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6617151 |
Method of closing a cell containment device with a wet seal
A method is provided for closing a containment device that involves wetting at least a portion of a permeable polymeric membrane such as tubular membrane with a liquid such as a cell suspension or...
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6613320 |
Defective CD4&plus T-cells that express active CD40-L
CD4 + cells obtained from individuals with defective CD40L gene and transfected with a vector containing CD40-L are described.
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6613319 |
Long-term expression of erythropoietin and growth hormone by transforming muscle cells
A process for increasing the circulating levels of gene products in a primate for extended period of time is provided. In accordance with that process, muscle cells of the mammal are transformed...
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6613961 |
Plants capable of metabolizing drugs and use thereof
Transgenic plants capable of metabolizing drugs are constructed by introducing a drug-metabolizing P450 molecular species into plants. These plants are capable of detoxifying and metabolizing...
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6607722 |
Methods for inducing the differentiation of monocytes into functional dendritic cells
A method for inducing differentiation of monocytes contained in an extracorporeal quantity of a subject's blood into functional dendritic antigen presenting cells is provided. The monocytes are...
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6605275 |
Isolation and preservation of fetal and neonatal hematopoietic stem and progenitor cells of the blood
The present invention relates to hematopoietic stem and progenitor cells of neonatal or fetal blood that are cryopreserved, and the therapeutic uses of such stem and progenitor cells upon thawing....
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6602680 |
Production of gabaergic cells
The invention features methods and compositions for the production of GABAergic cells, particularly GABAergic neurons. Production of GABAergic cells is accomplished by increasing activity of a Dlx...
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6599516 |
Malleable implant containing solid element that resorbs or fractures to provide access channels
A malleable implant for implantation into living tissue is prepared having access means for cells into the interior of the implant. The implant is capable of being deformed under pressure required...
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6596310 |
Method of artificial insemination by timed release of sperm from capsules or solid beads
A method is provided for encapsulating sperm in a particle wherein the particle provides for the timed release of the sperm. In particular, the method uses a gel forming polymer to form the...
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6596303 |
Pet food for maintenance of joint health and alleviation of arthritic symptoms in companion animals
A pet food product and process for producing the pet food product for use in maintenance of healthy joints and alleviation of arthritic symptoms in companion animals, the pet food comprising an...
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6596274 |
Biological material containing bone marrow stem cells partially or completely differentiated into connective tissue cells and a hyaluronic acid ester matrix
A biological material comprising two components is provided containing a first component comprising alternatively (1) a culture of autologous or homologous bone marrow stem cells partially or...
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6593511 |
Models of chronic and acute inflammatory diseases
Methods and compositions are provided for the creation and screening of non-human animal models having chronic inflammation. Immunocompromised host animals are injected with a population of...
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6592886 |
Producing stable cross-linked alginate gel by binding surplus cations with anions
A stable cross-linked alginate gel such as in the form of alginate gel beads encapsulating transplant materials is produced by binding surplus multivalent cations remaining after cross-linking...
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6589525 |
Method and device for preparing a dental implant by immersion in a culture of mesenchymal cells
The present invention concerns a method of manufacturing a dental implant comprising: preparing an implant composed of a root portion and a crown portion and constituted by an inert biocompatible...
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6585969 |
Non-viable keratinocyte cell composition or lysate for promoting wound healing
Cultures of keratinocyte cells are provided which are free from nonautologous fibroblasts and organ extracts, and which have a high speed of cell amplification for a minimum seeding density. The...
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6582957 |
Lipoxygenase proteins and polynucleotides encoding the same
The nucleotide and corresponding amino acid sequences are reported for a novel class of mammalian lipoxygenase proteins. The novel lipoxygenase encoding polynucleotides were obtained from human...
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6572895 |
Treatment of congestive heart failure
A method of treating congestive heart failure (CHF) in a human patient comprises treating an aliquot of the patient's blood ex vivo with at least one stressor selected from the group consisting of...
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6569428 |
Pharmaceutical products comprising endothelial cell precursors
Pharmaceutical products are provided comprising EC progenitors for use in methods for regulating angiogenesis, i.e., for enhancing or inhibiting blood vessel formation, in a selected patient and in...
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6569442 |
Preparation of polymer foam having gelled sol coating for intervertebral disc reformation
Methods and materials are provided for reforming degenerated intervertebral discs of the spine of a vertebrate and in particular the spine of a human. Tissue is evacuated from the nucleus pulposus...
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6558665 |
Encapsulating particles with coatings that conform to size and shape of the particles
Particles such as islet cells are encapsulated by a method that forms a coating of uniform thickness that conforms to the size and shape of the particles. Two substantially immiscible liquids of...
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6555118 |
Pharmaceutical preparation for the treatment of topical wounds and ulcers
A pharmaceutical preparation for the treatment of wounds and ulcers in humans and animals and a method of preparation of the same are provided here. The composition consists of an alcoholic extract...
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6555372 |
Composition for enhancing cellular immunogenicity comprising alpha-glycosylceramides
A composition for enhancing immunogenicity of tumor cells or pathogen-infected cells comprising a compound having an α-glycosylceramide structure or a salt or solvate thereof is provided. Tumor...
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6548059 |
Promotion of proliferation of adult corneal endothelial cells
Disclosed is a method of stimulating adult corneal endothelial cell proliferation, which includes incubation of corneal endothelium to a mitogen-containing medium and then to an agent that...
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6548297 |
Sheets of cultured epithelial cells used for wound repair and their cryopreservation
Methods of cryopreserving sheets of cultured epithelial cells are disclosed. The sheets of cultured epithelial cells are used for wound repair. The invention permits the use of preserved tissue...
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6544514 |
Compositions comprising, as the main ingredient, allogenic activated-C4&plus cells and method for producing and using the same
Compositions or medicaments comprising allogenic activated-CD4+ cells as the main ingredient, which are attributable to an organ or bone marrow transplantation donor, have an extremely beneficial...
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6544521 |
Immunoreactive peptide CTL epitopes of human cytomegalovirus pp150
The invention provides peptides which are immunogenic epitopes recognized by CD8 + class I MHC restricted cytotoxic T-lymphocytes of patients harboring latent cytomegalovirus (HCMV) infection. The...
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6544751 |
Methods of harvesting rare cells from blood products
The present invention provides methods of harvesting rare cells from blood products and/or obtaining products of the rare cells. The method includes contacting a blood product containing rare cells...
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6540994 |
Macrophages, process for preparing the same and their use as active substances of pharmaceutical compositions
The invention relates to macrophages which have at least one of the following properties: their cytotoxic activity without IFN-7 is increased by about 20 to 30% with respect to standard...
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6537567 |
Tissue-engineered tubular construct having circumferentially oriented smooth muscle cells
Improved methods for the production of tissue-engineered constructs, including muscular tissue constructs such as vascular constructs, are disclosed. The methods include the use of improved...
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6538174 |
Animal model for transplantation
The invention relates to an animal model of cancer. The animal carries a tumor xenograft and is immunosuppressed by administration of cyclosporin and ketoconazole. The model is useful for studying...
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6534097 |
Pest repellent
A pest deterrent compound includes water, calcium carbonate and hydrogen sulfide. The compound is successful in deterring white flies and other destructive insects from attacking plants. The plant...
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6528052 |
Method for in vivo ex vivo and in vitro repair and regeneration of cartilage and collagen and bone remodeling
A method for in vivo, ex vivo and in vitro regeneration of cartilage and collagen. In vivo, ex vivo and in vitro regeneration and de novo formation of articular cartilage and collagen by...
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6524852 |
Removing or increasing permeability of embryonic capsule to prepare equine embryos for cryopreservation
A method for preparing an equine embryo for cryopreservation is provided. The method includes collecting an equine embryo with its embryonic capsule. Then after collection the embryo is treated to...
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6521431 |
Biodegradable cross-linkers having a polyacid connected to reactive groups for cross-linking polymer filaments
Biodegradable cross-linkers are provided having a polyacid core with at least two acidic groups covalently connected to reactive groups usable to cross-link polymer filaments. Between at least one...
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6517833 |
Neural retinal cells and retinal pigment epithelium cells and their use in treatment of retinal disorders
Compositions comprising porcine retinal cells and methods for using the compositions to treat retinal disorders are described. The porcine retinal cells are preferably fetal neural retina cells or...
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6517872 |
FGFR3 as a marker for mesenchymal skeletal progenitor cells
The present invention concerns fibroblast growth factor receptor 3 (FGFR3) as a novel marker for mesenchymal skeletal progenitor cells. By utilizing this novel marker it was possible both to...
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6514493 |
cDNA clone for tumor rejection antigen gp110 and tumor peptide vaccine
An isolated cDNA molecule comprising an amino acid sequence encoding an amino-terminal protein fragment of murine glycoprotein 110 is disclosed. Therapeutic methods for treating tumor-bearing...
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6509147 |
Method for therapeutic immunmodulation of plasma
A process and set-up of therapeutic immunomodulation is provided for medicine. Many illnesses (i.e. Sepsis) are, among other things, characterized by a disruption of the immune system. In spite of...
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6500464 |
Bilayered collagen construct
This invention describes a collagen construct uniquely suited as a substrate for production of biologically active wound dressings, skin equivalents or skin substitutes. The collagen construct of...
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6497876 |
Method of stimulating an immune response with activated dendritic cells
Antigen-expressing, activated dendritic cells are disclosed. Such dendritic cells are used to present tumor, viral or bacterial antigens to T cells, and can be useful in vaccination protocols....
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6497875 |
Multilayer skin or dermal equivalent having a layer containing mesenchymal stem cells
A multilayer skin equivalent is formed having a scaffold layer containing dermis-forming cells, and a keratinocyte layer. The dermis-forming cells and keratinocytes are preferably autologous, and...
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6491912 |
Porcine cardiomyocytes and their use in treatment of insufficient cardiac function
Porcine cardiomyocytes and methods for using the cardiomyocytes to treat disorders characterized by insufficient cardiac function are described. The porcine cardiomyocytes are preferably embryonic...
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6485749 |
Absorbable &egr -Caprolactone polymers and medical devices
Crystalline, low melting ε-Caprolactone polymers which undergo accelerated hydrolysis, and their use as lubricant coatings and/or as coatings containing bioactive agents, as carriers of viable...
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6482645 |
Methods and compositions for producing artificial fascia
The present invention describes methods for producing artificial fascial slings and their subsequent use in treating subjects with urinary incontinence. The invention is based, in part, on the...
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6479066 |
Device having a microporous membrane lined deformable wall for implanting cell cultures
A device and method of using the device are provided for implanting cell cultures in a host. The device is formed of a deformable body, a microporous membrane and a sealable port. The shape of the...
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6479064 |
Culturing different cell populations on a decellularized natural biostructure for organ reconstruction
artificial organs are reconstructed using a three-dimensional scaffold produced by decellularizing biostructures from a donor organ. The three-dimensional scaffold is perfused with isolated...
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6479052 |
Spray delivery of cells
Provided is, among other things, a method of adhering cells to a target surface which is a tissue surface of a mammal or such a tissue surface coated with a biodegradable polymer sheet, comprising:...
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6475483 |
Method for in vitro proliferation of dendritic cell precursors and their use to produce immunogens for treating autoimmune diseases
A method for producing proliferating cultures of dendritic cell precursors is provided. Also provided is a method for producing mature dendritic cells in culture from the proliferating dendritic...
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6471958 |
Non-contracting tissue equivalent
The present invention provides a non-contracting tissue equivalent comprising at least one cellular component and at least one non-cellular component. The tissue equivalent closely resembles normal...
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6472210 |
Polymer scaffold having microporous polymer struts defining interconnected macropores
A polymer scaffold is provided having an extensively interconnected macroporous network with macropores having microporous struts as walls. Macropore diameter ranges from about 0.5 to about 3.5 mm....
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