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6599502 |
Intracellular delivery vehicles
The invention provides methods and compositions relating to intracellular delivering of agents to eukaryotic cells. The compositions include microbial delivery vehicles such as nonvirulent bacteria...
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6599737 |
Adenoviral vectors with tandem fiber proteins
The present invention provides an adenoviral gene transfer vector comprising a first fiber gene and a second fiber gene, wherein the fiber genes are different. The present invention also provides...
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6596270 |
Methods of administering adenoviral vectors
The present invention provides methods for administering an adenoviral gene transfer vector comprising an exogenous gene to an animal. One method involves utilizing systemic neutralizing antibodies...
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6596534 |
Utilization of osteocalcin promoter to deliver therapeutic genes to tumors
A therapeutic agent based on a recombinant adenovirus which employs an osteocalcin promoter for the expression of thymidine kinase can be administered intravascularly to treat metastatic cancer,...
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6596500 |
Binding of retinoids to M6P/IGF-II receptor
Disclosed are methods for inhibiting proliferation of a cell or inducing apoptosis. In general, the methods include the steps of providing an elevated level of M6P/IGF2R protein in the cell, and...
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6596271 |
Insect control method with genetically engineered biopesticides
Insect pests can be controlled by treating the pests or their loci with a combination of recombinant virus and organic insecticide. The recombinant virus preferably is a baculovirus. Combinations...
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6596698 |
Methods of inhibiting smooth muscle cell proliferation and preventing restenosis with a vector expressing RB2/p130
Methods of inhibiting vascular smooth muscle cell proliferation and preventing restenosis by transducing the vascular smooth muscle cells with a viral veactor expressing RB2/p130 are provided.
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6596535 |
Metabolically activated recombinant viral vectors and methods for the preparation and use
Recombinant viral vectors, especially parvovirus vectors such as adeno-associated virus (AAV) vectors, capable of enhanced expression of heterologous sequences, and methods for their construction...
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6596269 |
Methods of treating chronic pain
This invention pertains to the surprising discovery of novel compositions and methods which selectively treat chronic pain while not significantly affecting basal nociceptive, acute pain,...
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6593304 |
RECOMBINANT DNA COMPRISING DNA CODING FOR MYOSIN HEAVY CHAIN SM1 ISO-FORM PROTEIN INSERTED INTO VECTOR DNA MICROORGANISM CARRYING THE RECOMBINANT DNA, AND AN AGENT FOR TREATMENT OF ARTERIOSCLEROSIS COMPRISING THE RECOMBINANT DNA
The present invention relates to recombinant DNA comprising DNA coding for smooth-muscle-type myosin heavy chain SM1 isoform protein inserted into vector DNA, a microorganism carrying the...
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6593463 |
Modified MSP-1 nucleic acid sequences and methods for increasing MRNA levels and protein expression in cell systems
The invention provides modified recombinant nucleic acid sequences (preferably DNA) and methods for increasing the mRNA levels and protein expression of malarial surface protein MSP-1 which is...
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6589523 |
Agent for gene therapy of dilated cardiomyopathy
According to the present invention, there is provided a gene expression vector which is obtained by inserting a gene encoding sarcoglycan into an adeno-associated virus (AAV) vector. By...
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6589522 |
Vaccines against infections caused by YF virus; YF infectious cDNA, method for producing a recombinant YF virus from the YF infectious cDNA and plasmids to assemble the YF infectious cDNA
The present invention is related to a vaccine composition for humans against YF infections consisting essencially of a recombinant YF virus, YFiv5.2/DD, which is regenerated from YF infectious...
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6589782 |
Angiogenic factor and use thereof in treating cardiovascular disease
The present invention relates to a novel VEGF protein product, and nucleic acid encoding the novel protein product, comprising exons 1-6 and 8 of the VEGF gene, and its use thereof in treating the...
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6586227 |
Non-virulent Porphyromonas gingivalis mutant
The Porphyromonas gingivalis strain which is deposited at ATCC under accession number 202109. A pharmaceutical composition comprising the Porphyromonas gingivalis strain of the present invention.
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6582693 |
Recombinant MVA virus expressing the E2 gene of Bovine papillomavirus and its use in the therapy of tumors generated by papillomaviruses
A recombinant vaccinia virus derived from the vaccinia virus Ankara (MVA) encoding and capable of expressing the E2 gene of Bovine papillomavirus. Also, the use of the virus in the treatment of...
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6582725 |
Human PEA3 is a tumor suppressor for cancer cells
The present invention relates generally to the fields of cancer therapy and gene therapy. More particularly, it demonstrates that PEA3, as exemplified by mPEA3 and hPEA3, is a tumor suppressor and...
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6582694 |
Method for preparing a viral aerosol
A method for preparing a viral aerosol from a dilute viral suspension prepared by dissolving a virus in an aqueous solution containing 6-12 g/l of a monovalent cation salt, or 50-100 g/l of a...
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6582691 |
Expression vector for the production of dead proteins
The invention relates to an insect cell vector for the production of proteins from the DEAD protein family.
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6582947 |
Medical use of gene and vector encoding a multisubstrate deoxyribonucleoside kinase
By inserting a DNA or RNA sequence comprising a subsequence showing a homology of at least 60%, preferably at least 80%, and most preferably at least 90% of the DNA sequence of SEQ. ID. NO. 1 into...
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6582692 |
Recombinant adeno-associated virus virions for the treatment of lysosomal disorders
AAV expression vectors and recombinant virions produced using these vectors, which include genes coding for enzymes defective or missing in lysosomal storage disorders, are described. These...
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6579522 |
Replication deficient adenoviral TNF vector
An adenoviral vector comprising (a) an adenoviral genome deficient in the E4 region of the adenoviral genome, (b) a nucleic acid sequence coding for TNF, and (c) a radiation inducible promoter...
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6579855 |
Adenovirus-mediated gene therapy
An adenovirus having a functional thymidine kinase gene is useful in the treatment of brain tumors.
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6572863 |
Constitutive expression of non-infectious HIV-like particles
Non-infectious, non-replicating immunogenic HIV-like particles are produced by stable long-term constitutive expression in mammalian cells by eliminating elements toxic to the mammalian cells. An...
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6573099 |
Genetic constructs for delaying or repressing the expression of a target gene
The present invention relates generally to synthetic genes for modifying endogenous gene expression in a cell, tissue or organ of a transgenic organism, in particular a transgenic animal or plant....
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6569423 |
Methods of inducing nervous tissue regeneration
This invention relates to a method of regenerating nervous tissue by contacting the tissue with Schwann cells that express ΔSCIP. The inventors have demonstrated herein that Schwann cells...
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6569422 |
Genetically engineered cell culture adapted infectious bursal diseases virus (IBDV) mutants
The present invention relates to a method for the adaptation of infectious bursal disease viruses (IBDV) to growth in CEF cell culture. Changing the codons for amino acid residues 253 (Gln) and 284...
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6569426 |
Tresyl-monomethoxypolyethylene glycol-modified viruses having viral infectivity
Viruses are modified by coupling a polymer such as polyethylene glycol to obtain polymer-modified viruses that can exhibit reduced antigenicity while retaining infectivity, and which may exhibit...
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6570069 |
Nucleic acids encoding plant inhibitors of apoptosis and transgenic cells and plants expressing them
The present invention is generally directed to Inhibitor of Apoptosis Proteins (“IAPs”), nucleic acid molecules encoding IAPs, viral vectors, recombinant baculoviruses comprising an IAP,...
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6566128 |
Adenovirus vectors generated from helper viruses and helper-dependent vectors
The present invention provides an improved helper-dependent vector system for production of high capacity adenoviral cloning vectors. The invention makes use of the DNA size packaging constraints...
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6565844 |
Protein production and protein delivery
The present invention relates to DNA constructs that alter the expression of a targeted gene in a cell when the DNA construct is homologously recombined with a target site within the chromosomal...
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6566097 |
Feline cytokine protein
A novel feline cytokine protein having the activity to enhance the cytotoxic activity of feline cytotoxic T lymphocytes, a DNA sequence coding for said protein, a recombinant DNA for expressing...
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6562349 |
Otitis media vaccine
It has been discovered that a vaccine comprised of fimbrin, a filamentous protein derived from the bacterial surface appendages of non-typable Haemophilus influenzae is useful in studying,...
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6562348 |
Recombinant M. tuberculosis auxotrophic for leucine and vaccines using same
The present invention provides a recombinant M. tuberculosis mycobacterium that is auxotrophic for leucine. The present invention also provides a vaccine comprising a recombinant M. tuberculosis...
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6562335 |
NK-1 receptor antagonists for prevention of neurogenic inflammation in gene therapy
The present invention relates to a method for inhibiting a neurogenic inflammation caused or potentiated by an administration of viral vectors in gene therapy by administering to said mammal an...
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6559130 |
Destruction of the epithelium of an exocrine gland in the prophylactic and therapeutic treatment of cancer
The present invention provides prophylactic and therapeutic methods of treating the ductal epithelium of an exocrine gland, in particular a mammary gland, for disease, in particular cancer. The...
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6558663 |
Transgenic swine & swine cells having human HLA genes
Methods of promoting tolerance and inhibiting NK cell mediated attack in a human recipient to a swine graft are disclosed The methods include introducing into the recipient a swine hematopoietic...
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6555108 |
Implanting HSV-TK retrovirus producing cells to treat tumors
The present invention discloses compositions and methods for selective killing neoplastic cells. Retroviral vectors are used to selectively express a gene in neoplastic cells. The gene or gene...
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6555367 |
Complex of biotinylated viral vector and ligand for targeted gene delivery
The present invention provides a composition for targeted delivery of a nucleic acid to a cell comprising a biotinylated recombinant adenovirus, wherein biotin is covalently linked to the...
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6555107 |
Lentiviral nucleic acids and uses thereof
The invention provides non-primate lentiviral vectors, packaging cells and packaging plasmids based, for example, on feline and ungulate retroviruses. In particular, the packaging plasmids are...
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6551586 |
Malaria vaccine based upon the addition of a MSA1 peptide
The present invention relates to an expression vector which expresses a malaria MSA1 peptide in combination with a signal peptide and anchor peptide in a host animal. The MSA1 peptide is combined...
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6551588 |
Tumor radiosensitization using gene therapy
The invention provides a method of radiosensitizing a tumor in a subject by contacting the tumor with a cytokine or a nucleic acid molecule encoding a cytokine. The invention also provides a method...
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6551587 |
Vectors for tissue-specific replication
The invention generally relates to targeted gene therapy using recombinant vectors and particularly adenovirus vectors. The invention specifically relates to replication-conditional vectors and...
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6552003 |
Muscle reinnervation and motor axon sprouting by administering DNA sequences encoding NT-3 and CNTF
The present invention relates to methods and compositions for delivering nucleic acids to motor neurons by administering the nucleic acids to muscle tissue. The invention relates to methods for...
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6548070 |
Attenuated strains of mycobacteria
Attenuated strains of Mycobacterium, particularly species of the tuberculosis complex, have the mycobacterial cell entry (mce) gene functionally disabled. The gene may be disabled by an insertion...
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6544955 |
Method of sensitizing tumor cells with adenovirus E1A
The present invention is directed to methods of sensitizing a human tumor cell with adenovirus E1A. The methods involve treating a human tumor cell by, first, introducing into the tumor cell...
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6544779 |
Pseudo-type retroviral vectors with modifiable surface capsid proteins
The invention relates to pseudo-typed retroviral vectors having modified surface capsid proteins suitable for cell-specific transduction of a selected mammalian cell type (cell targeting), methods...
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6544771 |
Retroviral gene therapy vectors and therapeutic methods based thereon
Retroviral vectors are disclosed which include an insertion site for genes of interest and are capable of expressing high levels of the protein derived from the genes of interest in a wide variety...
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6544507 |
Anti-neoplastic viral agents
A viral DNA construct, and virus encoded thereby, is provided having one or more tumor specific transcription factor binding sites in place of one or more wild type transcription factor binding...
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6544957 |
Methods and reagents for facilitating transcription
A previously unknown histone acetylase inhibitor, 6-(1,3-Dioxo-1H, 3H-benzo[de]isoquinolin-2-yl)-hexanoic acid hydroxyamide, termed “scriptaid,” can be used to enhance transcription. Scriptaid...
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