Matches 201 - 250 out of 296 < 1 2 3 4 5 6 >


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6194207 Methods for the selective expansion of lymphocytes by in vitro cultivation  
The invention is directed to methods for the production of selected populations of lymphocytes. Lymphocytes produced can be isolated and purified using well known and established procedures to...
6165785 Bone marrow cultures for developing suppressor and stimulator cells for research and therapeutic applications  
A method of treatment using immune system suppressor cells and immune system stimulator cells comprises providing stem cells; combining the stem cells with lymphoid-derived cells to produce a...
6143292 Allogeneic cell therapy for cancer following allogeneic stem cell transplantation  
A method of treating a human cancer patient having a solid tumor comprising malignant cells is disclosed, wherein the patient having undergone a cancer therapy regimen comprising allogeneic stem...
6117424 Compositions of mononuclear phagocytes useful for promoting axonal regeneration  
Methods and compositions for the use of allogeneic mononuclear phagocytes to promote axonal regeneration in the central nervous system of a mammal are disclosed. In one embodiment, allogeneic...
6083751 Chimeric receptors for the generation of selectively-activatable TH-independent cytotoxic T cells  
The invention provides cytotoxic T lymphocytes that express a chimeric cell surface receptor. The chimeric receptor enables the lymphocytes to become activated and to proliferate (via a TH...
6077519 Methods for isolation and use of T cell epitopes eluted from viable cells in vaccines for treating cancer patients  
Methods are provided for eluting peptides that are bound to major histocompatibility complex ("MHC") molecules expressed on the cell surfaces of viable cells that have at least one MHC-peptide...
6074639 Ex vivo expansion of hematopoietic cells using interleukin-3 (IL-3) variant fusion proteins  
The present invention relates to fusion molecules composed of human interleukin-3 (hIL-3) variant or mutant proteins (muteins) functionally joined to a second colony stimulating factor (CSF),...
6033669 Methods for generating cytotoxic T cells and treatment of diseases thereby  
The present invention relates a novel class of biologically active compounds, to processes for their production and to their use in therapy. More particularly the invention provides immunogenic...
6033661 Composition and method for allogenetic mononuclear cell immunotherapy  
A method of treating autoimmune diseases is provided which involves administering an effective amount of allogeneic mononuclear cells or a molecule derived from these cells to an individual...
6030614 Ameliorating immunological rejection of allograft  
The invention provides a method to prevent or ameliorate hyperacute or acute rejection of a human donor organ transplanted to a human recipient. Hyperacute rejection would normally occur after a...
6022538 Method of treating malignancies  
A method of treating tumors which involves a synergistic combination of chemotherapy and cell therapy is provided. The method of the invention permits reduced amounts of chemotherapeutic agents to...
6018096 Animal model for engraftment, proliferation and differentiation of human hematopoietic stem cells  
A chimeric, non-human, genetically-immunocompetent mammal is disclosed. The hematopoietic system of the mammal has human passaged bone marrow stromal cells and human hematopoietic stem cells...
6017527 Activated dendritic cells and methods for their activation  
Antigen-expressing, activated dendritic cells are disclosed. Such dendritic cells are used to present tumor, viral or bacterial antigens to T cells, and can be useful in vaccination protocols....
6010697 Infusion of neutrophil precursors for treatment of neutropenia  
The invention provides a method of treating a patient having a reduced population of neutrophils following a myeloablative cancer treatment such as high dose chemotherapy. Following myeloablative...
5997860 Ex-vivo expansion of stem cells using combinations of interleukin-3 (IL-3) variants and other cytokines  
The present invention relates to human interleukin-3 (hIL-3) variant or mutant proteins (muteins) functionally co-administered with a other colony stimulating factors (CSF), cytokines,...
5993803 Method of reducing the severity of host vs graft reaction by down-regulating hsp60 autoimmunity  
A method for reducing the severity of host vs graft reaction (HVGR) by the transplant recipient of donor organ or tissue by the transplant recipient and is based on the discovery that hsp60...
5985656 Suppressor and progenitor cells  
Natural suppressor (NS) cells secrete a soluble protein suppressor factor (SF) which suppresses the mixed lymphocyte response. NS cells as described herein are null, i.e., have the phenotype...
5928639 Immunotherapy of cancer with allogeneic lymphocytes  
Methods have been discovered for treating minimal residual disease following removal of most or a substantial fraction of malignant cells from a cancer patient. An autologous stem cell transplant...
5885570 Induction of tolerance with modified immunogens  
A method is provided for inducing tolerance to T-cell mediated immunity. Particularly, tolerance is induced in a recipient mammal to a transplanted organ or tissue. Tolerance is induced by...
5882934 Composition and method for hemoglobin and cell analysis  
A cyanide-free lytic reagent composition and method for measuring the total hemoglobin concentration in a blood sample, for counting the number of leukocytes and for deferential counting of...
5874556 Hybrid genes for use in the production of TH -independent cytotoxic T cells  
Recombinant vectors are provided that render the proliferative response of activated lymphocytes, particularly cytotoxic T lymphocytes, of lessened dependency on T-helper cells. The vectors are...
5874307 Process for induction culture of cytotoxic T lymphocytes having killing activity against tumor cells  
A process for an induction culture of a cytotoxic T lymphocyte having cell killing activities against a tumor cell which comprises the step of coculturing a tumor tissue containing said tumor cell...
5849589 Culturing monocytes with IL-4, TNF-α and GM-CSF TO induce differentiation to dendric cells  
Disclosed is a method for inducing the differentiation of a monocyte into a dendritic cell, the method including the culturing of a monocyte in a medium including GM-CSF, IL-4, and TNF-α.
5846827 Methods for ex vivo therapy using peptide-loaded antigen presenting cells for the activation of CTL  
Methods for activating cytotoxic T lymphocytes (CTL) in vitro are presented in conjunction with methods for using the activated CTL for therapy in vivo. Additionally, a method for killing specific...
5837229 Uses of recombinant colony stimulating factor-1  
A colony stimulating factor, CSF-1, is a lymphokine useful in treating or preventing bacterial, viral or fungal infections, neoplasms, leukopenia, wounds, and in overcoming the immunosuppression...
5837476 Methods for determining disorders by assaying for a non-tyrosinase, tumor rejection antigen precursor  
The invention relates to nucleic acid molecules coding for a tumor rejection antigen precursor. Specifically, the tumor rejection antigen precursor, or `TRAP", is processed into at least one tumor...
5830464 Compositions and methods for the treatment and growth inhibition of cancer using heat shock/stress protein-peptide complexes in combination with adoptive immunotherapy  
The present invention relates to methods and compositions for eliciting an immune response and the prevention and treatment of primary and metastatic neoplastic diseases and infectious diseases....
5827642 Rapid expansion method ("REM") for in vitro propagation of T lymphocytes  
The present invention provides a rapid expansion method (termed "REM"), for quickly generating large numbers of T lymphocytes, including cytolytic and helper T lymphocytes. REM involves culturing...
5827644 Thiazine dyes used to inactivate HIV in biological fluids  
A method for using thiazine dyes, especially methylene blue, alone or in combination with low levels of light, to selectively inactivate or inhibit intracellular replication of specific viruses,...
5821108 Enrichment for a thymocyte subset having progenitor cell activity using c-kit as a selection marker  
A subpopulation in the CD4+ 8+ (DP) thymic blast population is identified that is the precursor for thymic T cells. All such progenitors are c-kit+. The c-kit+ subset expresses lower levels of CD4...
5820856 Modified TALL-104 cells to treat cancer  
This invention provides a method of using modified human cytotoxic TALL-104 cell line, which is characterized by activity against tumor cells. More particularly, the method comprises treating bone...
5820872 Methods and compositions for improving the effectiveness of X-irradiation therapy for the treatment of an internal solid tumor  
Methods and pharmaceutical compositions for improving the effectiveness of radiation therapy for treating a subject having an internal solid tumor malignancy are disclosed. The methods include...
5811301 In vitro method for producing differentiated universally compatible human blood cells  
In vitro production of clinically useful quantities of single species of mature, differentiated human blood cells is carried out by a method in which human pluripotent hematopoietic stem cells,...
5788964 Method for sensitization of cancer cells for killer cell mediated lysis  
The invention relates to a method of sensitizing cancer cells for a killer cell mediated lysis which involves administering to a patient an effective amount of antiestrogen and killer cells either...
5789147 Method for concentrating white cells from whole blood by adding a red cell sedimentation reagent to whole anticoagulated blood  
A therapeutic product formed from a high concentration of white blood cells having a high degree of cell viability. The white blood cells are sequestered from their normal population presence in...
5772994 Hematopoietic facilitatory cells and their uses  
The present invention relates to mammalian hematopoietic facilitatory cells (FC). In particular, it relates to the isolation, characterization and uses of the FC. The FC of the present invention...
5763280 Cyanide-free lytic reagent composition and method for hemoglobin and cell analysis  
A cyanide-free lytic reagent composition and method for measuring the total hemoglobin concentration in a blood sample, for counting the number of leukocytes and for deferential counting of three...
5756097 Lymphokine activated effector cells for antibody-dependent cellular cytotoxicity (ADCC) treatment of cancer and other diseases  
This invention relates to processes and compositions for the immunotherapeutic treatment of cancer and non-malignant tumors. More particularly, this invention relates to processes and compositions...
5733550 Method for enhancing the association of exogenous peptides with class I MHC molecules on the surface of antigen presenting cells with β-microglobulin  
The present invention provides a method for enhancing the association of exogenous peptides with class I MHC molecules on the surface of antigen presenting cells to thereby sensitize the target...
5731160 Induction of antigen specific T-lymphocyte responses by stimulation with peptide loaded MHC class I molecules on antigen processing defective mammalian cell lines  
Induction of an antigen-specific T-lymphocyte response in a T-lymphocyte culture, e.g. a primary cytotoxic T-lymphocyte (CTL) response, by loading antigen-presenting vehicles which carry empty MHC...
5725855 Method of treating tumors with CD8+ -depleted or CD4+ T cell subpopulations  
The present invention provides a method for enhancing the immunotherapeutic activity, e.g., antitumor activity, of immune cells by depleting immune cells of a cell subset that down-regulates the...
5723503 Biological treatment for rheumatoid arthritis  
A method of treating rheumatoid arthritis is provided which involves administering an effective amount of allogeneic mononuclear cells or a molecule derived from these cells to an individual...
5716616 Isolated stromal cells for treating diseases, disorders or conditions characterized by bone defects  
Methods of treating patients who are suffering from a disease, disorder or condition characterized by a bone cartilage or lung defect are disclosed. The methods comprising the step of intravenous...
5702702 Modified cytotoxic tall cell line and compositions and methods for manufacture and use thereof as therapeutic reagents for cancer  
The invention provides a modified human cytotoxic T cell line, which is characterized by dual activity in vitro and in vivo against malignant cells and virus-infected cells. Also provided are...
5698767 Human immune system in non-human animal  
Laboratory non-human animals in which the immune system of a donor is induced in and thrives in vivo and expresses the immune response of the donor animal in a recipient non-human animal of a...
5686068 Isolated peptides derived from MAGE-2, cytolytic T cells specific to complexes of peptide and HLA-A2 molecules, and uses thereof  
New peptides derived from the MAGE-2 molecule and which bind to HLA-A*0201 molecules are disclosed. Some of these are especially useful because, when complexed to their HLA-A*0201 partner...
5683886 Tumor rejection antigens which correspond to amino acid sequences in tumor rejection antigen precursor bage, and uses thereof  
A new family of tumor rejection antigen precursors, and the nucleic acid molecules which code for them, are disclosed. These tumor rejection antigen precursors are referred to as BAGE tumor...
5679347 Methods of isolating CD1-presented antigens, vaccines comprising CD1-presented antigens, and cell lines for use in said methods  
The present invention is based on the observation that CD1 functions to present foreign and autoimmune antigens to a select subpopulation of T-cells. Based on this observation, the present...
5676944 Ocular therapy with homologous macrophages  
The treatment of glaucoma and other conditions relating to diseased trabecular meshwork in the eye is effected by administration of macrophages and/or cytokines to the eye. Increased levels of...
5674487 Method for treating autoimmune diseases  
A method of treating autoimmune diseases is provided which involves administering an effective amount of allogeneic mononuclear cells or a molecule derived from these cells to an individual...

Matches 201 - 250 out of 296 < 1 2 3 4 5 6 >