|
Match
|
Document |
Document Title |
|
|
7390784 |
Administering bifunctional molecules containing a drug moiety and presenter protein ligand for therapy
Bifunctional molecules and methods for their use in the production of binary complexes in a host are provided. The bifunctional molecule is a conjugate of a drug moiety and a presenter protein...
|
|
|
7386398 |
Hepatitis C Virus NS5B polymerase inhibitor binding pocket
The HCV NS5B polymerase, when complexed with certain inhibitors, adopts a conformation in which the finger loop region defined by amino acid residues 18 to 35 is displaced to expose a binding...
|
|
|
7378090 |
Alleviation of the memory deficits and memory components of psychiatric dysfunctions by altering atypical PKM activity
Methods have been developed for alleviating memory problems or psychiatric dysfunctions that have a memory formation component. These methods are based on the finding that a truncated form of an...
|
|
|
7374874 |
Bacteriophages that infect Bacillus bacteria (Anthrax)
The invention provides bacteriophages that infect Bacillus bacteria, including Bacillus anthracis , and compositions containing the bacteriophages. The invention also provides methods for using...
|
|
|
7374754 |
Use of placental alkaline phosphatase to promote skin cell proliferation
Methods for stimulating proliferation of cells in the epidermis and dermis of mammalian skin are disclosed. The methods comprise the step of administering to an area of the skin a composition...
|
|
|
7371375 |
Protein
A nucleic acid comprising a nucleotide sequence encoding a lysin, which nucleotide sequence comprises the sequence shown in SEQ ID No. 1 or a variant, homologue or derivative thereof. A novel lysin...
|
|
|
7371366 |
GlcNAc phosphotransferase of the lysosomal targeting pathway
The present invention provides nucleotide and amino sequences of the lysosomal targeting pathway enzyme GlcNAc-phosphotransferase, methods of producing and methods of purifying this enzyme.
|
|
|
7355015 |
Matriptase, a serine protease and its applications
The invention is directed to a method of detecting a malignancy or a pre-malignant lesion in breast or other tissue, or a pathologic condition, by detecting the presence of single-chain or...
|
|
|
7351410 |
Treatment of Pompe's disease
The invention provides methods of treating Pompe's disease using human acid alpha glucosidase. A preferred treatment regime comprises administering greater than 10 mg/kg body weight per week to a...
|
|
|
7341720 |
Targeting of glycoprotein therapeutics
Methods of making ligand-decorated polymer conjugates of therapeutic glycoproteins are described. Improved targeting of glycoproteins to specific tissues is achieved by masking the natural...
|
|
|
7335384 |
Nutrient compositions for the treatment and prevention of inflammation and disorders associated therewith
The present disclosure describes a novel composition for the treatment and/or prevention of neurogenic inflammation. Such composition is also useful in the treatment and/or prevention of disease...
|
|
|
7335351 |
Immunotherapeutic methods targeted towards stratum corneum chymotryptic enzyme
The present invention discloses the protease stratum corneum chymotrytic enzyme (SCCE) is specifically over-expressed in ovarian and other malignancies. A number of SCCE peptides can induce immune...
|
|
|
7318917 |
Rapid assays for neurotransmitter transporters
The invention describes the finding that 4-(4-dimethylaminostyrl)-N-methylpyridinium or ASP + is a fluorescent substrate that is transported by several neurotransmitter transporters. Provided are...
|
|
|
RE39941 |
Amelioration of Dupuytren's disease
The cords of Dupuytren's disease are injected with collagenase, the hand is immediately immobilized and maintained immobile for several hours. The cord becomes relaxed or ruptured, relieving the...
|
|
|
7306927 |
Method of inducing immunity against stratum corneum chymotrytic enzyme
The disclosed nucleic acid primer sets, used in combination with quantitative amplification (PCR) of tissue cDNA, can indicate the presence of specific proteases in a tissue sample. The detected...
|
|
|
7297332 |
Protease, a gene therefor and the use thereof
The present invention relates to a protease, and more specifically to a protease derived from Aranicola proteolyticus , a gene coding for said enzyme, a gene expression system for said protease, a...
|
|
|
7273744 |
Heparanase-like polypeptides
The present invention provides a homologue to heparanase which is present in three splice variants.
|
|
|
7273607 |
Health enhancement method
A health enhancement system establishing a health enhancement program through which may be provided a group of natural products, vitamins and minerals, amino acids, herbs and essential oils that...
|
|
|
7273606 |
Solubilized CoQ-10 and carnitine
The present invention is directed to compositions and methods of delivery of CoQ-10 and an amino acid solubilized in monoterpenes. Use of monoterpenes as dissolving agents, greatly effects the...
|
|
|
7270814 |
Odor control compositions and methods
The present invention relates to the use of a carbohydrate oxidase to reduce or prevent malodor. The present invention also relates to a deodorizing composition comprising a carbohydrate oxidase.
|
|
|
7264799 |
Use of heparinases to decrease inflammatory response
Heparinase enzymes can be used as a medical treatment to reduce localized inflammatory responses. Treatment of activated endothelium with heparinase inhibits leukocyte rolling, adhesion and...
|
|
|
7252799 |
Methods for sterilizing preparations containing albumin
Methods are disclosed for sterilizing preparations containing albumin to reduce the level of one or more active biological contaminants or pathogens therein, such as viruses, bacteria (including...
|
|
|
7247441 |
Nucleic acid sequence and protein in addition to polypeptides coding for mannitol dehydrogenases or parts thereof and the production and use thereof in diagnosis and therapy
The invention relates to polypeptides made of mannitol-dehydrogenase of Cladosporium herbarum and Alternaria alternata nucleic acids coding therefor and the use thereof in diagnosis and therapy.
|
|
|
7241742 |
CYP1B1 nucleic acids and methods of use
The present invention provides nucleic acids containing transcriptional units that encode CYP1B1 polypeptides or portions thereof, wherein the transcriptional units lack sequences found in the...
|
|
|
7241442 |
Method for producing proteins suitable for treating lysosomal storage disorders
The present invention is based on the discovery that proteins produced in insect cell cultures are glycosylated in a unique manner that causes them to be selectively imported by cells that express...
|
|
|
7238350 |
Phytase polypeptides
The present invention relates to isolated polypeptides having phytase activity, the corresponding cloned DNA sequences, a process for preparing such polypeptides, and the use thereof for a number...
|
|
|
7235237 |
Methods of treating vascular diseases characterized by nitric oxide insufficiency
The present invention provides methods of treating or preventing vascular diseases caused by nitric oxide (NO) insufficiency. The methods encompass administering a composition comprising an...
|
|
|
7232576 |
Throat lozenge for the treatment of Streptococcus Group A
A lozenge for the treatment of Streptococcus Group A infections of the mouth, throat, and nasal passage is disclosed which comprises a lytic enzyme composition specific for Streptococcus Group...
|
|
|
7229959 |
Supplemented fibrin matrix delivery systems
This invention provides supplemented and unsupplemented tissue sealants as well as methods for their production and use thereof. Disclosed are tissue sealants supplemented with at least one...
|
|
|
7217294 |
Acellular matrix implants for treatment of articular cartilage, bone or osteochondral defects and injuries and method for use thereof
An acellular matrix implant for treatment of defects and injuries of articular cartilage, bone or osteochondral bone and a method for treatment of injured, damaged, diseased or aged articular...
|
|
|
7208301 |
Method for producing 6-0-α-D-glucopyranosyl-D-sorbitol
This invention concerns a method for enzymatic preparation of 6-O-α-D-glucopyranosyl-D-sorbitol (1,6-GPS) from isomaltulose. It is specified that the isomaltulose is put into an aqueous reaction...
|
|
|
7204980 |
Methods for inhibiting viral replication in vivo
The present invention is directed to methods of modulating viral replication in vivo comprising administering to an individual a therapeutically or prophylactically effective amount of a...
|
|
|
7198931 |
Phosphorylated glyoxalase I and its use
The present invention relates to a phosphorylated form of mammalian glyoxalase I. The present invention relates further to the use of phosphorylated mammalian glyoxalase I to modulate...
|
|
|
7189546 |
Polypeptide, cDNA encoding the same, and use of them
A new polypeptide prepared from human library by the SST method and a process for preparation of it; a cDNA encoding the polypeptide; a fragment selectively hybridizing with the sequence of the...
|
|
|
7189392 |
Injectable carrier formulations of hyaluronic acid derivatives for delivery of osteogenic proteins
An injectable formulation is disclosed for delivery of osteogenic proteins. The formulation comprises a pharmaceutically acceptable admixture of an osteogenic protein; and formulations comprising...
|
|
|
7182945 |
Anti-inflammatory peptides derived from C-reactive protein
A peptide corresponding to positions 62–71 of the sequence of human C-reactive protein (CRP) of the formula: Glu 62 -Ile-Leu-Ile-Phe-Trp-Ser-Lys-Asp-Ile 71 and modifications thereof obtained by...
|
|
|
7172751 |
D-amino acid peptides
The present invention provides compounds of the formula X—R 1 -D-[Dpr, Orn or Lys](A)-R 2 (Z)-D-[Dpr, Orn or Lys](B)—R 3 (Y)—NR 4 R 5 ; or R 1 (X)-D-[Dpr, Orn or Lys](A)-R 2 (Z)-D-[Dpr, Orn...
|
|
|
7169408 |
Bandage composition containing phage associated lytic enzymes useful for treating dermatological infections
The present invention discloses a composition for dermatological infections by the use of a lytic enzyme in a carrier suitable for topical application to dermal tissues. The method for the...
|
|
|
7169405 |
Methods and devices for the treatment of intervertebral discs
Methods for treating at least one condition of an intervertebral disc (e.g. protrusion, hemiation, discogenic pain, dehydration, or degeneration) in a patient in need thereof are provided. The...
|
|
|
7169399 |
Non-toxic double mutant forms of pertussis toxin as adjuvants
The invention relates to the use of an antigen which is a non-toxic double mutant form of pertussis toxin for the manufacture of a vaccine composition for intranasal administration to induce an...
|
|
|
7166281 |
Pharmaceutical composition and method for relieving itch, pain and swelling resulting from insect bites and stings
A pharmaceutical composition for relieving the itch, pain, and swelling resulting from insect bites and stings, and methods for producing and using the composition. The method preferably comprises...
|
|
|
7157556 |
Deglycosylated kringle 1-3 region fragments of plasminogen and methods of use
Disclosed are deglycosylated fragments of a kringle 1-3 region of plasminogen, nucleotides encoding deglycosylated kringle 1-3 region proteins and antibodies specific for deglycosylated kringle 1-3...
|
|
|
7157416 |
Stabilization of enzymes
Enzyme-containing formulations having improved stability and enzymatic activity in liquid medium, comprising one or more protease enzymes produced from any Bacillus bacteria, at least about 5%...
|
|
|
7157082 |
Cardioprotective therapies based on enzymatic elimination of lipid peroxides by allene oxide synthase
The present invention relates to methods and compositions related to the use of enzymes of the allene oxide synthase family for reducing myocardial ischemia reperfusion injury associated with...
|
|
|
7157081 |
Uses of aldose-1-epimerase (mutarotase) for diagnosis and therapy of inflammatory diseases and sepsis
Uses of aldose 1-epimerase (SEQ ID NO:3) from body fluids or body tissues in human and veterinary medicine as a marker peptide for diagnosis, for prognosis of the course and for monitoring of the...
|
|
|
7153504 |
Stabilized pancreas product
The present invention provides stabilized pancreas products useful, for example, as an animal feed additives. The invention also provides for feed additives and feed rations comprising a stabilized...
|
|
|
7150985 |
Bacteriolytic complex, method for producing said complex and strain for carrying out said method
The inventions relate to the field of medicine, veterinary and biotechnology and may be used for production of a drug for medical and veterinary purposes. A bacteriolytic complex, produced by the...
|
|
|
7147855 |
GIPs, a family of polypeptides with transcription factor activity that interact with goodpasture antigen binding protein
The present invention provides isolated GPBP-interacting 90 and 130 kDa polypeptides, and portions thereof (GIP90/130 polypeptides), antibodies to the GIP90/130 polypeptides, and pharmaceutical...
|
|
|
7141241 |
Use of bacterial phage associated lysing enzymes for treating upper respiratory illnesses
The present invention relates to an oral delivery system containing a bacteriophage associated lysin enzyme for the treatment of [ Streptococcus pneumoniae and] Hemophilus influenzae sinus/nasal...
|
|
|
7138149 |
Dietary supplements and methods for treating pain and inflammation
The invention provides compositions such as dietary supplements. Such compositions can be used to reduce pain, inflammation, stiffness, and/or discomfort associated with inflammatory conditions...
|