Matches 101 - 150 out of 296 < 1 2 3 4 5 6 >


Match Document Document Title
7722874 Methods for reducing T cell responsiveness to an autoantigen with anti-gp39 antibodies and antigen presenting cells  
Methods for inducing antigen-specific T cell tolerance are disclosed. The methods involve contacting a T cell with: 1) a cell which presents antigen to the T cell, wherein a ligand on the cell...
7722862 Regulatory T cells suppress autoimmunity  
The invention provides methods for producing an autoantigen-specific regulatory T cell enriched composition, and resultant compositions and methods of use.
7695713 Isolation and identification of T cells  
The present invention relates to improved autologous T cell vaccines and improved methods for their production. The invention is also directed to methods for treating autoimmune diseases such as...
7691392 Method of treating multiple myeloma using 17-AAG or 17-AG or a prodrug of either  
A method for treating multiple myeloma in a subject by administering 17-allylamino-17-demethoxy-geldanamycin or 17-amino geldanamycin, or a prodrug of either 17-AAG or 17-AG, to the subject.
7651685 Use of microchimeric cells in the treatment of malignancy  
Methods and formulations for the treatment of malignancies. Assessment of the incidence and scope of MC in control and cancer populations provides for the development of cellular therapy...
7638122 Stat3 antagonists and their use as vaccines against cancer  
The present invention relates to methods for treating and/or preventing cancer. In particular the present invention relates to ex vivo immunotherapeutic methods. The methods comprise decreasing...
7625879 Phosphohalohydrins, process for the production thereof and use thereof  
The invention provides compounds comprising at least one phosphohalohydrin group of the formula: where X is a halogen selected from among I, Br, Cl, R1 is selected from among —CH3 and...
7625557 Method for inducing selectively suppressed immune response to transplanted tissue or cells  
Transimmunization methods incorporating skin immunologic challenges are described for either selectively suppressing the immune response of recipients of transplanted tissue or cells or monitoring...
7560104 Compositions and methods for enhancement of major histocompatibility complex class I restricted antigen presentation  
Compositions and methods for eliciting an in vivo cytotoxic lymphocyte (CTL) response against a modified soluble protein antigen are disclosed. The modified soluble protein antigen comprises an...
7560105 Dendritic cells activated in the presence of glucocorticoid hormones are capable of suppressing antigen-specific T cell responses  
The present invention provides novel methods for immunotherapy. The invention provides immune cells and methods to generate them, with the capacity to at least in part reduce an immune response in...
7541025 Treatment of malignant tumor  
The invention provides a technology which utilizes donor lymphocyte infusion and by which malignant tumor can be treated without causing such an adverse effect as graft versus host disease. Thus,...
7501124 Methods of inducing T-cell non-responsiveness with anti-gp39 24-31 antibodies  
Methods for inducing T cell tolerance to a tissue or organ graft in a transplant recipeint are disclosed. The methods involve administering to a subject: 1) an allogeneic or xenogeneic cell which...
7488474 Method for detecting regulatory T cells using expression of folate receptor 4 as indicator, method for treating diseases using the detection method, pharmaceutical composition for immunostimulation, and method for treating diseases using the composition  
An object of the present invention is to provide a technique to distinguish between Treg cells and activated T cells in a live state. Another object of the present invention is to provide a...
7479269 Methods for selectively enriching TH1 and TH2 cells  
Methods for inducing a population of T cells to proliferate by activating the population of T cells and stimulating an accessory molecule on the surface of the T cells with a ligand which binds...
7419660 Vaccines for treatment of lymphoma and leukemia  
The present invention provides multivalent vaccines for the treatment of B-cell malignancies (e.g., lymphomas and leukemias). The present invention also provides methods for the production of...
7413865 Diagnostic method for a transmissible spongiform encephalopathy or prion disease  
A method is provided for the diagnosis of a transmissible spongiform encephalopathy (TSE) or prion disease in an animal which comprises assaying a sample obtained from said animal to determine the...
7413869 Method for determining potency of antigenic presenting cell based vaccines  
The present invention discloses methods useful in the preparation of immunostimulatory vaccines which include as one of their components, activated antigen presenting cells which are characterized...
7402307 Method for identifying and killing cancer cells  
The invention provides a method for activating a T lymphocyte by contacting the T lymphocyte with a dendritic cell (DC) that presents a telomerase reverse transcriptase (TRT) peptide in the...
7402430 MHC class II antigen-presenting systems and methods for activating CD4+ T cells  
The present invention relates to synthetic antigen-presenting matrices, their methods of making and their methods of use. One such matrix is cells that have been transfected to produce MHC...
7378277 Methods and compositions for transforming dendritic cells and activating T cells  
Recombinant dendritic cells are made by transforming a stem cell and differentiating the stem cell into a dendritic cell. The resulting dendritic cell is an antigen presenting cell which activates...
7378089 Gene therapy for the prevention of autoimmune disease  
Autoimmune disease is treated by the delivery of a suppressive agent to the site of disease. Delivery is accomplished by introducing an expression vector encoding the suppressive agent into cells...
7351409 Tumor antigens and CTL clones isolated by a novel procedure  
The present invention relates to isolation of cytotoxic T lymphocyte (CTL) clones. In particular, the present invention relates to isolated CTL clones that are specific for proteins of the MAGE...
7294331 Methods of using flt3-ligand in hematopoietic cell transplantation  
Ligands for flt3 receptors capable of transducing self-renewal signals to regulate the growth, proliferation or differentiation of progenitor cells and stem cells are disclosed. The invention is...
7291450 Preparation of a cell concentrate from a physiological solution  
The present invention is directed to methods and compositions regarding the preparation of an cell concentrate, such as, for example, an osteogenic cell concentrate, from a physiological solution,...
7288254 Use of immunotoxins to induce immune tolerance to pancreatic islet transplantation  
The invention provides a method of treating diabetes in a subject, comprising administering to the diabetic subject an immunotoxin, thereby reducing the subject's T-cell population, and...
RE39788 Gene therapy  
Primary human cells which are genetically engineered with DNA (RNA) encoding a marker or therapeutic which is expressed to be expressed in vivo. Such engineered cells may be used in gene therapy.
7232566 Methods for treating HIV infected subjects  
Methods for inducing a population of T cells to proliferate by activating the population of T cells and stimulating an accessory molecule on the surface of the T cells with a ligand which binds...
7195758 Methods of inducing a T cell mediated immune response by administering antigen presenting B cells  
We teach a strategy to obtain large quantities of desired APCs, activated B cells, which are superior in their capacity to present tumor protein antigen in a multiadministration protocol. Human B...
7175843 Methods for selectively stimulating proliferation of T cells  
Methods for inducing a population of T cells to proliferate by activating the population of T cells and stimulating an accessory molecule on the surface of the T cells with a ligand which binds...
7166423 Direct selection of cells by secretion product  
Cells can be labeled with products which they secrete and release in an efficient manner by coupling the cells at their surface to a specific binding partner for the product and allowing the...
7160723 Cell separation compositions and methods  
The invention provides compositions and methods for cell separation. These reagents and techniques specifically agglutinate cells via surface antigen recognition and can be used to recover even...
7122182 Oncolytic virus therapy  
A method of treating a human subject with cancer is disclosed. A pharmaceutical composition is administered to the subject, the pharmaceutical composition comprising human leukocytes and a...
7118924 Method for producing human antibodies in SCID mice which uses dendritic cells pulsed with antigen-antibody complexes and antigen-antibody complexes as immunizing agents  
An improved method for producing human antibodies in SCID mice is provided. The improvement includes the use of dendritic cells pulsed with antigen-antibody complexes and antigen-antibody...
7078034 In vitro activated γ δ lymphocytes  
Patients who develop increased numbers of γδ+ cytotoxic T lymphocytes 2–6 months after allogeneic bone marrow transplantation are less likely to relapse than those who do not. The γδ+ T cells...
7070771 Methods of expressing chimeric mouse and human CD40 ligand in human CD40+ cells  
This invention relates to genes which encode accessory molecule ligands, such as the CD40 ligand and their use for immunomodulation, vaccination and treatments of various human diseases, including...
7029671 Method for activating human antigen-presenting cells, activated human antigen-presenting cells, and use thereof  
The invention relates to a method for activating human-derived antigen-presenting cells by in vitro cultivation with at least one of the glycoside compounds represented by formula (A) or salts...
6984382 Bifunctional protein, preparation and use  
A bifunctional protein comprising: 1) a single-chain antibody directed against a suitable antigen on a tumour cell, 2) a hinge region comprising from about 40 to about 200 amino acids joined to...
6984383 Method of transplanting cells by contacting donor cells with B7-1-and B7-2-specific immunoglobulins  
The invention relates to a humanized anti-B7-2 antibody that comprises a variable region of nonhuman origin and at least a portion of an immunoglobulin of human origin. The invention also pertains...
6962695 Modification of interferon alpha production  
A process for the production of α-interferon comprising the steps: i) inducing of human leukocytes by means of a virus; ii) treating the leukocytes with an enhancing agent selected from: a)...
6929792 Modified dendritic cells and use therefor  
The invention provides isolated dendritic cells genetically modified to express a selectin polypeptide, optionally treated with activated platelets or membrane microparticles thereof. The...
6926893 Multi-stage cascade boosting vaccine  
Humoral and cellular immune responses against tumor cells and infectious agents are induced in a mammal using a vaccine comprising antibodies and anti-idiotype antibodies that mimic an epitope of...
6892140 Immunogenic cancer peptides and uses thereof  
This invention relates to novel general methods and compositions that provide cancer-specific or highly cancer-associated antigens useful for diagnosis and treatment of cancer.
6838081 Methods for enhancing antigen-presenting cells and anti-tumor responses in a human patient  
The present invention provides methods for enhancing the development of APC from precursor cells by administering a combination of GM-CSF and IL-4. The precursor cells include: cells contained in...
6821516 Macrophages, process for preparing the same and their use as active substances of pharmaceutical compositions  
The invention relates to macrophages which have at least one of the following properties: their cytotoxic activity without IFN-γ is increased by about 20 to 30% with respect to standard...
6821513 Method for enhancing hematopoiesis  
A method is provided for enhancing hematopoiesis. The method includes transplanting at least a therapeutically effective portion of an isolated vascular tissue into a subject, wherein the vascular...
6805861 Immunotherapy using cytotoxic T lymphocytes (CTL)  
A method of treating a patient with a disease wherein the patient contains diseased cells which cells contain, or are associated with, an abnormal molecule or an abnormally elevated amount of a...
6803036 Use of cytokines, cells and mitogens to inhibit graft versus host disease  
The field of the invention is generally related to pharmaceutical agents useful in treating graft-versus-host disease (GVHD) in patients that have received allogenic bone marrow transplants.
6759035 Method to prevent graft rejection using TGF-beta to induce T suppressor cells  
The invention relates to compositions and methods useful for preventing graft rejection in a recipient following organ transplantation.
6747010 NKT cell-activating agents containing α-glycosylceramides  
An objective of the present invention is to provide NKT cell-activating agents, therapeutic agents for autoimmune diseases (for example, systemic lupus erythematosus, systemic sclerosis,...
6716422 Vaccine adjuvants for immunotherapy of melanoma  
The invention provides methods of inducing the production of cytolytic T lymphocytes directed against malignancy or infectious agent by a mammal and treating such disease such that deleterious...

Matches 101 - 150 out of 296 < 1 2 3 4 5 6 >