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9040035 Treatment of pain using placental stem cells  
Provided herein are methods of treatment of an individual having pain, e.g., neuropathic pain, comprising administering to the individual a therapeutically effective amount of tissue culture...
8999949 Induced activation in dendritic cells  
The present invention is directed to a composition and method which to treat diseases and to enhance a regulated immune response. More particularly, the present invention is drawn to compositions...
8981073 Hepatitis C virus gene  
Disclosed are an HCV gene having higher replication efficiency and higher reinfection efficiency than the known HCV gene of genotype 1b, an RNA replicon having this gene, a cell infected with this...
8968720 Heat shock protein GP96 vaccination and methods of using same  
The invention provides a tumor cell genetically modified to express a nucleic acid encoding a secreted form of a heat shock protein (hsp) gp96 polypeptide. The invention also provides a method of...
8961999 Methods and compositions for bone formation  
A method and system to induce bone growth by locally delivering bone morphogenetic proteins (BMPs) to the target location for a prolonged period without invasive procedures are disclosed. The new...
8956606 Malignant tumor cell suppressor protein, malignant tumor cell suppressor gene, maligant tumor cell suppressive viral vector, and kit using the same  
A malignant tumor cell suppressor protein (a) or (b): (a) a protein comprising an amino acid sequence represented by SEQ ID No. 1; or(b) a protein comprising an amino acid sequence represented by...
8951511 Compositions for improving migration potential of stem cells  
The present invention relates to a composition for improving the migration potential of a stem cell, a method for evaluating the migration potential of a stem cell and a method for screening an...
8945923 Antigen-specific clonal expansion of B cells  
The present invention provides recombinant proteins comprising the amino acid sequence of an intracellular segment of CD40 and an amino acid sequence mediating the association of the recombinant...
8940292 Enhancement of angiogenesis to grafts using cells engineered to produce growth factors  
The present invention provides methods and compositions of engineered cells for use in the continuous or transient delivery of growth factors and angiogenesis modulating agents, such as vascular...
8936807 Use of the cathelicidin LL-37 and derivatives thereof for wound healing  
Use of the antimicrobial cathelicidin peptide II-37, N-terminal fragments of LL-37 or extended sequences of LL-37 having 1-3 amino acids in the C-terminal end, for stimulating proliferation of...
8932577 Treatment of limb ischemia  
The present invention uses neural stem cells in the manufacture of a medicament for the treatment of a patient suffering peripheral arterial disease. The invention is particularly suited for...
8932576 Robust expression of a bioactive mammalian protein in Chlamydomonas chloroplast  
Methods and compositions are disclosed to engineer chloroplast comprising heterologous mammalian genes via a direct replacement of chloroplast Photosystem II (PSII) reaction center protein coding...
8933298 Mutated eIF4E sequences from potato which impart resistance to potato virus Y  
The present invention relates to a nucleic acid molecule encoding a mutant form of wild-type translation initiation factor eIF4E, which has an amino acid sequence of SEQ ID NO: 1, wherein the...
8926959 System for optical stimulation of target cells  
Stimulation of target cells using light, e.g., in vivo, is implemented using a variety of methods and devices. According to an example embodiment of the present invention, target cells are...
8916184 Artificial tissue systems and uses thereof  
An implant system and a method for controlling the natural and artificial microenvironments surrounding an implanted device using an artificial tissue system (ATS) and includes methods of...
8906359 Recombinant retrovirus pseudotyped with a E2 alphavirus glycoprotein  
Methods and compositions are provided for delivery of a polynucleotide encoding a gene of interest, typically an antigen, to a dendritic cell (DC). The virus envelope comprises a DC-SIGN specific...
8906631 Method for identifying, expanding and removing adult stem cells and cancer stem cells  
Described are the use of stem cell markers for the isolation of stem cells and the use of the obtained stem cells in, for example, research or treatment, such as for the preparation of a...
8900567 Treatment of cone cell degeneration with transfected lineage negative hematopoietic stem cells  
A method of preserving cone cells in the eye of a mammal suffering from a retinal degenerative disease comprises isolating from the bone marrow of the mammal a lineage negative hematopoietic stem...
8901093 Custom vectors for treating and preventing pancreatic cancer  
The present invention is directed to a system for treating individuals at risk of developing or suffering from pancreatic cancer. The system comprises administering to the individual a recombinant...
8889641 Modified virus vectors and methods of making and using the same  
The present invention provides AAV capsid proteins (VP1, VP2 and/or VP3) comprising a modification in the amino acid sequence in the three-fold axis loop 4 and virus capsids and virus vectors...
8889118 Anticancer agent containing dendritic cell having RNA virus transferred thereinto  
The present invention provides anticancer agents comprising dendritic cells introduced with RNA viruses. The present invention also provides methods for producing anticancer agents, which comprise...
8883716 Method for treating damaged tissue of the CNS  
Devices and methods for treating diseases associated with loss of neuronal function are described. The methods are designed to promote proliferation, differentiation, migration, or integration of...
8877176 Methods for promoting wound healing and muscle regeneration with the cell signaling protein Nell1  
The present invention provides methods for promoting wound healing and treating muscle atrophy in a mammal in need. The method comprises administering to the mammal a Nell1 protein or a Nell1...
8877177 Chemokine containing apheresis column and methods of use  
An apheresis column loaded with a solid support comprises one or more chemokines, in particular biotinylated chemokines, immobilized directly or indirectly on the support, in particular on a...
8871194 Method for transforming a hair follicle  
To provide a transformed hair follicle and a method for transferring a gene to a mammal by means of the transformed hair follicle. The invention provides a method for producing a transformed hair...
8865153 Microorganisms for imaging and/or treatment of tumors  
Modified viruses encoding transporter proteins and methods for preparing the modified viruses are provided. Vaccines that contain the viruses are provided. The viruses also can be used in...
8865154 Recombinant factor VIII having enhanced stability following mutation at the A1-C2 domain interface  
The invention relates to a recombinant factor VIII that includes one or more mutations at an interface of A1 and C2 domains of recombinant factor VIII. The one or more mutations include...
8858928 Gene therapy vectors for adrenoleukodystrophy and adrenomyeloneuropathy  
The present invention provides compositions comprising retroviral vectors, transduced cells, and methods of using the same for gene therapy. In particular, the present invention relates to...
8858929 Optically sensitive cell network  
A neural network is disclosed. The neural network comprises a plurality of optogenetically modified neural cells being three-dimensionally distributed in a hydrogel medium and being disconnected...
8859520 Methods for therapy of neurodegenerative disease of the brain  
A specific clinical protocol for use toward therapy of defective, diseased and damaged neurons in the mammalian brain by delivering a definite concentration of recombinant neurotrophin, into a...
8858990 Capsule of thermogenic cells for treating a metabolic disease  
Described herein are methods and devices for treating a metabolic disease that involve implanting a micro-device into a tissue of a subject having a metabolic disease. The micro-device includes a...
8859273 Methods of using HCN genes to treat cardiac arrhythmias  
The subject invention is directed to methods of treating cardiac pacing dysfunction by administering HCN genes, alone or in combination with other genes.
8852576 Modified sodium iodide symporter proteins and uses thereof  
A modified sodium iodide symporter (NIS) protein is provided. The modified NIS protein comprises an amino acid sequence of SEQ ID NO.1 with the proviso that at least one amino acid residue within...
8852927 Microorganisms for imaging and/or treatment of tumors  
Modified viruses encoding transporter proteins and methods for preparing the modified viruses are provided. Vaccines that contain the viruses are provided. The viruses also can be used in...
8846028 Mitochondrial enhancement of cells  
Certain embodiments disclosed herein include, but are not limited to, at least one of compositions, methods, devices, systems, kits, or products regarding rejuvenation or preservation of stem...
8840881 Methods and compositions for treating prostate cancer or inducing a humoral immune response against prostate cancer  
The present invention relates to prostate cancer markers, compositions comprising such markers, and methods of using such markers to induce or increase an immune response against prostate cancer....
8841260 Methods and compositions for treating Huntington's Disease  
Disclosed herein are methods and compositions for treating or preventing Huntington's Disease.
8835398 Promoters exhibiting endothelial cell specificity and methods of using same for regulation of angiogenesis  
Isolated polynucleotide sequences exhibiting endothelial cell specific promoter activity, novel cis regulatory elements and methods of use thereof enabling treatment of diseases characterized by...
8834862 Methods, compositions and devices utilizing stinging cells/capsules for conditioning a tissue prior to delivery of an active agent  
Methods, compositions and devices utilizing stinging cells/capsules for conditioning a tissue prior to delivery of a pharmaceutical agent are described.
8828652 Elimination of N-glycolylneuraminic acid from animal products for human use  
The application is in the field of transgenic (non-human) organisms, sialic acid chemistry, metabolism and antigenicity. More particularly, the invention is related to a method to produce...
8822647 Method and compositions using a chimeric antigen receptor for enhanced anti-tumor effector functioning of T cells  
Integration of costimulatory signaling domains within a tumor targeting chimeric antigen receptor (CAR), such as the IL13Rα2 specific IL13-zetakine (IL13ζ), enhances T cell-mediated responses...
8822216 DNA regulatory element for the expression of transgenes in neurons of a subject and uses thereof  
The present invention provides for a method of evaluating whether a compound is effective in activating a calcium-calmodulin dependent kinase IIα promoter in a human neuronal cell which comprises:...
8808685 Method of treatment using organotypically cultured skin tissue comprising NIKS cells that express exogenous HIF-1α  
The present invention relates to in vitro cultured skin tissue, and in particular to cultured skin tissue comprising exogenous genes encoding angiogenic growth factors. In some embodiments, the...
8809618 Transgenic mouse for screening and for studies of the pharmacodynamics and pharmacokinetics of ligands acting on the oestrogen receptor and its intracellular receptors, and method for the preparation thereof  
The object of the invention is a method for the production of a non-human transgenic mammal by means of which it is possible to monitor in vivo and in all the tissues the state of activation of...
8808684 Epidermal growth factor receptor (EGFR) and methods of use in adenoviral-associated virus type 6 (AAV6) transduction  
Comparative gene analysis (CGA) was combined with pathway visualization software to identify a positive correlation between AAV6 transduction and epidermal growth factor receptor (EGFR)...
8795650 Derivation of unlimited quantities of neutrophils or monocyte/dendritic cells  
A method to generate unlimited numbers of macrophage/dendritic cells or neutrophils from mice, using conditional Hox oncoproteins is disclosed. The invention further includes the establishment of...
8790924 Reversible platelet inhibition  
The present invention relates, in general, to receptors and to platelet aggregation and, in particular, to a method of inhibiting platelet aggregation using an aptamer that binds to and inhibits...
8790636 Human skin equivalents expressing exogenous polypeptides  
The present invention relates generally to compositions for wound closure. More specifically, the present invention provides human skin equivalents engineered to express exogenous polypeptides...
8784799 Duplexed parvovirus vectors  
The present invention provides duplexed parvovirus vector genomes that are capable under appropriate conditions of forming a double-stranded molecule by intrastrand base-pairing. Also provided are...
8778330 En vivo generated tissue system  
The present invention relates to methods of generating an ex vivo tissue-like system in a bioreactor system capable of supporting continuous production of, and output of cells and tissues and an...