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9181527 T cell receptor-deficient T cell compositions  
The invention is directed to modified T cells, methods of making and using isolated, modified T cells, and methods of using these isolated, modified T cells to address diseases and disorders. In...
9034317 Composition for inhibiting tumor cell proliferation  
This invention pertains to cancer immunotherapy, by providing a proinflammatory dendritic cell (DC), which has been stimulated to maturation ex vivo by specific treatment, a method for such...
9028812 ***WITHDRAWN PATENT AS PER THE LATEST USPTO WITHDRAWN LIST***
T cell receptor-deficient T cell compositions
 
The invention is directed to modified T cells, methods of making and using isolated, modified T cells, and methods of using these isolated, modified T cells to address diseases and disorders. In...
9011867 Use of specific peptides in the preparation of a medicament for the treatment of monoclonal gammopathy of undetermined significance (MGUS) or of smoldering multiple myeloma (SMM)  
The present invention relates to the use of a peptide comprising or essentially consisting of a sequence motif as shown in SEQ ID NO: 1 for the preparation of a medicament for the treatment of...
8992907 Compositions for treating an intestinal inflammatory condition  
Compositions comprising human Tr1 cells directed to a food antigen from common human diet and methods for treating an intestinal inflammatory condition.
8986679 Somatic stem cells  
A method of treating a cellular proliferative disorder in a subject by obtaining from a subject a bodily fluid sample containing a plurality of cells, incubating the sample with EDTA or heparin in...
8961957 Therapy and method for intratumorally introducing cytotoxic T lymphocyte and/or NKT cell with anti-TNF and/or anti-IL-10  
The invention relates to therapy and methods of applying the therapy to cancer patients. The invention includes introducing intratumorally cytotoxic T lymphocyte and/or NKT cells, and prior to,...
8932806 Method for identifying t-cell stimulating protein fragments  
The invention relates to a method for identifying T-cell stimulating protein fragments using the following steps: a) detecting the amino acid sequence of an antigen; b) subdividing the found amino...
8926964 Methods of generating natural killer cells  
Provided herein are methods of producing natural killer cells using a two-step expansion and differentiation method. Also provided herein are methods of suppressing tumor cell proliferation, of...
8916147 Universal donor-derived tolerogenic cells for inducing non-syngeneic transplantation tolerance  
The present invention provides a method of treating a disease in a subject in need thereof via non-syngeneic graft administration without or with reduced concomitant graft rejection. The method...
8911739 Methods of preventing rejection of transplanted tissue by administering anti-CD40L antibody and dendritic cells loaded with Hsp60sp peptide  
A method is provided for preventing rejection by an immune system of a recipient subject of a tissue transplanted from a donor subject into the recipient subject without the need for long-term...
8889124 Tolerogenic populations of dendritic cells  
Tolerogenic populations of dendritic cells are provided, where the dendritic cells are characterized by expression of select tissue-specific homing receptors including the chemokine receptors...
8877182 Expansion of NK cells  
A method of obtaining expanded and activated natural killer (NK) cells with the phenotype CD3−CD56+ and NK-like T cells with the phenotype CD3+CD56+ comprises providing a cell sample of peripheral...
8865160 Treatment of disease conditions via administration of DNA repair enzyme  
The present invention is directed to compositions and methods of preserving viability of islets of Langerhans for transplantation, and treating various diseases and other abnormal or pathological...
8852581 Treatment of inflammatory bowel disease  
A method of treating inflammatory bowel disease (IBD) comprises collecting regulatory T cells in an activated or non-activated state from a patient's sentinel lymph nodes draining bowel segments...
8795653 Methods for repressing B cell autoantibody secretion and for treating autoimmune disorders by administration of hematopoietic stem cells and macrophage-colony stimulating factor  
The invention provides isolated regulatory immune cells as well as cell cultures and conditioned media derived therefrom. Also provided are methods of repressing B cell autoantibody production...
8741642 Methods for producing autologous immune cells resistant to myeloid-derived suppressor cells effects  
Methods for the ex vivo generation of cells of the innate (NKT cells and NK cells) and adaptive (T cells) immune systems for use in adoptive cell transfer (ACT) are provided. The NKT cells render...
8728481 Agents that engage antigen-presenting cells through dendritic cell asialoglycoprotein receptor (DC-ASGPR)  
The present invention includes compositions and methods for making and using anti DC-ASGPR antibodies that can, e.g., activate DCs and other cells.
8728465 Use of toll-like receptor ligands as adjuvants to vaccination therapy for brain tumors  
Compositions comprising dendritic cells pulsed with tumor lysate and at least one toll-like receptor (TLR) ligand which may be used for eliciting a specific immune response in a mammal in need...
8709405 Cancer vaccines containing epitopes of oncofetal antigen  
Disclosed are fragments of oncofetal antigen, otherwise known as immature laminin receptor protein that specifically stimulate one T cell subclass. The fragments may be formulated into...
8709404 Immunotherapy in cancer treatment  
The present invention relates to a novel method of cancer immuno-therapy and to a kit for use in this method. Specifically, the present invention relates to a novel method of collecting...
8697060 Treatment method for relapsing-remitting multiple sclerosis  
Disclosed is a method for treating relapsing-remitting multiple sclerosis in a patient by administering to the patient autologous, ex vivo-expanded CD4+CD25+Foxp3+CD127low T reg cells when the...
8697107 Flowable implant with crosslinkable surface membrane  
A flowable biomedical implant for application to a bone defect to promote bone growth is provided. The flowable biomedical implant comprises a carrier matrix including a biodegradable...
8697846 Methods of making monoclonal antibodies using fusion-peptide epitope adoptive transfer (F-PEAT) technology  
Disclosed are compositions and methods for related to monoclonal antibodies specific for single amino acid variation in an antigen.
8685732 Biomaterial based on Wharton's jelly from the human umbilical cord  
The present invention relates to a biomaterial, specifically a hydrogel, formed from the extracellular matrix of the umbilical cord for its application in regenerative medicine. The invention...
8673293 Use of modified cells for the treatment of multiple sclerosis  
The present invention describes blood cells chemically coupled with immunodominant myelin peptides and their use in the treatment of Multiple Sclerosis.
8673296 Method and composition for producing a cellular allogeneic vaccine  
The present invention relates to a method for the production of a cellular allogeneic vaccine, which is based upon an allogeneic APC, comprising the following steps: isolation of an APC from a...
8658159 Method to induce and expand therapeutic alloantigen-specific human regulatory T cells in large-scale  
Methods for inducing, expanding, and/or generating alloantigen-specific regulatory T cells. Alloantigen-specific regulatory T cells can be induced, expanded, and/or generated from naive CD4+CD25−...
8652462 Immune regulation  
A method of regulating the immune system of a subject that involves removing antigen presenting cells from subject and loading preselected class II peptide fragments onto the subjects APC's...
8603815 CD4+ CD25− T cells and Tr1-like regulatory T cells  
The invention provides CD4+CD25− T cells and Tr1-like regulatory T cells (i.e., contact-independent Type 1-like regulatory T cells), processes for their production and their use for regulatory...
8597636 Method for treating autoimmune diseases and compositions therefor  
A method of cell-based therapy for treating an autoimmune disease is disclosed. The method is directed at stimulating leukocytes and/or dendritic cells to interrupt autoimmunity in a host. The...
8586029 Prevention or treatment of immune-relevant disease by modification of microfloral populations  
The present invention is a method for preventing or treating an immune-relevant disease by modulating commensal microbiota populations via antibiotics, exogenous microbiota and/or probiotics.
8580269 Survivin peptides for autoimmune therapies  
Compositions and methods for stimulating an immune response against cells that express survivin are provided. The method is suitable for prophylaxis and/or therapy of autoimmune disorders. The...
8562974 Method for expanding Cd4+ Cd25+ T regulator cells  
A method for generating/expanding in vitro a CD4+CD25+ T regulatory (Tr) cell and the use thereof in the treatment of diseases associated with a cell-mediated immune response (including T- and...
8540982 Methods for inducing a natural killer (NK) cell-mediated immune response and for increasing NK cell activity  
This disclosure relates to methods of inducing a natural killer (NK) cell-mediated immune response and increasing NK activity in a mammal for the treatment of tumors and virus infections,...
8524248 Methods to diagnose and immunize against the virus causing human Merkel cell carcinoma  
The present invention provides isolated or substantially purified polypeptides, nucleic acids, and virus-like particles (VLPs) derived from a Merkel cell carcinoma virus (MCV), which is a...
8518391 Monocytes as a gene delivery vector for secreted proteins to treat Alzheimer'S disease  
Disclosed is a method for the treatment of a neurodegenerative disorder by isolating a plurality of monocytic cells and introducing a vector containing a gene that expresses a protease capable of...
8518397 Notch induced natural killer cell generation and therapeutic uses  
A method of preparing differentiated NK cells by ex vivo expansion includes the steps of; (1) isolating a plurality of CD34+ hematopoietic cells; (2) culturing the cells in a medium, wherein the...
8506954 Tumor vaccination in combination with hematopoietic cell transplantation for cancer therapy  
In one aspect, the present invention provides a method for treating cancer comprising tumor cell vaccination in combination with hematopoietic and immune cell transplantation. In some embodiments,...
8501168 Cell lines, compositions comprising them for the treatment of melanomas, procedures to prepare the compositions, and treatment methods  
Cell lines, compositions comprising them for the treatment of melanomas, procedures to prepare the compositions, and treatment methods. More particularly, the invention relates to diverse human...
8492146 Process for producing a human T-cell population having both cytotoxic and immunosuppressive activities  
A human T cell population which has both cytotoxic and immunosuppressive activities, is efficiently produced by first fractionating CD2-positive CD14-negative cells from mononuclear cells...
8444969 Neutrophil-depleted platelet rich plasma formulations for cardiac treatments  
Compositions and methods for preparing neutrophil-depleted platelet rich plasma are provided. Generally, these compositions comprise a higher concentration of platelets and depressed...
8444965 Tumor cells from immune privileged sites as base cells for cell-based cancer vaccines  
The present invention relates to tumor cell-based vaccines and methods of using same, wherein the vaccines are based on naturally immune privileged tumor cells that have been genetically modified...
8445275 Induction of dendritic cell development with macrophage-colony stimulating factor (M-CSF)  
A method of inducing dendritic cell (DC) development by administering Macrophage-Colony Stimulating Factor (M-CSF) is provided. M-CSF induces DCs to differentiate into Subtypes, for example...
8440459 Platelet rich plasma formulations for cardiac treatments  
Compositions for platelet rich plasma (PRP) are provided. Generally, these compositions comprise a higher concentration of platelets and white blood cells than whole blood. The concentrations of...
8420612 Diabetes treatment methods and drug targets therefor  
Provided are methods of treating insulin resistance or type II diabetes. Disrupting CAP in the macrophage can alter the inflammatory response associated with impaired insulin action and ultimately...
8420078 Methods and immunogenic cell preparations for treating antigen-associated diseases  
A method of inhibiting growth of, reducing or eliminating a cell population of a subject in need thereof is disclosed. The method comprises (a) thermally, mechanically and/or chemically damaging...
8394368 Method for producing a composition for promoting survival of transplanted hematopoietic stem cell  
HLA matched activated lymphocytes in mononuclear cells separated from peripheral blood or umbilical cord blood are proliferated and activated. After separating and collecting, the HLA matched...
8361794 Cells expressing a modified T cell receptor  
This invention provides a cell presenting at least one T cell receptor (TCR) anchored to the membrane by a transmembrane sequence, said TCR comprising an interchain disulfide bond between...
8354275 Induction of dendritic cell development with macrophage-colony stimulating factor (M-CSF)  
A method of inducing dendritic cell (DC) development by administering Macrophage-Colony Stimulating Factor is provided. M-CSF induces DCs to differentiate into subtypes, for example plasmacytoid...

Matches 1 - 50 out of 296 1 2 3 4 5 6 >