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6984522 |
Isolation and use of solid tumor stem cells
A small percentage of cells within an established solid tumor have the properties of stem cells. These solid tumor stem cells give rise both to more tumor stem cells and to the majority of cells in...
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6984380 |
Treatment of diseases involving faulty MHC class I antigen complex presentation
Methods of treating autoimmune diseases, such as diabetes, characterized by faulty MHC class I antigen complex presentation are disclosed which involve exposure of the immune system of an...
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6982087 |
Vectors derived from South African Arbovirus No. 86
Provided herein are alphavirus vectors derived from South African Arbovirus No. 86 (S.A.AR86) comprising attenuating mutations and methods of making the same. Also provided are improved viral...
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6982082 |
Gene therapy by cell specific targeting
This invention is directed to a modified cyclosporin A and to a modified, genetically engineered version of its receptor, cyclophilin. This invention is further directed to a method for treating...
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6979568 |
Vector for the expression of two foreign genes
A vector expressing two foreign genes by using RRE sequence and controlling the ratio of the expression doses of these genes owing to the modification is provided. This vector, which can be...
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6979448 |
Chimaeric plant viruses with mucin peptides
Mucin peptide epitopes are inserted into the coat protein of a plant virus (e.g., a comovirus such as CPMV) having a beta-barrel structure at an immunogenically effective site, such as in a loop...
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6979677 |
Inhibition of vascular smooth muscle cell proliferation
A method for inhibiting restenosis associated with mechanical injury of a blood vessel. An adenoviral vector encoding a suicide gene such as thymidine kinase is directly administered to the injured...
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6972350 |
Pest-resistant plants comprising a construct encoding a vacuole targeting sequence and avidin or streptavidin
This invention relates to nucleic acids encoding chimeric polypeptides comprising vacuole targeting sequences and sequences encoding avidin or streptavidin. The nucleic acids are useful for...
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6967018 |
Adiponectin gene therapy
Adiponectin cDNA was cloned into AAV serotypes 1, 2, and 5-based expression vectors. Virions containing these vectors were administered to the livers of rat subjects via portal vein injection. A...
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6967076 |
Method for producing recombinant cells for detecting HIV
Recombinant expression vectors and methods are provided for detecting HIV and monitoring HIV drug resistance. The method comprises: taking a culture of cells; adding a recombinant viral vector into...
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6964762 |
Composition and method for stimulating immune response to pathogen using complex adenoviral vector
Genetic vaccines and methods are provided for enhancing the immunity of a host such as a human to one or more pathogens. In one aspect, a method of enhancing the immunity of a host to a pathogen is...
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6962814 |
Decellularized tissue engineered constructs and tissues
New methods for producing tissue engineered constructs and engineered native tissues are disclosed. The methods include producing a tissue engineered construct by growing cells in vitro on a...
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6962977 |
Protein having pesticidal activity, DNA encoding the protein, and noxious organism-controlling agent and method
The invention provides a noxious organism-controlling agent effective to control pests that have acquired a resistance to conventional Bt agents, and which has activity on Coleoptera pests. Also,...
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6962815 |
AAV2 vectors and methods
The invention relates to Adeno-associated virus vectors. In particular, it relates to Adeno-associated virus vectors with modified capsid proteins and materials and methods for their preparation...
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6960469 |
Adenoviral vectors encoding an antibody fused to a CD4 extracellular domain
Genetically modified cell implant comprising an exogenous nucleotide sequence coding for all or part of an antibody, method for the preparation of such an implant and its therapeutic use for the...
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6958147 |
Use of VEGF-C to prevent restenosis
The present invention provides materials and methods for preventing stenosis or restenosis of a blood vessel using Vascular Endothelial Growth Factor C (VEGF-C) and/or Vascular Endothelial Growth...
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6958226 |
Packaging cells comprising codon-optimized gagpol sequences and lacking lentiviral accessory proteins
Novel packaging cell lines useful for generating viral accessory protein independent HIV-derived retroviral vector particles, methods of constructing such packaging cell lines and methods of using...
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6955808 |
Capsid-modified recombinant adenovirus and methods of use
The present invention describes recombinant adenoviral vectors modified by incorporating targeting ligands or label into viral capsid or structural proteins. In one embodiment, single-chain...
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6953687 |
Vectors for delivering viral and oncogenic inhibitors
Cell transformation vectors for inhibiting HIV and tumor growth are provided. Optionally, the vectors encode RNAses such as EDN. Cells transduced by the vectors and methods of transforming cells...
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6953575 |
Methods of treating central nervous system disorders using viral vectors
Methods of delivering viral vectors, particularly recombinant AAV virions, to the CNS are provided. Also provided are methods of treating Parkinson's Disease.
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6946448 |
In utero oral nucleic acid immunization
Methods of nucleic acid immunization comprising the in utero delivery of nucleic acid molecules that encode one or more selected antigens to a vertebrate fetus are disclosed.
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6946126 |
Replicating adenovirus vectors
The present invention provides replicating [100K−] adenovirus vectors that have an impairment in 100K activity. In particular preferred embodiments, the impairment is the result of a deletion in...
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6943012 |
Helper dependent adenoviral vector system and methods for using the same
A helper dependent adenoviral vector system is provided. The subject helper dependent adenoviral vector system is made up of: (1) a “gutless” adenoviral vector that include cis-acting human...
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6943026 |
Antitumour vector constructs and methods
Compositions for targeting expression of a gene such as an antitumor gene may contain a first nucleic acid construct in which expression of a first gene is controlled by a first promoter whose...
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6942855 |
Viral vectors having reduced virulence
The present invention provides recombinant vaccinia virus having a deletion of the region encoding the C-terminal seven amino acids of the E3L gene product and comprising exogenous DNA....
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6943015 |
Large scale production of packaged alphavirus replicons
Large-scale packaging of alphavirus replicons is accomplished by co-transfecting host cells with three RNA molecules: (1) an alphavirus replicon comprising a sequence encoding a heterologous...
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6939540 |
Method of enhancing bone density
The present invention is directed to a method for enhancing bone density or formation. In accordance with the method, a nucleic acid encoding an angiogenic protein is administered to a cell in a...
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6936595 |
Tumour-specific vector for gene therapy
The invention relates to a vector for the gene therapeutic treatment of tumours, especially in connection with radiotherapy. Said vector is provided with a therapeutic gene in the DNA sequence...
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6936594 |
Gene therapy for cerebrovascular disorders
By introducing hepatocyte growth factor (HGF) gene and/or vascular endothelial growth factor (VEGF) gene into the subarachnoid space in humans, cerebrovascular disorders such as cerebrovascular...
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6936257 |
Recombinant Venezuelan equine encephalitis virus vaccine
A prophylactic or therapeutic vaccine for use in protecting mammals such as humans or animals against Venezelan Equine Encephalitis virus (VEE) is described. In particular, the vaccine comprises a...
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6936243 |
Adeno-associated viral vector-mediated delivery of DNA to cells of the liver
The instant invention provides methods of expressing polynucleotides in the cells of the liver comprising administering viral particles comprising a recombinant AAV vector into a mammal, preferably...
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6933145 |
Materials and methods for delivery and expression of heterologous DNA in vertebrate cells
The subject invention pertains to recombinant entomopox vectors which are useful for the delivery and stable expression of heterologous DNA in vertebrate cells. Specifically exemplified is a...
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6932980 |
Method of making microalgal-based animal foodstuff supplements, microalgal-supplemented animal foodstuffs and method of animal nutrition
The present invention is to a safe, biodegradable trace metal binding system that effectively delivers chromium, cobalt, copper, iron, manganese, molybdenum, selenium and zinc to animals. The...
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6929948 |
Lineage specific cells and progenitor cells
A method for generating a culture that is purified or enriched in respect of cells of a selected lineage is described in which selectable marker, which is differentially expressed in cells of the...
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6929792 |
Modified dendritic cells and use therefor
The invention provides isolated dendritic cells genetically modified to express a selectin polypeptide, optionally treated with activated platelets or membrane microparticles thereof. The invention...
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6929946 |
Gene delivery vectors provided with a tissue tropism for smooth muscle cells, and/or endothelial cells
A gene delivery vehicle having been provided with at least a tissue tropism for cells selected from the group of smooth muscle cells, endothelial cells, and/or liver cells. The tissue tropism is...
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6929799 |
D-alanine racemase mutants of mycobacteria and uses therefore
The present invention is directed to D-alanine racemase mutants of mycobacterial species. The D-alanine racemase gene (alrA) is involved in the systhesis of D-alanine, a basic component of...
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6926890 |
Non-invasive approach for assessing tumors in living animals
A means for following the growth of experimental neoplasms involves administering recombinant tumor cells containing an expression construct encoding a secretable marker to an experimental animal...
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6926893 |
Multi-stage cascade boosting vaccine
Humoral and cellular immune responses against tumor cells and infectious agents are induced in a mammal using a vaccine comprising antibodies and anti-idiotype antibodies that mimic an epitope of...
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6926889 |
Recombinant bacteria for use in insect control
The present invention relates to recombinant bacteria genetically engineered from insect hosts to express toxic gene products in a pest insect. The present invention also relates to a method of...
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6926888 |
Alginate capsules for use in the treatment of brain tumor
Encapsulated producer cells which are capable of expressing a molecule which is an inhibitor of CNS tumour growth provide a novel approach to the treatment of tumours, such as brain tumors which...
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6924128 |
Packaging cell lines for generation of high titers of recombinant AAV vectors
AAV vectors may have utility for gene therapy but heretofore a significant obstacle has been the inability to generate sufficient quantities of such recombinant vectors in amounts that would be...
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6923957 |
Salmonella vaccine materials and methods
Attenuated mutant Salmonella bacteria containing inactivated virulence genes are provided for use in safe, efficacious vaccines.
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6923972 |
Methods for use of genetically modified tumor-targeted bacteria with reduced virulence
The present invention is directed to mutant Salmonella sp. having a genetically modified msbB gene in which the mutant Salmonella is capable of targeting solid tumors. The present invention...
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6921663 |
Adenovirus vector
The present invention provides a method for constructing a fiber-mutant adenovirus vector in which a foreign peptide is introduced by a simple system into the fiber HI loop-coding gene of...
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6919075 |
Bacteriophage displaying aβ epitopes and method of use
A method of immunizing against plaque forming diseases using display technology is provided. The method utilize novel agents, or pharmaceutical compositions for vaccination against plaque forming...
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6916477 |
Attenuated forms of bovine viral diarrhea virus
The present invention is directed to a method of producing attenuated forms of bovine viral diarrhea (BVD) virus by mutating the N pro protease gene. The invention includes the attenuated viruses...
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6916490 |
Controlled release of bioactive substances
The present invention contemplates in part coacervates in which a bioactive substance and delivery agent are encapsulated therein for controlled release. In certain embodiments, said bioactive...
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6916793 |
Selenium-containing pro-drugs for cancer therapy
Methods for inhibiting the growth of tumor cells by combination treatment with a selenium-containing prodrug and an enzyme for which it is a substrate are described. The treatment also enhances the...
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6913753 |
Incapacitated whole-cell immunogenic bacterial compositions
The invention features incapacitated whole cell bacterial immunogenic compositions produced by infecting a bacterium with Lys minus bacteriophage, which are deficient in the lysin protein. Lys...
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