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7163678 |
Reovirus for the treatment of ral-mediated cellular proliferative disorders
Methods for treating proliferative disorders, by administering reovirus to a ral-mediated proliferative disorder, are disclosed. The reovirus is administered so that it ultimately directly contacts...
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7163820 |
Escherichia coli strain for an oral vaccine against post-weaning diarrhea in pigs
The invention relates to a strain suitable for producing a live, orally applicable Escherichia coli vaccine for the prevention of post-weaning diarrhoea in pigs, and the procedure suitable for...
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7160539 |
Regulation of T cell-mediated immunity by tryptophan
A mechanism of macrophage-induced T cell suppression is the selective elimination of tryptophan and/or increase in one or more tryptophan metabolites within the local macrophage microenvironment...
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7157435 |
Methods for modulation of the effects of aging on the primate brain
The invention provides a clinically useful protocol for delivery of recombinant nervous system growth factors into the aging mammalian brain. The invention is particularly useful in tempering and...
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7157079 |
Combined tumor suppressor gene therapy and chemotherapy in the treatment of neoplasms
In one embodiment, this invention provides methods of treating mammalian cancer or hyperproliferative cells, said method comprising contacting said cells with a tumor suppressor protein or tumor...
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7151090 |
Methods for enhancing graft survival by modulating heme oxygenase activity
Methods are provided wherein the survival of an organ transplant is enhanced by introducing into cells of the transplant a nucleic acid molecule that modulates heme oxygenase-I activity therein....
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7147861 |
Human cytomegalovirus glycoprotein O as a new drug target and subunit vaccine candidate
A method of designing a new anti-CMV drug is disclosed. In one embodiment, the invention comprises (a) analyzing the binding of glycoprotein O to a glycoprotein O receptor and (b) designing a...
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7147848 |
Recombinant poliovirus for the treatment of cancer
The present invention is directed to non-pathogenic, oncolytic, recombinant polioviruses for the treatment of various forms of malignant tumors. The recombinant polioviruses of the invention are...
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7147846 |
Prosthetic grafts
An improved prosthetic graft for the bypass, replacement or repair of vessels and organs that are in contact with blood flow is disclosed. The prosthetic graft includes a porous prosthetic implant...
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7148040 |
Method of rapid production of hybridomas expressing monoclonal antibodies on the cell surface
The present invention relates to genetically altered hybridomas, myelomas and B cells. The invention also relates to utilizing genetically altered hybridomas, myelomas and B cells in methods of...
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7148201 |
Use of human plasma hyaluronidase in cancer treatment
The invention is based on the discovery of methods for purification of an acid active hyaluronidase found in human plasma (hpHAse), including both biochemical and immunoaffinity purification...
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7141551 |
Wound and cutaneous injury healing with a nucleic acid encoding perlecan
A description of a biomolecule named Perlecan which is added internally or topically, or is expressed from exogenously added nucleic acids, as a whole or in part, to a healing wound to improve the...
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7141662 |
Nucleic acids encoding novel proteins in enteroaggregative Escherichia coli (EAEC)
Novel proteins and their corresponding nucleotide sequences in enteroaggregative Escherichia coli (EAEC) are provided. In particular, Aap and the five gene cluster (aat) of the AA probe region of...
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7141395 |
Biological control of crown gall disease
The present invention provides a method for controlling crown gall disease in plants using an effective quantity of α-proteobacteria that produces trifolitoxin (TFX). The present invention also...
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7138379 |
Use of the interferon receptor 2c polypeptide chain to enhance the anti-growth effects of type I interferons
The present invention is directed towards a method of potentiating the anti-growth effects of type I interferon (IFN) on cells in a target cell population comprising increasing the number of...
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7138381 |
Compositions containing nucleic acids and ligands for therapeutic treatment
Preparations of conjugates of a receptor-binding internalized ligand and a cytocide-encoding agent and compositions containing such preparations are provided. The conjugates contain a polypeptide...
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7138112 |
Plasmid maintenance system for antigen delivery
The present invention relates generally to a Plasmid Maintenance System for the stabilization of expression plasmids encoding foreign antigens, and methods for making and using the Plasmid...
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7138569 |
Nucleic acids encoding pseudomonas hop proteins and use thereof
The present invention relates to isolated nucleic acid molecules encoding a type III—secreted bacterial protein capable of modifying a cell death pathway in a plant cell. One aspect of the...
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7135171 |
Endothelial precursor cells for enhancing and restoring vascular function
The invention provides methods of treating and preventing loss of tissue vascularization that can occur, for example, upon aging.
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7128916 |
Bacteriophage-mediated immunisation
The present invention relates to vaccines comprising a bacteriophage which has been engineered to express an immunogenic protein/peptide and wherein the surface of the bacteriophage has not been...
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7125706 |
Method for the production and purification of adenoviral vectors
The present invention addresses the need to improve the yields of viral vectors when grown in cell culture systems. In particular, it has been demonstrated that for adenovirus, the use of...
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7125549 |
Methods and compositions for efficient gene transfer using transcomplementary vectors
The invention includes a viral vector method and composition comprising transcomplementary replication incompetent viral vectors, preferably adenoviral vectors, which are cotransformed to a...
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7125548 |
Streptococcus suis vaccines and diagnostic tests
The invention relates to Streptococcus suis infection in pigs, vaccines directed against those infections and tests for diagnosing Streptococcus suis infections. The invention provides an...
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7122195 |
Mutant mycobacteria for use in therapy
This invention relates to recA mutant mycobacteria, particularly mutants of mycobacterial species which are members of the Mycobacterium tuberculosis complex, such as M. bovis BCG and M....
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7122181 |
Lentiviral vector-mediated gene transfer and uses thereof
The present invention provides lentiviral vectors that are useful in human gene therapy for inherited or acquired proliferative ocular disease. It furnishes methods to exploit the ability of...
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7122179 |
Live genetically attenuated malaria vaccine
Method for inoculating a vertebrate host against malaria, by administering to the host a live Plasmodium organism that is genetically engineered to disrupt a gene whose expression is up-regulated...
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7122180 |
DNA vectors containing mutated HIV proviruses
The present invention pertains to mutated, non-infectious HIV viral particles, vectors for production of such particles and vaccines employing such vectors. The non-infectious particles are...
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7118738 |
Recombinant pox virus for immunization against MUC1 tumor-associated antigen
Recombinant pox viruses capable of expressing an immunogenic fragment of the MUC1 tumor-associated antigen are disclosed. The recombinant viruses can be used as vaccines to prevent the...
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7118755 |
Herpes viruses for immune modulation
An attenuated herpes virus which lacks a functional vhs gene or a functional equivalent thereof, but which has a functional UL43 gene or functional equivalent thereof, stimulates an immune response...
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7118888 |
Gene expression vaccine
An effective prophylactic mucosal gene expression vaccine (GXV), made up of a cocktail of at least 4 different plasmid DNAs encoding corresponding RSV antigens, coacervated with chitosan to...
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7115257 |
ARPE-19 as a platform cell line for encapsulated cell-based delivery
ARPE-19 cells were evaluated as a platform cell line for encapsulated and unencapsulated cell-based delivery technology. ARPE-19 cells were found to be hardy (the cell line is viable under...
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7115269 |
Attenuated Salmonella strain used as a vehicle for oral immunization
The present invention is directed to an attenuated Salmonella comprising a eukaryotic expression vector for delivery of the eukaryotic expression vector to a eukaryotic cell. Delivery may be to...
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7115258 |
Vesicular monoamine transporter gene therapy in parkinson's disease
The present invention provides methods and compositions for the therapeutic intervention of Parkinson's disease. More particularly, methods of making and sequestering dopamine are disclosed....
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7115391 |
Production of recombinant AAV using adenovirus comprising AAV rep/cap genes
This invention relates to novel adenoviruses useful in the production of high titers of recombinant adeno-associated virus (rAAV) comprising a foreign DNA insert and methods of making these...
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7112321 |
Adeno-associated virus-mediated delivery of GDNF to skeletal muscles
Compositions and methods for delivering GDNF to skeletal muscles to result in a therapeutic effect are disclosed. The compositions and methods use adeno-associated virus (AAV)-based gene delivery...
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7108855 |
Purified hepatitis C virus envelope proteins for diagnostic and therapeutic use
The present invention relates to a method for purifying recombinant HCV single or specific oligomeric envelope proteins selected from the group consisting of E1 and/or E2 and/or E1/E2,...
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7109029 |
Vector constructs
The present invention provides novel viral vectors and methods useful for the minimization of leaky gene expression, and, in particular, of nonspecific transcriptional read-through of genes. Such...
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7109397 |
Pseudomonas syringae harpins, HopPtoP and HopPmaHPto, and their uses
The present invention relates to isolated DNA molecules that encode proteins or polypeptides which elicit a hypersensitive response in plants. One aspect of the present invention involves an...
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7105156 |
Method of using an adenoviral vector encoding a retinoblastoma protein to treat hyperproliferating cells
Disclosed are methods of controlling cell cycle progression by introducing into a cell to be controlled a composition selected from the group consisting of p56 RB protein, a fragment of the p56 RB...
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7105494 |
Viral and non-viral vectors as vehicles for delivering transgenes for treating bone pathologies
The present invention relates to a method for treating bone pathologies comprising delivering a viral or non-viral delivery vehicle comprising genetic information (e.g. a transgene) encoding a...
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7105157 |
Methods for treating cancers and pathogen infections using antigen-presenting cells loaded with RNA
The present invention relates to cells and methods for treating or preventing tumor formation or infections with pathogens in a patient. The cells of the invention are antigen-presenting cells...
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7101704 |
Antigen presenting mesenchymal stem cells
Disclosed is a mesenchymal stem cell and/or cell of the adipocyte lineage that (i) has been modified to have at least one exogenous antigen bound to at least one primary surface molecule of said...
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7101543 |
Genetically modified cells expressing a TGFβ inhibitor, the cells being lung cancer cells
The present invention relates to compositions comprising a therapeutically effective amount of genetically modified cells containing a genetic construct expressing a TGFβ inhibitor effective to...
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7101540 |
Targeted retrograde gene delivery to motor neurons
Methods are disclosed for delivering a heterologous gene to a cell body of a neuron by contacting a muscle tissue innervated by the neuron with a viral vector comprising a heterologous gene,...
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7101708 |
Hematopoietic cell composition for use in transplantation
Cell compositions consisting essentially of mammalian hematopoietic CXCR4 + stem and progenitor capable to migrate in response to stromal-derived factor 1 (SDF-1) and/or capable to adhere to...
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7101542 |
Cell-mediated targeting of toxins to pathogenic cells
The invention features vectors encoding immunotoxic fusion proteins containing targeting domains and toxic domains, targeting cells transduced with the vectors, methods of making the targeting...
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7101558 |
High yield pertussis vaccine production strain and method for making same
The present invention provides a vaccine production strain of Bordetella bronchiseptica that produces a pertussis toxin in high yield. The present invention provides a method for creating a ...
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7101541 |
Utilization of non-viral sequences for minus-strand DNA transfer and gene reconstitution
A retroviral vector for gene reconstitution is provided that includes a 3′ portion of a heterologous nucleic acid sequence 5′ of a first att site and a 5′ portion of the heterologous nucleic...
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7097842 |
Modified vaccinia virus ankara for the vaccination of neonates
The invention concerns the use of a virus for the preparation of a medicament for the vaccination, treatment, or protection, of a neonatal or prenatal animal, including a human, wherein the virus...
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7097829 |
Transgenic cells transfected with pituitary tumor transforming gene (PTTG)) expression vectors and uses therefor
Described are cells transfected with expression vectors containing pituitary tumor transfer gene (PTTG) and uses therefor. The PTTG nucleic acids may be operatively linked to a vector, optionally...
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