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7785602 |
Recombinant porcine adenovirus vector
This invention relates to a recombinant vector including a recombinant porcine adenovirus, stably incorporating and capable of expression of at least one heterologous nucleotide sequence. The...
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7785887 |
Adenovirus E1B-55K single amino acid mutants and methods of use
Adenoviral mutants are described that have single amino acid mutations in the E1B-55K protein which mutations effect the p53 binding/inactivation and the late functions of the E1B-55K protein in a...
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7780961 |
Self-containing Lactococcus strain
The invention relates to a recombinant Lactococcus strain, with environmentally limited growth and viability. More particularly, it relates to a recombinant Lactococcus that can only survive in...
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7776321 |
Mutable vaccines
The invention relates to methods and materials useful for targeting antigenic determinants of mutable pathogens for somatic hypermutation. These methods and materials can be used to induce an...
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7776320 |
Methods for therapeutic use of brain derived neurotrophic factor in the entorhinal cortex
A protocol for use of growth factors to stimulate neuronal cell growth and activity in trkB receptor containing cortical tissues, including the entorhinal and hippocampal cortices. The method...
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7776323 |
Streptococcus suis vaccines and diagnostic tests
The invention relates to Streptococcus suis infection in pigs, vaccines directed against those infections and tests for diagnosing Streptococcus suis infections. The invention provides an...
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7776322 |
Modified viral vector particles
This invention relates to viral vector particles, including capsid proteins with an attachment site for the specific chemical modification of the vector particles. Furthermore, the invention...
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7776592 |
Human renal stem cells
The present disclosure provides human renal stem cells. Also described are human renal stem cells isolated from the papillary region of the human kidney and methods of isolating the same. Also...
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7772205 |
Gene therapy for renal failure
The present invention relates to recombinant vectors expressing the BMP-7 polypeptide in host cells and to pharmaceutical compositions comprising such recombinant vectors. The invention also...
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7771967 |
Nucleic acid encoding apolipoprotein E-I3
The present invention provides nucleic acids comprising a nucleotide sequence encoding an apolipoprotein E (apoE) splice variant, e.g., an unprocessed apoE, that retains intron 3; and vectors and...
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7767202 |
Modulation of systemic immune responses by transplantation of hematopoietic stem cells transduced with genes encoding antigens and antigen presenting cell regulatory molecules
The invention provides methods and compositions for the modulation of systemic immune responses by transplantation of hematopoietic stem cells transduced with genes encoding antigens and antigen...
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7758855 |
DNA promoters and anthrax vaccines
The invention is related to intracellularly induced bacterial DNA promoters and vaccines against Bacillus anthracis.
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7758854 |
Anti-microbial agents
Antimicrobial agents that can serve as replacements to conventional pharmaceutical antibiotics are disclosed. The antimicrobial agents comprise conjugatively transmissible plasmids that kill...
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7754467 |
Surface expression of biologically active proteins in bacteria
Methods and compositions for targeting heterologous polypeptides to bacterial cell walls are provided.
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7754482 |
Artificial antigen presenting cells and uses therefor
The invention relates to novel artificial antigen presenting cells (aAPCs). The aAPC comprises at least one stimulatory ligand and at least one co-stimulatory ligand where the ligands each...
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7749510 |
Methods of eliciting or boosting a cellular immune response
Site-specific Listeria integration vectors and methods for their use are provided. The subject vectors include a bacteriophage integrase gene and a bacteriophage attachment site, where in many...
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7749745 |
Viral vectors and their use in therapeutic methods
The invention provides viral vectors (e.g., herpes viral vectors) and methods of using these vectors to treat disease.
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7749493 |
Chimeric adenoviruses
The present invention provides methods and vector systems for the generation of chimeric recombinant adenoviruses. These hybrid adenoviruses contain a genome that is derived from different...
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7749492 |
AAV vectors and methods
The invention relates to Adeno-associated virus vectors. In particular, it relates to Adeno-associated virus vectors with modified capsid proteins and materials and methods for their preparation...
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7745416 |
Method for in vivo regulation of cardiac muscle contractility
A method for regulating in vivo calcium transport in cardiac muscle of animals suffering from congestive heart failure is disclosed. According to the method, calcium ATPase activity (which...
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7745214 |
Methods of obtaining neural stem cells
A transgenic, non-human mammal useful for assessing the effect of candidate chemotherapeutic drugs on the growth of brain tumors in vivo is provided. Incorporated into the genome of the transgenic...
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7745698 |
Peptide extension for enhancement of transgene expression in chloroplasts
The invention provides a novel method of controlling gene expression in plastids, using a peptide extension that can be fused to a desired protein, expression cassettes that include the genetic...
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7745700 |
Insecticidal proteins derived from Bacillus thuringiensis
The present invention relates to the field of plant pest control, particularly insect control. Provided are nucleotide sequences from Bacillus thuringiensis encoding insecticidal proteins....
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7740864 |
Vaccines for diseases of fish
Fish are immunized by a mass vaccination method, such as by immersion in water containing an attenuated strain of a pathogenic bacterium that does not effectively cause disease in fish when the...
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7740835 |
Anaerobic bacterium as a drug for cancer gene therapy
The present invention provides a bacterium belonging to the genus Bifidobacterium , by which DNA coding for a protein having an antitumor activity or DNA coding for a protein having the activity...
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7740836 |
Methods and compositions for recovering or improving visual function
There are disclosed methods and compositions for recovering or improving visual function in a mammal, by means of adeno-associated viral vectors suitable for gene delivery to mammalian retina.
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7740867 |
Method for identification of virulence determinants
Disclosed are methods for the determination of virulence determinants in bacteria and in particular bacteria of the genus Mycobacterium . Also disclosed are compositions and methods for...
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7736641 |
Role for SRY in Parkinson's disease
The present invention relates to a method for treating or preventing Parkinson's disease in a patient, the method comprising administering to the patient a therapeutically effective population of...
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7736640 |
Methods of treating and detecting cancer using viruses
The invention provides a method of treating cancer in a mammal comprising administering to the mammal an effective amount of virus, particularly Newcastle Disease Virus or other Paramyxovirus. The...
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7737331 |
Bacillus thuringiensis crystal polypeptides, polynucleotides, and compositions thereof
The present invention provides insecticidal polypeptides related to Bacillus Cry2 polypeptides. Nucleic acids encoding the polypeptides of the invention are also provided. Methods for using the...
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7731952 |
Avirulent oncolytic herpes simplex virus strains engineered to counter the innate host response
The present invention relates to an avirulent, oncolytic herpes simplex virus modified from a wild-type herpes simplex virus so that both γ 1 34.5 genes of the virus have been deleted and each...
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7732203 |
Method for transdifferentiating mesenchymal stem cells into neuronal cells
This inventive discloses a method for transdifferentiating mesenchymal stem cells into neuronal cells, which comprises increasing the level of a basic helix-loop-helix (bHLH) transcription factor...
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7727522 |
Lentiviral vectors derived from SIVsmm/PBj14, method for their production and uses thereof
The invention relates to retroviral vectors (known as lentiviral vectors), which are used to transfer genes into cells that are at cell cycle stage G0, to methods for their production and to the...
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7727971 |
Use of placental growth factor for treating ischemic muscle disease
The present invention relates to prevention and treatment of strokes and ischemic diseases and to post-ischemic therapeutic treatment. The invention furthermore relates to the use of a growth...
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7727543 |
Biodegradable carrier and method for preparation thereof
A biodegradable carrier is produced for preservation and/or controlled delivery of biologically active agents where said biodegradable carrier is a silica xerogel which is made from water and...
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7723111 |
Activated dual specificity lymphocytes and their methods of use
The present invention relates to preventive, therapeutic, and diagnostic compositions and methods employing lymphocytes having T-cell receptors and chimeric receptors. In particular, the invention...
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7722861 |
Attenuated Mycobacterium tuberculosis vaccines
Non-naturally occurring mycobacteria in the Mycobacterium tuberculosis complex are provided. These mycobacteria have a deletion of an RD1 region or a region controlling production of a vitamin,...
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7723564 |
Compositions and methods for modulation of KSR1 and KSR2 interactions
Materials and methods for identifying agents which modulate KSR mediated signal transduction are provided.
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7722860 |
Live genetically engineered protozoan vaccine
The invention provides methods for inducing an immune response in a vertebrate host against a protozoan parasite, comprising administering to the host a live protozoan parasite that is genetically...
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7718165 |
Live genetically attenuated malaria vaccine
Method for inoculating a vertebrate host against malaria, by administering to the host a live Plasmodium organism that is genetically engineered to disrupt a liver-stage-specific gene function.
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7718626 |
ErbB3 binding protein compositions and methods of use
A method of repressing a cell-cycle gene, which is regulated by an E2F transcription factor, in a cell, wherein the method comprises contacting the cell with a cell-cycle gene-repressing amount of...
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7708986 |
Targeted vectors for cancer immunotherapy
This invention provides compositions and methods for treating cancer. More specifically this invention is directed to a targeted retroviral vector comprising a cytokine gene that can be...
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7708977 |
Method for diagnosis and treatment of vascular disease
A method for diagnosing decreased vascular function is disclosed. The method includes assaying the number of endothelial progenitor cells. A method for detecting increased cardiovascular risk is...
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7709457 |
Methods and compositions for delivery of pharmaceutical agents
Methods and compositions for delivering pharmaceutical agents into cells, in particular urothelial cells of the bladder, are provided. In the methods and compositions of the invention, a...
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7704493 |
Mesenchymal stem cells as a vehicle for ion channel transfer in syncytial structures
This invention provides a composition for delivery of a gene to a syncytial structure comprising stem cells incorporated with the gene. This invention also provides a composition for ion channel...
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7704964 |
Methods and compounds for the targeting of protein to exosomes
The present invention relates to compositions and methods for selectively expressing a polypeptide in a membrane vesicle. The invention also relates to genetic constructs and recombinant cells...
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7704272 |
Method for introducing an ultraviolet light activated viral vector into the spinal column
In accordance with the present invention, methods and structures are provided for the treatment of functional spinal unit injuries through the use of light activated gene therapy to induce bone...
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7704491 |
Recombinant human metapneumovirus and its use
Recombinant HMPV (rHMPV) and related immunogenic compositions and methods are provided. The rHMPVs, including chimeric and chimeric HMPV vectors viruses, provided according to the current...
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7700574 |
Modulation of RANKL expression
Compounds, compositions and methods are provided for modulating the expression of RANKL. The compositions comprise oligonucleotides, targeted to nucleic acid encoding RANKL. Methods of using these...
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7700090 |
Co-culture of placental stem cells and stem cells from a second source
The present invention relates to a combination of placental stem cells and stem or progenitor cells derived from a second source, wherein the combination shows improved engraftment as compared to...
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