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6472210 |
Polymer scaffold having microporous polymer struts defining interconnected macropores
A polymer scaffold is provided having an extensively interconnected macroporous network with macropores having microporous struts as walls. Macropore diameter ranges from about 0.5 to about 3.5 mm....
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6465226 |
Preparing small microcapsules containing high concentration of cells or tissue
Biologically active substances such as cells or tissue are microencapsulated by methods that provide a high proportion of microcapsules containing a core of the biologically active substance as...
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6465001 |
Treating medical conditions by polymerizing macromers to form polymeric materials
Water soluble macromers are modified by addition of free radical polymerizable groups, such as those containing a carbon-carbon double or triple bond, which can be polymerized under mild conditions...
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6461865 |
Calreticulin-deficient cells
The invention relates to calreticulin-deficient cells. The cells can be either homozygous or heterozygous for the calreticulin mutation.
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6455048 |
Prevention of primary and metastatic neoplastic diseases with hsp70-peptide complexes
The present invention relates to methods and compositions for eliciting an immune response and the prevention and treatment of primary and metastatic neoplastic diseases and infectious diseases....
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6454804 |
Engineered tissue annulus fibrosis augmentation methods and apparatus
Living annulus fibrosis cells are combined with annulus fibrosis extracellular matrix obtained from recently deceased human or animal donors to restore disc function and eliminate pain in patients...
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6451305 |
Methods for stimulating T cell responses to tumor cells expressing LFA-3 and a CD28 or CTLA4 ligand
Methods for stimulating a T cell response to a tumor cell in a subject with a tumor which involve modifying the tumor cell to express a CD2 ligand and a CD28 or CTLA4 ligand, are disclosed. Methods...
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6444205 |
Transplantation of neural cells for the treatment of chronic pain or spasticity
Methods for using neural cells to treat chronic pain and/or spasticity are described. The neural cells can be derived from any mammal, and are preferably human or porcine in origin. The neural...
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6444236 |
Compositon containing medicinal herbs and young antlers of cornu cervi
A composition is provided for use in health foods for promoting the circulation of blood, prepared from medicinal herbs, including Lycium chinense Miller, Agastache rugosa (Fischer et Meyer) O....
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6432399 |
Treatment of stress and preconditioning against stress
Symptoms of stress such as elevated blood pressure in mammals are treated, and mammalian bodies are preconditioned to manifest reduced adverse reactions to subsequently encountered stresses, by...
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6432653 |
Device and process for cell capture and recovery
Devices, processes and compositions are provided for effective separation of cells from a mixture of cells, where depletion or positive selection may be employed to provide a cellular population of...
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6428802 |
Preparing artificial organs by forming polylayers of different cell populations on a substrate
Compositions and methods are provided for producing multilayered artificial organs comprising heterogenous polylayers. Polylayers comprising homogenous cell populations are created on one side of a...
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6426222 |
Method for inducing osteoblast differentiation of human extramedullary adipose tissue cells
A method for inducing osteoblast differentiation and/or for obtaining cells engaged in osteoblast differentiation, starting from human extramedullary adipose tissue cells, comprising the step...
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6426214 |
Cell encapsulating device containing a cell displacing core for maintaining cell viability
Cell encapsulating devices capable of maintaining large numbers of viable cells are provided containing an inert, substantially cell-free core that displaces cells, a permeable membrane and a zone...
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6413538 |
Bioactive glass or ceramic substrates having bound cell adhesion molecules
Non-crystalline, porous bioactive glass and ceramic materials are prepared that permit in vitro formation of bone tissue when exposed to a tissue culture medium and inoculated with cells. The...
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6403080 |
Methods of modulating an immune response to antigen, and cells for use in the method
Disclosed are methods and compositions wherein opsonin-enhanced cells, that is, cells which have been 1) modified so as to express an opsonin from a recombinant nucleic acid, 2) modified so as to...
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6403104 |
Hapten-conjugated mammalian cells and methods of making and using thereof
The present invention is directed to mammalian cells conjugated to a hapten and methods of making and using thereof. Conjugating hapten to mammalian cells is a useful way of preventing cells from...
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6399070 |
Methods and compositions for eliciting an immune response with hsp90-peptide complexes
The present invention relates to methods and compositions for eliciting an immune response and the prevention and treatment of primary and metastatic neoplastic diseases and infectious diseases....
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6399058 |
Methods for treating ocular diseases
Methods, for lowering intraocular pressure by implanting in the anterior chamber encapsulated cells which secrete an intraocular pressure lowering substance.
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6399060 |
Composition having nematicidal activity
A pesticide composition that includes a metabolite from a fungus selected from homeocarpic basidiomycetes and homeocarpic ascomycetes is described. In one embodiment, the fungus from which the...
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6399057 |
Method for the propagation of hair
Method of reproduction of hair, which method comprises the following steps: (1) removal of hair in the anagen phase from one or more donor regions in such a way that the bulb characteristic of...
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6399069 |
Prevention of infectious diseases with hsp70-peptide complexes
The present invention relates to methods and compositions for eliciting an immune response and the prevention and treatment of primary and metastatic neoplastic diseases and infectious diseases....
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6391306 |
Treatment of infectious diseases with hsp90-peptide complexes
The present invention relates to methods and compositions for eliciting an immune response and the prevention and treatment of primary and metastatic neoplastic diseases and infectious diseases....
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6383481 |
Method for transplantation of hemopoietic stem cells
This invention relates to a method of transplanting hemopoietic stem cells which Comprises subjecting a recipient to a radiation treatment using an effective exposure dose for hemopoietic stem cell...
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6383491 |
Prevention of infectious diseases with hsp90-peptide complexes
The present invention relates to methods and compositions for eliciting an immune response and the prevention and treatment of primary and metastatic neoplastic diseases and infectious diseases....
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6383492 |
Treatment of infectious diseases with gp96-peptide complexes
The present invention relates to methods and compositions for eliciting an immune response and the prevention and treatment of primary and metastatic neoplastic diseases and infectious diseases....
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6383494 |
Methods and composition for eliciting an immune response with gp96-peptide complexes
The present invention relates to methods and compositions for eliciting an immune response and the prevention and treatment of primary and metastatic neoplastic diseases and infectious diseases....
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6379953 |
Ligands that modulate differentiation of mesenchymal stem cells
Disclosed are compositions and methods for accelerating the differentiation of human MSCs into the osteogenic lineage with resultant enhanced de novo bone formation. This makes possible improved...
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6379672 |
Prevention of infectious diseases with gp96-peptide complexes
The present invention relates to methods and compositions for eliciting an immune response and the prevention and treatment of primary and metastatic neoplastic diseases and infectious diseases....
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6375953 |
Treatment of infectious diseases with HSP70-peptide complexes
The present invention relates to methods and compositions for eliciting an immune response and the prevention and treatment of primary and metastatic neoplastic diseases and infectious diseases....
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6375950 |
Methods for inducing T cell unresponsiveness to donor tissue or organ in a recipient with gp39 antagonists
Methods for inducing T cell tolerance to a tissue or organ graft in a transplant recipeint are disclosed. The methods involve administering to a subject: 1) an allogeneic or xenogeneic cell which...
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6376238 |
Culture media for neurons, methods for preparing the culture media, and methods for culturing neurons
The present invention is directed to a culture medium for neurons prepared by adding albumin to a culture supernatant obtained from a culture of primary astroglial cells in a trophic medium...
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6376245 |
Associations of antagonistic prokaryotes with eukaryotes
The invention provides a process for protecting whole eukaryotes or parts thereof from an invasive attack from an invasive agent which comprises, selecting a prokaryotic bacterium which is capable...
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6372210 |
Method for repopulating human bone marrow comprising culturing CD34&plus cells in a serum free medium
A serum-free medium which supports the proliferation and differentiation of CD34 + cells purified from normal bone marrow, peripheral blood of patients treated with cytokines, and umbilical cord...
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6368592 |
Method of delivering oxygen to cells by electrolyzing water
Oxygen is supplied to cells in vitro or in vivo by generating oxygen with an oxygen generator that electrolyzes water to oxygen and hydrogen. Oxygen can be generated substantially without...
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6368858 |
Modulation of multicellular aggregates by pressure from growth in a matrix
Cells in a matrix or in the matrix in a vessel are grown to form a multicellular aggregate. Pressure is exerted on the growing cells by the matrix or the matrix together with the vessel due to...
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6368593 |
Enhanced immunogenic cell populations prepared using H2 receptor antagonists
This invention provides a method to enhance alloactivation in a mixed lymphocyte culture. Alloactivated cells are effective in treating tumors when implanted into a tumor site or coinjected with...
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6368859 |
Methods and compositions for producing a fascial sling
The present invention describes methods for producing artificial fascial slings and their subsequent use in treating subjects with urinary incontinence. The invention is based, in part, on the...
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6365153 |
Mechanically elongated neuronal cells and methods for producing and using these cells
Mechanically elongated neuronal cells and methods of mechanically producing elongated cells are provided. Also provided are methods for transplanting elongated neuronal cells into an animal for...
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6365385 |
Methods of culturing and encapsulating pancreatic islet cells
Cells, preferably isolated pancreatic islet cells, are treated with a compound or a combination of compounds selected from an antioxidant, an anti-cytokine, an anti-endotoxin and an antibiotic. The...
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6352557 |
Treating degenerative disc disease through transplantion of extracellular nucleus pulposus matrix and autograft nucleus pulposus cells
Living nucleus pulposus cells are combined with nucleus pulposus extracellular matrix obtained from recently deceased human or animal donors to restore disc function and eliminate pain in patients...
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6352694 |
Methods for inducing a population of T cells to proliferate using agents which recognize TCR/CD3 and ligands which stimulate an accessory molecule on the surface of the T cells
Methods for inducing a population of T cells to proliferate by activating the population of T cells and stimulating an accessory molecule on the surface of the T cells with a ligand which binds the...
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6352707 |
Transplant encapsulation in a hydrogel matrix to obscure immune recognition
Immune recognition of a transplant such as tissue implanted in a host mammal is obscured by encapsulating the transplant in a hydrogel matrix containing gelatin, dextran, at least one nitric oxide...
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6350445 |
Method of treating cancer with a tumor cell line having modified cytokine expression
The present invention provides a method of treating cancer comprising (a) obtaining a tumor cell line, (b) modifying the tumor cell line to render it capable of producing an increased level of a...
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6348444 |
Human growth hormone to stimulate hematopoiesis and immune reconstitution after hematopoietic stem cell transplantation in humans
The invention relates to the use of human growth hormone for the manufacture of a medicament for stimulating hematopoiesis and immune reconstitution to be administered to a patient in need thereof...
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6340369 |
Treating degenerative disc disease with harvested disc cells and analogues of the extracellular matrix
Living intervertebral disc cells are harvested, cultured and combined with type-specific collagen-glycosaminoglycan extracellular matrix analogues to restore disc function and eliminate pain in...
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6333031 |
Receptor derived peptides as modulators of receptor activity
Oligopeptides having an amino acid sequence corresponding to a receptor's extracellular domain, and having sequence similarity to regulatory peptides from MHC class I antigens, enhance or replace...
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6333028 |
Method of using haptenized ovarian carcinoma tumor cells
The present invention is directed to compositions and methods of treating cancer. The compositions of the present invention include a composition prepared from a tumor cell which is hapten modified...
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6328969 |
Method and compositions for stimulation of an immune response to a differentiation antigen stimulated by an altered differentiation antigen
Tolerance of the immune system for self differentiation antigens can be overcome and an immune response stimulated by administration of a therapeutic differentiation antigen. The therapeutic...
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6326465 |
Immunomodulatory polypeptides derived from the invariant chain of MHC class II
Polypeptides derived from a proteolytically cleaved portion of the invariant chain of MHC class II, termed CLIP, have been found to have immune modulatory properties. Depending on the portions of...
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