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7247297 |
Use of DF3/MUC1 regulated expression in gene therapy
The present invention provides for improved vectors for use in gene therapy. Utilizing the cancer specific DF3/MUC1 promoter to drive a replication essential gene, vectors are made conditionally...
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7247472 |
Simian adenovirus nucleic acid and amino acid sequences, vectors containing same, and methods of use
A recombinant vector comprising capsid proteins derived from simian adenovirus Pan5, Pan6, Pan7, SV1, SV25 or SV39 sequences are described. These vectors contain a heterologous gene under the...
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7244423 |
Methods for therapy of neurodegenerative disease of the brain
A specific clinical protocol for use toward therapy of defective, diseased and damaged cholinergic neurons in the mammalian brain, of particular usefulness for treatment of neurodegenerative...
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7244434 |
Replicons of pestviruses that do not express C and or E1 protein and infectious viral particles containing same, that can be used in vaccines
The present invention provides new Pestiviral RNA genomes (replicons) that are able to replicate, and can be packaged into infectious viral particles in cells that complement the missing...
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7244878 |
Increasing salt tolerance in plants by overexpression of vacuolar Na+ /H+ transporters
The invention is isolated nucleic acid molecules encoding Na + /H + exchanger polypeptides for extrusion of monovalent cations from the cytosol of cells to provide the cell with increased salt...
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7241447 |
Adeno-associated virus vectors and uses thereof
The invention provides an isolated and purified DNA molecule comprising at least one DNA segment, a biologically active subunit or variant thereof, of a circular intermediate of adeno-associated...
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7241742 |
CYP1B1 nucleic acids and methods of use
The present invention provides nucleic acids containing transcriptional units that encode CYP1B1 polypeptides or portions thereof, wherein the transcriptional units lack sequences found in the...
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7241591 |
Adenovirus comprising a gene coding for glutathione peroxidase
The present invention relates to a defective adenovirus comprising at least a DNA sequence coding for all or an active part of glutathione peroxidase or a derivative thereof. It also relates to...
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7238528 |
Means and methods for fibroblast-like or macrophage-like cell transduction
The invention provides a nucleic acid delivery vehicle with or having been provided with at least a tissue tropism for fibroblast-like or macrophage-like cells, preferably synoviocytes. In one...
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7238346 |
High capacity recombinant adenoviral vector for treatment of hemophilia A
The invention relates to adenoviral vectors. More particularly, this invention relates to recombinant high capacity adenoviral vectors which can be employed in the treatment of hemophilia A, as...
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7238345 |
Recombinant microorganism expressing meningococcal class 1 outer membrane protein
Outer-membrane vesicles, Class 1 outer membrane proteins of Neisseria meningitidis, fragments or oligopeptides containing epitopes of the Class I OMP can be used to immunize against meningococcal...
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7238674 |
Methods for delivering DNA to muscle cells using recombinant adeno-associated virus vectors
The use of recombinant adeno-associated virus (AAV) virions for delivery of DNA molecules to muscle cells and tissue is disclosed. The invention allows for the direct, in vivo injection of...
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7235235 |
Alphavirus RNA replicon systems
The present invention provides a helper cell for expressing an infectious, replication defective, alphavirus particle in an alphavirus-permissive cell. The helper cell includes (a) a first helper...
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7235234 |
Bacterial delivery system
We describe a bacterial delivery system for the delivery of DNA and antigens into cells. We constructed an attenuated bacterial vector which enters mammalian cells and ruptures delivering...
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7235236 |
Polynucleotide encoding human adenylylcyclase VI and uses thereof for enhancing cardiac function
The present invention relates to polynucleotides encoding human adenylylcyclase VI and uses thereof for enhancing cardiac function. The present invention can thus be used in the treatment of heart...
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7235395 |
Lactic acid bacteria as agents for treating and preventing allergy
The present invention pertains to novel strains of lactic acid bacteria capable of reducing an individual's tendency to react allergic against a variety of different allergens. In particular, the...
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7226587 |
Compositions and methods for systemic administration of sequences encoding bone morphogenetic proteins
Compositions and methods for systemic administration of DNA encoding bone morphogenic proteins for promotion of osteogenesis are disclosed. The compositions and methods of the invention may be...
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7223389 |
Compositions and methods for treatment of cancer
The present invention discloses lentogenic viral strains useful in the treatment of cancer. A preferred viral strain of Newcastle Disease Virus (NDV) is specifically characterized in terms of...
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7223593 |
Herpes virus strains for gene therapy
The present invention provides a herpes virus with improved oncolytic properties which comprises a gene encoding an immunomodulatory cytokine and which lacks a functional ICP34.5 gene and a...
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7223390 |
Insertion of furin protease cleavage sites in membrane proteins and uses thereof
Cleavage site for the protease furin is inserted between domains of a membrane glycoprotein. Upon cleavage by furin in the trans-Golgi network, the protein is separated into individual...
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7220418 |
Delivery of trefoil peptides
The present invention relates to a microorganism, preferably a bacterial strain, preferably a non-pathogenic strain, preferably a non-invasive strain, preferably a food grade strain, preferably a...
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7220582 |
Stem cells that transform to beating cardiomyocytes
Disclosed herein is a novel isolated population of stem cells, called spoc cells, that can be induced, either in vivo or in vitro, to differentiate into cardiomyocytes. Methods are disclosed herein...
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7214858 |
Plant genes encoding trehalose metabolism enzymes
This invention relates to isolated nucleic acid fragments encoding trehalose metabolism enzymes, more specifically, alpha, alpha-trehalase, alpha, alpha-trehalose-phosphate synthase or...
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7214369 |
Devices and processes for distribution of genetic material to mammalian limb
A process is described for the delivery of a therapeutic polynucleotide to limb muscle tissue suffering from or potentially suffering from ischemia. The polynucleotide is inserted into a mammalian...
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7211248 |
Enhancement of transfection of DNA into the liver
A method for transfection of DNA or RNA encoding apo A1 into the liver to regulate lipid metabolism comprises injection of a solution containing the DNA or RNA gene into the liver in combination...
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7211247 |
Lentivirus vectors for gene transfer to alveolar epithelial cells
The present invention demonstrates that VSV-G-pseudotyped lentivirus vectors efficiently transduce AEC in primary culture and in vivo with transduction favored by virus application from the apical...
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7208164 |
Ovo immunization against infectious bronchitis
The present invention is directed to processes and compositions for protecting host animals (e.g., chickens) from exposure to virulent infectious bronchitis virus. In ovo administration of live,...
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7202067 |
Carotene synthase gene and uses therefor
Described herein is a novel three domain gene from Schizochytrium , denoted carotene synthase, that encodes a protein with three different enzymatic activities: phytoene dehydrogenase (PD),...
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7202227 |
Multifunctional molecular complexes for gene transfer to cells
A multifunctional molecular complex for the transfer of a nucleic acid composition to a target cell is provided The complex is comprised of A) said nucleic acid composition and B) a transfer moiety...
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7201898 |
Methods and compounds for controlled release of recombinant parvovirus vectors
The invention uses recombinant parvoviruses, and particularly recombinant adeno-associated virus (rAAV) to deliver genes and DNA sequences for gene therapy following manipulation of the therapeutic...
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7198785 |
Systems and methods related to degradation of uremic toxins
The present invention generally relates to the treatment of uremic toxins in vivo using uremic toxin-treating enzymes, and/or cells capable of producing uremic toxin-treating enzymes or otherwise...
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7199286 |
Plant-derived novel pathogen and SAR-induction chemical induced promoters, and fragments thereof
The Arabidopsis NI16 gene was isolated in a yeast 2-hybrid screen via its interaction with the NIM1 protein and encodes a protein involved in the regulation of SAR gene expression in plants. NI16...
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7198951 |
Adeno-associated virus (AAV) serotype 9 sequences, vectors containing same, and uses therefor
Sequences of a serotype 9 adeno-associated virus and vectors and host cells containing these sequences are provided. Also described are methods of using such host cells and vectors in production of...
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7198783 |
Sensitization of neoplastic cells to radiation therapy with reovirus
The present invention relates to methods of sensitizing neoplastic cells to irradiation by using oncolytic viruses, particularly reoviruses. Also provided are methods of treating or ameliorating a...
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7195896 |
Complementary adenoviral vector systems and cell lines
The present invention provides multiply deficient adenoviral vectors and complementing cell lines. Also provided are recombinants of the multiply deficient adenoviral vectors and a therapeutic...
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7192579 |
Methods of gene therapy using nucleic acid sequences for ATP-binding cassette transporter
The present invention provides nucleic acid and amino acid sequences of an ATP binding cassette transporter and mutated sequences thereof associated with macular degeneration. Methods of detecting...
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7192771 |
Plant promoter sequence
Aspects of the invention concern an isolated nucleic acid consisting of the nucleotide sequence of SEQ ID NO:1 operably associated with a heterologous nucleotide sequence.
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7192580 |
Purging of cells using viruses
The subject invention relates to viruses that are able to purge (reduce or eliminate) undesirable cells in a mixture of cells. Undesirable cells can include neoplastic cells, cells mediating...
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7189401 |
Live attenuated viruses for use as vectors or vaccines
The present invention provides modified viral genomes for use as vaccines or vectors, which are improved in their ability to retain attenuating mutations. The genomes are from viruses that...
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7189557 |
Process for the intracellular over-production of streptokinase using genetically engineered strain of E. coli
An improved process for the production of streptokinase using a genetically engineered strain of Escherichia coli which overproduces streptokinase intracellularly and more particularly, the...
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7189561 |
Production of adenovirus vectors with reduced levels of replication competent adenovirus contamination
Methods, cells and recombinant adenoviral vectors are disclosed that permit the production of recombinant adenoviral vector stocks with reduced levels of contamination by replication competent...
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7186898 |
Nucleic acid molecules from maize and their use for the production of modified starch
Nucleic acid molecules are described encoding a starch granule-bound protein from maize as well as methods and recombinant DNA molecules for the production of transgenic plant cells and plants...
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7182944 |
Methods of increasing distribution of nucleic acids
This invention provides a method of increasing the volume of distribution of a nucleic acid encoding a therapeutic agent in a tissue in a subject during localized delivery, comprising administering...
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7179457 |
Modified nodavirus RNA for gene delivery
The invention provides a nodavirus RNA1 molecule modified to include a heterologous insertion which is downstream of its replicase ORF and, preferably, its B2 ORF. The insertion preferably...
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7179467 |
DCMP2 polypeptide
Nucleic acids encoding various lymphocyte cell proteins from mammalian, including primate, reagents related thereto, including specific antibodies, and purified proteins are described. Methods of...
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7179646 |
Gene expression using T cell factor responsive element
Disclosed are DNA elements and constructs useful for obtaining tumor-selective gene expression in tumors having a mutated β-catenin/APC pathway. In particular, the use of these constructs to...
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7175840 |
Compositions for gene therapy of rheumatoid arthritis including a gene encoding an anti-angiogenic protein or parts thereof
The present invention relates to the compositions for a gene therapy of rheumatoid arthritis including a gene encoding an anti-angiogenic protein or parts thereof. More specifically, the present...
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7176186 |
Stimulation of cell-mediated immune responses by targeted particulate genetic immunization
The present invention relates to various methods of genetic immunization for the purpose of providing antigen-specific immunity in a mammalian host, including a human host. The invention is based...
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7169384 |
Tumor suppressor CAR-1
The present invention relates to a new tumor suppressor, designated CAR-1, the gene for which is located on the short arm of human chromosome 1. This gene is directly implicated in colon, kidney...
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7169383 |
Attaching substances to micro-organisms
The invention relates to surface display of proteins on micro-organisms via the targeting and anchoring of heterologous proteins to the outer surface of cells such as yeast, fungi, mammalian and...
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