|
Match
|
Document |
Document Title |
|
|
8105575 |
Expression vectors with improved safety
The present invention relates to the use of internal promoters in mammalian expression vectors including plasmid vectors and enhancer-deleted retroviral vectors. The retroviral vectors have...
|
|
|
8106027 |
Development of a preventive vaccine for filovirus infection in primates
The present invention relates generally to viral vaccines and, more specifically, to filovirus vaccines and methods of eliciting an immune response against a filovirus or disease caused by...
|
|
|
8105574 |
Simian adenovirus nucleic acid and amino acid sequences, vectors containing same, and methods of use
A recombinant vector comprises simian adenovirus sequences and a heterologous gene under the control of regulatory sequences. A cell line which expresses simian adenovirus gene(s) is also...
|
|
|
8105806 |
Process for preparing optically active amino acids using a whole-cell catalyst
The present invention relates to a process for preparing, in particular, enantiomerically enriched L-α-amino acids, in particular those of the general formula (I). In this connection, the process...
|
|
|
8106026 |
Development of a preventive vaccine for filovirus infection in primates
The present invention relates generally to viral vaccines and, more specifically, to filovirus vaccines and methods of eliciting an immune response against a filovirus or disease caused by...
|
|
|
8105592 |
Heavy chain and single domain antibodies
The present invention relates to heavy chain immunoglobulins or fragments thereof of the VHH or VNAR type, or domain antibodies (dAbs) of the heavy or light chains of immunoglobulins or fragments...
|
|
|
8101826 |
Expression of Cry3B insecticidal protein in plants
The present invention discloses methods and compositions comprising a group of novel expression cassettes which provide significantly improved levels of accumulation of Coleopteran inhibitory Cry3B...
|
|
|
8101169 |
Ocular gene therapy using avalanche-mediated transfection
The present invention provides a method of treating an ocular disease in a subject. In a first step, a nucleic acid is introduced into cells or a tissue. The nucleic acid is introduced by electron...
|
|
|
8097260 |
Lipid a deficient mutants of Neisseria meningitidis
The invention provides lipid A deficient mutant Neisseria meningitidis cells, pharmaceutical compositions incorporating such cells, and methods of using such cells.
|
|
|
8097453 |
Recombinant viral-based malaria vaccines
Described are vaccines against malarial infections, which are based on recombinant viral vectors, such as alpha viruses, adenoviruses, or vaccinia viruses. The recombinant viral-based vaccines can...
|
|
|
8092791 |
Method of producing herpes simplex virus amplicons, resulting amplicons, and their use
The present invention relates to a method for producing herpes simplex virus (HSV) amplicon particles which includes co-transfecting a host cell with the following: (i) an amplicon vector...
|
|
|
8093042 |
Lentiviral triplex DNA, and vectors and recombinant cells containing lentiviral triplex DNA
The present invention provides nucleic acid, vectors, viruses, and recombinant cells comprising triple-stranded structures, such as those resulting from central initiation and termination of HIV-1...
|
|
|
8084041 |
Use of mycrobacterial vaccines in CD4+ or CD8+ lymphocyte-deficient mammals
Methods of treating a mammal that is deficient in CD4+ and/or CD8+ lymphocytes are provided. The methods comprise inoculating the mammal with an attenuated mycobacterium in the M. tuberculosis...
|
|
|
8084024 |
Method for producing antibodies
The present invention relates to a method for producing antibodies and to antibodies produced by this method. In one embodiment the invention relates to a method for producing an antibody that...
|
|
|
8080402 |
Surface expression method of peptides P5 and Anal3 using the gene encoding poly-gamma-glutamate synthetase
The present invention relates to a method for expressing each of peptide antibiotics P5 3 and Anal3 35 having amphiphilicity and showing antibacterial, antifungal and anticancer activities 61, 63,...
|
|
|
8076100 |
Molecular clones with mutated HIV gag/pol, SIV gag and SIV env genes
Nucleic acid constructs containing HIV-1 gag/pol and SIV gag or SIV env genes which have been mutated to remove or reduce inhibitory/instability sequences are disclosed. Viral particles and host...
|
|
|
8075879 |
Brucella melitensis mutants and methods
Certain attenuated mutants of Brucella, especially B. melitensis, B. abortus, B. suis and B. ovis, when administered to a human or animal trigger a protective immune response such that subsequent...
|
|
|
8076305 |
Biological pacemakers including mutated hyperpolarization-activated cyclic nucleotide-gated (HCN) channels
A composition for implantation into cardiac tissue includes a biological pacemaker that, when implanted, expresses an effective amount of a mutated hyperpolarization-activated and cyclic...
|
|
|
8076131 |
Settings for recombinant adenoviral-based vaccines
The present invention provides new uses of recombinant adenoviral vectors in vaccination regimens, such as prime/boost set-ups and subsequent vaccinations and applications for gene therapy....
|
|
|
8071084 |
Vaccine for protection against Shigella sonnei disease
Compositions and methods for protecting a susceptible host against an infection of Shigella sonnei are disclosed. Such compositions and methods are useful for protecting the host against bacillary...
|
|
|
8071113 |
Live, oral vaccine for protection against Shigella dysenteriae serotype 1
The invention relates to Salmonella typhi Ty21a comprising core-linked Shigella dysenteriae serotype 1 O-specific polysaccharide (O-Ps) and DNA encoding O antigen biosynthesis, said DNA selected...
|
|
|
8067014 |
Chimeric AAV capsid proteins
Recombinant adeno-associated viral (AAV) capsid proteins are provided. Methods for generating the recombinant adeno-associated viral capsid proteins and a library from which the capsids are...
|
|
|
8058248 |
Foot and mouth disease virus vaccine comprising interferons
Early protection of susceptible animals against foot and mouth disease (FMD) may be achieved by inoculating the animals with a vaccine comprising an interferon DNA sequence. One day after...
|
|
|
8058251 |
Devices, systems and methods for improving memory and/or cognitive function through brain delivery of siRNA
The present invention relates to devices, systems, and methods for improving memory and/or cognitive function by brain delivery of compositions of small interfering RNA or vectors containing the...
|
|
|
8058253 |
Growth hormone releasing hormone treatment to decrease cholesterol levels
This invention is related to compositions and methods for decreasing cholesterol levels in a subject. The method utilizes a nucleic acid expression construct that encodes a...
|
|
|
8052967 |
Stable adenoviral vectors and methods for propagation thereof
Provided are methods and means to increase the stability and/or the packaging capacity of recombinant adenoviruses, by overexpression of pIX in an adenoviral packaging cell, by retaining at least a...
|
|
|
8053421 |
DNA vaccines against tumor growth and methods of use thereof
A DNA vaccine suitable for eliciting an immune response against cancer cells comprises a polynucleotide construct operably encoding an a Fra-1 protein, such as a polyubiquitinated human Fra-1...
|
|
|
8052966 |
Methods and compositions for treating metastatic cancer
Methods and compositions for producing targeted delivery vectors are provided. Such vectors are useful for treating neoplastic disorders. Also provided are protocols for administering targeted...
|
|
|
8052965 |
Viruses with enhanced lytic potency
Described is a replication competent recombinant virus, being capable to replicate and having lytic capacity in target cells, the said cell being hampered in the p53 dependent apoptosis pathway,...
|
|
|
8048409 |
Cellular therapy to heal vascular tissue
The present invention encompasses methods and apparatus for minimizing the risks inherent in endovascular grafting for blood vessel therapy and repair. The invention involves delivering adult stem...
|
|
|
8048433 |
Deacylation of LPS in gram negative bacteria
The current invention provides new Gram negative polypeptides exhibiting lipid A 3-O-deacylase activity and are capable of modifying and/or detoxifying gram negative LPS. The present invention also...
|
|
|
8048410 |
In vivo and ex vivo gene transfer into renal tissue using gutless adenovirus vectors
A method for treating a renal disease in a subject is disclosed. The method includes administering into a kidney of the subject with an effective amount of a gutless adenoviral vector containing a...
|
|
|
8048428 |
DNA composition encoding an immunogenic VEGF receptor peptide and methods of use thereof
A DNA composition effective for inhibiting endothelial cell proliferation comprises a DNA construct operably encoding a vascular endothelial growth factor (VEGF) receptor polypeptide, which can be...
|
|
|
8043611 |
Regulated nucleic acid expression system
The present invention provides nucleic acid constructs, expression systems, and methods relating to the regulation of gene expression. The invention may be applied to regulate the expression of any...
|
|
|
8043612 |
Infection and treatment of neoplasms with vesicular stomatitis virus
The subject invention relates to viruses that are able to replicate and thereby kill neoplastic cells with a deficiency in the IFN-mediated antiviral response, and their use in treating neoplastic...
|
|
|
8044266 |
AXMI-008, a delta-endotoxin gene and methods for its use
Compositions and methods for conferring pesticidal activity to bacteria, plants, plant cells, tissues and seeds are provided. Compositions comprising a coding sequence for a delta-endotoxin and...
|
|
|
8034331 |
Method of delivery of nucleic acids to peripheral neurons
The invention provides for methods for delivering a nucleic acid into a peripheral neuron by identifying a target neuron in a dorsal root ganglion and intrathecally delivering a vector comprising...
|
|
|
8034791 |
Activation of Egr-1 promoter by DNA damaging chemotherapeutics
The present invention relates to methods of inducing expression of a polynucleotide encoding a therapeutic polypeptide, e.g., TNF-α, in a cell comprising contacting the cell with a construct...
|
|
|
8034356 |
Monoparamunity inducers based on attenuated rabbit myxoma viruses
The present invention relates to monoparamunity inducers based on paramunizing viruses or viral components of a myxomavirus strain from rabbits with typically generalizing disease, to a method for...
|
|
|
8034330 |
Modified organs and cells for xenotransplantation
It has been discovered that there are at least two significant antigens present on the cells of animal species such as pigs that elicit an immune or inflammatory response immediately upon...
|
|
|
8029777 |
Helicobacter system and uses thereof
Helicobacter based preparations comprising a pharmacologically active molecule of interest are disclosed, as well as methods of preparing and using said preparations. In particular, Helicobacter...
|
|
|
8029778 |
Methods of using TICAM-1, an adapter protein that binds toll-like receptor 3
A novel adaptor protein and its gene are provided. The novel adaptor protein has a property of binding to mammalian Toll-like receptor 3, which controls type I interferon production that is...
|
|
|
8026415 |
Defensin polynucleotides and methods of use
Methods and compositions for modulating development and defense responses are provided. Nucleotide sequences encoding defensin proteins are provided. The sequences can be used in expression...
|
|
|
8021653 |
Shuttle vector for Bifidobacterium and Escherichia coli
The present invention provides a shuttle vector for a microorganism of the genus Bifidobacterium (BM) and Escherichia coli having a wide host range and a large copy number in BM and capable of...
|
|
|
8021671 |
Pro-apoptotic bacterial vaccines to enhance cellular immune responses
Whole-cell vaccines and methods for their use in producing protective immune responses in vertebrate hosts subsequently exposed to pathogenic bacteria. The present invention involves a method of...
|
|
|
8017387 |
Telomerase reverse transcriptase fusion protein, nucleotides encoding it, and uses thereof
Polynucleotides encoding telomerase reverse transcriptase (TERT) fusion proteins are provided, the TERT fusion proteins comprising a TERT protein, or functional variant thereof, fused to a...
|
|
|
8012469 |
Universal GM-CSF expressing bystander human K562 cell line
The present invention provides a universal immunomodulatory cytokine-expressing bystander cell line, a composition comprising such a cell line and a cancer antigen, a method of making such a cell...
|
|
|
8012466 |
Immunogenic compositions for activating γδ T cells
Disclosed are compositions, kits, and methods for activating, expanding, or stimulating γδ T cells that include recombinant attenuated microbes. The compositions may include pharmaceutical...
|
|
|
8012467 |
Multivalent vaccines comprising recombinant viral vectors
The invention relates to vaccines comprising recombinant vectors, such as recombinant adenoviruses. The vectors comprise heterologous nucleic acids encoding for at least two antigens from one or...
|
|
|
8007780 |
AAV vectors for gene delivery to the lung
Methods of making and using recombinant AAV vectors and virions for gene delivery to the lung are described. The recombinant AAV virions are derived from caprine AAV and bovine AAV, both of which...
|