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7097842 |
Modified vaccinia virus ankara for the vaccination of neonates
The invention concerns the use of a virus for the preparation of a medicament for the vaccination, treatment, or protection, of a neonatal or prenatal animal, including a human, wherein the virus...
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7097829 |
Transgenic cells transfected with pituitary tumor transforming gene (PTTG)) expression vectors and uses therefor
Described are cells transfected with expression vectors containing pituitary tumor transfer gene (PTTG) and uses therefor. The PTTG nucleic acids may be operatively linked to a vector, optionally...
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7098191 |
Hyperthermic inducible expression vectors for gene therapy and methods of use thereof
Expression constructs using an inducible amplification system to drive expression of a therapeutic gene or other genes of interest in mammalian cells are provided, as well as methods of using the...
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7094398 |
Recombinant adenoviral vectors expressing chimeric fiber proteins for cell specific infection and genome integration
The present invention provides for novel chimeric Ad-vectors carrying transgene, or portions of transgenes for stable and efficient gene transfer into diverse cell types or tissues in a CAR- and/or...
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7094400 |
Transkaryotic implantation
The present invention provides a method of altering the concentration or level of expression of a desired gene product in a recipient subject which involves administering to a recipient a...
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7094399 |
Use of spliceosome mediated RNA trans-splicing to confer cell selective replication to adenoviruses
The present invention provides methods and compositions for conferring tumor selective cell death on cancer cells expressing specific target precursor messenger RNA molecules (cancer cell selective...
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7094410 |
DNA vaccine against proliferating endothelial cells and methods of use thereof
A DNA vaccine effective for inhibiting endothelial cell proliferation comprises a DNA construct operably encoding a vascular endothelial growth factor (VEGF) receptor protein. This invention...
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7091029 |
High titer recombinant AAV production
The invention includes methods and compositions for the production of high titer recombinant adeno-associated virus (rAAV). The disclosed rAAV are useful in gene therapy applications. Methods are...
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7090837 |
Compositions and methods for tissue specific targeting of lentivirus vectors
This disclosure provides lentiviral vectors containing an attachment incompetent fusogenic polypeptide and a heterologous targeting polypeptide. Also provided are lentiviral packaging constructs,...
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7091040 |
P450/acetaminophen genetically directed enzyme prodrug therapy (GDEPT)
The invention hereindescribed relates to a form of cancer therapy which exploits the cytotoxic properties of acetaminophen when converted to NABQI by the metabolic activity of tumour cell specific...
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7087582 |
Combination for site-specifically transforming cells in vivo comprising a double-balloon catheter and nucleic acid comprising a gene encoding P21
The present invention provides a combination including a double-balloon catheter and a nucleic acid encoding the cyclin dependent kinase inhibitor p21. The nucleic acid may also encode HLA-B7, an...
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7087226 |
Lysin-deficient bacteriophages having reduced immunogenicity
The present invention features therapeutic bacteriophage deficient in the lysin protein (“Lys minus” phage). Lys minus bacteriophage are incapable of facilitating efficient lysis of the...
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7087741 |
Nucleic acids encoding novel proteins in enteroaggregative escherichia coli (EAEC)
Novel proteins and their corresponding nucleotide sequences in enteroaggregative Escherichia coli (EAEC) are provided. In particular, Aap and the five gene cluster (aat) of the AA probe region of...
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7083979 |
Methods for enhanced retroviral-mediated gene transfer
A method to increase the efficiency of transduction of hematopoietic and other cells by retroviruses includes infecting the cells in the presence of fibronectin or fibronectin fragments. The...
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7078032 |
Delivery of therapeutic biologicals from implantable tissue matrices
Normal cells, such as fibroblasts or other tissue or organ cell types, are genetically engineered to express biologically active, therapeutic agents, such as proteins that are normally produced in...
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7078031 |
Pseudotyped lentiviral vectors and uses thereof
A vector system that will produce a pseudotyped lentiviral vector that can be used to deliver a desired gene is disclosed. The vector constructs that are described include a number of modifications...
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7078028 |
Anti-neoplastic viral agents
A viral DNA construct, and virus encoded thereby, is provided having one or more tumour specific transcription factor binding sites in place of one or more wild type transcription factor binding...
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7078029 |
Herpes simplex virus strains
The present invention provides an HSV having a genome with a mutation of a TAATGARAT sequence such that, in the presence of a ICP4 gene product, a native immediate early gene is expressed from the...
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7078191 |
Composition and method for the detection of diseases associated with amyloid-like fibril or protein aggregate formation
The present invention relates to novel compositions useful for elucidating the onset or progress of diseases such as Huntington's disease, that are associated with the formation of fibrils or...
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7078593 |
Sequence regulating the anther-specific expression of a gene and its use in the production of androsterile plants and hybrid seeds
The regulatory sequence is useful for the specific expression in anther of a nucleotide sequence of interest, for example, a sequence whose controlled expression under the regulatory sequence...
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7078030 |
Oncolytic adenovirus
Viral vectors and methods of making such vectors are described that preferentially kill neoplastic but not normal cells, the preferred vector being an adenovirus that has the endogenous promoters...
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7074400 |
Regulatory constructs comprising intron 3 of prostate specific membrane antigen gene
The invention provides regulatory constructs comprising intron 3 of the prostate specific membrane antigen gene (PSMA). An isolated nucleic acid molecule encoding the partial sequence of intron 3...
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7074398 |
Retroviral vectors carrying senescent cell derived inhibitors 1 (SDI-1)or antisense SDI-1 nucleotide sequences
The present invention relates to retroviral vectors carrying DNA sequences encoding SDI-1, function analogues of SDI-1, or fragments thereof, or antisense SDI-1 DNA sequences, and especially...
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7074772 |
Design principle for the construction of expression constructs for gene therapy
The invention concerns an expressible nucleic acid construct, which contains only the sequence information necessary for expressing a gene for RNA or protein synthesis. Expression constructs of...
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7074399 |
Treatment of inflammation with p20
The present invention provides compositions, methods, and kits for treating inflammation and regulating inflammatory responses including cytokine, prostanoid, prostaglandin, and growth factor...
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7070771 |
Methods of expressing chimeric mouse and human CD40 ligand in human CD40+ cells
This invention relates to genes which encode accessory molecule ligands, such as the CD40 ligand and their use for immunomodulation, vaccination and treatments of various human diseases, including...
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7067122 |
Modified live Edwardsiella tarda vaccine for aquatic animals
A safe and effective live vaccine against Edwardsiella tarda in fish was created through the induction of rifampicin resistance in a native Edwardsiella tarda isolate. Single immersion exposure...
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7067121 |
Transplants for myocardial scars
A method is provided for forming a graft in heart tissue which comprises the transplantation of cells chosen from cardiomyocytes, fibroblasts, smooth muscle cells, endothelial cells and skeletal...
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7067120 |
Cytokine gene modified antigen-presenting cell/tumor cell conjugate, its preparation and use
The present invention provides an antigen-presenting cell(APC)/tumor cell conjugate, wherein the antigen-presenting cell (APC) is modified by a cytokine gene selected from the group consisting of...
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7067309 |
Defective adenoviruses and corresponding complementation lines
Novel defective adenoviruses for the transfer and expression of an exogenous nucleotide sequence in a host cell or organism. The invention also relates to novel complementation lines and to the...
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7063851 |
Herpes viruses for immune modulation
A method of stimulating an immune response in a human or animal subject, which method comprises administering to a subject in need thereof an effective amount of an attenuated herpes virus which:
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7063835 |
Virus strains
The present invention relates to non-laboratory virus strains, for example of herpes viruses such as HSV, with improved oncolytic and/or gene delivery capabilities as compared to laboratory virus...
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7060688 |
Products and methods for controlling the suppression of the neoplastic phenotype
A method for gene therapy for cancers wherein chromosomal location of an inactive or defective cancer suppressing gene is established, a replacement gene which is preferably cloned is then used to...
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7060687 |
Live vaccines for allergy treatment
The invention relates to transformed bacteria of the genus Lactobacillus or Streptococcus, the bacteria having a DNA molecule that includes (1) a nucleotide sequence that encodes a protein...
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7060497 |
Adeno-associated viral vector-based methods and compositions for introducing an expression cassette into a cell
Methods and compositions are provided for introducing an expression cassette into a cell. In the subject methods, a population of at least two distinct adeno-associated viral particles is provided,...
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7056897 |
Inducible expression vectors and methods of use thereof
The present invention relates to inducible gene expression constructs and methods of inducing gene expression using a combination of inducing agents.
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7056502 |
Recombinant aav vectors with AAV5 capsids and AAV5 vectors pseudotyped in heterologous capsids
A pseudotyped rAAV is described, which contains sequences derived from AAV5. A method for producing rAAV pseudotyped with AAV5 capsid is described in which the rep proteins of the serotype or any...
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7056699 |
Lentiviral LTR-deleted vector
A vector capable of transducing non-dividing and/or slowly dividing cells is provided, wherein the vector is a lentiviral LTR-deleted vector. Also provided is a method for producing a protein of...
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7052692 |
Role of tyrosine phosphorylation of a cellular protein in adeno-associated virus 2-mediated transgene expression
The present invention identifies a protein, designated the D-sequence-binding protein (D-BP), is phosphorylated at tyrosine residues and blocks AAV-mediated transgene expression in infected cells...
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7052904 |
Hybrid adeno-retroviral vector for the transfection of cells
An adenovirus, including adenoviral capsid proteins, and a replication-defective adenoviral vector that includes a 5′ retroviral LTR nucleic acid sequence, a 3′ retroviral LTR nucleic acid...
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7048920 |
Recombinant oncolytic adenovirus for human melanoma
The invention provides melanoma cell specific adenovirus vectors, which preferentially replicate in melanoma cells.
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7049132 |
Stress-responsive induction of a therapeutic agent and methods of use
This invention relates to compositions and methods for selective expression of a heterologous nucleic acid sequence in a targeted tissue, and more particularly to the glucose regulated protein 78...
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7045122 |
Salmonella vaccine
The present invention relates to live attenuated Salmonella strains comprising a first attenuating mutation, that are not capable of making functional RecA. The invention also relates to these...
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7045344 |
Adenoviral vector and methods for making and using the same
In vitro methods for making a recombinant adenoviral genome, as well as kits for practicing the same and the recombinant adenovirus vectors produced thereby, are provided. In the subject methods,...
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7045123 |
DNA encoding Pseudomonas syringae hypersensitive response elicitor and its use
The present invention is directed to an a isolated DNA molecule from Pseudomonas syringae that encodes a protein or polypeptide which elicits a hypersensitive response in plants. This isolated...
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7045348 |
Adenoviral vector incorporating zipper peptide-modified fiber protein and uses thereof
The present invention provides a recombinant adenovirus vector targeted by zipper peptides. The vector contains a fiber protein modified by insertion of a first zipper peptide that can crosslink to...
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7045347 |
Helper dependent adenovirus vectors based on integrase family site-specific recombinases
This invention provides helper-dependent adenovirus cloning vectors and helper adenoviruses, and methods for making and Using such preparations, wherein the helper adenoviruses contain recombinase...
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7041876 |
Oomycete-resistant transgenic plants by virtue of pathogen-induced expression of a heterologous hypersensitive response elicitor
The present invention relates to a chimeric gene that includes a first DNA molecule encoding a hypersensitive response elicitor protein or polypeptide, a promoter operably linked 5′ to the first...
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7041653 |
Gene transcription and ionizing radiation: methods and compositions
The present invention provides a DNA molecule comprising a radiation responsive enhancer-promoter operatively linked to an encoding region that encodes at least one polypeptide. An encoding region...
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7041284 |
Recombinant adenoviral vector and method of use
This invention provides a recombinant adenovirus expression vector characterized by the partial or total deletion of the adenoviral protein IX DNA and having a gene encoding a foreign protein or a...
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