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7390483 Universal GM-CSF expressing bystander human K562 cell line  
The present invention provides a universal immunomodulatory cytokine-expressing bystander cell line, a composition comprising such a cell line and a cancer antigen, a method of making such a cell...
7381710 Combined DNA vaccine and biological modifiers for cancer therapy  
The present invention relates to the combination of a DNA vaccination strategy that makes use of a nucleic acid encoding an immunogenic polypeptide, with a non-immunosuppressive inducer of tumor...
7381405 Methods of preparing lymphocytes that express interleukin-2 and their use in the treatment of cancer  
The invention provides methods of preparing autologous T-lymphocytes for re-introduction into a patient having cancer, which method comprises obtaining peripheral blood mononuclear cells (PBMCs)...
7378277 Methods and compositions for transforming dendritic cells and activating T cells  
Recombinant dendritic cells are made by transforming a stem cell and differentiating the stem cell into a dendritic cell. The resulting dendritic cell is an antigen presenting cell which activates...
7378087 Method of enhancing an immune response  
A method of enhancing an immune response to an antigen is provided. The method involves augmenting the level of a TAP molecule in a target cell bearing the antigen. Preferably, the TAP molecules...
7371515 Identifying and characterizing genes  
The invention provides methods and materials for identifying and characterizing genes related to phenotypes such as cancer and cell survivability. Also provided in the invention are cells and...
7371374 Neural transplantation using pluripotent neuroepithelial cells  
The subject invention pertains to a novel method of correction of behavioral and/or psychological deficits made possible by the intracerebral transplantation of pluripotent neuroepithelial cells....
7368107 Tumor antigen peptides derived from cyclophilin B  
Tumor antigen peptides derived from cyclophilins or derivatives thereof having the functionally equivalent properties; medicaments, prophylactics, or diagnostics for tumors comprising as an active...
7342002 Molecular vaccine linking an endoplasmic chaperone polypeptide to an antigen  
This invention provides compositions and methods for inducing and enhancing immune responses, such as antigen-specific cytotoxic T lymphocyte (CTL) responses, using chimeric molecules comprising...
7341719 Myoblast therapy for cosmetic treatment  
Compositions and methods of treating mammalian diseases using myoblasts, and/or their physical, genetic, chemical derivatives. Myogenic cells that are normal, or genetically or phenotypically...
7338655 Gene therapy using TGF-β  
The subject invention is related to a cell-mediated gene therapy treatment for orthopedic disease using a member belonging to the transforming growth factor-β (TGF-β) superfamily. TGF-β gene...
7335505 Materials and methods relating to protein aggregation in neurodegenerative disease  
The present invention provides methods of proteolytically converting a precursor protein (e.g. tau) to a product fragment (e.g., a 12 kd fragment) in a stable cell line, wherein the precursor...
7335353 Porcine cells comprising an adenovirus E3 gene region  
The complete nucleotide sequence of the genome of porcine adenovirus type 3 (PAV-3) is provided. Methods for construction of infectious PAV genomes by homologous recombination in procaryotic cells...
7335351 Immunotherapeutic methods targeted towards stratum corneum chymotryptic enzyme  
The present invention discloses the protease stratum corneum chymotrytic enzyme (SCCE) is specifically over-expressed in ovarian and other malignancies. A number of SCCE peptides can induce immune...
7332643 Ferritin light subunit variant-encoding nucleic acids, polypeptides, transgenic animals comprising the same, antibodies thereto, and methods of use thereof  
Nucleic acids encoding a novel ferritin light chain variant, a ferritin light chain variant polypeptide, ferritin light chain variant polypeptide-specific antibodies, and methods of use thereof are...
7332337 Viral vectors having tissue tropism for T-lymphocytes, B- and mast cells  
The present invention relates to methods of introducing an expressible non-viral nucleic acid sequence into a T lymphocyte cell, a B-cell, or a mast cell, comprising contacting the cell with a...
7326692 Induction of immunity using inhibitors of granzymes  
The present invention provides methods for enhancing host immunity to a virus and/or a cancer and methods for enhancing the cytotoxic T-cell (CTL) mediated immune responses by providing granzyme B...
7323445 Methods and compositions for healing and repair of articular cartilage  
Methods and compositions are provided for the treatment of articular cartilage defects and disease involving the combination of tissue, such as osteochondral grafts, with active growth factor. The...
7320787 Redirection of cellular immunity by protein tyrosine kinase chimeras  
Disclosed is a method of directing a cellular response in a mammal by expressing in a cell of the mammal a chimeric receptor which causes the cells to specifically recognize and destroy an...
7316812 Cells expressing anti-Fc receptor binding components  
Cells transformed to express on their surface a component which binds to an Fc receptor of an effector cell are disclosed. Also disclosed are expression vectors used to transform the cells. Once...
7314864 Humanin, a polypeptide suppressing neuronal death  
The present invention provides polypeptides that suppresses neuronal death associated with Alzheimer's disease. Using a neuronal cell system, wherein the expression of familial Alzheimer's disease...
7312077 Insulin-secreting immortalized liver cell line modified by glucose sensitivity  
The present invention provides a cell line which can be substituted for β cells in human mature pancreatic islets and express insulin in a glucose-concentration dependent manner, and enables the...
7312026 MRP-related ABC transporter encoding nucleic acids and methods of use thereof  
Novel human MOAT genes and their encoded proteins are provided herein. The MRP-related ABC transporters encoded by the disclosed nucleic acid sequences play a pivotal role in the efflux of...
7306927 Method of inducing immunity against stratum corneum chymotrytic enzyme  
The disclosed nucleic acid primer sets, used in combination with quantitative amplification (PCR) of tissue cDNA, can indicate the presence of specific proteases in a tissue sample. The detected...
7306793 Defective recombinant adenoviruses expressing cytokines for antitumor treatment  
A recombinant nucleic acid used for the production of a defective adenovirus containing an inserted sequence coding for a cytokine under the control of a promoter in the genomic sequence of the...
7297540 Methods of generating tissue using devitalized, acellular scaffold matrices derived from micro-organs  
Methods of generating, and isolating adult stem cells and utilizing such cells and/or embryonic stem cells in generating tissue of a specific function and micro-architecture are provided.
7291605 Methods of treating various cancers using melanoma differentiation associated protein-7  
This invention provides a method for reversing the cancerous phenotype of a cancer cell by introducing a nucleic acid having the melanoma differentiation associated gene (mda-7) into the cell under...
7291597 Growth factor therapy mobilization of stem cells into the peripheral blood  
Stem cells are mobilized into the peripheral blood by a method comprising the steps of: (i) administering to an individual at least one of the following: FGF1 and FGF2, and also at least one of the...
7291454 Transgenic animals and cell lines for screening drugs effective for the treatment or prevention of Alzheimer's disease  
Disclosed are transgenic animals and transfected cell lines expressing a protein associated with Alzheimer's Disease, neuroectodermal tumors, malignant astrocytomas, and glioblastomas. Also...
7285540 Medicament comprising HGF gene  
The present invention relates to a medicament comprising a HGF gene. The medicament of the present invention may be topically applied to the target organs so that the effects can be selectively...
7285527 Tumor radiosensitization using gene therapy  
The invention provides a method of radiosensitizing a tumor in a subject by contacting the tumor with a cytokine or a nucleic acid molecule encoding a cytokine. The invention also provides a method...
7276234 Method of acquiring immunological tolerance  
The aim of the present invention is to provide a method of acquiring immunological tolerance to a foreign DNA or its expression product whereby the foreign DNA such as a vector carrying a foreign...
7270810 Veto cells effective in preventing graft rejection and devoid of graft versus host potential  
A method of transplanting a transplant derived from a donor into a recipient is disclosed. The method comprises the steps of (a) transplanting the transplant into the recipient; and (b)...
7268120 Methods for treating cancer using cytokine-expressing polynucleotides  
The present invention provides a pharmaceutical composition, comprising a non-infectious, non-integrating polynucleotide construct comprising a polynucleotide encoding an interferon ω and one or...
7261887 Leishmania as carriers for the delivery of proteins and peptides  
Methods for delivering potentially therapeutic or prophylactic protein and peptide agents to mammalian cells are provided. The agents are delivered by mutant trypanosomatid protozoa that have been...
7261884 Live genetically attenuated malaria vaccine  
Method for inoculating a vertebrate host against malaria, by administering to the host a live Plasmodium organism that is genetically engineered to disrupt a liver-stage-specific gene function.
RE39788 Gene therapy  
Primary human cells which are genetically engineered with DNA (RNA) encoding a marker or therapeutic which is expressed to be expressed in vivo. Such engineered cells may be used in gene therapy.
7252819 Methods and compositions for correction of cardiac conduction disturbances  
The invention provides methods for establishing electrical coupling between cardiomyocytes and recombinant cells which have been genetically engineered to express a connexin protein such as...
7250293 Complementing cell lines  
A packaging cell line capable of complementing recombinant adenoviruses based on serotypes from subgroup B, preferably adenovirus type 35. The cell line is preferably derived from primary diploid...
7247480 Method for producing dendritic cells  
Disclosed are embryonic stem cell-derived dendritic cells, genetically modified immature dendritic cells capable of maturation, as well as methods for the production of such cells. In one...
7247298 Treatment of brain damage  
The present invention relates to the treatment of brain damage by cellular transplantation. According to one aspect of the invention, a method for treating a motor, sensory and/or cognitive deficit...
7241742 CYP1B1 nucleic acids and methods of use  
The present invention provides nucleic acids containing transcriptional units that encode CYP1B1 polypeptides or portions thereof, wherein the transcriptional units lack sequences found in the...
7238528 Means and methods for fibroblast-like or macrophage-like cell transduction  
The invention provides a nucleic acid delivery vehicle with or having been provided with at least a tissue tropism for fibroblast-like or macrophage-like cells, preferably synoviocytes. In one...
7238347 Suicidal mutant Leishmania vaccine  
The present invention discloses the use of a mutant Leishmania as a suicidal vaccine wherein the mutant Leishmania is responsive to external signals to become porphyric and commit suicidal...
7235236 Polynucleotide encoding human adenylylcyclase VI and uses thereof for enhancing cardiac function  
The present invention relates to polynucleotides encoding human adenylylcyclase VI and uses thereof for enhancing cardiac function. The present invention can thus be used in the treatment of heart...
7235233 Serotype 5 adenoviral vectors with chimeric fibers for gene delivery in skeletal muscle cells or myoblasts  
The invention provides means and methods for transduction of a skeletal muscle cell and/or a muscle cell specific precursor thereof. Provided is the use of a gene delivery vehicle derived from an...
7220582 Stem cells that transform to beating cardiomyocytes  
Disclosed herein is a novel isolated population of stem cells, called spoc cells, that can be induced, either in vivo or in vitro, to differentiate into cardiomyocytes. Methods are disclosed herein...
7217571 Gene therapy by small fragment homologous replacement  
A method for gene therapy using small fragment homologous replacement. The method introduces small fragments of exogenous DNA into regions of endogenous genomic DNA virtually homologous to the...
7211569 Synthetic human papilloma virus genes  
Synthetic DNA molecules encoding papillomavirus proteins are provided. The codons of the synthetic molecules are codons preferred by the projected host cell. The synthetic molecules may be used as...
7211247 Lentivirus vectors for gene transfer to alveolar epithelial cells  
The present invention demonstrates that VSV-G-pseudotyped lentivirus vectors efficiently transduce AEC in primary culture and in vivo with transduction favored by virus application from the apical...