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7431922 |
Bioadhesive directed somatic cell therapy
The subject invention is related to a cell-mediated gene therapy treatment using a cell composition that includes bioadhesive material. The bioadhesive material allows targeted and localized...
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7429376 |
Methods of screening for compounds that improve engraftment
The invention provides for methods of screening for compounds that increase the expression of P-selectin, SDF-1, and/or CXCR4 on facilitatory cells (FCs). The invention also provides for methods of...
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7425443 |
Treatment of diabetes with synthetic beta cells
Disclosed is a method for obtaining glucose-regulated expression of active insulin in the cells of a mammalian subject. The method involves delivering into the subject a genetic construct...
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7422736 |
Somatic pluripotent cells
The present invention discloses a cultured somatic animal cell having a normal karyotype; the cell develops into an embryoid body when induced in vitro, or develops into a teratoma when introduced...
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7419660 |
Vaccines for treatment of lymphoma and leukemia
The present invention provides multivalent vaccines for the treatment of B-cell malignancies (e.g., lymphomas and leukemias). The present invention also provides methods for the production of...
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7419950 |
Methods of inhibiting ectopic calcification
The invention provides a method of inhibiting ectopic calcification in an individual. The method consists of administering to the individual a therapeutically effective amount of osteopontin or a...
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7413733 |
Antigen transduced T cells used as a delivery system for antigens
A delivery system comprising a T cell comprising at least one antigen capable of loading antigen-presenting-cells with the antigen.
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7404950 |
Induced activation in dendritic cell
The present invention is directed to a composition and method which to treat diseases and to enhance a regulated immune response. More particularly, the present invention is drawn to compositions...
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7402308 |
Method of delivering genes to the central nervous system of a mammal
The invention provides a method of delivering a selected DNA sequence to the central nervous system of a mammal by administering to said mammal a neurotropic virus, said virus containing a selected...
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7403883 |
Three-dimensional in-vitro spinal models and methods of analyzing substance distribution therein
An in-vitro model apparatus of a human spine and methods for detecting and analyzing substance distribution patterns therein. In one embodiment, the model apparatus includes a column body defining...
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7402307 |
Method for identifying and killing cancer cells
The invention provides a method for activating a T lymphocyte by contacting the T lymphocyte with a dendritic cell (DC) that presents a telomerase reverse transcriptase (TRT) peptide in the context...
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7399751 |
Production of a biological factor and creation of an immunologically privileged environment using genetically altered Sertoli cells
The present invention provides a method of providing an individual with a biological factor or intermediate thereof which comprises introducing into the individual Sertoli cells genetically altered...
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7396528 |
Corneal cells expressing active agents and methods of use thereof
The invention relates to methods of modifying cells of corneal tissue to express an active agent, to modified corneal tissue, to vectors utilised in such methods and to methods of xeno- and...
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7393525 |
Method for introducing and expressing genes in animal cells, and live invasive bacterial vectors for use in the same
A method for introducing and expressing genes in animal cells is disclosed comprising infecting said the animal cells with live invasive bacteria, wherein bacteria contain a eukaryotic expression...
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7393526 |
Systemic gene delivery vehicles for the treatment of tumors
The present invention relates to the field of cellular and molecular therapy with modified (genetically or growth factor engineered) and unmodified stem cells (SCs). More particularly, the...
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7390483 |
Universal GM-CSF expressing bystander human K562 cell line
The present invention provides a universal immunomodulatory cytokine-expressing bystander cell line, a composition comprising such a cell line and a cancer antigen, a method of making such a cell...
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7381710 |
Combined DNA vaccine and biological modifiers for cancer therapy
The present invention relates to the combination of a DNA vaccination strategy that makes use of a nucleic acid encoding an immunogenic polypeptide, with a non-immunosuppressive inducer of tumor...
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7381405 |
Methods of preparing lymphocytes that express interleukin-2 and their use in the treatment of cancer
The invention provides methods of preparing autologous T-lymphocytes for re-introduction into a patient having cancer, which method comprises obtaining peripheral blood mononuclear cells (PBMCs)...
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7378277 |
Methods and compositions for transforming dendritic cells and activating T cells
Recombinant dendritic cells are made by transforming a stem cell and differentiating the stem cell into a dendritic cell. The resulting dendritic cell is an antigen presenting cell which activates...
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7378087 |
Method of enhancing an immune response
A method of enhancing an immune response to an antigen is provided. The method involves augmenting the level of a TAP molecule in a target cell bearing the antigen. Preferably, the TAP molecules...
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7371515 |
Identifying and characterizing genes
The invention provides methods and materials for identifying and characterizing genes related to phenotypes such as cancer and cell survivability. Also provided in the invention are cells and...
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7371374 |
Neural transplantation using pluripotent neuroepithelial cells
The subject invention pertains to a novel method of correction of behavioral and/or psychological deficits made possible by the intracerebral transplantation of pluripotent neuroepithelial cells....
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7368107 |
Tumor antigen peptides derived from cyclophilin B
Tumor antigen peptides derived from cyclophilins or derivatives thereof having the functionally equivalent properties; medicaments, prophylactics, or diagnostics for tumors comprising as an active...
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7341719 |
Myoblast therapy for cosmetic treatment
Compositions and methods of treating mammalian diseases using myoblasts, and/or their physical, genetic, chemical derivatives. Myogenic cells that are normal, or genetically or phenotypically...
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7342002 |
Molecular vaccine linking an endoplasmic chaperone polypeptide to an antigen
This invention provides compositions and methods for inducing and enhancing immune responses, such as antigen-specific cytotoxic T lymphocyte (CTL) responses, using chimeric molecules comprising...
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7338655 |
Gene therapy using TGF-β
The subject invention is related to a cell-mediated gene therapy treatment for orthopedic disease using a member belonging to the transforming growth factor-β (TGF-β) superfamily. TGF-β gene...
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7335353 |
Porcine cells comprising an adenovirus E3 gene region
The complete nucleotide sequence of the genome of porcine adenovirus type 3 (PAV-3) is provided. Methods for construction of infectious PAV genomes by homologous recombination in procaryotic cells...
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7335351 |
Immunotherapeutic methods targeted towards stratum corneum chymotryptic enzyme
The present invention discloses the protease stratum corneum chymotrytic enzyme (SCCE) is specifically over-expressed in ovarian and other malignancies. A number of SCCE peptides can induce immune...
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7335505 |
Materials and methods relating to protein aggregation in neurodegenerative disease
The present invention provides methods of proteolytically converting a precursor protein (e.g. tau) to a product fragment (e.g., a 12 kd fragment) in a stable cell line, wherein the precursor...
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7332643 |
Ferritin light subunit variant-encoding nucleic acids, polypeptides, transgenic animals comprising the same, antibodies thereto, and methods of use thereof
Nucleic acids encoding a novel ferritin light chain variant, a ferritin light chain variant polypeptide, ferritin light chain variant polypeptide-specific antibodies, and methods of use thereof are...
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7332337 |
Viral vectors having tissue tropism for T-lymphocytes, B- and mast cells
The present invention relates to methods of introducing an expressible non-viral nucleic acid sequence into a T lymphocyte cell, a B-cell, or a mast cell, comprising contacting the cell with a...
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7326692 |
Induction of immunity using inhibitors of granzymes
The present invention provides methods for enhancing host immunity to a virus and/or a cancer and methods for enhancing the cytotoxic T-cell (CTL) mediated immune responses by providing granzyme B...
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7323445 |
Methods and compositions for healing and repair of articular cartilage
Methods and compositions are provided for the treatment of articular cartilage defects and disease involving the combination of tissue, such as osteochondral grafts, with active growth factor. The...
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7320787 |
Redirection of cellular immunity by protein tyrosine kinase chimeras
Disclosed is a method of directing a cellular response in a mammal by expressing in a cell of the mammal a chimeric receptor which causes the cells to specifically recognize and destroy an...
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7316812 |
Cells expressing anti-Fc receptor binding components
Cells transformed to express on their surface a component which binds to an Fc receptor of an effector cell are disclosed. Also disclosed are expression vectors used to transform the cells. Once...
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7314864 |
Humanin, a polypeptide suppressing neuronal death
The present invention provides polypeptides that suppresses neuronal death associated with Alzheimer's disease. Using a neuronal cell system, wherein the expression of familial Alzheimer's disease...
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7312026 |
MRP-related ABC transporter encoding nucleic acids and methods of use thereof
Novel human MOAT genes and their encoded proteins are provided herein. The MRP-related ABC transporters encoded by the disclosed nucleic acid sequences play a pivotal role in the efflux of...
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7312077 |
Insulin-secreting immortalized liver cell line modified by glucose sensitivity
The present invention provides a cell line which can be substituted for β cells in human mature pancreatic islets and express insulin in a glucose-concentration dependent manner, and enables the...
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7306793 |
Defective recombinant adenoviruses expressing cytokines for antitumor treatment
A recombinant nucleic acid used for the production of a defective adenovirus containing an inserted sequence coding for a cytokine under the control of a promoter in the genomic sequence of the...
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7306927 |
Method of inducing immunity against stratum corneum chymotrytic enzyme
The disclosed nucleic acid primer sets, used in combination with quantitative amplification (PCR) of tissue cDNA, can indicate the presence of specific proteases in a tissue sample. The detected...
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7297540 |
Methods of generating tissue using devitalized, acellular scaffold matrices derived from micro-organs
Methods of generating, and isolating adult stem cells and utilizing such cells and/or embryonic stem cells in generating tissue of a specific function and micro-architecture are provided.
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7291454 |
Transgenic animals and cell lines for screening drugs effective for the treatment or prevention of Alzheimer's disease
Disclosed are transgenic animals and transfected cell lines expressing a protein associated with Alzheimer's Disease, neuroectodermal tumors, malignant astrocytomas, and glioblastomas. Also...
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7291605 |
Methods of treating various cancers using melanoma differentiation associated protein-7
This invention provides a method for reversing the cancerous phenotype of a cancer cell by introducing a nucleic acid having the melanoma differentiation associated gene (mda-7) into the cell under...
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7291597 |
Growth factor therapy mobilization of stem cells into the peripheral blood
Stem cells are mobilized into the peripheral blood by a method comprising the steps of: (i) administering to an individual at least one of the following: FGF1 and FGF2, and also at least one of the...
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7285540 |
Medicament comprising HGF gene
The present invention relates to a medicament comprising a HGF gene. The medicament of the present invention may be topically applied to the target organs so that the effects can be selectively...
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7285527 |
Tumor radiosensitization using gene therapy
The invention provides a method of radiosensitizing a tumor in a subject by contacting the tumor with a cytokine or a nucleic acid molecule encoding a cytokine. The invention also provides a method...
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7276234 |
Method of acquiring immunological tolerance
The aim of the present invention is to provide a method of acquiring immunological tolerance to a foreign DNA or its expression product whereby the foreign DNA such as a vector carrying a foreign...
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7270810 |
Veto cells effective in preventing graft rejection and devoid of graft versus host potential
A method of transplanting a transplant derived from a donor into a recipient is disclosed. The method comprises the steps of (a) transplanting the transplant into the recipient; and (b)...
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7268120 |
Methods for treating cancer using cytokine-expressing polynucleotides
The present invention provides a pharmaceutical composition, comprising a non-infectious, non-integrating polynucleotide construct comprising a polynucleotide encoding an interferon ω and one or...
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7261884 |
Live genetically attenuated malaria vaccine
Method for inoculating a vertebrate host against malaria, by administering to the host a live Plasmodium organism that is genetically engineered to disrupt a liver-stage-specific gene function.
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