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6838285 |
Site specific recombinase based method for producing adenoviral vectors
Site-specific recombinase based methods for making a recombinant adenoviral genome, as well as kits for practicing the same and the recombinant adenovirus vectors produced thereby, are provided. In...
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6838281 |
Cells expressing fusion proteins of immunoglobulins
The invention provides methods and compositions for inducing and maintaining tolerance to epitopes or antigens containing the epitopes. The compositions include expression cassettes and vectors...
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6821516 |
Macrophages, process for preparing the same and their use as active substances of pharmaceutical compositions
The invention relates to macrophages which have at least one of the following properties: their cytotoxic activity without IFN-γ is increased by about 20 to 30% with respect to standard...
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6821511 |
Methods of using adeno-associated virus rep protein
A composition for delivering at least one DNA sequence encoding a desired protein or polypeptide (such as a therapeutic agent) to a cell. The composition comprises an adeno-associated virus rep...
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6812205 |
Suppression of vascular disorders by mucosal administration of heat shock protein peptides
Disclosed herein are methods for treating vascular disorders in mammals. The methods involve administering one or more agents selected from the group consisting of a heat shock protein (HSP), a...
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6808702 |
Treatment of disorders by implanting stem cells and/or progeny thereof into gastrointestinal organs
A method of treating a disorder, typically a gastrointestinal disorder, that includes implanting stem cells and/or progeny thereof into a gastrointestinal organ of a subject. Also, a method of...
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6805861 |
Immunotherapy using cytotoxic T lymphocytes (CTL)
A method of treating a patient with a disease wherein the patient contains diseased cells which cells contain, or are associated with, an abnormal molecule or an abnormally elevated amount of a...
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6803184 |
MPR-related ABC transporter encoding nucleic acids and methods of use thereof
Novel human MOAT genes and their encoded proteins are provided herein. The MRP-related ABC transporters encoded by the disclosed nucleic acid sequences play a pivotal role in the efflux of...
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6800480 |
Methods and materials for the growth of primate-derived primordial stem cells in feeder-free culture
Methods and materials for culturing primate-derived primordial stem cells are described. In one embodiment, a cell culture medium for growing primate-derived primordial stem cells in a...
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6800466 |
Biological fertilizer compositions comprising sludge
The present invention provides biological fertilizer compositions that comprise yeast cells and sludge. The yeast cells of the invention have an enhanced ability to fix atmospheric nitrogen,...
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6797269 |
Mesenchymal stem cells as immunosuppressants
The present invention provides a method to modulate immune responses using antigen presenting human mesenchymal stem cells to induce specific T cell anergy. The present invention also provides a...
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6794370 |
Method for treating cancer using camptothecin derivatives and 5-fluorouracil
A combination therapy for treating cancer including administering at least one camptothecin derivative in conjunction with another anticancer agent. The combination therapy is preferably used as a...
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6787356 |
Cell expansion system for use in neural transplantation
The invention provides a method of culturing cells which includes a proliferating step in which the number of precursor cells is expanded and a differentiating step in which the expanded precursor...
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6783756 |
Methods for regulating gene expression
A method for regulating expression of a tet operator-linked gene in a cell of a subject is disclosed. In one embodiment, the method involves introducing into the cell a nucleic acid molecule...
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6784162 |
Gene therapy method for reducing risk of atherosclerosis
A single point mutation in the human lipoprotein lipase gene which results in an A→G nucleotide change at codon 291 (nucleotide 1127) of the lipoprotein lipase gene, and a substitution of serine...
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6780639 |
Antibiotic inducible/repressible genetic construct for gene therapy or gene immunization
The present invention is related to an antibiotic inducible/repressible genetic construct for controlling the transcription of a gene of interes: by a cell. The genetic construct comprises a...
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6776985 |
Encapsulated cells producing viral particles
The present invention relates to encapsulated cells producing viral particles, especially retroviral particles containing the genome of a retroviral vector carrying therapeutic genes, to methods...
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6776986 |
Inhibition of HIV-1 replication by antisense RNA expression
Novel antisense sequences to the unspliced or single spliced portions of mRNA transcript from HIV-1 provirus, optionally co-expressed with an inhibitory transdominant mutant HIV-1 protein, are...
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6776987 |
Enhancement of cardiac chronotropy
Molecularly-mediated and cellular-based β-adrenergic receptor-dependent biological pacemakers are disclosed. Methods of using these compositions to improve cardiac chrontropic responsiveness by...
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6773702 |
Use of combretastatin A4 and its prodrugs as an immune enhancing therapy
A method of treating immune suppression in a warm-blooded animal bearing a tumor, by administering to the animal an amount of combretastatin A4 and/or a prodrug thereof effective to enhance immune...
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6770260 |
Method preventing depletion of non-autologous hematopoietic cells and animal model systems for use thereof
The invention provides methods for preventing depletion of non-autologous hematopoietic cells. Animal model systems using the method are also provided as are methods of treatment using...
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6770749 |
P53-specific T cell receptor for adoptive immunotherapy
The present invention relates to molecular cloning of cDNA for both A and B chains of hu p53-specific, HLA restricted mu TCR, transfer of the cDNA to hu T cells, and functional expression of the...
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6767928 |
Mineralization and biological modification of biomaterial surfaces
Disclosed are advantageous methods for patterning and/or mineralizing biomaterial surfaces. The techniques described are particularly useful for generating three-dimensional or contoured bioimplant...
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6767535 |
Suppressing tumor formation using cells expressing JE/monocyte chemoattractant protein-1
A method of suppressing tumor formation in a vertebrate by administering JE/MCP-1 is described. Also described are methods of treating localized complications of malignancies and methods of...
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6764676 |
Compositions and methods for protecting animals from lentivirus-associated disease such as feline immunodeficiency virus
The present invention is directed to a novel strain of feline immunodeficiency virus, designated herein as FIV-141, and to attenuated forms of the virus produced by mutating specific regions of the...
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RE38556 |
Recombinant adeno viruses comprising an inserted gene encoding apolipoprotein and their use in gene therapy for dyslipoproteinemias
The present invention concerns defective recombinant adenoviruses containing an inserted gene encoding apolipoproteins, pharmaceutical compositions comprising the adenovirus, and their use for the...
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6761886 |
Biological fertilizer compositions comprising cattle manure
The present invention provides biological fertilizer compositions that comprise yeast cells and cattle manure. The yeast cells of the invention have an enhanced ability to fix atmospheric nitrogen,...
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6759038 |
Metastasis models using green fluorescent protein (GFP) as a marker
A method to follow the progression of metastasis of a primary tumor, which method comprises removing fresh organ tissues from a vertebrate subject which has been modified to contain tumor cells...
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6759036 |
Fibrocyte-base vaccine formulations
There is disclosed a fibrocyte-based vaccine formulations made from isolated fibrocytes. There is further disclosed a method for establishing an immune response against a specific antigen by...
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6749833 |
Design and planning system for improving the survival rate of injected structures
The present invention includes a method for evaluating the acceptability of a device for the delivery of cells in a cell implantation therapy comprising: determining a first rate of cell survival...
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6737052 |
Induction of programmed cell death by N5 gene
The present invention concerns methods and compositions for treating cancer in a subject. These methods and compositions utilize the activities associated with the N5 gene product, p84N5. p84N5...
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6737271 |
Compound, composition and method for the treatment of inflammatory and inflammatory-related disorders
The present invention concerns a compound consisting of RNA, in particular RNA extracted from yeast, a pharmaceutical composition comprising such RNA and a method for the treatment of inflammatory...
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6733998 |
Micromonospora echinospora genes coding for biosynthesis of calicheamicin and self-resistance thereto
An isolated gene cluster of Micromonospora echinospora which codes for calicheamicin biosynthesis. The biosynthetic gene cluster contains genes encoding proteins and enzymes used in the...
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6733746 |
Hematopoietic cell culture nutrient supplement
The present invention provides a serum-free supplement which supports the growth of hematopoietic cells in culture. Also provided are a medium comprising a basal medium supplemented with the...
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6730303 |
Fused G-CSF and IL-3 proteins and uses thereof
Disclosed are novel multi-functional hematopoietic receptor agonist proteins, DNAs which encode the multi-functional hematopoietic receptor agonists proteins, methods of making the multi-functional...
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6723531 |
Method for modulating expression of exogenous genes in mammalian systems, and products related thereto
In accordance with the present invention, there are provided various methods for modulating the expression of an exogenous gene in a mammalian subject employing modified ecdysone receptors. Also...
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6719969 |
Treatment of liver disease and injury with CXC chemokines
Disclosed is the surprising discovery that CXC chemokines function to induce rapid hepatocyte proliferation and liver regeneration after injury. The invention thus provides a range of compositions...
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RE38490 |
Method for identifying metastatic sequences
The invention relates to methods for the identification of metastatic sequences. Cells from a cell line or an animal tissue are treated to form a cell line predisposed to metastasis. Treated cells...
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6716823 |
Noninvasive genetic immunization, expression products therefrom, and uses thereof
Disclosed and claimed are methods of non-invasive genetic immunization in an animal and/or methods of inducing a systemic immune or therapeutic response in an animal, products therefrom and uses...
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6713065 |
Methods of using hedgehog proteins to modulate hematopoiesis and vascular growth
This application pertains to methods and compositions that modulate proliferation and/or differentiation of undifferentiated mesodermally-derived cells so as to have an effect on at least one of...
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6713055 |
Glycosyltransferase vectors for treating cancer
This disclosure provides a system for specifically killing cancer cells which can be used in the course of human therapy. Vectors of the invention comprise an encoding sequence for a...
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6703016 |
Apoptotic bodies, monocyte derived cells containing the same, a process for their preparation and their uses as vaccines
The present invention relates to apoptotic bodies derived from human tumor cells or cell lines recovered from patient's tumor biopsy and induced to apoptotis, said apoptotic bodies having the...
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6699483 |
Cancer treatments
The invention relates to a product comprised of specific combinations of cell lines intended for use as an allogeneic immunotherapy agent for the treatment of prostate cancer in humans. The...
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6699972 |
Chimeric protein and method of controlling tumor growth using the protein
A chimeric protein expressed from a transgene tranduced into a mammalian tumor cell and method of using the chimeric protein for cancer treatment. The chimeric protein comprises an effector and an...
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6696420 |
Adenoviral vector with a deletion in the E1A coding region expressing a hetorologous protein
Recombinant DNA modified by a nucleotide sequence coding for a specific polypeptide sequence whose expression is sought, this recombinant DNA being appropriate to the transformation of eucaryotic...
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6696272 |
Products and methods for gaucher disease therapy
The invention relates to products and methods for medical treatment of Gaucher disease and, in particular, an improved Gcc DNA for insertion into any applicable expression vector for gene therapy...
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6692738 |
Delivery of therapeutic biologicals from implantable tissue matrices
Normal cells, such as fibroblasts or other tissue or organ cell types, are genetically engineered to express biologically active, therapeutic agents, such as proteins that are normally produced in...
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6692965 |
Isolation of living cells and preparation of cell lines based on detection and quantification of preselected cellular ribonucleic acid sequences
The invention is directed to reliable and efficient detection of mRNAs as well as other RNAs in living cells and its use to identify and, if desired, separate cells based on their desired...
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6692737 |
In vivo protein production and delivery system for gene therapy
The present invention relates to transfected primary and secondary somatic cells of vertebrate origin, particularly mammalian origin, transfected with exogenous genetic material (DNA) which encodes...
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6689757 |
Methods for vaccination and vaccines therefor
The invention relates to methods of and compositions for vaccinating a mammal against a disease, wherein a mixture is administered which includes (i) a nucleic acid which encodes a first epitope...
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