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5985656 |
Suppressor and progenitor cells
Natural suppressor (NS) cells secrete a soluble protein suppressor factor (SF) which suppresses the mixed lymphocyte response. NS cells as described herein are null, i.e., have the phenotype IL-2R...
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5985290 |
Purified pancreatic tumor cell lines and related compositions and method
The present invention provides a method of treating cancer comprising (a) obtaining a tumor cell line, (b) modifying the tumor cell line to render it capable of producing an increased level of a...
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5981165 |
In vitro induction of dopaminergic cells
A culture method for inducing the expression of tyrosine hydroxylase in neural cells is provided. Mammalian CNS neural cells are cultured in the presence of a fibroblast growth factor and at least...
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5980887 |
Methods for enhancing angiogenesis with endothelial progenitor cells
In accordance with the present invention, EC progenitors can be used in a method for regulating angiogenesis, i.e., enhancing or inhibiting blood vessel formation, in a selected patient and in some...
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5980888 |
Keratinocytes attached to microcarriers for treatment of skin wounds
Epithelial cells are attached to microcarriers to form a transplantation material for treatment of skin wounds. Preferably, keratinocyte-covered microcarriers are prepared using microcarriers...
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5980893 |
Agonist murine monoclonal antibody as a stimulant for megakaryocytopoiesis
A class of murine monoclonal antibodies that is capable of stimulating megakaryocytopoiesis in vitro has been raised against human megakaryocytic cells. The monoclonal antibody BAH-1 specifically...
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5976780 |
Encapsulated cell device
A macroencapsulation device for somatic cells using ultrapurified Na alginate and polysulfone hollow fibers of 30 kDa molecular weight cutoff. Ultrapurified Na alginate material is used which has a...
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5976526 |
Injectable bladder muscle cells-polymer suspension for treatment of vesicoureteral reflux and incontinence
A method of treatment of vesicoureteral reflux, incontinence and other defects is described wherein bladder muscle cells are mixed with a liquid polymeric material to form a suspension. This is...
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5976878 |
Method and apparatus for preparing composite skin replacement
A method and apparatus for forming a permanent, composite skin replacement consisting of an epidermal component and a porous, resorbable, biosynthetic laminated dermal membrane component for use in...
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5972592 |
Increasing reproductive efficiency of bull semen using fucose or a compound with a fucose moiety
Inclusion of fucose or fucose-containing bull sperm monovalent binding oligosaccharide in semen extender increases the reproductive efficiency of bull semen extended therewith, for artificial...
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5972332 |
Wound treatment with keratinocytes on a solid support enclosed in a porous material
Devices and methods for enhancing the healing of wounds, especially chronic wounds (e.g., diabetic wounds), are provided involving the use of keratinocytes. Keratinocytes are grown on a...
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5968829 |
Human CNS neural stem cells
Isolation, characterization, proliferation, differentiation and transplantation of mammalian neural stem cells is disclosed.
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5965436 |
Method of isolating mesenchymal stem cells associated with isolated megakaryocytes by isolating megakaryocytes
The present invention is directed to isolated and purified human mesenchymal stem cells, to a method for isolating, purifying, and culturally expanding human mesenchymal stem cells (i.e....
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5961972 |
Isolated porcine pancreatic cells for use in treatment of diseases characterized by insufficient insulin activity
Isolated porcine pancreatic cells, isolated populations of such cells and methods for isolating and using the cells to treat subjects with diseases characterized by insufficient insulin activity...
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5958404 |
Treatment methods for disease using co-localized cells and Sertoli cells obtained from a cell line
A method of treating a disease is provided that results from a deficiency of a biological factor which comprises administering to a mammal Sertoli cells and cells that produce the biological...
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5951976 |
Opsonin-enhanced cells, and methods of modulating an immune response to an antigen
Disclosed are methods and compositions wherein opsonin-enhanced cells, that is, cells which have been 1) modified so as to express an opsonin from a recombinant nucleic acid, 2) modified so as to...
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5948426 |
Method and article to induce hematopoietic expansion
An article and method to create retrievable sites of implantable and transplantable bone marrow, in a human or animal recipient, by implanting bone-marrow inducing conjugates of collagen and...
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5948442 |
Stimulating ENTEROGENIN compositions and methods for their isolation and use
This patent relates to the obtaining of two pharmaceutical forms--pulvis and ampules of the veterinary medical preparation "Enterogenin". The bioactive ingredient of the preparation is isolated by...
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5945576 |
Mouse model of psoriasis
Methods and compositions for preparing a mouse model of an inflammatory skin condition are disclosed. The methods involve administering donor lymphocytes to a recipient immune deficient mouse to...
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5945101 |
Skin model system
This invention relates to a skin model system that can be used as an in vitro test system or which can be used for therapeutic purposes. The skin model system comprises a three-dimensional,...
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5942437 |
Method and media for enhancing viability maturation, and cryopreservation of cells
A method to increase viability, number, survival and maturation of cells for transplantation or cryopreservation by culturing the cells with Sertoli cells or with sertoli-cell conditioned media...
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5942225 |
Lineage-directed induction of human mesenchymal stem cell differentiation
Methods for in vitro or ex vivo lineage directed induction of isolated, culture expanded human mesenchymal stem cells comprising contacting the mesenchymal stem cells with a bioactive factor...
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5935606 |
Reversing excitotoxic CNS damage by cellular implantation
The use of certain types of CNS transplants in preventing and reversing excitotoxic CNS damage.
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5928945 |
Application of shear flow stress to chondrocytes or chondrocyte stem cells to produce cartilage
Mammalian cells capable of producing cartilage are cultured under a shear flow stress of about 1 to about 100 dynes/cm 2 to produce artificial cartilage for surgical transplantation to replace...
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5928936 |
Cell culture container that self-seals after cannula penetration made of porous sheets
A container for growing cells in a culture medium is made by sealing two sheets of gas-permeable elastomeric material such as made of silicone together to enclose a culture chamber. A portion of...
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5927004 |
Beneficial insect compositions and method of making same
The compositions of the invention are the in-situ prepared spray coated beneficial insects, which may be the beneficial insect alone, or within the confines of a host. The method of making the...
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5928947 |
Mammalian multipotent neural stem cells
The invention includes mammalian multipotent neural stem cells and their progeny and methods for the isolation and clonal propagation of such cells. At the clonal level the stem cells are capable...
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5922598 |
Reducing tissue immunogenicity by induction of apoptosis
A cell is subjected to apoptosis, a genetically programmed autolysis of the cell. Cells of a specific type, classified by function, maturity, source, etc. can be effectively removed from a mixture...
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5919700 |
Method of proliferating natural killer cells with IL-16
The invention relates to a method of stimulating the proliferation of natural killer cells with in vitro IL-16. A mixed lymphocyte cell population which contains natural killer cells can be nylon...
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5914121 |
Formation of human bone in vivo using ceramic powder and human marrow stromal fibroblasts
An in vivo model for human bone metabolism. Human marrow stromal fibroblasts are isolated, expanded in culture, combined with ceramic powder (hydroxyapatite) delivery vehicles with or without...
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5912236 |
Broad-spectrum tumor suppressor genes gene products and methods for tumor suppressor gene therapy
The present invention relates to a broad-spectrum tumor suppressor gene and the protein expressed by that gene in appropriate host cells. The protein is a second in-frame AUG codon-initiated...
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5912174 |
Stem cell and lymphocyte storage
Methods of stabilizing lymphocytes and/or stem cells obtained from a mammal by suspending them in an aqueous medium comprising gelatin.
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5910424 |
Metastatic melanoma cell lines from monodelphis domestica for use in anti-cancer agent discovery
A cell line of metastatic, pigmented, malignant melanoma cells made by exposing a litter of Monodelphis domestica suckling young to an accumulated dose of ultraviolet radiation and then continuing...
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5908624 |
Antigenic modulation of cells
The present invention is directed to a non-immunogenic cellular composition comprising: a cell having a cell surface and antigenic determinants on the cell surface; a linker molecule covalently...
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5908782 |
Chemically defined medium for human mesenchymal stem cells
A composition and method for maintaining the viability of human mesenchymal precursor cells in a serum-free environment which composition includes (1) a minimum essential medium; (2) serum albumin;...
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5902745 |
Cell encapsulation device
The present invention is directed to a cell encapsulation device that permits rapid and straightforward cell transfer into the device. The preferred device includes components that allow a user to...
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5888814 |
Recombinant host cells encoding TNF proteins
A virion expression system for a desired protein packaged in an envelope derived from a retrovirus useful in administering proteins which cross cell membranes in order to serve their function....
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5888499 |
Method for increasing neutrophil populations using in vitro-derived human neutrophil precursor cells
A suspension comprising human neutrophil precursor cells, wherein the cellular component is comprised of at least about 16% human myeloblasts and promyeclocytes, which have been derived from...
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5888705 |
Compositions and method of stimulating the proliferation and differentiation of human fetal and adult pancreatic cells ex vivo
A method of inducing the proliferation and/or differentiation of human adult pancreatic cells entails contacting primary cultures of such cells with Hepatocyte Growth Factor/Scatter Factor...
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5888497 |
Agarose coated agarose beads containing cancer cells that produce material which suppresses cancer cell proliferation
Implantable beads which contain agarose and optionally collagen, and are coated with agarose have incorporated within cells which produce diffusible biological products. The beads may be used as...
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5871985 |
Particulate non cross-linked chitosan core matrices for encapsulated cells
Vehicles containing cells for implanting in the tissue of an individual are prepared having cells dispersed in a particulate, essentially non cross-linked chitosan core matrix that is enclosed...
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5871728 |
Method of regulating dendritic cell maturation
A novel transplantation method for enhancing tolerogenicity in a host mammal to a transplant graft specimen from a donor mammal is disclosed. According to this method, immature mammalian dendritic...
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5869037 |
Adenoviral-mediated gene transfer to adipocytes
The present invention provides for in vivo gene transfer to adipocytes mediated by adenovirus and, in particular, the in vivo transfer of toxic genes as a means of reducing adiposity, as well as...
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5869035 |
Methods and compositions for inducing complement destruction of tissue
The invention discloses methods and compositions for killing tumor cells in animals. Through transfer techniques, cancer cells are engineered to express an epitope which is targeted by natural...
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5866115 |
Process for preparing dendritic cells, cells thus produced and containers for carrying out this process
Dendritic cells are of interest therapeutically as antigen-presenting cells. A process is disclosed in which peripheral blood cells are first isolated and the CD 34 antigen-expressing blood...
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5866150 |
Antibacterially active extracts from the marine algae chaetoceros and methods of use
The present invention relates to the use of extracts obtained from the marine algae Chaetoceros as antibacterially active agents and to compositions containing such agents for use against...
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5866757 |
Engraftment and development of xenogeneic cells in normal mammals having reconstituted hematopoetic deficient immune systems
Non-human chimeric mammals are created from a mammal having hematopoietic cells replaced with hematopoietic cells from a hematopoietic deficient mammal donor, and optionally in which xenogeneic...
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5866415 |
Materials for healing cartilage and bone defects
The invention concerns methods for the production of in vitro constituted biological materials and their subsequent use as implants for healing cartilage and bone defects. A biological composite...
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5863531 |
In vitro preparation of tubular tissue structures by stromal cell culture on a three-dimensional framework
A stromal cell-based three-dimensional cell culture system is provided which can be used to culture a variety of different cells and tissues in vitro for prolonged periods of time. The stromal...
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5861315 |
Use of stem cell factor and soluble interleukin-6 receptor for the ex vivo expansion of hematopoietic multipotential cells
Stem cell factor in combination with soluble interleukin-6 receptor, interleukin-6, for gp130 signaling, supports the proliferation, differentiation and terminal maturation of blood cells from...
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