|
Match
|
Document |
Document Title |
|
|
6540995 |
Encapsulated cells producing cytochrome P450
The present invention relates to capsules encapsulating cytochrome P450 producing cells and cytochrome P450 producing retroviral packaging cells. Furthermore, the present invention relates to the...
|
|
|
6541219 |
Therapeutic Gene
Polynucleotide sequences and vectors containing them, for use in gene therapy, the polynucleotide sequences comprising two or more therapeutic genes operably linked to a promoter and encoding a...
|
|
|
6537523 |
Diagnosis and treatment of cancer having clonal macrophage involvement
The presence of clonal macrophages in pre-cancerous and cancerous tissue represents an early stage of the disease in which clonal expansion of macrophages occurs due to HIV integration or other...
|
|
|
6537540 |
Methods and composition for lowering the level of tumor necrosis factor (TNF) in TNF-associated disorders
The present invention provides recombinant adeno-associated virus (rAAV) vectors encoding a tumor necrosis factor (TNF) antagonist and methods using these vectors to reduce levels of TNF in a...
|
|
|
6537541 |
Implantation of HSV-TK retrovirus producer cells to destroy glioma
The present invention discloses compositions and methods for selectively killing neoplastic cells. Retroviral vectors are used to selectively express a gene in neoplastic cells. The gene or gene...
|
|
|
6537542 |
Targeted introduction of DNA into primary or secondary cells and their use for gene therapy and protein production
The present invention relates to a method of gene or DNA targeting in cells of vertebrate, particularly mammalian, origin. That is, it relates to a method of introducing DNA into primary or...
|
|
|
6537594 |
Vaccina virus comprising cytokine and/or tumor associated antigen genes
Attenuated recombinant viruses containing DNA coding for a cytokine and/or a tumor associated antigen, as well as methods and compositions employing the viruses, are disclosed and claimed. The...
|
|
|
6538174 |
Animal model for transplantation
The invention relates to an animal model of cancer. The animal carries a tumor xenograft and is immunosuppressed by administration of cyclosporin and ketoconazole. The model is useful for studying...
|
|
|
6534052 |
Cardiac function comprising implantation of embryonic stem cell in which differentiation has been initiated
The present invention is a method for markedly improving cardiac function and repairing heart tissue in a living mammalian subject after the occurrence of a myocardial infarction. The method is a...
|
|
|
6531307 |
Adenoviral vectors encoding a cytokine and a conditionally lethal gene
The present invention provides recombinant viral vectors carrying a vector construct which directs the expression of a gene product (eg. HSVTK) that activates a compound with little or no...
|
|
|
6531123 |
Lentiviral vectors
The present invention contemplates novel lentiviral vectors which exhibit strong promoter activity in human and other cells. Vectors are provided which are packaged efficiently in packaging cells...
|
|
|
6531456 |
Gene therapy for the treatment of solid tumors using recombinant adeno-associated virus vectors
The use of recombinant adeno-associated virus (AAV) virions for the treatment of solid tumors is disclosed. The invention provides for the use of recombinant AAV virions to deliver an AAV vector...
|
|
|
6531313 |
Invasive bacterial vectors for expressing alphavirus replicons
The present invention is directed to a bacterial delivery system for delivering alphavirus replicon DNA into an animal or animal cells with the replicon encoding one or more heterologous genes to...
|
|
|
6528481 |
NG2/HM proteoglycan-binding peptides that home to angiogenic vasculature and related methods
The present invention provides angiogenic vasculature homing molecules that bind to NG2/HM proteoglycan, including, for example, a peptide comprising the amino acid sequence TAASGVRSMH (SEQ ID...
|
|
|
6528304 |
Eukaryotic cells expressing at their surface at least an HLA-G isoform and their applications
The invention concerns the use of a eukaryotic cell coding for at least an HLA-G isoform, to obtain an immunomodulating medicine for inhibiting the activity of killer cells, in particular NK cells...
|
|
|
6528250 |
Equine infectious anemia challenge model for testing vaccines, diagnostics and treatments
The invention relates to a method for infecting equines with an equine infectious anemia virus (EIAV) in order to reproduce a natural infection challenge model. More specifically, the invention...
|
|
|
6524856 |
Use of consensus sequences for targeted homologous gene isolation and recombination in gene families
The invention relates to compositions and methods for targeting sequence modifications in one or more genes of a related family of genes using enhanced homologous recombination techniques. These...
|
|
|
6524571 |
Methioninase gene therapy for tumor treatment
A depletion method to inhibit tumor growth includes introducing a viral expression system capable of expressing methioninase or a fusion protein containing methioninase into a tumor contained in a...
|
|
|
RE38009 |
Zeaxanthin formulations for human ingestion
Preparations are disclosed containing the 3R-3′R stereoisomer of zeaxanthin as a sole detectable isomer, packaged for oral ingestion by humans as a therapeutic drug or nutritional supplement....
|
|
|
6525030 |
Gene delivery to periosteal cells by microneedle injection
Direct gene transfer of genetic material into an external or internal target cell site (“microseeding”), in optional combination with a wound treatment chamber, are particularly effective as a...
|
|
|
6524573 |
Method of suppressing tumor cell growth by administering a decorin gene or gene product
A method of suppressing tumor growth is provided wherein decorin gene or its gene products are administered so that epidermal growth factor receptor activity is induced. This specific mechanism has...
|
|
|
6524572 |
Targeting recombinant virus with a bispecific fusion protein ligand in coupling with an antibody to cells for gene therapy
Use of recombinant viral vector for gene therapy is hampered by the native virus-host interaction. Non-specific gene transfection causes adverse effects in gene therapy. To solve this problem, a...
|
|
|
6521602 |
Anti-neoplastic compositions and uses thereof
Disclosed is a nucleic acid composition consisting essentially of a first nucleic acid sequence encoding a chimeric CDKi protein and a second nudeic acid sequence encoding an adenovirus E4 protein,...
|
|
|
6521225 |
AAV vectors
The present invention is directed to a recombinant adenovirus vector comprising two inverted terminal repeats (ITRs) each of which comprises a D-sequence having (i) from 5 to 15 native nucleotides...
|
|
|
6517836 |
Nitrophenylaziridine compounds and their use as prodrugs
A range of aziridin-1-yl nitrobenzamides are provided for use as prodrugs in conjunction with nitroreductase (NR) enzymes. The amides may have 1 or 2-substituents which may be bulky and polar. For...
|
|
|
6518255 |
Multiple site delivery of adenoviral vector directly into muscle for the induction of angiogenesis
The present invention provides a method for enhancing the level of perfusion of blood to a target tissue, treating a target tissue suffering from or at risk of suffering from ischemic damage,...
|
|
|
6518413 |
Utrophin gene expression
Nucleic acid from which a polypeptide with utrophin function can be expressed, especially mini-genes and chimaeric constructs. Expression significantly decreases the severity of the dystrophic...
|
|
|
6517828 |
C-CAM as an angiogenesis inhibitor
The present invention relates generally to the fields hyperproliferative disease and angiogenesis. More particularly, the present invention demonstrates that a C-CAM1 cytoplasmic domain is...
|
|
|
6518062 |
Enzyme combinations for destroying proliferative cells
Enzyme combinations useful for destroying cells, particularly proliferative cells, are disclosed. In particular, a combination of the following enzymes has been found to enhance the toxicity of...
|
|
|
6514943 |
Method and composition for preserving viruses
The present invention provides a method and a composition for preserving a virus. The virus is placed in a liquid carrier with a stabilizing agent selected from the group consisting of polysorbate...
|
|
|
6506378 |
Vesicular monoamine transporter gene therapy in Parkinson's disease
The present invention provides methods and compositions for the therapeutic intervention of Parkinson's disease. More particularly, methods of making and sequestering dopamine are disclosed....
|
|
|
6506415 |
Method of inducing resistance to tumor growth
A method of inducing resistance to tumor growth comprising placing tumor cells in culture in vitro supplemented with a pro-apoptotic agent for a period of time, transferring the tumor cells into a...
|
|
|
6503498 |
Apolipoprotein A-1 adenovirus vector compositions and methods
The present disclosure demonstrates the successful use of adenovirus mediated gene transfer to increase HDLc in mammalian cells and in mice. BALB/c mice were infected with recombinant adenovirus...
|
|
|
6503501 |
Targetable vector particles
A vector particle (eg., a retroviral vector particle) containing a chimeric envelope includes a receptor binding region that binds to a receptor of a target cell. The receptor of the target cell is...
|
|
|
6503502 |
Nucleotide sequences, proteins, drugs and diagnostic agents of use in treating cancer
Tumor Suppressor Activated Pathway (TSAP) genes and nucleotide sequences therefore as well as vectors and cells containing such nucleotide sequences and various uses therefore are described. The...
|
|
|
6503500 |
Biocontrol agent containing an endotoxin gene
The invention provides a biocontrol agent against larvae of mosquitoes and blackflies comprising transgenic Anabaena PCC 7120 carrying a synergistic combination of the endotoxin genes CryIVA and...
|
|
|
6503499 |
Viral vector complexes having adapters of predefined valence
The invention concerns an improvement in the art of inserting and expressing foreign gene into eukaryotic cells. The invention particularly concerns methods and compositions whereby viral vectors...
|
|
|
6503540 |
Cloning and characterization of bves, a novel gene expressed in heart and uses thereof
The present invention is directed to cloning and characterization of bves (blood vessel/epicardial substance), a cDNA expressed in developing and adult heart and skeletal muscle cells in chick,...
|
|
|
6503886 |
Compositions containing nucleic acids and ligands for therapeutic treatment
Preparations of conjugates of a receptor-binding internalized ligand and a cytocide-encoding agent and compositions containing such preparations are provided. The conjugates contain a polypeptide...
|
|
|
6503503 |
Allogeneic cellular vaccine
Vaccination with an allogeneic cell line modified with genetic material encoding specific protein antigens is an effective technique for the delivery of protein antigens to the host's antigen...
|
|
|
6500420 |
Recombinant vasoactive protein from salivary gland of the black fly
The invention is drawn to vasodilative proteins from the salivary glands of the species, Simulium. The protein additionally has immunomodulating activities. Methods for recombinant production of...
|
|
|
6500419 |
Method for introducing and expressing RNA in animal cells
The invention pertains to a method for introducing RNA molecules into eukaryotic cells, wherein the RNA molecules are capable of being translated in the eukaryotic cells or is an antisense RNA or a...
|
|
|
6498239 |
Sterol glycosyl transferases
The invention relates to DNA sequences coding for sterol glucosyl transferases as well as the use thereof to modify the content and/or the structure of sterol glycosides and/or their synthetic...
|
|
|
6497874 |
Recombinant phages
The present invention relates to bacteriophages for use in the treatment or prophylaxis of bacterial infections, especially mucosal bacterial infections such as Heliobacter pylori infections, in...
|
|
|
6497882 |
Recombinant swinepox virus
This invention provides a recombinant swinepox virus comprising a foreign DNA sequence inserted into the swinepox virus genomic DNA, wherein the foreign DNA sequence is inserted within a HindIII K...
|
|
|
6497873 |
Recombinant Rhabdovirus containing a heterologous fusion protein
This invention relates to a composition comprising a recombinant or genetically engineered Rhabdovirus that expresses a Fusion Protein, such as the F protein of the Paramyxovirus SV5 strain. This...
|
|
|
6497872 |
Neural transplantation using proliferated multipotent neural stem cells and their progeny
The invention provides methods of transplanting multipotent neural stem cell progeny to a host by obtaining a population of cells derived from mammalian neural tissue containing at least one...
|
|
|
6495132 |
Method for producing polypeptides
There is provided a method for producing a polypeptide using a recombinant baculovirus according to the present invention, wherein said recombinant baculovirus is constructed by ligating the...
|
|
|
6495131 |
Interleukin-3 gene therapy for cancer
Means and methods for treating tumors in a mammal, in particular, malignant solid tumors, using adenovirus derived material and interleukin-3 (“IL-3 ”). Tthe adenovirus derived material...
|
|
|
6495364 |
Mx-1 conditionally immortalized cells
This invention relates to methods and compositions of controlling cell distribution within a bioartificial organ by exposing the cells to a treatment that inhibits cell proliferation, promotes cell...
|