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6022737 |
Formulations for non-viral in vivo transfection in the lungs
Formulations useful in improving non-viral in vivo transfection of DNA in the lungs are provided. Formulations which comprise DNA with various additives are prepared and delivered to the lungs...
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6013516 |
Vector and method of use for nucleic acid delivery to non-dividing cells
A recombinant retrovirus capable of infecting a non-dividing cell and a method of producing such a virus is provided. The recombinant retrovirus is preferably of lentivirus origin and is useful for...
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6013526 |
Modified protein for gene transfer and process for producing the same
The present invention relates to a process for producing a conjugate of a biologically active peptide or protein having at least one glutamine residue with a high-molecular weight substance...
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6010694 |
Fibrillin 1 gene comprising duplication mutation and compositions and kits using the same
Human fibroblast cells that comprise a gene construct that comprises a duplication mutated fibrillin 1 gene operably linked to functional regulatory elements and compositions comprising such cells...
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6008336 |
Compacted nucleic acids and their delivery to cells
Nucleic acids are compacted, substantially without aggregation, to facilitate their uptake by target cells of an organism to which the compacted material is administered. The nucleic acids may...
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6007807 |
Induction of tumour immunity by injection of hybrid cells
A hybrid fusion cell comprising: a) a malignant B cell which expresses an idiotypic antibody; and b) a hybridoma which expresses an antibody which is capable of being internalized on a...
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6004550 |
Intracellular expression of carboxypeptidase G2 in a nitrogen mustard prodrug system
The invention provides a two component system for gene-directed enzyme prodrug therapy which comprises: (a) a vector which encodes a carboxypeptidase which is expressed within a cell; and (b) a...
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6001350 |
Genetic modification of endothelial cells
Endothelial cells transduced with genetic material encoding a polypeptide or protein of interest and, optionally, a selectable marker, as well as methods for making and using the transduced...
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5993799 |
Methods of using genetically engineered cells that produce insulin in response to glucose
The present disclosure relates to the application of genetic engineering to provide artificial β cells, i.e. cells which can secrete insulin in response to glucose. This is achieved preferably...
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5993801 |
Gene therapy using stromal cells
A method of causing production and secretion into the bloodstream of a human patient of a biologically active enzyme for which the human patient suffers a deficiency; the method involves...
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5993800 |
Methods for prolonging the expression of a heterologous gene of interest using soluble CTLA4 molecules and an antiCD40 ligand
The invention provides a method for enhancing the expression of a gene of interest by a cell, the cell (a) comprises a recombinant nucleic acid sequence encoding and (b) is capable of expressing...
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5985656 |
Suppressor and progenitor cells
Natural suppressor (NS) cells secrete a soluble protein suppressor factor (SF) which suppresses the mixed lymphocyte response. NS cells as described herein are null, i.e., have the phenotype IL-2R...
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5985290 |
Purified pancreatic tumor cell lines and related compositions and method
The present invention provides a method of treating cancer comprising (a) obtaining a tumor cell line, (b) modifying the tumor cell line to render it capable of producing an increased level of a...
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5985266 |
Radiation enhanced therapy for tumors expressing a gene for viral thymidine kinase in the presence of a 5-halogengated pyrimidine
The present invention pertains to combination radio therapy of tumors and more specifically to pharmaceutical compositions, and methods of treatment by gene therapy designed to sensitize tumors in...
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5980885 |
Growth factor-induced proliferation of neural precursor cells in vivo
A method is described for inducing in vivo proliferation of precursor cells located in mammalian neural tissue by administering to the mammal a fibroblast growth factor and at least one additional...
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5980886 |
Recombinant vectors for reconstitution of liver
A combination of retroviral and adenoviral vectors are used for high efficiency gene transfer into hepatocytes, resulting in long term gene expression. Hepatocytes are transduced in vivo with a...
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5976536 |
Neisseria mutants, lipooligosaccharides and immunogenic compositions
Provided herein are mutant strains of Neisseria meningitidis which produce lipooligosaccharide (LOS) differing from the wild-type LOS in structure as well as the mutant LOS molecules and...
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5972900 |
Delivery of nucleic acid to cells
Nucleic acids are compacted, substantially without aggregation, to facilitate their uptake by target cells of an organism to which the compacted material is administered. The nucleic acids may...
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5968775 |
Hepatitis C virus infected cell systems
The present invention is directed to extracorporeal cell systems infected with hepatitis C virus (HCV). The present invention also relates to products of such cell systems and their use as vaccines...
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5965787 |
HLA-DRBI peptides with specific binding affinity for HLA-DQ molecules: prevention and treatment of rheumatoid arthritis
Disclosed are transgenic mice carrying a human HLA-DQ sgene. The transgenic mice are deficient in mouse H-2 class II molecules. Such mice provide animal model systems to identify peptides useful...
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5965124 |
Replication-competent recombinant viral vaccines and method of producing same
Replication-competent recombinant viruses, particularly replication-competent recombinant polioviruses, which include (1) exogenous nucleic acid sequences which encode an exogenous polypeptide and...
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5965126 |
use of mutant alkyltransferases for gene therapy to protect from toxicity of therapeutic alkylating agents
The present invention relates to methods of treating neoplastic disease whereby gene therapy treatments are employed in combination with a chemotherapy regime. A combinational therapy with...
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5965441 |
HSV/AAV hybrid amplicon vectors
The present invention relates to a hybrid vector system which incorporates elements of herpesvirus and adeno-associated virus and which is capable of expressing a gene product in eukaryotic cells....
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5962427 |
In vivo gene transfer methods for wound healing
The present invention relates to an in vivo method for specific targeting and transfer of DNA into mammalian repair cells. The transferred DNA may include any DNA encoding a therapeutic protein of...
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5962424 |
Methods and compositions for targeting selectins
Disclosed are a variety of compositions and methods for use in specifically targeting the L-selectin or preferably, the E-selectin marker following its cell surface induction, e.g., using ionizing...
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5962320 |
Engineered antigen presenting cells and methods for their use
Autologous, heterologous or xenogeneic primary cells or cell lines are genetically modified ex vivo to render the cells capable of processing and presenting selected antigens to cells of the immune...
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5958403 |
Methods and compounds for prevention of graft rejection
Disclosed is a method of localized immunosuppression which may be used for preventing graft rejection or for preventing tissue destruction due to autoimmune disease. Also disclosed is a protein...
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5955258 |
Process for the lysis of a culture of lactic acid bacteria by means of a lysin, and uses of the resulting lysed culture
The invention provides a process for the lysis of a culture of lactic acid bacteria, or a product containing such culture e.g. cheese, by means of a lysin through the in situ production of a...
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5951975 |
Induction of CTLs specific for natural antigens by cross priming immunization
The present invention relates to prophylactic and therapeutic methods of anti-tumor immunization. These methods are based on cross-priming a mammalian host to natural MHC class I restricted tumor...
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5951976 |
Opsonin-enhanced cells, and methods of modulating an immune response to an antigen
Disclosed are methods and compositions wherein opsonin-enhanced cells, that is, cells which have been 1) modified so as to express an opsonin from a recombinant nucleic acid, 2) modified so as to...
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5948675 |
Host-vector system which can be used in gene therapy
The invention relates to a system for expressing a transgene in a target cell or a human or animal cell, characterized in that it consists of a eukaryotic cell established as a line, into which...
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5942434 |
Nucleic acid constructs comprising hypoxia response elements
Nucleic acid constructs comprising hypoxia response elements in operable linkage with a coding sequence of a gene of interest are disclosed. In particular, such nucleic acid constructs comprise...
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5942496 |
Methods and compositions for multiple gene transfer into bone cells
Disclosed are methods, compositions, kits and devices for use in transferring nucleic acids into bone cells in situ and/or for stimulating bone progenitor cells. Type II collagen and, particularly,...
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5939400 |
DNA vaccination for induction of suppressive T cell response
A pro-inflammatory T response is specifically prevented by the injection into a recipient of DNA encoding the variable region of a T cell receptor. In response to the vaccination, T cells...
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5935569 |
Genetic anticancer vaccine
Genetic anticancer vaccine for stimulation of patient's immune system to eradicate cancer, particularly malignant melanoma. The objective of the invention is genetic modification of allogeneic...
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5935567 |
Cytokine IP-10 as an anti-tumor agent
Methods and therapeutic compositions for treating neoplasms by administration of the polypeptide IP-10, or a suitable DNA vector encoding the polypeptide IP-10.
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5935568 |
Gene therapy for effector cell regulation
The present invention provides a nucleic acid-based therapeutic composition to treat an animal with disease by controlling the activity of effector cells, including T cells, macrophages, monocytes...
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5928637 |
Methods of inducing multidrug resistance using human MDR1 cDNA
The present invention provides for vectors carrying a cDNA containing the entire coding region of the human multidrug resistance gene (MDR1) and for a method for introducing MDR1 cDNA into cells...
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5929044 |
Protein solder composition and method of use
The present invention provides a composition comprising a protein solder, a bioactive compound, and a vehicle for delivering the bioactive compound into a target cell having a genome. The present...
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5928638 |
Methods for gene transfer
The present invention provides a method for optimizing gene transfer into hematopoietic stem cells (HSCs) by contacting the cells with hydroxyurea prior to gene transfer to induce HSCs in G0 into...
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5929041 |
Method for preventing and treating sensorineural hearing loss and vestibular disorders using glial cell line-derived neurotrophic factor(GDNF) protein product
The present invention relates generally to methods for preventing and/or treating injury or degeneration of cochlear (and vestibular) hair cells and spiral ganglion neurons (as well as vestibular...
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5925565 |
Internal ribosome entry site, vector containing it and therapeutic use
A novel internal ribosome entry cite and a novel region for the encapsidation of a retrotransposon and murine VL30s in particular are disclosed. A vector and a eukaryotic cell containing said cite...
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5916554 |
Use of pouch for implantation of living cells
A biocompatable and biostable flexible pouch for use e.g., in implanting cell bodies producing therapeutic agents, featuring, in various aspects, either encapsulated or unencapsulated cell bodies...
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5912236 |
Broad-spectrum tumor suppressor genes gene products and methods for tumor suppressor gene therapy
The present invention relates to a broad-spectrum tumor suppressor gene and the protein expressed by that gene in appropriate host cells. The protein is a second in-frame AUG codon-initiated...
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5911983 |
Gene therapy for Gaucher disease using retroviral vectors
The present invention relates to gene therapy for Gaucher disease using retroviral vectors which express the glucocerebrosidase gene. Methods are provided for transduction of autologous...
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5912172 |
Endowing lymphocytes with antibody specificity
There are produced recombinant gene pairs which endow mononuclear cells, mainly various lymphocyte type cells, with antibody-type specificity. In specific gene pairs the rearranged gene pairs code...
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5908623 |
Compositions and methods for the delivery of biologically active molecules using genetically altered cells contained in biocompatible immunoisolatory capsules
This invention provides improved devices and methods for long-term, stable expression of a biologically active molecule using a biocompatible capsule containing genetically engineered cells for the...
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5908777 |
Lipidic vector for nucleic acid delivery
A simple, rapid method for creating a lipidic vector for delivery of a therapeutic molecule entails bringing the molecule into contact with a polycation, thereby forming a complex, and then mixing...
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5908923 |
Method of using transdominant negative retroviral integrase in the treatment of retroviral infection
A method of using a transdominant negative integrase gene to make at least one cell resistant to a retroviral infection which includes retroviral infections resulting from HIV; a method for...
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5906817 |
Biocompatible implant for the expression and in vivo secretion of a therapeutic substance
The invention relates to an implant obtained by assembling in vitro various elements in order to form a neo-organ which is introduced preferably in the peritoneal cavity of the recipient. The...
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