 Tumor specific delivery of therapeutic agents via liposomase  
Clostridium novyi is an obligate anaerobe that can infect hypoxic regions within experimental tumors. We found that mice bearing large, established tumors were often cured when treated with C....
8440183 Angiogenin complexes (ANGex) with lipid-based substrates and uses thereof  
Stabilized angiogenin compositions and methods of preparing stabilized angiogenin compositions by immobilization on a lipid-based substrate, such as a phospholipid or Coenzyme-Q10, are disclosed.
8431121 Specifically targeted catalytic antagonists and uses thereof  
This invention provides chimeric molecules that are catalytic antagonists of a target molecule. The catalytic antagonists of this invention preferably comprise a targeting moiety attached to an...
8426220 Utilization of shield effect for dopamine detection and reagent development  
The present invention relates to fusion proteins of monoamine oxidase B (MAO B)-green fluorescent protein (GFP) and utilizes “shield effect” to detect the dopamine under physiological condition,...
8394372 Stabilized protease composition  
A composition is provided, which comprises a serine protease; a reversible inhibitor of said serine protease; and a stabilizing agent M having the formula I: Also provided are uses of the...
8383102 Fusion of peptidoglycan hydrolase enzymes to a protein transduction domain allows eradication of both extracellular and intracellular gram positive pathogens  
Lysostaphin is a bacteriocin secreted by S. simulans to kill S. aureus, and has been shown to also be a potent antimicrobial for many antibiotic-resistant strains of S. aureus. By adding a ˜13...
8383380 Segmented polymers and their conjugates  
Segmented water soluble polymers, containing a higher molecular weight segment linked to a lower molecular weight segment, are described. In one embodiment, the polymer segments are poly(ethylene...
8361442 Oxime conjugates and methods for their formation and use  
The present invention relates to biodegradable biocompatible polyketals, methods for their preparation, and methods for treating animals by administration of biodegradable biocompatible...
8349318 Use of specifically engineered enzymes to enhance the efficacy of prodrugs  
The invention provides methods for enhancing efficiency of prodrugs by specifically engineered enzymes with altered or enhanced activity and broader substrate specificity towards nucleoside...
Matches 1 - 50 out of 394 1 2 3 4 5 6 7 8 >