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7037510 |
Hybrids of M. tuberculosis antigens
The present invention discloses fusion proteins of the immunodominant antigens ESAT-6 and Ag85B from Mycobacterium tuberculosis or homologues thereof, and a tuberculosis vaccine based on the...
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7037712 |
DNA encoding ovine adenovirus (OAV287) and its use as a viral vector
A genome of an ovine adenovirus designated OAV287 is isolated from sheep and sequenced. Portions of the genome not essential for maintenance or viability of the virus can be deleted or altered. A...
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7034010 |
Use of recombinant gene delivery vectors for treating or preventing lysosomal storage disorders
Gene delivery vectors, such as, for example, recombinant FIV vectors, and methods of using such vectors are provided for use in treating or preventing retinal diseases of the eye and diseases of...
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7034116 |
Methyltransferase gene and enzyme
A novel cytosine-5 DNA methyltransferase, isolated from Chlorella virus NYs-1, and its encoded enzyme are disclosed. The methyltransferase recognizes a GpC dinucleotide in DNA. Methods of using the...
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7033834 |
Methods and means for targeted gene delivery
A method for producing viral gene delivery vehicles which can be transferred to pre-selected cell types by using targeting conjugates. The gene delivery vehicles comprise: 1) the gene of interest;...
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7034137 |
Isolated mammalian membrane protein genes; related reagents
Nucleic acids encoding various lymphocyte cell proteins from mammalian, including primate, reagents related thereto, including specific antibodies, and purified proteins are described. Methods of...
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RE39078 |
Recombinant adenoviruses for gene therapy in cancers
The invention concerns recombinant viruses comprising a heterologous DNA sequence under the control of expression signals specifically active in tumor cells, and their preparation and use in the...
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7033585 |
Immunologically privileged cells and uses thereof
The invention is directed to immunologically privileged cells, e.g., autologous, allogeneic, and xenogeneic intermediate lobe pituitary cells, for delivering polypeptides, e.g., insulin, to a...
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7030099 |
Tumor specific promoters of the midkine gene that allow for selective expression in P53-inactivated cells
A DNA comprising a 609 bp base sequence from −559 to +50 when the first base sequence of exon 1 of the midkine gene, a human retinoic acid-responsive growth/differentiation factor was set as +1,...
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7029668 |
Stimulation of angiogenesis via enhanced endothelial expression of syndecan-4 core proteins
The present invention provides tangible means and methods for stimulation of angiogenesis via enhanced endothelial expression of core proteins having a syndecan-4 cytoplasmic region...
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7029682 |
Inactivated vaccine against feline calicivirosis
Immunogenic preparations and vaccines, in particular which are inactivated, effective against feline calicivirosis, based on an FCV virus strain 431 as deposited at the CNCM under the accession...
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7029667 |
DNA encoding Erwinia amylovora hypersensitive response elicitor and its use
The present invention is directed to an isolated DNA molecule from Erwinia amylovora that encodes a protein or polypeptide which elicits a hyersensitive response in plants. This isolated DNA...
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7030295 |
Modified Cry3A toxins and nucleic acid sequences coding therefor
Compositions and methods for controlling plant pests are disclosed. In particular, novel nucleic acid sequences encoding modified Cry3A toxins having increased toxicity to corn rootworm are...
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7029666 |
Uses for non-autologous mesenchymal stem cells
Methods and devices using non-autologous mesenchymal stem cells comprising treating a recipient in need thereof with an effective amount of non-autologous mesenchymal stem cells, including methods...
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7025970 |
Modified poxviruses, including modified smallpox virus vaccine based on recombinant drug-sensitive vaccinia virus, and new selection methods
The present invention provides recombinant poxviruses, such as vaccinia virus, that contain an integrated exogenous sequence, such as a foreign gene, encoding a prodrug converting polypeptide that...
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7026113 |
EIA vaccine and diagnostic
The invention provides an equine infectious anemia (EIA) vaccine that provides immunity to mammals, especially equines, from infection with equine infectious anemia virus (EIAV) and which allows...
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7025967 |
Recombinant protein production in bovine adenovirus expression vector system
The present invention relates novel live bovine adenovirus (BAV) expression vector systems in which part or all of one or both of the early region 1 (E1) and early region 3 (E3) genes are deleted...
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7022320 |
Mycobacterium tuberculosis immunization
Recombinant nucleic acid molecules are described. The molecules have a sequence or sequences encoding at least two M. tuberculosis antigens. Vectors and compositions containing these molecules...
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7022319 |
Vectors carrying therapeutic genes encoding antimicrobial peptides for gene therapy
The present invention relates to recombinant vectors carrying sequences encoding naturally occurring antimicrobial peptides or derivatives thereof for the treatment of mammalian tumours and viral...
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7022321 |
Use of marrow-derived glial progenitor cells as gene delivery vehicles into the central nervous system
The present disclosure relates to a method for introducing a hematopoietic cell into the brain of a mammal, by administering bone marrow-derived progenitor cells into the body of the mammal by...
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7022897 |
Polynucleotides encoding Δ-endotoxins toxic to lepidoptera and coleoptera, and method of use
Disclosed are novel polynucleotides encoding Lepidopteran- and Coleopteran-active δ-endotoxin polypeptides and compositions comprising the polypeptides. Also disclosed are vectors, transformed...
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7018628 |
Vectors derived from baculovirus and use for transferring nucleic acids into nerve cells of vertebrates
The invention concerns novel recombinant viruses and their use for gene-transfer into nerve cells of vertebrates. The invention also concerns pharmaceutical compositions comprising said recombinant...
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7018835 |
Recombinant double-stranded RNA phage, and use of the same
A recombinant double stranded RNA (dsRNA) phage expresses dsRNA-encoded genes in eukaryote cells. Recombinant dsRNA phage are useful for the expression of dsRNA expression cassettes encoding...
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7014847 |
Methods for preventing reovirus recognition for the treatment of cellular proliferative disorders
The present invention pertains to methods for preventing reovirus recognition in the treatment of cellular proliferative disorders, and particularly ras-mediated cellular proliferative disorders,...
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7015205 |
Melanoma vaccine and methods of making and using same
An immunotherapeutic vaccine providing antigen presenting cells that have been pulsed with a disrupted cell preparation which includes enucleated cytosol and cell membranes of cancer cells infected...
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7015204 |
Protective immunity or immunological tolerance induced with RNA particularly total cellular RNA
Effective anti-tumor immunity is induced in mice utilizing RNA-pulsed epidermal cells (EC) for in vivo immunization or by injecting RNA intradermally into naïve mice. A vaccine comprising total...
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7011828 |
Implanting neural progenitor cells derived for human embryonic stem cells
The present invention relates to undifferentiated human embryonic stem cells, methods of cultivation and propagation and production of differentiated cells. In particular it relates to the...
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7011976 |
Adenovirus vectors specific for cells expressing alpha-fetoprotein and methods of use thereof
Replication competent adenoviral vectors specific for cells expressing alfa-fetoprotein (AFP) are provided. These replication-competetent adenoviral vectors comprise adenovirus genes essential for...
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7005127 |
Mixed-cell gene therapy
The subject invention is directed to a mixed cell composition to generate a therapeutic protein at a target site by providing a first population of mammalian cells transfected or transduced with a...
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7005126 |
Method for tumor treatment using infusion of xenogeneic cells to induce hyperacute rejection and innocent bystander effect
A method for treating tumors. Through infusion or xenotransplantation of xenogeneic cells, such as infusion of murine cells into the peritoneal cavity of humans, a hyperacute rejection response to...
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7005562 |
SAR and pathogen-inducible promoter
The Arabidopsis NI16 gene was isolated in a yeast 2-hybrid screen via its interaction with the NIM1 protein and encodes a protein involved in the regulation of SAR gene expression in plants. NI16...
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7005424 |
Nucleic acid encoding an E1A gene product sensitizes HER-2/neu overexpressing cancer cells to chemotherapy
The present invention relates to methods for the inhibition, of the gene product of the neu oncogene, p185neu tyrosine kinase. Over-expression of the neu oncogene leads to chemoresistance. The...
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7005277 |
Defective adenoviruses and corresponding complementation lines
Novel defective adenoviruses for the transfer and expression of an exogenous nucleotide sequence in a host cell or organism. The invention also relates to novel complementation lines and to the...
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7001756 |
Microorganism strain of GM-020 of Lactobacillus rhamnosus and its use for treating obesity
The present invention provides an isolated microorganism strain, Lactobacillus rhamnosus GM-020, which is found to be effective in treating obesity and a complication thereof. The use of the ...
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7001764 |
Compositions comprising tissue specific adenoviral vectors
Compositions comprising host cell specific adenovirus vehicles are provided for transfecting target host cells. The compositions comprise replication competent adenovirus having an adenovirus gene...
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6998117 |
Cancer treatment with retroviral vectors comprising wild-type p53
Disclosed are methods and compositions for the selective manipulation of gene expression through the preparation of retroviral expression vectors for expressing antisense sequences, such as K-ras...
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6998118 |
Targeted retrograde gene delivery for neuronal protection
Methods are disclosed for transducing neurons with heterologous genes using retrograde viral transport. The methods disclosed employ substantially non-toxic vectors, such as adeno-associated virus...
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6995010 |
Gene transfer method
A method of transferring a foreign gene into cells, characterized by involving: the step of transferring into the cells with the use of an adenovirus vector, a first nucleic acid, which has a...
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6991900 |
Methods for identifying an essential gene in a prokaryotic microorganism
Methods are provided for the rapid identification of essential or conditionally essential DNA segments in any species of haploid cell (one copy chromosome per cell) that is capable of being...
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6991787 |
Methods of preparing bone marrow stromal cells for use in gene therapy
This invention relates to sequential methods of cryopreserving bone marrow stromal cells that are transfected and used for gene therapy by transplantation. These methods include the following steps...
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6991792 |
Prevention of autoimmune diabetes by immunogene therapy using recombinant vaccinia virus expressing glutamic acid decarboxylase
A vaccine including recombinant vaccinia virus (ATCC VR-1354) having an inserted gene for coding glutamic acid decarboxylase is used for preventing type 1 diabetes mellitus. The glutamic acid...
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6991786 |
Anti-microbial biotherapeutic agents: alternatives to conventional pharmaceutical antibiotics
Novel antimicrobial agents that can serve as replacements to conventional pharmaceutical antibiotics are disclosed. The antimicrobial agents comprise conjugatively transmissible plasmids that kill...
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6991935 |
Target cell-specific adenoviral vectors containing E3 and methods of use thereof
The invention provides adenoviral vectors (preferably replication competent) comprising both an E3 sequence and at least one adenoviral gene under transcriptional control of a target cell-specific...
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6989375 |
Enhanced expression of transgenes
The present invention provides for improved methods of gene transfer, both in vitro and in vivo. By treating neoplastic cells with a DNA-damaging agent prior to transduction with a transgene, the...
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6989268 |
Recombinant adenoviral vector and methods of use
This invention provides a recombinant adenovirus expression vector characterized by the partial or total deletion of the adenoviral protein IX DNA and having a gene encoding a foreign protein or a...
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6986887 |
Universal stem cells
The subject invention pertains to materials and methods for preparing multi-potential stem cells having a pre-selected expression of MHC antigens. Stem cells of the subject invention can be used to...
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6987096 |
Antiviral proteins and peptides, DNA coding sequences therefor, and uses thereof
The present invention provides antiviral proteins (collectively referred to as cyanovirins), conjugates thereof, DNA sequences encoding such agents, host cells containing such DNA sequences,...
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6984379 |
Gene therapy by administration of genetically engineered CD34+ cells obtained from cord blood
A method of providing a therapeutic effect in a human patient which comprises administering to the patient CD34+ cells obtained from cord blood. The CD34+ cells have been engineered with at least...
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6984522 |
Isolation and use of solid tumor stem cells
A small percentage of cells within an established solid tumor have the properties of stem cells. These solid tumor stem cells give rise both to more tumor stem cells and to the majority of cells in...
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6984380 |
Treatment of diseases involving faulty MHC class I antigen complex presentation
Methods of treating autoimmune diseases, such as diabetes, characterized by faulty MHC class I antigen complex presentation are disclosed which involve exposure of the immune system of an...
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