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7390483 |
Universal GM-CSF expressing bystander human K562 cell line
The present invention provides a universal immunomodulatory cytokine-expressing bystander cell line, a composition comprising such a cell line and a cancer antigen, a method of making such a cell...
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7390482 |
Drug for auditory dysfunction
The present invention provides a pharmaceutical preparation for hearing impairment, which is suitable for gene therapy of hearing impairment, that is, a pharmaceutical preparation for hearing...
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7387894 |
Recombinant viral-based malaria vaccines
The present invention relates to novel vaccines against malaria infections, based on recombinant viral vectors, such as alpha viruses, adenoviruses or vaccinia viruses. The recombinant viral-based...
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7387645 |
Cellular therapy to heal vascular tissue
The present invention encompasses methods and apparatus for minimizing the risks inherent in endovascular grafting for blood vessel therapy and repair. The invention involves delivering adult stem...
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7381710 |
Combined DNA vaccine and biological modifiers for cancer therapy
The present invention relates to the combination of a DNA vaccination strategy that makes use of a nucleic acid encoding an immunogenic polypeptide, with a non-immunosuppressive inducer of tumor...
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7378569 |
Transgenic pigs carrying both hHO-1 and hDAF transgenes for xenotransplantation
The invention provides a transgenic animal carrying two transgenes, one encoding a human decay accelerating factor (hDAF) and the other encoding a human heme oxygenase-1 (hHO)-1, which are useful...
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7378273 |
Expression vectors
The present invention provides novel regulatory elements and vectors for the expression of one or more proteins in a host cell. The present invention also provides methods for expressing one or...
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7378087 |
Method of enhancing an immune response
A method of enhancing an immune response to an antigen is provided. The method involves augmenting the level of a TAP molecule in a target cell bearing the antigen. Preferably, the TAP molecules...
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7378086 |
Retroviral vector having an ovalbumin promoter
Vectors and methods are provided for introducing genetic material into cells of a chicken or other avian species. More particularly, vectors and methods are provided for transferring a transgene to...
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7374752 |
Reovirus for the treatment of cellular proliferative disorders
Methods for treating proliferative disorders, by administering reovirus to a Ras-mediated proliferative disorder, are disclosed. The reovirus is administered so that it ultimately directly contacts...
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7371374 |
Neural transplantation using pluripotent neuroepithelial cells
The subject invention pertains to a novel method of correction of behavioral and/or psychological deficits made possible by the intracerebral transplantation of pluripotent neuroepithelial cells....
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7364740 |
Molecular differences between species of the M. tuberculosis complex
Specific genetic deletion are identified in mycobacteria isolates, including variations in the M. tuberculosis genome sequence between isolates, and numerous deletion present in BCG as compared...
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7364728 |
Recombinant organisms producing insect toxins and methods for constructing same
This invention is a method for constructing recombinant organisms that produce proteins lethal to the larvae of insects. Nucleotide sequences were isolated from Bacillus popilliae that encode two...
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7364727 |
Metastatic colon cancer specific promoter and uses thereof
Colon cancer specific promoter sequences and adenovirus vehicles are provided. By providing for transcriptional initiating regulation dependent upon transcription factors that are only active in...
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7364726 |
Pharmaceutical composition for cancer treatment containing cells that express a membrane cytokine
This invention comprises cellular vaccines and methods of using them in cancer immunotherapy, particularly in humans. The vaccines comprise a source of tumor-associated antigen, and a...
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7361354 |
Methods for treating malignancies expressing ICAM-1 using coxsackie a group viruses
There is disclosed a method of killing abnormal cells such as malignant cells including melanoma cells, using a virus recognizing at least one of a cell adhesion molecule and a complement...
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7355099 |
AXMI-004, a delta-endotoxin gene and methods for its use
Compositions and methods for conferring pesticidal activity to bacteria, plants, plant cells, tissues and seeds are provided. Compositions comprising a coding sequence for a delta-endotoxin...
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7351881 |
AXMI-008, a delta-endotoxin gene and methods for its use
Compositions and methods for conferring pesticidal activity to bacteria, plants, plant cells, tissues and seeds are provided. Compositions comprising a coding sequence for a delta-endotoxin and...
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7351697 |
Tumor-specific vector for gene therapy
The invention relates to a vector for the gene therapeutic treatment of tumors, especially in connection with radiotherapy. Said vector is provided with a therapeutic gene in the DNA sequence...
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7347998 |
Method of delivering therapeutic agents to site of tissue injury
A viral or non-viral vector particle having a modified viral surface protein wherein the viral surface protein is modified to include a targeting polypeptide including a binding region which binds...
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7344872 |
Method for rapid screening of bacterial transformants and novel simian adenovirus proteins
Chimpanzee serotype C68 proteins, peptides, and polypeptide are provided. Also provided are novel adenoviruses derived from these proteins, as well as compositions containing these proteins and...
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7344711 |
Use of adenoviruses mutated in the VA genes for cancer treatment
This invention refers to the use of an adenovirus for cancer treatment, being this adenovirus defective in its virus-associated (VA) RNAs. Said adenovirus has a mutation in the VAI or VAII gene...
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7344710 |
Combination bacteriolytic therapy for the treatment of tumors
Current chemotherapeutic approaches for cancer are in part limited by the inability of drugs to destroy neoplastic cells within poorly vascularized compartments of tumors. We have here...
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7342002 |
Molecular vaccine linking an endoplasmic chaperone polypeptide to an antigen
This invention provides compositions and methods for inducing and enhancing immune responses, such as antigen-specific cytotoxic T lymphocyte (CTL) responses, using chimeric molecules comprising...
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7341718 |
Neuronal gene transfer of adenovirus and herpes virus vectors
The present invention is related to compositions and methods for the delivery of nucleic acids to neurons in a mammal, and uses thereof. The present invention specifically discloses the use of...
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7338656 |
Composition and method to alter lean body mass and bone properties in a subject
A method for decreasing the body fat proportion, increasing lean body mass, increasing bone density, or improving the rate of bone healing, or all, of a subject. Embodiments of the invention...
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7338655 |
Gene therapy using TGF-β
The subject invention is related to a cell-mediated gene therapy treatment for orthopedic disease using a member belonging to the transforming growth factor-β (TGF-β) superfamily. TGF-β gene...
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7335505 |
Materials and methods relating to protein aggregation in neurodegenerative disease
The present invention provides methods of proteolytically converting a precursor protein (e.g. tau) to a product fragment (e.g., a 12 kd fragment) in a stable cell line, wherein the precursor...
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7332337 |
Viral vectors having tissue tropism for T-lymphocytes, B- and mast cells
The present invention relates to methods of introducing an expressible non-viral nucleic acid sequence into a T lymphocyte cell, a B-cell, or a mast cell, comprising contacting the cell with a...
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7332324 |
Attenuated vaccine useful for immunizations against Coccidioides spp. infections
A Coccidioides spp. fungus that is attenuated by the loss of endosporulation potential of the fungus wherein said fungus does not replicate when transformed into the parasitic phase.
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7329807 |
High-efficiency fusogenic vesicles, methods of producing them, and pharmaceutical compositions containing them
The present invention relates to novel fusogenic vesicles as highly efficient and versatile encapsulation systems for delivering a substance of choice, such as nucleic acids, proteins, peptides,...
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7326692 |
Induction of immunity using inhibitors of granzymes
The present invention provides methods for enhancing host immunity to a virus and/or a cancer and methods for enhancing the cytotoxic T-cell (CTL) mediated immune responses by providing granzyme B...
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7323623 |
RHIZOC3 nucleic acid molecules
The present invention is directed to nucleic acid molecules tat encode defensive polypeptides and methods of their use in enhancing disease resistance of a plant to a fungal pathogen. Vectors,...
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7323165 |
Production of pancreatic islet cells and delivery of insulin
The present invention relates to the production of islet cells and insulin in a subject by providing for expression of an islet transcription factors in the pancreas of the subject, by for example,...
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7320963 |
Methods and compositions for delivery of pharmaceutical agents
Methods and compositions for delivering pharmaceutical agents into cells, in particular urothelial cells of the bladder, are provided. In the methods and compositions of the invention, a...
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7320787 |
Redirection of cellular immunity by protein tyrosine kinase chimeras
Disclosed is a method of directing a cellular response in a mammal by expressing in a cell of the mammal a chimeric receptor which causes the cells to specifically recognize and destroy an...
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7318919 |
Adenovirus vectors for gene therapy
Gene Therapy vectors, which are especially useful for cystic fibrosis, and methods for using the vectors are disclosed.
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7316812 |
Cells expressing anti-Fc receptor binding components
Cells transformed to express on their surface a component which binds to an Fc receptor of an effector cell are disclosed. Also disclosed are expression vectors used to transform the cells. Once...
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7314912 |
AAv scleroprotein, production and use thereof
The invention relates to a structural protein of adeno-associated virus (AAV) which comprises at least one mutation which brings about an increase in the infectivity of the virus.
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7311907 |
Lentiviral packaging cells
Novel packaging cell lines which produce recombinant retrovirus, free of detectable helper-virus are disclosed. Also disclosed are methods of making the cell lines and methods of producing...
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7309814 |
Nucleic acid molecules encoding bacterial autoinducer inactivation protein as targets for engineering disease resistance
The present invention relates to isolated nucleic acid molecules encoding a bacterial autoinactivation protein and methods for increasing disease resistance and preventing or reducing bacterial...
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7306794 |
Methods and compositions for the treatment of defects in lipoprotein metabolism
The invention provides a recombinant viral vector comprising the DNA of, or corresponding to, at least a portion of the genome of an adenovirus, which portion is capable of infecting a hepatic...
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7306793 |
Defective recombinant adenoviruses expressing cytokines for antitumor treatment
A recombinant nucleic acid used for the production of a defective adenovirus containing an inserted sequence coding for a cytokine under the control of a promoter in the genomic sequence of the...
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7306792 |
Tumor therapy with alphavirus-based and high affinity laminin receptor-targeted vectors
The present invention relates to methods and compositions for treating tumors using vectors that preferentially target tumor cells. In particular, the invention relates to Sindbis virus vectors...
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7297685 |
Use of pro-apoptotic factors in treatment of atherosclerosis
The present invention features a novel method of treating vascular disease that involves modifying smooth muscle cells to express a gene encoding a protein having both anti-inflammatory and...
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7297540 |
Methods of generating tissue using devitalized, acellular scaffold matrices derived from micro-organs
Methods of generating, and isolating adult stem cells and utilizing such cells and/or embryonic stem cells in generating tissue of a specific function and micro-architecture are provided.
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7294334 |
Methods and compositions to treat myocardial conditions
Methods, devices, kits and compositions to treat a myocardial infarction. In one embodiment, the method includes the prevention of remodeling of the infarct zone of the ventricle using a...
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7291454 |
Transgenic animals and cell lines for screening drugs effective for the treatment or prevention of Alzheimer's disease
Disclosed are transgenic animals and transfected cell lines expressing a protein associated with Alzheimer's Disease, neuroectodermal tumors, malignant astrocytomas, and glioblastomas. Also...
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7291325 |
Method for producing target proteins by deleting or amplifying ibpA and/or ibpB gene coding for inclusion body-associated proteins
A method for producing target proteins by deleting or amplifying ibpA and/or ibpB genes coding for inclusion body-associated proteins. Two methods for producing target proteins using ibpA and/or...
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7285542 |
Hyperthermic inducible expression vectors for gene therapy and methods of use thereof
Methods and compositions are provided for transgene expression in target cells. Expression constructs using an inducible amplification system to drive expression of a therapeutic gene or other gene...
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