Matches 51 - 100 out of 296 < 1 2 3 4 5 6 >


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8318153 Method of medically treating an individual  
A method immunizing an individual that minimizes the amount of antigen or attenuated organism needed and the number of doses and clinic visits required, while making possible polyvalent...
8282964 Ex-vivo treatment of peripheral plasmacytoid dendritic cells with IFN-lambda  
The present invention provides an ex vivo method of treating plasmacytoid dendritic cells (pDC) in Th2- or Th17-associated diseases by modulating the cytokine expression or secretion using...
8241621 Stem cell mediated treg activation/expansion for therapeutic immune modulation  
Disclosed are cells, methods of modulating cells, and therapeutic uses of the cells for the immune modulation of mammals in need thereof. Immune modulation including alteration of cytokine...
8231868 Method for suppressing immune system response to transplanted tissue or cells  
Methods are provided for suppressing the immune system response in recipients of transplanted organs, tissues or cells. An extracorporeal quantity of blood from the intended transplant recipient...
8211422 Chimeric receptor genes and cells transformed therewith  
Chimeric receptor genes suitable for endowing lymphocytes with antibody-type specificity include a first gene segment encoding a single-chain Fv domain of a specific antibody and a second gene...
8211425 Method for treating disseminated cancer  
The present invention discloses an immunotherapeutic method for treating a patient suffering from a disseminated cancer by administering expanded tumour-reactive CD4+ helper and/or CD8+...
8211424 Method for treating malignant melanoma  
The present invention discloses an immunotherapeutic method for treating patients suffering from malignant melanoma, by administering expanded tumour-reactive CD4+ helper and/or CD8+ T-lymphocytes...
8206701 Semi-allogenic anti-tumour vaccine with HLA haplo-identical antigen-presenting cells  
The present invention relates to semi-allogeneic antigen-presenting cells into which proteins and/or peptides or RNA or DNA or cDNA, respectively, encoding said proteins and/or peptides which are...
8206702 Method for expansion of tumour-reactive T-lymphocytes for immunotherapy of patients with cancer  
The present invention discloses an improved method for expansion and activation of tumor-reactive lymphocytes, in particular CD4+ helper and/or CD8+ T-lymphocytes, which may be used for treating...
8187587 Immunotherapeutic methods targeted toward stratum corneum chymotryptic enzyme  
The present invention discloses the protease stratum corneum chymotrytic enzyme (SCCE) is specifically over-expressed in ovarian and other malignancies. A number of SCCE peptides can induce immune...
8163275 Multi-lineage progenitor cells  
Fetal blood multi-lineage progenitor cells that are capable of a wide spectrum of transdifferentiation are described.
8153120 Methods for inducing a natural killer (NK) cell-mediated immune response and for increasing NK cell activity  
The present invention relates to the discovery of novel methods of inducing a natural killer (NK) cell-mediated immune response and increasing NK activity in a mammal for the treatment of tumors...
8142772 Attack of tumor cells with missing, low or aberrant MHC expression by combining non MHC-restricted T-cells/NK-cells and MHC-restricted cells  
This invention is directed to therapeutic compositions containing non-MHC-restricted Tcells/NK-cells in combination with MHC-restricted T-cells and especially to therapeutic compositions, which...
8137663 Oncolytic virus therapy  
A method of treating a human subject with cancer is disclosed. A pharmaceutical composition is administered to the subject, the pharmaceutical composition comprising human leukocytes and a...
8128922 Superior molecular vaccine linking the translocation domain of a bacterial toxin to an antigen  
Nucleic acids encoding a chimeric or fusion polypeptide which polypeptide comprises a first domain comprising a translocation polypeptide; and a second domain comprising at least one antigenic...
8124069 Immunogenic peptides  
The invention provides relatively short immunogenic peptides, and biologically active variants thereof, associated with leukemia which elicit an immune response. Nucleic acids encoding the...
8101173 Method for treating urinary bladder cancer  
The present invention discloses an immunotherapeutic method for treating a patient suffering from urinary bladder cancer by administering expanded tumour-reactive CD4+ helper and/or CD8+...
8097243 Microparticle-based transfection and activation of dendritic cells  
The present invention provides an effective method for the transfection of dendritic cells by non-viral methods. The present invention provides this benefit by incubating dendritic cells and a...
8084236 Compositions and methods for modifying cell surface glycans  
Methods and compositions for modifying glycans (e.g., glycans expressed on the surface of live cells or cell particles) are provided herein.
8075882 Adoptive immune cells for tumor vaccines  
Adoptive immune cells obtained by a method including (a) obtaining mammalian antigen-presenting associated cells; (b) culturing the resulting cells from step (a) in a culture liquid contained in a...
8076134 CD4+CD25− T cells and Tr1-like regulatory T cells  
The invention provides CD4+CD25− T cells and Tr1-like regulatory T cells (i.e., contact-independent Type 1-like regulatory T cells), processes for their production and their use for regulatory...
8076132 Dendritic cell tumor injection (DCTI) therapy  
The invention relates to a method of treating tumor cells within a patient wherein immature dendritic cells developed from the patient's monocyte cells and a lymphocyte cultured medium (LCM)...
8066989 Method of treating tumor growth and metastasis by using trifunctional antibodies to reduce the risk for GvHD in allogeneic antitumor cell therapy  
The present invention refers to a method of treating tumor growth and metastasis in a mammal, the treating comprising administering allogeneic effector cells together with trifunctional bispecific...
8034332 Interleukin-secreting natural killer cell lines and methods of use  
This invention relates to a natural killer cell line termed NK-92 and to NK-92 cell lines that have been modified by transfection with a vector to confer advantageous properties. The invention...
8021658 Alternative splice forms of proteins as basis for multiple therapeutic modalities  
Peptides or antibodies derived from alternative splice forms of proteins associated with a disease or physiologic condition are used as therapeutic or prophylactic agents. Peptides and antibodies...
8017110 Induction of and maintenance of nucleic acid damage in pathogens using riboflavin and light  
A process for damaging and maintaining damage to the nucleic acids of pathogens such as white blood cells, bacteria and viruses which may be contained in blood or blood components. This process...
8012470 Method for ex vivo immunization using heterologous intact bispecific and/or trispecific antibodies  
According to the invention there is described a method for ex vivo immunization of humans and animals comprising the following steps of: a) isolating autologous tumor cells;b) treating the tumor...
8007785 Method for treating colon cancer with tumour-reactive T-lymphocytes  
The present invention discloses an immunotherapeutic method for treating patients suffering from colon cancer, by administering expanded tumour-reactive CD4+ helper and/or CD8+ T-lymphocytes...
8003093 B cell-based vaccine loaded with the ligand of natural killer T cell and antigen  
The present invention relates to a B cell-based vaccine loaded with the ligand of natural killer T cell and antigen for the prevention and treatment of disease, more precisely, an...
7993638 Cancer treatment combining lymphodepleting agent with CTLs and cytokines  
In a cancer treatment combining cell therapy with chemotherapy, autologous CD8+ T cells are obtained from a patient, activated ex vivo by contacting them with xenogenic antigen presenting cells...
7988963 Use of allogeneic cell lines to load antigen presenting cells to elicit or eliminate immune responses  
Novel antigen-presenting cells, including but not limited to dendritic cells, that are loaded with antigens from dead or dying cells including allogenic cell lines, and the methods for making such...
7988951 Method for inducing selectively suppressed immune response to transplanted tissue or cells  
Transimmunization methods incorporating skin immunologic challenges are described for either selectively suppressing the immune response of recipients of transplanted tissue or cells or monitoring...
7985409 Tr1 cells for use in atherosclerosis  
The present invention relates to a method of treating or preventing atherosclerosis comprising administering to a mammal in need of such a treatment a) an antigen which has been used to activate...
7972594 Ablative immunotherapy  
The invention disclosed herein relates generally to immunotherapy and, more specifically, to the use of immunotherapy for treating tumors and pathogen infected tissues by first priming patients...
7951364 CaR receptor as a mediator of migratory cell chemotaxis and/or chemokinesis  
This invention relates to methods and compositions for modulating movement of eukaryotic cells with migratory capacity. More specifically, the invention relates to methods and compositions for...
7951365 Method for expansion of tumour-reactive T-lymphocytes for immunotherapy of patients with specific cancer types  
Methods for treating a patient suffering from a neoplastic disease are disclosed and described. A number of diseases can be treated under the present methods, including without limitation gall...
7943138 Survivin peptides as cancer vaccines  
Provided are compositions and methods for treating survivin expressing cancers. The compositions contain peptide survivin peptide mimics with improved MHC-I binding characteristics. The method...
7923203 Method of use of a platelet/nucleated cell concentrate from bone marrow or blood to treat a bone defect  
The present invention is directed to methods and compositions regarding the preparation of an cell concentrate, such as, for example, an osteogenic cell concentrate, from a physiological solution,...
7901673 Induction of and maintenance of nucleic acid damage in pathogens using riboflavin and light  
A process for damaging and maintaining damage to the nucleic acids of pathogens such as white blood cells, bacteria and viruses which may be contained in blood or blood components. This process...
7871606 Use of stimulated peripheral-blood mononuclear cells for the treatment of cancerous diseases  
The invention relates to the use of peripheral-blood mononuclear cells that have been stimulated via cascade priming (CAPRI cells) for the purpose of providing an agent for the treatment of...
7837990 In vivo expanded NKT cells and methods of use thereof  
This invention relates to the in vivo expansion of NKT cells by their exposure to mature dendritic cells expressing α-galactosyl ceramide and to methods of use thereof in modulating immune...
7833969 Tumor-associated peptides binding promiscuously to human leukocyte antigen (HLA) class II molecules  
The present invention relates to immunotherapeutic methods, and molecules and cells for use in immunotherapeutic methods. In particular, the present invention relates to the immunotherapy of...
7833970 Tumor-associated peptides binding promiscuously to human leukocyte antigen (HLA) class II molecules  
The present invention relates to immunotherapeutic methods, and molecules and cells for use in immunotherapeutic methods. In particular, the present invention relates to the immunotherapy of...
7785583 In situ maturation of dendritic cells  
A method for eliciting an immune response to an antigen in a subject via (a) loading isolated antigen presenting cells with an antigen ex vivo; and (b) administering the antigen presenting cells...
7771998 Pharmaceutical composition for inducing an immune response in a human or animal  
The present invention relates to a pharmaceutical composition for inducing an immune response in a human or animal, comprising dendritic cells loaded with at least five cancer/testis antigen and...
7763243 In situ immunization  
The arming of activated T cells (ATC) with BiAbs can overcome major barriers for successful adoptive immunotherapy. The BiAb approach takes the advantage of the targeting specificity of monoclonal...
7745402 Method of treating pancreatitis  
The present invention provides a method of treating pancreatitis comprising administering to a human in need thereof an effective amount of hemin. The administration of hemin is preferably...
7731950 Attack of tumor cells with missing, low or aberrant MHC expression by combining non MHC-restricted T-cells/NK-cells and MHC-restricted cells  
This invention is directed to therapeutic compositions containing non-MHC-restricted T-cells/NK-cells in combination with MHC-restricted T-cells and especially to therapeutic compositions, which...
7731953 Methods for use of TSLP and agonists and antagonists thereof  
Methods are disclosed herein for specifically inducing proliferation of CD4+ T cells. The methods are of use in treating immunodeficiencies, such as an immunodeficiency produced by infection with...
7727523 Method for suppressing immune system response to transplanted tissue or cells  
Methods are provided for suppressing the immune system response in recipients of transplanted organs, tissues or cells. An extracorporeal quantity of blood from the intended transplant recipient...

Matches 51 - 100 out of 296 < 1 2 3 4 5 6 >