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7618623 |
Hybrid adeno-retroviral vector for the transfection of cells
An adenovirus, including adenoviral capsid proteins, and a replication-defective adenoviral vector that includes a 5′ retroviral LTR nucleic acid sequence, a 3′ retroviral LTR nucleic acid...
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7608257 |
Sensitization of chemotherapeutic agent resistant neoplastic cells with a virus
The present invention relates to a method of increasing the sensitivity of neoplastic cells to chemotherapeutic agents by using a virus, a method of treating proliferative disorders with a virus...
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7601347 |
Methods and compositions for controlled release of bioactive compounds
A controlled release pharmaceutical dosage form for bacteriophage is presented. The dosage form is prepared by drying the active ingredient together with a dispersion or solution of...
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7601345 |
Lentivirus vectors for gene transfer to alveolar epithelial cells
The present invention demonstrates that VSV-G-pseudotyped lentivirus vectors efficiently transduce AEC in primary culture and in vivo with transduction favored by virus application from the apical...
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7595042 |
Oncolytic virus therapy
A method of treating a human subject with cancer is disclosed. A pharmaceutical composition is administered to the subject, the pharmaceutical composition comprising human leukocytes and a...
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7588929 |
Production of bacteriophage compositions for use in phage therapy
The present invention relates to the use of bacteriophages to treat infectious diseases. The invention provides a method for intermediate to large scale commercial production of bacteriophage...
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7588768 |
Attenuated negative strand viruses with altered interferon antagonist activity for use as vaccines and pharmaceuticals
The present invention relates, in general, to attenuated negative-strand RNA viruses having an impaired ability to antagonize the cellular interferon (IFN) response, and the use of such attenuated...
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7585675 |
Inhibition of HIV and SHIV replication with antisense interleukin-4
A method of treating or preventing SHIV or HIV infection in a subject comprising administering a therapeutically effective amount of a antisense IL-4. The antisense IL-4 inhibits viral replication...
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7582478 |
Cleaved serum response factor in cardiac diagnosis and therapy
The present invention is directed to the cleavage of serum response factor as it relates to cardiac disease. In specific embodiments, failing cardiac tissue is diagnosed in tissues comprising...
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7582291 |
Bacteriophage lysins for Enterococcus faecalis, Enterococcus faecium and other bacteria
The present disclosure relates to bacteriophage lysins useful for the reduction of certain bacterial populations, including methods and compositions for the treatment of various bacterial...
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7569219 |
Recombinant double-stranded RNA phage, and use of the same
A recombinant double stranded RNA (dsRNA) phage expresses dsRNA-encoded genes in eukaryote cells. Recombinant dsRNA phage are useful for the expression of dsRNA expression cassettes encoding...
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7569217 |
Porcine adenovirus E1 and E4 regions
The present invention relates to the characterization of the porcine adenovirus E1 and E4 regions. The complete nucleotide sequence of the genome of porcine adenovirus type 3 (PAV-3), providing the...
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7563617 |
Hybrid adenovirus/adeno-associated virus vectors and methods of use thereof
The invention provides recombinant vectors including adenovirus/adeno-associated virus (Ad/AAV) vectors and mini-adenovirus (mAd) vectors. Further, the invention provides cells containing these...
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7534613 |
Methods of treating parkinson's disease using viral vectors
Methods of delivering viral vectors, particularly recombinant AAV virions, to the CNS are provided. Also provided are methods of treating Parkinson's Disease.
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7521239 |
Photochemical internalization for virus-mediated molecule delivery into the cyosol
A method for introducing a molecule into the cytosol of a cell in which the cell is contacted with a photosensitizing agent, the cell is irradiated with light of a wavelength effective to activate...
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7504255 |
Compositions and methods for generation of infectious hepatitis C virus in immortalized human hepatocytes
The present invention provides a cell line capable producing infectious hepatitis C virus 1a (HCV 1a) particles in culture. Disclosed are compositions and methods for an HCV 1a (clone H77)...
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7491525 |
Specific proliferation in tumour cell which can express antioncogene with high efficiency and the use of it
The present invention provides a recombinant virus, which highly expresses a cancer therapeutic gene and specifically proliferates in tumor cells, and a method for the proliferation of the same. In...
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7491387 |
Disinfection of foodstuffs
A method of disinfection of livestock is provided. The method comprises administering at least one bacteriophage in an effective amount to said livestock to reduce the number of Campylobacter spp ...
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7485318 |
Biodegradable carrier and method for preparation thereof
A biodegradable carrier is produced for preservation and/or controlled delivery of biologically active agents where the biodegradable carrier is a silica xerogel which is made from water and silane...
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7485292 |
Method of treating a malignancy in a subject via direct picornaviral-mediated oncolysis
There are provided methods for treatment of abnormal cells such as cancer cells in a mammal. The methods involve treating the mammal with virus selected from echoviruses and modified forms and...
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7481998 |
Ex vivo and in vivo expression of the thrombomodulin gene for the treatment of cardiovascular and peripheral vascular diseases
The present invention relates to methods and compositions for treatment of cardiovascular and peripheral vascular diseases using ex vivo and in vivo gene delivery technologies. One aspect of the...
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7476382 |
Reovirus for the treatment of neoplasia
Methods for treating neoplasia, by administering reovirus to a Ras-mediated neoplasm, are disclosed. The reovirus is administered so that it ultimately directly contacts cells of the neoplasm....
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7465583 |
Duplexed parvovirus vectors
The present invention provides duplexed parvovirus vector genomes that are capable under appropriate conditions of forming a double-stranded molecule by intrastrand base-pairing. Also provided are...
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7459153 |
Viral vectors for gene therapy
Adenovirus types 11p and 4p show a higher binding affinity and infectivity than type 5 for endothelial and carcinoma cell lines. Adenovirus type 11p shows a stronger binding to cells for neural...
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7445929 |
Recombinant adenovirus vector having a reduced side effect
The present invention provides a novel adenovirus vector for which inflammation during the in vivo administration thereof is alleviated by inhibiting the induction of expression of an adenovirus...
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7438901 |
Virulent phages to control Listeria monocytogenes in foodstuffs and in food processing plants
The present invention relates to virulent (lytic) Listeria monocytogenes phage from the Myoviridae family, preferably P100, alone or in combination with other virulent phages. P100 and the...
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7435434 |
Phage resistant bacteria
The invention relates to an S thermophilus bacterium which is resistant to attack by at least one bacteriophage, a method of production of the bacterium and a composition which comprises the...
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7419829 |
Vector system
The present invention provides a vector system comprising a mutated post-transcriptional regulatory element. In particular, the present invention relates to a mutated WPRE sequence that can...
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7419817 |
Scalable purification of AAV2, AAV4 or AAV5 using ion-exchange chromatography
The present invention provides methods of purifying adeno-associated virus (AAV) particles. These AAV particles include AAV2, AAV4 and AAV5 particles. The present invention also provides AAV...
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7410644 |
Recombinant pox virus for immunization against tumor-associated antigens
Recombinant pox viruses capable of expressing cell-encoded, tumor-associated antigens are disclosed. The recombinant viruses are useful for evoking an immune response against the antigen.
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7404960 |
Multivalent vaccine composition having increased stability of capsular polysaccharide
A vaccine composition comprising two valences is provided: (i) a first valence which is adjuvant-enhanced with aluminum hydroxide and (ii) a second valence which contains a polysaccharide of...
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7399750 |
Methods for cardiac gene transfer
Methods for the delivery of genes to improve cardiac function including the use of viral vectors, isolation of the heart from systemic circulation, and induction of hypothermia/cardiac arrest are...
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7393527 |
Method for limiting the growth of cancer cells using an attenuated measles virus
A method for treating cancer cells is provided comprising directly or systemically administering a therapeutically effective dose of an attenuated measles virus. In one embodiment, the...
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