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6911220 |
Allogeneic and xenogeneic transplantation
The invention provides methods for restoring or inducing immunocompetence, the methods including the step of introducing donor thymic tissue into the recipient. The invention also provides methods...
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6911199 |
Targeted adenovirus vectors for delivery of heterologous genes
Modification of internal sites of the adenovirus fiber protein and hexon protein permit effective targeting of adenovirus vectors. Accessible sites to redirect adenovirus targeting were identified....
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6905678 |
Gene delivery vectors with cell type specificity for mesenchymal stem cells
Methods and associated materials for transducing mesenchymal stem cells with a desired nucleic acid. Mesenchymal stem cells are a recently discovered kind of stem cell for which suitable transfer...
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6902730 |
Semaphorin gene: Semaphorin W
The present invention provides Semaphorin W inhibiting neurite outgrowth, and a gene therefor, as well as other Semaphorins hybridizing to said Semaphorin W gene, modified proteins or partial...
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6902906 |
Bacteria attenuated by a non-reverting mutation in each of the aroC, ompF and ompC genes, useful as vaccines
The invention provides a bacterium attenuated by a non-reverting mutation in each of the aroC gene, the ompF gene and the ompC gene. The bacterium is useful as a vaccine. The bacterium may, for...
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6902929 |
Retroviral vectors, methods for their preparation and their use for gene transfer into CD4-positive cells
The invention relates to the production and use of retroviral vectors for cell specific gene transfer, specially to a production method of retroviral vectors containing capsid particles of murine...
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6903248 |
DNA constructs and methods to impart resistance to at least one virus on plants
The present invention is directed to a DNA construct comprising a first DNA molecule having a length insufficient to independently impart resistance to a virus to plants transformed with said first...
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6902731 |
Methods of treating hyperproliferative disorders using retinoblastoma fusion proteins
Fusions of the transcription factor E2F and the retinoblastoma protein RB are provided, along with methods of treatment of hyperproliferative diseases.
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6902732 |
Identification and characterization of a gene which protects cells from programmed cell death and uses therefor
The present invention relates to genes, referred to herein as cell death-protective genes, which protect cells against programmed cell death by antagonizing the activities of genes which cause cell...
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6899870 |
Induction of apoptic or cytotoxic gene expression by adenoviral mediated gene codelivery
The present invention generally relates to viral vectors and their use as expression vectors for transforming human cells, both in vitro and in vivo. More particularly, the present invention...
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6900032 |
Human PTTG polypeptide and method for producing it
Polypeptides are expressed by the pituitary-tumor-transforming-gene (PTTG), formerly known as pituitary-tumor-specific-gene (PTSG), and nucleic acids encode them. Examples are the human and rat...
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6900010 |
Compositions and methods for detecting human immunodeficiency virus
Methods are provided for screening natural and synthetic anti-HIV agents using recombinant cells that are rendered susceptible to productive infection of various strains, subtypes or clades of HIV...
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6899871 |
Gene delivery system and methods of use
A recombinant replication competent retrovirus for gene deliver and gene therapy is provided. The recombinant retrovirus has a heterologous nucleic acid sequence, a sequence encoding a cell- or...
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6896881 |
Therapeutic methods and compositions using viruses of the recombinant paramyxoviridae family
The invention relates to compositions and methods for treating a patient having a tumor in order to reduce tumor size, comprising administering to the patient a replication-competent...
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6893634 |
Encapsulated cells producing cytochrome P450
The present invention relates to capsules encapsulating cytochrome P450 producing cells and cytochrome P450 producing retroviral packaging cells. Furthermore, the present invention relates to the...
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6891085 |
Nucleic acid encoding the FUS6 antimicrobial polypeptide of Agrotis ipsilon and its use to enhance disease resistance in a plant
The methods and compositions of the present invention find use in impacting microbial pathogens and in enhancing disease resistance to pathogens, particularly by plants. The compositions of the...
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6890528 |
Cells for the production of helper dependent adenoviral vectors
The present invention relates to cells for the production of helper dependent adenoviral vectors, including at least the following genic units: a first genic unit comprising an adenovirus defective...
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6891084 |
DNA encoding raffinose synthase from soybean
The present invention provides a DNA encoding a raffinose synthase from soybean and vectors containing the same. Also provided are plants and host cells transformed with the DNA sequence and...
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6890542 |
Leishmania vaccine
The present invention relates to the use of a live mutant Leishmania in the preparation of a vaccine and to vaccine formulations for use in immunizing mammals, such as dogs and/or humans. The...
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6887856 |
Protection from ionizing irradiation or chemotherapeutic drug damage by in vivo gene therapy
A method of protecting a subject against an agent that elicits production of toxic free radicals, superoxide anions, or heavy metal cations in the subject is disclosed which entails in vivo...
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6887464 |
Advanced antigen presentation platform
The present invention provides particles for the presentation of haptens for the purpose of eliciting an immune response. The amino acid sequences of the monomers which make up the particles are...
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6887857 |
Microparticle protection of therapeutic agents
The present invention is directed to the use of microparticles to protect the pharmaceutical effectiveness of a pharmaceutically active agent. According to one embodiment, a pharmaceutically...
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6884414 |
Recombinant influenza viruses expressing tumor-associated antigens as antitumor agents
The present invention relates to the engineering of recombinant influenza viruses that express tumor-associated antigens. Expression of tumor-associated antigens by these viruses can be achieved by...
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6884431 |
Method for treating proliferative diseases with p27 and fusions thereof
The present invention is directed to a method of vascular proliferative disease by administering in vivo a gene encoding p27.
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6884576 |
Methods of monitoring HIV drug resistance
A method is provided for detecting a presence of HIV virus in a sample comprising: taking a culture of recombinant cells which (a) are capable of cell division, (b) express CD4 receptor and one or...
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6881402 |
Inhibiting apoptosis with adenovirus RID protein
A method for inhibiting apoptosis of a cell expressing a death receptor of the TNFR family is disclosed. The method involves treating the cell with a Receptor Internalization and Degradation (RID)...
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6881410 |
Treatment of E. faecium infection
The present invention provides bacterial and fungal ABC transporter proteins, immunogenic fragments thereof, neutralising agents specific thereto and binding agents specific thereto for therapeutic...
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6878372 |
Methods of preventing and treating flavivirus infection in animals
The invention provides methods of preventing and treating flavivirus infection in animals.
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6875429 |
Metastasis inducing DNA's
The invention relates to metastasis inducing DNA's, a method of identifying such DNA's and their use in diagnosis and therapy. It includes a method of screening and recovering met-DNA comprising...
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6872576 |
Antigens embedded in thermoplastic
The invention relates to an immunoassays, binding assays, solid phase substrates ( 12 ) and other devices with an antigen or antibody or ligand or receptor ( 11 ) embedded into a solid phase...
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6872386 |
Oral vaccines
This invention features an oral vaccine that includes a multiple-cell organism for use as food for an aquatic animal to be vaccinated, and a single-cell organism fed to, and as a result,...
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6866842 |
Muscle-derived cells (MDCs) for treating muscle-or bone-related injury or dysfunction
The present invention provides muscle-derived cells, preferably myoblasts and muscle-derived stem cells, genetically engineered to contain and express one or more heterologous genes or functional...
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6867022 |
Replication deficient adenovirus vectors and methods of making and using them
The invention provides novel replication deficient adenovirus vectors and methods for making and using these viruses. The invention also provides vector systems and kits using a serotype specific...
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6863884 |
Pseudotyped retroviral vectors
The present invention provides pseudotyped retroviral vectors and packaging systems and methods of using such vectors for retroviral-mediated gene transfer. In particular, the present invention...
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6858205 |
GP64-null baculoviruses pseudotyped with heterologous envelope proteins for gene therapy
A pseudotyped baculovirus comprises a deletion, inactivation or reduction from regulation of a baculovirus envelope protein gene, and is engineered to express an envelope protein from another virus...
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6855537 |
Macrophage-infecting parasites expressing a granulocyte macrophage colony stimulated factor
Strains of Leishmania and other macrophage-infecting parasites are provided which express the GM-CSF gene which are useful in treating hosts infected by the parasite and in protecting hosts against...
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6855806 |
Thymosin beta 10-like proteins and nucleic acids encoding same
Disclosed herein are novel human nucleic acid sequences. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies which immunospecifically-bind to the polypeptide, as...
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6855866 |
Polynucleotides useful for modulating transcription
The invention provides polynucleotides for expression of genes in suspensor cells in plants and methods for using such polynucleotides.
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6855314 |
AAV5 vector for transducing brain cells and lung cells
The present invention provides methods of delivering nucleic acids to specific regions, tissues and cell types of the CNS. More particularly the invention provides methods of delivering nucleic...
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6852704 |
Reverse gene therapy
The invention relates to compositions and methods for reverse gene therapy, wherein a gene therapy vector encoding a gene product (e.g. a protein) which is usually only expressed in cells of an...
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6852703 |
Tumor targeted vector
A vector comprising a nucleotide sequence of interest (“NOI”) encoding a product of interest (“POI”) is described. The NOI and/or the POI is capable of recognizing a tumor, such that in use...
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6849611 |
Implantation of biological pacemaker that is molecularly determined
This invention provides for a method of inducing a current in the heart in a subject which comprises contacting a cell of the heart of a subject with a compound in a sufficient amount to induce a...
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6849446 |
Modified bovine adenovirus having altered tropism
The present invention provides modified bovine adenoviruses comprising a modification in a capsid protein wherein said protein is associated with adenovirus tropism and wherein said modification is...
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6846652 |
Viral vectors having enhanced effectiveness with reduced virulence
The present invention provides methods of use of recombinant vaccinia virus from which the region encoding the N-terminal 83 or 54 amino acids of the E3L gene product has been deleted, or amino...
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6846625 |
Method for identifying validated target and assay combination for drug development
The invention comprises methods useful within a larger process for identifying compounds and/or designing further compounds with activity to produce a desired phenotype (for example, growth...
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6846488 |
Chimeric antigen-enterotoxin mucosal immunogens
The present invention provides methods of inducing immune responses by recombinant antigen-enterotoxin chimeric mucosal immunogens that contain the A2/B subunits of cholera toxin or heat-labile...
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6846482 |
Insect control agent
The invention includes an expression vector engineered to produce double-stranded RNA (dsRNA) within a pest to be controlled. The dsRNA inhibits expression of at least one gene within the pest,...
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6844188 |
Methods and modified cells for the treatment of cancer
The present invention provides methods of preventing and/or treating cancers (including tumors). In one preferred embodiment, the invention is practiced to induce regression of an existing cancer...
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6841373 |
Herpes virus complementing cell line
The present invention is directed to a cell line capable of supporting replication of a growth-defective Herpes Simplex Virus strain; specifically a replication-defective HSV-2 double mutant....
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6841722 |
Nucleic acid encoding the arabidopsis SSE1 protein and a method of using it to modify plant storage reserves
Disclosed is a Arabidopsis sse1 gene, which is responsible for protein and oil body biogenesis. The invention further provides methods for using the disclosed gene for modifying the components of...
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