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7022522 |
Macroporous polymer scaffold containing calcium phosphate particles
A polymer scaffold is provided comprising an extensively interconnected macroporous network. The polymer scaffold embodies macropores having a diameter in a range of 0.5-3.5 mm, and preferably in a...
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7019192 |
Composition for filling bone defects
The invention is directed toward a formable bone composition for application to a bone defect site to promote new bone growth at the site which comprises a new bone growth inducing compound of...
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7018632 |
Method for ex vivo immunization using heterologous intact bispecific and/or trispecific antibodies
According to the invention there is described a method for ex vivo immunization of humans and animals comprising the following steps:
a) isolating autologous tumor cells; b) treating the...
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7014849 |
Keratinocyte culture and uses thereof
The present invention relates to the treatment of skin defects by organotypically-cultured autologous keratinocytes isolated from the outer root sheath of anagen or growing hair. Methods for...
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7014859 |
Entomopathogenic nematode for control of insect pests
A nematode collected from Diaprepes abbreviatus was identified and described as a new species, Steinernema diaprepesi n. sp. The new species can be distinguished from other species of the genus...
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7011829 |
Tissue filler
Disclosed are a tissue filler and tissue reconstruction method using the same that enables missing or reduced tissue of a body to recover to a normal state thereof, and the tissue filler comprised...
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7009039 |
Plasma protein matrices and methods for their preparation
A freeze dried biocompatible matrix comprising plasma proteins, useful as implants for tissue engineering as well as in biotechnology, and methods of producing the matrix are provided. Mechanical...
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7001767 |
Method for in vitro propagation of the agent responsible for transmissible spongiform encephalopathies
The invention concerns a method for in vitro propagation of the agent responsible for transmissible spongiform encephalopathies, or prion, comprising steps which consist in: providing a culture or...
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6995013 |
Cell-scaffold composition containing five layers
A cell-scaffold composition that comprised of at least five layers of biocompatible material, each of which layers is coated with a biological sealant material and contains different cells The...
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6995299 |
Propagation of human hepatocytes in non-human animals
The present invention relates to the preparation of non-human animals having chimeric livers, whereby some or substantially all of the hepatocytes present are human hepatocytes. It is based, at...
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6994851 |
Method of inducing a CTL response
A method of inducing a cytotoxic T-lymphocyte (CTL) response to an antigen is disclosed. The method involves delivering the antigen to the lymphatic system of an animal regularly over a sustained...
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6994853 |
Time-staggered utilization of tumor cells in combination with intact antibodies for immunization
The invention relates to the time-staggered utilization of tumor cells in combination with intact, preferably heterologous antibodies for the immunization of humans and animals.
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6989271 |
Schwann cells originating in myeloid interstitial cells
There is provided a method of inducing bone marrow stromal cells to differentiate into bone marrow stromal cell-derived Schwann cells in vitro, comprising the steps of: collecting bone marrow...
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6984383 |
Method of transplanting cells by contacting donor cells with B7-1-and B7-2-specific immunoglobulins
The invention relates to a humanized anti-B7-2 antibody that comprises a variable region of nonhuman origin and at least a portion of an immunoglobulin of human origin. The invention also pertains...
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6977084 |
Pet food containing Perna canaliculus for maintenance of joint health and alleviation of arthritic symptoms
A pet food product and process for producing the pet food product for use in maintenance of healthy joints and alleviation of arthritic symptoms in companion animals, the pet food comprising an...
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6977076 |
Methods for obtaining from Chlorella extract polysaccharides having immunomodulating properties
Chlorella extracts containing high molecular weight Chlorella polysaccharide and polysaccharide complexes show immune modulatory, specifically immune stimulatory, activity. The polysaccharide...
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6977073 |
Method for stimulating an immune response
A method is described whereby dendritic cells derived from the CD34+ and CD 34−hematopoietic cell lineages are directed to become programmable antigen presenting cells. The programmed cells may...
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6974576 |
Chlorella composition having high molecular weight polysaccharides and polysaccharide complexes
Chlorella extracts containing high molecular weight Chlorella polysaccharide and polysaccharide complexes show immune modulatory, specifically immune stimulatory, activity. The polysaccharide...
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6969523 |
Collagen/glycosaminoglycan matrix stable to sterilizing by electron beam radiation
Compositions of cross-linked collagen and a glycosaminoglycan are provided which retain characteristics rendering them useful as tissue engineering matrices or scaffolds following terminal...
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6969608 |
Pharmaceuticals containing multipotential precursor cells from tissues containing sensory receptors
Current sources of neural stem and progenitor cells for neural transplantation are essentially inaccessible in living animals. This invention relates to neural precursor cells (stem cells,...
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6967029 |
Method for increasing hematopoietic progenitor cells by stem cell factor
Novel stem cell factors, oligonucleotides encoding the same, and methods of production, are disclosed. Pharmaceutical compositions and methods of treating disorders involving blood cells are also...
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6964765 |
Inhibitors of apoptosis
The invention provides methods and compositions relating to novel human cellular inhibitor of apoptosis proteins (c-IAP1/2) comprising a series of defined structural domain repeats and/or a RING...
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6964869 |
Method and composition for skin grafts
A chimeric skin comprising immortalized human keratinocyte cells cocultured with donor keratinocytes is disclosed.
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6962775 |
Wound repair dressings and methods for their preservation
Methods and products relating the preservation of cultured mammalian epithelial or mesenchymal cells are provided. The methods involve the pre-treatment of epithelial cells with a solution...
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6958149 |
Repair of larynx, trachea, and other fibrocartilaginous tissues
Provided herein are methods and devices for inducing the formation of functional replacement nonarticular cartilage tissues and ligament tissues. These methods and devices involve the use of...
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6955809 |
Retinal cell grafts
Surgical instruments, surgical techniques, grafts, cell and tissue isolation techniques, and a method for transplanting retinal cells, including photoreceptors, retinal pigment epithelium, and...
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6953576 |
Method of modulating tumor immunity
Novel cells and molecules involved in tumor immunity are disclosed. The novel cells are regulatory T-cells having the phenotype CD3 + αβ-TcR + CD4 − CD8 − CD44 − CD28 − NK1.1 − . The...
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6949252 |
Method for preparing an implantable multilayer tissue construct
The present invention relates to compositions and methods for preparing tissues or tissue constructs. In selected embodiments, the invention relates to the construction of a multi-layered...
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6943021 |
Three dimensional vaginal tissue model containing immune cells
Disclosed is a cervico-vaginal tissue equivalent comprised of vaginal epithelial cells and immune cells, cultured at the air-liquid interface. The tissue equivalent is capable of being infected...
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6942873 |
Microfabrication of membranes containing projections and grooves for growing cells
The present invention provides a novel substrate for use in growing cells and for the study of mechanobiology. The membrane of the present invention comprises appropriate microtopography and...
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6942879 |
Bioartificial filtration device for filtering blood to mimic kidney function
A novel cell seeded hollow fiber bioreactor is described as a potential bioartificial kidney. Endothelial cells along with pericyte, vascular smooth muscle, and/or mesangial cells or any...
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6942639 |
Autologous platelet gel delivery system
The delivery system of the present invention is comprised of at least two chambers which store, individually, an activated blood component and an inactivated blood component. The first chamber...
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6929792 |
Modified dendritic cells and use therefor
The invention provides isolated dendritic cells genetically modified to express a selectin polypeptide, optionally treated with activated platelets or membrane microparticles thereof. The invention...
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6926893 |
Multi-stage cascade boosting vaccine
Humoral and cellular immune responses against tumor cells and infectious agents are induced in a mammal using a vaccine comprising antibodies and anti-idiotype antibodies that mimic an epitope of...
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6927207 |
Recombinant mistletoe lectines
The present invention relates to isolated mistletoe lectin polypeptides and the pharmaceutical composition comprising the polypeptides thereof. Also, the present invention relates to processes for...
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6923959 |
Method of pre-inducing a state of immune tolerance before organ transplantation
Methods and compositions are described for the treatment of type I insulin-dependent diabetes mellitus and other conditions using newly identified stem cells that are capable of differentiation...
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6913762 |
Stent having non-woven framework containing cells
Implantable medical devices that include a non-woven framework are described, as well as methods of using such devices to deliver therapeutic compounds to a patient.
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6911202 |
Cosmetic repair using cartilage producing cells and medical implants coated therewith
A method of cosmetically repairing a skin contour irregularity in a subject is provided. The method is effected by introducing cartilage producing cells into the skin contour irregularity thereby...
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6911201 |
Method of producing undifferentiated hemopoietic stem cells using a stationary phase plug-flow bioreactor
A method of expanding/maintaining undifferentiated hemopoietic stem cells or progenitor cells by obtaining undifferentiated hemopoietic stem cells or progenitor cells; and either seeding the...
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6902932 |
Helically organized silk fibroin fiber bundles for matrices in tissue engineering
The present invention provides a novel silk-fiber-based matrix having a wire-rope geometry for use in producing a ligament or tendon, particularly an anterior cruciate ligament, ex vivo for...
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6899873 |
Method of forming micro-tubular polymeric materials
The present invention discloses the design and fabrication of highly porous (up to 97%) scaffolds from biodegradable polymers with a novel phase-separation technique to generate controllable...
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6900055 |
Preparation of porous silicone rubber for growing cells or living tissue
A method of making a silicone rubber having a structure adapted for growth of cells or living tissue, which comprises contacting a silicone rubber precursor with a biologically-acceptable...
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6897060 |
Composition comprising multipotent neural stem cells for generation of hematopoietic cells
Multipotent neural stem cell (MNSC) progeny are induced to generate cells of the hematopoietic system by placing the MNSC progeny in a hematopoietic-inducing environment. The hematopoietic-inducing...
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6893634 |
Encapsulated cells producing cytochrome P450
The present invention relates to capsules encapsulating cytochrome P450 producing cells and cytochrome P450 producing retroviral packaging cells. Furthermore, the present invention relates to the...
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6890527 |
Methods of treatment
A method of producing active immunity against a bacterial or protozoal disease in a subject comprises administering to the subject a vaccine conjugate comprising a live bacteria or protozoa and a...
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6887488 |
Nano-calcium phosphates/collagen based bone substitute materials
The present invention relates to a nano-calcium phosphates/collagen composite that mimics the natural bone, both in composition and microstructure, as well as porous bone substitute and tissue...
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6878371 |
Therapeutic angiogenesis by bone marrow-derived cell transplantation in myocardial ischemic tissue and skeletal muscle ischemic tissue
This invention provides methods of forming new blood vessels in diseased or damaged tissue in a subject, methods of increasing blood flow to diseased or damaged tissue in a subject, and methods of...
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6875442 |
Process for growing tissue in a biocompatible macroporous polymer scaffold and products therefrom
A polymer scaffold is provided comprising an extensively interconnected macroporous network. The polymer scaffold embodies macropores having a diameter in a range of 0.5-3.5 mm, and preferably in a...
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6875430 |
Mesenchymal stem cells for prevention and treatment of immune responses in transplantation
A method of reducing an immune response to a transplant in a recipient by treating said recipient with an amount of mesenchymal stem cells effective to reduce or inhibit host rejection of the...
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6872389 |
Liver stem cell
The invention provides methods of isolating a primary liver stem cell by identifying a cell doublet containing a hepatocytes and the stem cell and isolating the doublet from liver tissue.
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