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8163275 |
Multi-lineage progenitor cells
Fetal blood multi-lineage progenitor cells that are capable of a wide spectrum of transdifferentiation are described.
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8153120 |
Methods for inducing a natural killer (NK) cell-mediated immune response and for increasing NK cell activity
The present invention relates to the discovery of novel methods of inducing a natural killer (NK) cell-mediated immune response and increasing NK activity in a mammal for the treatment of tumors...
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8142772 |
Attack of tumor cells with missing, low or aberrant MHC expression by combining non MHC-restricted T-cells/NK-cells and MHC-restricted cells
This invention is directed to therapeutic compositions containing non-MHC-restricted Tcells/NK-cells in combination with MHC-restricted T-cells and especially to therapeutic compositions, which...
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8137663 |
Oncolytic virus therapy
A method of treating a human subject with cancer is disclosed. A pharmaceutical composition is administered to the subject, the pharmaceutical composition comprising human leukocytes and a...
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8128922 |
Superior molecular vaccine linking the translocation domain of a bacterial toxin to an antigen
Nucleic acids encoding a chimeric or fusion polypeptide which polypeptide comprises a first domain comprising a translocation polypeptide; and a second domain comprising at least one antigenic...
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8124069 |
Immunogenic peptides
The invention provides relatively short immunogenic peptides, and biologically active variants thereof, associated with leukemia which elicit an immune response. Nucleic acids encoding the...
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8101173 |
Method for treating urinary bladder cancer
The present invention discloses an immunotherapeutic method for treating a patient suffering from urinary bladder cancer by administering expanded tumour-reactive CD4+ helper and/or CD8+...
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8097243 |
Microparticle-based transfection and activation of dendritic cells
The present invention provides an effective method for the transfection of dendritic cells by non-viral methods. The present invention provides this benefit by incubating dendritic cells and a...
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8084236 |
Compositions and methods for modifying cell surface glycans
Methods and compositions for modifying glycans (e.g., glycans expressed on the surface of live cells or cell particles) are provided herein.
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8076134 |
CD4+CD25− T cells and Tr1-like regulatory T cells
The invention provides CD4+CD25− T cells and Tr1-like regulatory T cells (i.e., contact-independent Type 1-like regulatory T cells), processes for their production and their use for regulatory p...
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8076132 |
Dendritic cell tumor injection (DCTI) therapy
The invention relates to a method of treating tumor cells within a patient wherein immature dendritic cells developed from the patient's monocyte cells and a lymphocyte cultured medium (LCM)...
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8075882 |
Adoptive immune cells for tumor vaccines
Adoptive immune cells obtained by a method including (a) obtaining mammalian antigen-presenting associated cells; (b) culturing the resulting cells from step (a) in a culture liquid contained in a...
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8066989 |
Method of treating tumor growth and metastasis by using trifunctional antibodies to reduce the risk for GvHD in allogeneic antitumor cell therapy
The present invention refers to a method of treating tumor growth and metastasis in a mammal, the treating comprising administering allogeneic effector cells together with trifunctional bispecific...
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8034332 |
Interleukin-secreting natural killer cell lines and methods of use
This invention relates to a natural killer cell line termed NK-92 and to NK-92 cell lines that have been modified by transfection with a vector to confer advantageous properties. The invention...
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8021658 |
Alternative splice forms of proteins as basis for multiple therapeutic modalities
Peptides or antibodies derived from alternative splice forms of proteins associated with a disease or physiologic condition are used as therapeutic or prophylactic agents. Peptides and antibodies...
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8017110 |
Induction of and maintenance of nucleic acid damage in pathogens using riboflavin and light
A process for damaging and maintaining damage to the nucleic acids of pathogens such as white blood cells, bacteria and viruses which may be contained in blood or blood components. This process...
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8012470 |
Method for ex vivo immunization using heterologous intact bispecific and/or trispecific antibodies
According to the invention there is described a method for ex vivo immunization of humans and animals comprising the following steps of: a) isolating autologous tumor cells;b) treating the tumor...
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8007785 |
Method for treating colon cancer with tumour-reactive T-lymphocytes
The present invention discloses an immunotherapeutic method for treating patients suffering from colon cancer, by administering expanded tumour-reactive CD4+ helper and/or CD8+ T-lymphocytes...
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8003093 |
B cell-based vaccine loaded with the ligand of natural killer T cell and antigen
The present invention relates to a B cell-based vaccine loaded with the ligand of natural killer T cell and antigen for the prevention and treatment of disease, more precisely, an immunotherapeutic...
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7993638 |
Cancer treatment combining lymphodepleting agent with CTLs and cytokines
In a cancer treatment combining cell therapy with chemotherapy, autologous CD8+ T cells are obtained from a patient, activated ex vivo by contacting them with xenogenic antigen presenting cells...
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7988951 |
Method for inducing selectively suppressed immune response to transplanted tissue or cells
Transimmunization methods incorporating skin immunologic challenges are described for either selectively suppressing the immune response of recipients of transplanted tissue or cells or monitoring...
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7988963 |
Use of allogeneic cell lines to load antigen presenting cells to elicit or eliminate immune responses
Novel antigen-presenting cells, including but not limited to dendritic cells, that are loaded with antigens from dead or dying cells including allogenic cell lines, and the methods for making such...
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7985409 |
Tr1 cells for use in atherosclerosis
The present invention relates to a method of treating or preventing atherosclerosis comprising administering to a mammal in need of such a treatment a) an antigen which has been used to activate in...
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7972594 |
Ablative immunotherapy
The invention disclosed herein relates generally to immunotherapy and, more specifically, to the use of immunotherapy for treating tumors and pathogen infected tissues by first priming patients...
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7951365 |
Method for expansion of tumour-reactive T-lymphocytes for immunotherapy of patients with specific cancer types
Methods for treating a patient suffering from a neoplastic disease are disclosed and described. A number of diseases can be treated under the present methods, including without limitation gall...
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7951364 |
CaR receptor as a mediator of migratory cell chemotaxis and/or chemokinesis
This invention relates to methods and compositions for modulating movement of eukaryotic cells with migratory capacity. More specifically, the invention relates to methods and compositions for...
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7943138 |
Survivin peptides as cancer vaccines
Provided are compositions and methods for treating survivin expressing cancers. The compositions contain peptide survivin peptide mimics with improved MHC-I binding characteristics. The method...
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7923203 |
Method of use of a platelet/nucleated cell concentrate from bone marrow or blood to treat a bone defect
The present invention is directed to methods and compositions regarding the preparation of an cell concentrate, such as, for example, an osteogenic cell concentrate, from a physiological solution,...
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7901673 |
Induction of and maintenance of nucleic acid damage in pathogens using riboflavin and light
A process for damaging and maintaining damage to the nucleic acids of pathogens such as white blood cells, bacteria and viruses which may be contained in blood or blood components. This process...
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7871606 |
Use of stimulated peripheral-blood mononuclear cells for the treatment of cancerous diseases
The invention relates to the use of peripheral-blood mononuclear cells that have been stimulated via cascade priming (CAPRI cells) for the purpose of providing an agent for the treatment of...
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7837990 |
In vivo expanded NKT cells and methods of use thereof
This invention relates to the in vivo expansion of NKT cells by their exposure to mature dendritic cells expressing α-galactosyl ceramide and to methods of use thereof in modulating immune ...
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7833970 |
Tumor-associated peptides binding promiscuously to human leukocyte antigen (HLA) class II molecules
The present invention relates to immunotherapeutic methods, and molecules and cells for use in immunotherapeutic methods. In particular, the present invention relates to the immunotherapy of...
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7833969 |
Tumor-associated peptides binding promiscuously to human leukocyte antigen (HLA) class II molecules
The present invention relates to immunotherapeutic methods, and molecules and cells for use in immunotherapeutic methods. In particular, the present invention relates to the immunotherapy of...
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7785583 |
In situ maturation of dendritic cells
A method for eliciting an immune response to an antigen in a subject via (a) loading isolated antigen presenting cells with an antigen ex vivo; and (b) administering the antigen presenting cells to...
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7771998 |
Pharmaceutical composition for inducing an immune response in a human or animal
The present invention relates to a pharmaceutical composition for inducing an immune response in a human or animal, comprising dendritic cells loaded with at least five cancer/testis antigen and no...
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7763243 |
In situ immunization
The arming of activated T cells (ATC) with BiAbs can overcome major barriers for successful adoptive immunotherapy. The BiAb approach takes the advantage of the targeting specificity of monoclonal...
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7745402 |
Method of treating pancreatitis
The present invention provides a method of treating pancreatitis comprising administering to a human in need thereof an effective amount of hemin. The administration of hemin is preferably...
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7731950 |
Attack of tumor cells with missing, low or aberrant MHC expression by combining non MHC-restricted T-cells/NK-cells and MHC-restricted cells
This invention is directed to therapeutic compositions containing non-MHC-restricted T-cells/NK-cells in combination with MHC-restricted T-cells and especially to therapeutic compositions, which...
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7731953 |
Methods for use of TSLP and agonists and antagonists thereof
Methods are disclosed herein for specifically inducing proliferation of CD4+ T cells. The methods are of use in treating immunodeficiencies, such as an immunodeficiency produced by infection with...
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7727523 |
Method for suppressing immune system response to transplanted tissue or cells
Methods are provided for suppressing the immune system response in recipients of transplanted organs, tissues or cells. An extracorporeal quantity of blood from the intended transplant recipient is...
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7722862 |
Regulatory T cells suppress autoimmunity
The invention provides methods for producing an autoantigen-specific regulatory T cell enriched composition, and resultant compositions and methods of use.
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7722874 |
Methods for reducing T cell responsiveness to an autoantigen with anti-gp39 antibodies and antigen presenting cells
Methods for inducing antigen-specific T cell tolerance are disclosed. The methods involve contacting a T cell with: 1) a cell which presents antigen to the T cell, wherein a ligand on the cell...
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7695713 |
Isolation and identification of T cells
The present invention relates to improved autologous T cell vaccines and improved methods for their production. The invention is also directed to methods for treating autoimmune diseases such as...
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7691392 |
Method of treating multiple myeloma using 17-AAG or 17-AG or a prodrug of either
A method for treating multiple myeloma in a subject by administering 17-allylamino-17-demethoxy-geldanamycin or 17-amino geldanamycin, or a prodrug of either 17-AAG or 17-AG, to the subject.
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7651685 |
Use of microchimeric cells in the treatment of malignancy
Methods and formulations for the treatment of malignancies. Assessment of the incidence and scope of MC in control and cancer populations provides for the development of cellular therapy approaches...
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7638122 |
Stat3 antagonists and their use as vaccines against cancer
The present invention relates to methods for treating and/or preventing cancer. In particular the present invention relates to ex vivo immunotherapeutic methods. The methods comprise decreasing...
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7625557 |
Method for inducing selectively suppressed immune response to transplanted tissue or cells
Transimmunization methods incorporating skin immunologic challenges are described for either selectively suppressing the immune response of recipients of transplanted tissue or cells or monitoring...
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7625879 |
Phosphohalohydrins, process for the production thereof and use thereof
The invention provides compounds comprising at least one phosphohalohydrin group of the formula: where X is a halogen selected from among I, Br, Cl, R1 is selected from among —CH3 and —...
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7560105 |
Dendritic cells activated in the presence of glucocorticoid hormones are capable of suppressing antigen-specific T cell responses
The present invention provides novel methods for immunotherapy. The invention provides immune cells and methods to generate them, with the capacity to at least in part reduce an immune response in...
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7560104 |
Compositions and methods for enhancement of major histocompatibility complex class I restricted antigen presentation
Compositions and methods for eliciting an in vivo cytotoxic lymphocyte (CTL) response against a modified soluble protein antigen are disclosed. The modified soluble protein antigen comprises an...
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