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7390484 |
Self-contained adipose derived stem cell processing unit
Cells present in processed lipoaspirate tissue are used to treat patients. Methods of treating patients include processing adipose tissue to deliver a concentrated amount of stem cells obtained...
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7384630 |
Chimeric pancreas
Novel methods, tissues and compositions for increasing the pancreatic mass of a mammalian recipient including harvesting immature pancreatic tissue from a mammalian donor and transplanting said...
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7378088 |
Base material for regenerating an air sinus and regeneration method thereof
The instant invention provides a base material characterized by having a continuous three-dimensional honeycomb structure for regenerating an air sinus. The invention further provides methods for...
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7378087 |
Method of enhancing an immune response
A method of enhancing an immune response to an antigen is provided. The method involves augmenting the level of a TAP molecule in a target cell bearing the antigen. Preferably, the TAP molecules...
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7375077 |
In vivo synthesis of connective tissues
The in vivo synthesis of connective tissue by fibroblast or fibroblast precursor cells ensconced within a biocompatible scaffold is disclosed. The cells are preferably present in a biocompatible...
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7371575 |
Process for ex vivo formation of mammalian bone and uses thereof
The present invention concerns methods for the ex vivo formation of mammalian bone and subsequent uses of the bone. A critical and distinguishing feature of the present invention are defined tissue...
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7364729 |
Method of inducing a CTL response
Disclosed herein are methods for inducing an immunological CTL response to an antigen by sustained, regular delivery of the antigen to a mammal so that the antigen reaches the lymphatic system....
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7361334 |
Method of treatment of diabetes through induction of immunological tolerance
A method of creating tolerance to transplanted cells, tissue, or organs without the need for continuous immunosuppression. A tolerizing dose of a cell or tissue within a membrane structure is...
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7361333 |
Prevention of diabetes through induction of immunological tolerance
A method of creating tolerance to transplanted cells, tissue, or organs without the need for continuous immunosuppression. A tolerizing dose of a cell or tissue within a membrane structure is...
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7354702 |
Processing tissue to produce a biopolymer scaffold for tissue engineering
A method of forming and preserving a bioremodelable, biopolymer scaffold material by subjecting animal tissue, particularly fetal or neo-natal tissue, to chemical and mechanical processing. The...
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7351584 |
Hepatocyte bioreactor system for long term culture of functional hepatocyte spheroids
A rotating wall vessel is used as a culture vessel and bioreactor for the cultivation of hepatocytes in the form of spheroids to generate a culture with many properties of the intact liver. These...
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7351408 |
Glycoconjugates and methods
Methods for making the functionalized glycoconjugates include (a) contacting a cell with a first monosaccharide, and (b) incubating the cell under conditions whereby the cell (i) internalizes the...
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7348176 |
Chamber with adjustable volume for cell culture and organ assist
The invention features modular chambers for culturing cells in which the volume of a chamber can be adjusted without compromising the seal or sterility of the chamber. The invention is based on the...
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7347999 |
Methods of treatment of hematopoietic disorders
A composition comprising bone marrow cells (BMC) and demineralized bone matrix (DBM) and/or mineralized bone matrix (MBM), optionally comprising bone morphogenetic protein (BMP), particularly for...
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7341719 |
Myoblast therapy for cosmetic treatment
Compositions and methods of treating mammalian diseases using myoblasts, and/or their physical, genetic, chemical derivatives. Myogenic cells that are normal, or genetically or phenotypically...
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7338657 |
Injectable microspheres for tissue construction
The present invention relates to injectable compositions comprising biocompatible, hydrophilic, non-toxic and substantially spherical microspheres associated with stem cells useful for tissue...
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7335354 |
Methods for the reduction of malignant tumors by an eosinophil/helminth therapy
The invention is a method of reducing malignant tumor sizes in mammals by eliciting activated eosinophils to infiltrate the tumor by using helminth excretory and secretory antigens, helminth ova,...
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7335353 |
Porcine cells comprising an adenovirus E3 gene region
The complete nucleotide sequence of the genome of porcine adenovirus type 3 (PAV-3) is provided. Methods for construction of infectious PAV genomes by homologous recombination in procaryotic cells...
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7332158 |
Compositions and treatments for myelosuppression by ex vivo activated immune cells
The disclosure includes protocols of activating and administering human blood cells to myelosuppressed patients, including patients treated for cancer, e.g., by chemotherapy or radiation. The...
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7332157 |
Methods for human allografting
A method of preparing a human recipient for a graft from a human which includes: inducing mixed chimerism in the recipient (e.g., by administering to the recipient irradiation or chemotherapy),...
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7329543 |
Red blood cells loaded with S-nitrosothiol and uses therefor
Red blood cells can be loaded with low molecular weight nitrosylating agents, such as S-nitrosothiols, to act as a delivery system for NO + groups to tissues. Loaded red blood cells can be used in...
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7326570 |
Induction of tubular morphogenesis using pleiotrophin
Provided are methods and compositions for constructing stable mammalian embryonic epithelial tissues and organs as well as constructing kidney tissue, and treating renal failure. Disclosed are...
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7323445 |
Methods and compositions for healing and repair of articular cartilage
Methods and compositions are provided for the treatment of articular cartilage defects and disease involving the combination of tissue, such as osteochondral grafts, with active growth factor. The...
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7323190 |
Cell delivery system comprising a fibrous matrix and cells
Cell storage and delivery systems and methods for storing and delivering viable cells to a mammal are disclosed. The cell storage and delivery systems include a biodegradable and/or bioabsorbable...
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7316927 |
Culture of goblet cells
The invention encompasses isolation, culture and characterization of goblet cells in vitro from mammalian conjuctiva. Goblet cells can be cultured from conjunctiva of such mammals as, e.g., humans,...
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7314615 |
IκB Kinase-β (IKKβ) binding antibodies and methods of using same
The present invention provides an isolated nucleic acid molecules encoding IκB kinase (IKK) catalytic subunit polypeptides, which are associated with an IKK serine protein kinase that...
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7306943 |
Keratinocytes useful for the treatment of wounds
The invention relates to new keratinocytes which may be cultured in vitro and the advantageous use thereof for preparing a product which can be used to treat acute and chronic wounds.
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7297331 |
Beads containing restricted cancer cells producing material suppressing cancer cell proliferation
Compositions of matter are described which contain restricted cancer cells. When so restricted, the cells produce an unexpectedly high amount of material which suppresses cancer cell proliferation....
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7297330 |
Low dose haptenized tumor cell and tumor cell extract immunotherapy
This invention relates to compositions comprising haptenized tumor cells and extracts thereof, methods for preparing the compositions, vaccines comprising such haptenized tumor cells, and methods...
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7294334 |
Methods and compositions to treat myocardial conditions
Methods, devices, kits and compositions to treat a myocardial infarction. In one embodiment, the method includes the prevention of remodeling of the infarct zone of the ventricle using a...
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7294331 |
Methods of using flt3-ligand in hematopoietic cell transplantation
Ligands for flt3 receptors capable of transducing self-renewal signals to regulate the growth, proliferation or differentiation of progenitor cells and stem cells are disclosed. The invention is...
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7291450 |
Preparation of a cell concentrate from a physiological solution
The present invention is directed to methods and compositions regarding the preparation of an cell concentrate, such as, for example, an osteogenic cell concentrate, from a physiological solution,...
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7288255 |
Prevention of immunoreactivity by depleting or inhibiting antigen presenting cells
The invention includes compositions and methods for depleting antigen presenting cells, or for impairing the biological function of antigen presenting cells, which compositions are useful for...
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7285415 |
Oligodendrocytes derived from human embryonic stem cells for remyelination and treatment of spinal cord injury
This invention provides populations of neural cells bearing markers of glial cells, such as oligodendrocytes and their precursors. The populations are generated by differentiating pluripotent stem...
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7282201 |
Methods of promoting the growth or differentiation of hematopoietic stem or progenitor cells by non-muscle type cofilin
This invention has as its object providing promoters of the growth and/or differentiation of hematopoietic stem cells and/or hematopoietic progenitors which are useful as therapeutics of diseases...
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7279156 |
Apoptotic entities for use in treatment of endothelium dysfunction disorders
Treatment and/or prophylaxis of endothelial dysfunction-related disorders in mammalian patients is effected by administering to the patient effective amounts of apoptotic bodies and/or apoptotic...
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7273756 |
Method for chondrocyte expansion with phenotype retention
The present invention provides a method that maintains chondrocyte phenotype during serial expansion by culturing a population of chondrocytes in a defined serum-free culture medium containing...
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7273607 |
Health enhancement method
A health enhancement system establishing a health enhancement program through which may be provided a group of natural products, vitamins and minerals, amino acids, herbs and essential oils that...
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7270829 |
Industrial production of meat using cell culture methods
A meat product containing in vitro produced animal cells in a three dimensional form and a method for producing the meat product.
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7270813 |
Coupling agents for orthopedic biomaterials
The invention provides a method for the preparation of bone-polymer composites wherein the mineral portion of the bone is treated with a coupling agent before being incorporated into a...
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7261884 |
Live genetically attenuated malaria vaccine
Method for inoculating a vertebrate host against malaria, by administering to the host a live Plasmodium organism that is genetically engineered to disrupt a liver-stage-specific gene function.
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7259012 |
Use of oxidized lipoproteins for differentiation of precursor cells into mature dendritic cells
The invention concerns a method for differentiating precursor cells into mature dendritic cells, comprising placing the precursor cells in a medium suitable for their differentiation and adding to...
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7255880 |
Treatment of endothelin-related disorders
Endothelin-related disorders in mammals can be alleviated by administration to such patients of one or more aliquots of mammalian blood subjected to two or more stressors selected from temperature...
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7250286 |
Methods for the in vitro culture of Sporozoea sp. and uses thereof
The invention relates to a method of excysting and growing protozoal oocysts by in vitro tissue culture resulting in production of a continuous culture of merozoites. The invention also provides an...
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7244552 |
Artificial dermis and production method therefor
Artificial dermis ( 1 ) obtained from plasma with platelets ( 2 ) and human fibroblasts. The plasma with platelets ( 2 ) is obtained from the fractionating of total blood ( 4 ) from the patient ( 8...
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7244442 |
Method for making devices using polyhydroxyalkanoate having pyrogen removed
Polyhydroxyalkanoates (PHAs) from which pyrogen has been removed are provided for use in numerous biomedical applications. PHAs which have been chemically modified to enhance physical and/or...
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7232566 |
Methods for treating HIV infected subjects
Methods for inducing a population of T cells to proliferate by activating the population of T cells and stimulating an accessory molecule on the surface of the T cells with a ligand which binds the...
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7229808 |
Bioreactor
The present invention relates to a process for producing a bioreactor using viable immobilized biological material and to the bioreactor itself. More particularly, the present invention relates to...
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7223596 |
Malignant endothelial cell line and uses thereof in models for angiogenesis
An immortalized hemangiosarcoma cell line of malignant canine endothelial cells which possesses surface expression characteristics and growth factor and cytokine expression profiles typical of...
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7223391 |
Method for treating mammals with modified mammalian blood
An improved method for treating or preventing a pathological condition in a mammalian subject in which modified mammalian blood is administered to the subject. The method comprises administering to...
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