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5789150 |
Process for the sterilization of biological compositions using UVA1 irradiation
An improvement in a process for inactivating extracellular and intracellular viruses in a platelet containing composition is presented. The improvement in the process comprises adding a sensitizer...
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5788963 |
Isolation and/or preservation of dendritic cells for prostate cancer immunotherapy
Methods and compositions for use of human dendritic cells to activate T cells for immunotherapeutic responses against primary and metastatic prostate cancer are disclosed. In one embodiment, human...
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5785964 |
Three-dimensional genetically engineered cell and tissue culture system
The present invention relates to a three-dimensional cell culture system which can be used to culture a variety of different cells and tissues in vitro for prolonged periods of time. In accordance...
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5786213 |
Inhibition of endogenous gastrin expression for treatment of colorectal cancer
The present invention discloses is for the treatment of colon cancer. The expression of gastrin by colon cancers is inhibited by the use of antisense gastrin expression. Methods are disclosed for...
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5785965 |
VEGF gene transfer into endothelial cells for vascular prosthesis
Endothelial cells derived from subcutaneous adipose tissue are genetically modified to express the endothelial cell-specific angiogenic factor VEGF. The modified cells are sodded onto a vascular...
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5780447 |
Recombinant adeno-associated viral vectors
The present invention provides a vector comprising an enhancer element and a nuclear matrix association region inserted between an inverted terminal repeat of adeno-associated virus. The vector can...
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5766585 |
Systemic gene treatment of connective tissue diseases with IRAP-1
The present invention relates to methods of therapeutic or prophylactic treatment of connective tissue diseases by systemic or local delivery of a nucleic acid sequence to a mammalian host....
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5767364 |
Endo-1,4-beta-D-glucanase
A sequence encoding an enzyme having a xyloglucan-specific endo-(1-4)-beta-D-glucanase activity, and functional equivalents thereof, is disclosed. Also disclosed are vectors comprising such...
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5762926 |
Method of grafting genetically modified cells to treat defects, disease or damage of the central nervous system
Methods of genetically modifying donor cells by gene transfer for grafting into the central nervous system to treat defective, diseased or damaged cells are disclosed. The modified donor cells...
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5763416 |
Gene transfer into bone cells and tissues
Disclosed are methods, compositions and devices for use in transferring nucleic acids into bone cells in situ. The transfer of an osteotropic gene into bone progenitor cells is described, which...
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5762927 |
Thymus tolerance in primates
Disclosed is a method of inhibiting a rejection response by a primate to a transplanted organ. One exposes the primate to a mutant diphtheria toxin linked to anti-CD3 antibody so as to largely...
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5759535 |
Immunotherapeutic strategies for the treatment of cancer
The present invention is directed to a method for the treatment of neoplastic disease comprising administering to a mammal having a tumor a cellular immunogen comprising an allogeneic population of...
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5759765 |
Human liver epithelial cell lines
Immortalized cell lines derived from normal adult human liver are described which express phenotypic characteristics of normal adult liver epithelial cells. The invention further provides methods...
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5759536 |
Use of fas ligand to supress T-lymphocyte-mediated immune responses
A method for inhibiting T-lymphocyte-mediated immune responses, including those directed against autologous and/or heterologous tissues, e.g., by a recipient mammal of a transplanted tissue, said...
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5753491 |
Use of neuro-derived fetal cell lines for transplantation therapy
The present invention generally relates to methods for treating a host by implanting genetically unrelated cells in the host. More particularly, the present invention provides human fetal...
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5753221 |
Transformed erythrocytes, process for preparing the same, and their use in pharmaceutical compositions
The invention relates to compositions of erythrocytes that have been modified following hypotonic lysis and resealing by addition of 2',3'-dideoxycytidine-5'-triphosphate (ddCTP) or...
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5750102 |
Double transfectants of the MHC genes as cellular vaccines for immuno prevention of tumor metastasis
The present invention relates to anti-tumor vaccines comprising at least one type of tumor cell into each of which at least two genes encoding MHC proteins of different haplotypes have been...
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5741486 |
Safe vectors for gene therapy
The present invention provides retroviral vectors comprising direct repeats flanking a sequence that is desired to be deleted upon reverse transcription in a host cell. In a preferred embodiment...
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5739006 |
Process of feeding juvenile fish with astaxanthin-containing zooplankton
The present invention relates to astaxanthin-containing zooplankton such as Brachionus pricatilis obtained by culturing, a method for culturing the zooplankton in a liquid containing astaxanthin...
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5736387 |
Envelope fusion vectors for use in gene delivery
The invention provides retroviral vectors which can be used for directing gene delivery to a specific sub-population of mammalian cells. The vectors comprise chimeric targeting proteins which...
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5733543 |
Introduction of HIV-protective genes into cells by particle-mediated gene transfer
Foreign genes may be stably introduced into T cells, monocytes, macrophages, dendrites, and hematopoietic stem cells by particle-mediated gene transfer. Introduction of an HIV protective gene into...
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5716821 |
Prevention and treatment of respiratory tract disease
Recombinant methods for recovering wildtype or engineered negative stranded, non-segmented RNA virus genomes containing non-coding 3' and 5' regions (e.g. leader or trailer regions) surrounding...
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5710037 |
Retroviral vector particles
A retroviral vector which includes a nucleic acid sequence encoding a retroviral envelope. The nucleic acid sequence encoding a retroviral envelope includes a first nucleic acid sequence encoding a...
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5707864 |
Nucleic acids encoding mutated human immunodeficiency virus matrix proteins
Nucleic acid constructs encoding mutated human immunodeficiency virus matrix proteins are described. The mutated proteins lower the incorporation of envelope polypeptides in viral particles,...
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5707865 |
Retroviral vectors for expression in embryonic cells
Retroviral plasmid vectors which include an enhancer region obtained from a virus selected from the group consisting of Myeloproliferative Sarcoma Virus and polyoma virus, and a primer binding site...
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5705151 |
Gene therapy for T cell regulation
The present invention provides a nucleic acid-based therapeutic composition to treat an animal with disease by controlling the activity of effector cells, including T cells, macrophages, monocytes...
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5702702 |
Modified cytotoxic tall cell line and compositions and methods for manufacture and use thereof as therapeutic reagents for cancer
The invention provides a modified human cytotoxic T cell line, which is characterized by dual activity in vitro and in vivo against malignant cells and virus-infected cells. Also provided are...
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5700690 |
Compositions and methods for inhibiting fibrogenesis
Vectors, or naked DNA, containing a promoter for an FSP1 gene and a downstream gene capable of attenuating fibroblasts and their function are provided. Methods of using these vectors to inhibit...
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5698443 |
Tissue specific viral vectors
Host cell specific adenovirus vehicles are provided for transfecting target host cells. By providing for transcriptional initiating regulation dependent upon transcription factors that are only...
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5690927 |
Use of neuro-glial fetal cell lines for transplantation therapy
Human fetal neuro-derived cell lines are implanted into host tissues. The methods allow for treatment of a variety of neurological disorders and other diseases. A preferred cell line is SVG.
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5690926 |
Pluripotential embryonic cells and methods of making same
The claimed invention is directed towards non-murine pluripotential cells that have the ability to be passaged in vitro for at least 20 passages and which differentiate in culture into a variety of...
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5688773 |
Method of selectively destroying neoplastic cells
A method for selectively killing nervous system and peripheral neoplastic cells is provided. Viral vectors are used to selectively express a cytochrome P450 gene in neoplastic cells, whose gene...
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5681562 |
Lymphokine gene therapy of cancer
A novel method of tumor immunotherapy is described comprising the genetic modification of cells resulting in the secretion of cytokine gene products to stimulate a patient's immune response to...
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5674486 |
Cancer immunotherapy with carrier cells
A novel method of tumor immunotherapy is described comprising the genetic modification of cells resulting in the secretion of cytokine gene products to stimulate a patient's immune response to...
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5672493 |
De novo induction of cells exhibiting characteristics of macrophages utilizing feline sarcoma virus
This invention relates to cells that demonstrate characteristics of tissue macrophages (CCTM), including all substances obtained therefrom, such CCTM are induced from human fibroblasts (HF) by the...
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5670148 |
Combined cellular and immunosuppressive therapies
Novel regimens are provided for administering foreign genetically modified allogeneic cells to a host by combining the administration of the cells with a reduced regimen of an immunosuppressive...
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5665350 |
Cell cycle dependent transplantation and ex vivo gene therapy
Methods for the enhancement of bone marrow stem cell engraftment are provided for use in transplantation therapy and ex vivo gene therapy of a mammal. The methods involve the transplantation of...
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5658565 |
Inducible nitric oxide synthase gene for treatment of disease
The present invention discloses a full-length human hepatocyte iNOS cDNA clone and various gene therapy applications utilizing an iNOS DNA sequence. In preferred embodiments of the disclosed...
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5656605 |
Device to promote drug-induced nerve regeneration
The invention relates generally to a system for promoting regeneration of a damaged nerve. In particular, the invention comprises: (1) a guide tube constructed to be attached to the damaged nerve;...
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5656475 |
Use of lymphocytes transformed with herpesvirus saimiri in a process for replicating viruses of the HIV type which cause immune deficiency
A process is disclosed for replicating viruses of the HIV type which cause immune deficiency, in which process lymphocytes are employed which have been transformed with herpesvirus saimiri.
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5656267 |
Implantable cells that alleviate chronic pain in humans
This invention provides a method of alleviating chronic pain in humans. Viable, implantable cells are selected which release neuroactive substances that reduce chronic pain. The cells are cultured...
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5651965 |
Bacillus thuringiensis toxins and genes active against nematodes
The invention concerns novel isolates of Bacillus thuringiensis (B.t.) which contain a toxin(s) which is active against nematodes. This B.t. toxin(s) or B.t. isolate(s) can be used to treat animals...
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5652130 |
Retroviral vectors expressing tumor necrosis factor (TNF)
A drug delivery virion which contains an expression system for the desired protein active ingredient packaged in an envelope derived from a retrovirus is especially useful in administering...
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5643890 |
Synthetic oligonucleotides which mimic telomeric sequences for use in treatment of cancer and other diseases
A method of inhibiting proliferation of immortal cells or cells that express telomerase is disclosed. The method includes introduction of synthetic oligonucleotides which mimic telomere motifs....
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5637483 |
Irradiated tumor cell vaccine engineered to express GM-CSF
A method of altering the specific, systemic immune response of an individual to a target antigen by the co-administration of a cytokine an adhesion or accessory molecule and the target antigen. The...
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5635399 |
Retroviral vectors expressing cytokines
A drug delivery virion which contains an expression system for the desired protein active ingredient packaged in an envelope derived from a retrovirus is especially useful in administering...
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5629469 |
Thiol protease inhibitor
A novel thiol protease inhibitor peptide is isolated from Diabrotica virgifera designated virgiferin. The DNA encoding virgiferin and modified virgiferin peptides are claimed. These sequences maybe...
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5628995 |
Control of Ostrinia
A method to combat or control Ostrinia nubilalis by contacting such insects with a CryIB protein or a combination of a CryIB protein and a CryIAb or CryIAc protein.
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5628781 |
Implant materials, methods of treating the surface of implants with microvascular endothelial cells, and the treated implants themselves
Implant materials having porosity are provided by the present invention. Methods for treating a synthetic or naturally occurring implant, such as a vascular graft, intended for implantation in a...
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5626850 |
Non-shedding live herpesvirus vaccine
The present invention is concerned with a genetically modified live herpesvirus vaccine of which the live herpesviruses are not shed into the environment by a vaccinated animal. This can he...
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