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6841540 |
Immunomodulation by genetic modification of dendritic cells and B cells
The present invention provides a CD40-targeted gene delivery system and a CD40-targeted recombinant adenoviral vector for genetic manipulation of dendritic cells and B cells. Also provided are...
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6838446 |
Vector for expression of GPI-enzyme hybrid
This invention relates particularly to gene directed enzyme prodrug therapy (GDEPT) using post translational glycosylphosphatidylinositol (GPI addition to a prodrug activating enzyme to enable...
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6838285 |
Site specific recombinase based method for producing adenoviral vectors
Site-specific recombinase based methods for making a recombinant adenoviral genome, as well as kits for practicing the same and the recombinant adenovirus vectors produced thereby, are provided. In...
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6838281 |
Cells expressing fusion proteins of immunoglobulins
The invention provides methods and compositions for inducing and maintaining tolerance to epitopes or antigens containing the epitopes. The compositions include expression cassettes and vectors...
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6824770 |
Adenovirus gene expression system
The invention is directed to an adenoviral vector comprising (a) at least one insertion site for cloning a heterologous gene, and, in an orientation opposite to the direction of transcription of...
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6824771 |
Infectivity-enhanced conditionally-replicative adenovirus and uses thereof
A modified adenovirus capable of overcoming the problem of low level of coxsackle-adenovirus receptor (CAR) expression on tumor cells and methods of using such adenovirus are provided. The fiber...
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6821751 |
Hypoxia responsive transcription enhancer element from yeast
The present invention is directed to DNA elements that enhance cellular gene expression in response to anaerobic growth or the presence of certain inducing agents. The enhancer element may be...
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6821512 |
Compositions and methods for increasing packaging and yield of recombinant adenoviruses using multiple packaging signals
A recombinant adenoviral vector which has multiple adenovirus packaging domains is provided. This vector has advantages over conventional adenoviral vectors in packaging plasmid vectors into...
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6821511 |
Methods of using adeno-associated virus rep protein
A composition for delivering at least one DNA sequence encoding a desired protein or polypeptide (such as a therapeutic agent) to a cell. The composition comprises an adeno-associated virus rep...
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6821957 |
Vectors and methods for immunization or therapeutic protocols
The present invention shows that DNA vaccine vectors can be improved by removal of CpG-N motifs and optional addition of CpG-S motifs. In addition, for high and long-lasting levels of expression,...
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6818209 |
Retroviral delivery system
A retroviral delivery system capable of transducing a target site is described. The retroviral delivery system comprises a first nucleotide sequence coding for at least a part of an envelope...
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6818442 |
AIDS DNA vaccine that prevents SIVmac239 virus infection in monkeys
The present invention relates to a plasmid carrying simian immunodeficiency virus (SIV)-derived genes. Particularly, the present invention relates to the plasmid pSIV/GE which carrys gag, protease,...
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6814963 |
Baculovirus-based expression system
Compositions and methods are provided that relate to a recombinant virus-based vector, e.g., a baculovirus-based vector, that allows the expression of an exogenous target protein in non-permissive...
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6815200 |
Modified adenovirus containing a fiber replacement protein
The utility of adenovirus vectors (Ad) for gene therapy is restricted by their inability to selectively transduce disease-affected tissues. This limitation may be overcome by the derivation of...
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6814962 |
Recombinant viruses and their use for treatment of atherosclerosis and other forms of coronary artery disease and method, reagent, and kit for evaluating susceptibility to same
Recombinant viruses comprising a heterologous DNA sequence coding for a lipase involved in lipoprotein metabolism. The invention also concerns the preparation and use in therapy of said recombinant...
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6808905 |
Lentiviral vectors encoding clotting factors for gene therapy
Recombinant lentiviruses and transfer vectors for transgene delivery as well as methods for gene therapy using such vectors are disclosed. The invention provides a third generation lentiviral...
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6808702 |
Treatment of disorders by implanting stem cells and/or progeny thereof into gastrointestinal organs
A method of treating a disorder, typically a gastrointestinal disorder, that includes implanting stem cells and/or progeny thereof into a gastrointestinal organ of a subject. Also, a method of...
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6805858 |
Methods for the administration of adenovirus p53
Described are simplified and efficient methods for preparing recombinant adenovirus using liposome-mediated cotransfection and the direct observation of a cytopathic effect (CPE) in the transfected...
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6800281 |
Lentiviral-mediated growth factor gene therapy for neurodegenerative diseases
Disclosed and claimed are methods for treating or preventing neurodegenerative diseases, conditions or maladies or symptoms or physiology associated therewith, such as treating or preventing...
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6800479 |
Recombinant adenoviruses expressing interleukin-18 protein and gene therapy using them
The present invention relates to recombinant adenoviruses expressing interleukin-18 protein, and gene therapy using them. More particularly, the invention provides recombinant adenoviruses...
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6797265 |
Deleted adenovirus vectors and methods of making and administering the same
The present invention provides deleted adenovirus vectors. The inventive adenovirus vectors carry one or more deletions in the IVa2, 100K, polymerase and/or preterminal protein sequences of the...
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6794188 |
Retrovirus vectors derived from avian sarcoma leukosis viruses permitting transfer of genes into mammalian cells and therapeutic uses thereof
Recombinant avian sarcoma leukosis virus (ASLV)-derived retrovirus vectors having an expanded host range are described. The host range is expanded by the replacement of the ASLV envelope gene by an...
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6793927 |
Construction of Pasteurella haemolytica vaccines
Methylation of DNA can be a critical step in the introduction of DNA into P. haemolytica . A methyltransferase has been isolated and molecularly cloned for this purpose. Use of the...
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6793918 |
In vivo stimulation of angiogenic activity
Angiogenesis is stimulated by introducing two replication-deficient adenovirus vectors to the endothelial cells or proximate to the endothelial cells of an organism. The first vector encodes VEGF-B...
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6790442 |
Genomic DNA encoding a polypeptide capable of inducing the production of interferon-&ggr
Disclosed is a genomic DNA encoding a polypeptide capable of inducing the production of interferon-γ by immunocompetent cells. The genomic DNA efficiently expresses the polypeptide with high...
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6790838 |
Combinations and methods for promoting in vivo liver cell proliferation and enhancing in vivo liver-directed gene transduction
Combinations and methods for inducing a semi-synchronous wave of liver cell proliferation in vivo and combinations and methods for inducing a semi-synchronous wave of liver cell proliferation and...
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6787351 |
Adenovirus carrying gag gene HIV vaccine
An adenoviral vector is described which carries a codon-optimized gag gene, along with a heterologous promoter and transcription terminator. This viral vaccine can effectively prevent HIV infection...
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6783979 |
Vectors encoding HCN channels and MiRP1
This invention provides for a chamber and system designed for use in assaying drug effects on heart rate. The chamber consists of a series of wells, each 3 mm by 3 mm in inner diameter. Cardiac...
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6784162 |
Gene therapy method for reducing risk of atherosclerosis
A single point mutation in the human lipoprotein lipase gene which results in an A→G nucleotide change at codon 291 (nucleotide 1127) of the lipoprotein lipase gene, and a substitution of serine...
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6783762 |
Product and method for obtaining specific immunization with one or more antigens
A large number of recombinant of viral and bacterial systems has been engineered as vectors to express foreign genes for vaccination and/or gene therapy. A common problem is the immune response to...
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6780409 |
Glutamic acid decarboxylase (GAD) based delivery system
The invention provide methods and compositions for localized delivery of a vector comprising a therapeutic agent to a specific region of the brain that is overstimulated in neurodegenerative...
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6780407 |
Pox virus comprising DNA sequences encoding CEA and B7 antigen
Attenutated recombinant viruses containing DNA coding for a cytokine and/or a tumor associated antigen, as well as methods and compositions employing the viruses, are disclosed and claimed. The...
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6780408 |
Genes encoding hybrid bacillus thuringiensis toxins
The present invention provides, inter alia, a B.t. hybrid toxin fragment comprising at its C-terminus domain III of a first Cry protein, or a part of said domain or a protein substantially similar...
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6776985 |
Encapsulated cells producing viral particles
The present invention relates to encapsulated cells producing viral particles, especially retroviral particles containing the genome of a retroviral vector carrying therapeutic genes, to methods...
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6776996 |
Pesticidal matrices
The present invention provides improved coated pesticidal matrices and a process for their preparation. The present invention also provides a wettable powder pesticidal composition containing the...
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6776993 |
Tuberculosis vaccine
The present invention relates to novel recombinant vaccines providing protective immunity against tuberculosis. Further, the present invention refers to novel recombinant nucleic acid molecules,...
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6776987 |
Enhancement of cardiac chronotropy
Molecularly-mediated and cellular-based β-adrenergic receptor-dependent biological pacemakers are disclosed. Methods of using these compositions to improve cardiac chrontropic responsiveness by...
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6773702 |
Use of combretastatin A4 and its prodrugs as an immune enhancing therapy
A method of treating immune suppression in a warm-blooded animal bearing a tumor, by administering to the animal an amount of combretastatin A4 and/or a prodrug thereof effective to enhance immune...
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6774120 |
Methods of inducing regulated pancreatic hormone production in non-pancreatic islet tissues
Disclosed are methods and pharmaceutical compositions for inducing pancreatic hormone production.
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6770479 |
Anthrax vaccine
Using the nontoxic PA protein from B. anthracis , a method and composition for use in inducing an immune response which is protective against anthrax in subjects is described.
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6770273 |
Vaccine based on attenuated Haemophilus somnus
The present invention provides a method for protecting cattle from diseases such as septicemia, pneumonia or abortion by immunizing them with an H. somnus vaccine. Provided are natural isolates...
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6770632 |
Folypolyglutamyl synthetase gene transfer to enhance antifolate
Methods of killing neoplastic cells are provided. The invention relates to the use of folylpolyglutamyl synthetase (FPGS) gene transfer to enhance the sensitivity of several types of tumor cells to...
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6770275 |
Live attenuated RTC-producing bacteria of the family
The present invention relates to live attenuated RTX-toxin producing bacteria of the family Pasteurellaceae, of which the attenuation is due to the fact that they produce RTX toxin in a...
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6770274 |
Viral mutant HSV mediated destruction of neoplastic cells
The present invention is drawn to compositions and methods for selectively killing neoplastic cells. Altered viruses are utilized which are capable of replication in neoplastic cells while sparing...
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6770283 |
DNA expression systems based on alphaviruses
The disclosure describes recombinant alphavirus RNA molecules and expression of heterologous proteins therefrom in animal cells. Recombinant alphaviruses of the present invention, when made to...
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6767928 |
Mineralization and biological modification of biomaterial surfaces
Disclosed are advantageous methods for patterning and/or mineralizing biomaterial surfaces. The techniques described are particularly useful for generating three-dimensional or contoured bioimplant...
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6767535 |
Suppressing tumor formation using cells expressing JE/monocyte chemoattractant protein-1
A method of suppressing tumor formation in a vertebrate by administering JE/MCP-1 is described. Also described are methods of treating localized complications of malignancies and methods of...
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6764674 |
Adenovirus E1B shuttle vectors
Provided are replication competent, recombinant adenovirus vectors containing mutations in the E1B region which permit the easy deletion of a gene or genes therein, and optionally the substitution...
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6764675 |
Herpes simplex virus expressing foreign genes and method for treating cancers therewith
An anti-cancer pharmaceutical composition includes a herpes simplex virus (HSV) vector into which a nucleic acid sequence encoding an anti-cancer agent selected from interleukin-12, GM-CSF, and CD...
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6761884 |
Vectors including foreign genes and negative selective markers
A vector, in particular a retroviral vector, which includes a heterologous or foreign gene and a gene encoding a negative selective marker. The negative selective marker enables one to kill cells...
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