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7618623 |
Hybrid adeno-retroviral vector for the transfection of cells
An adenovirus, including adenoviral capsid proteins, and a replication-defective adenoviral vector that includes a 5′ retroviral LTR nucleic acid sequence, a 3′ retroviral LTR nucleic acid...
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7615686 |
Expression and use of novel pesticidal toxins
A novel pesticidal toxin isolated from Bacillus thuringiensis that is highly active against a wide range of lepidopteran insect pests is disclosed. The DNA encoding the pesticidal toxin can be...
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7612164 |
Cardiac muscle function and manipulation
This invention relates to polypeptides which affect myocardial cell differentiation and organisation of cardiac muscle contractile units, assay for identifying such polypeptides, and methods for...
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7608256 |
Methods to increase transgene expression from bacterial-based delivery systems by co-expressing suppressors of the eukaryotic type I interferon response
Bacterial delivery systems with improved transgene expression are provided. The recombinant bacterial delivery systems deliver transgenes of interest and suppressors of the eukaryotic Type I...
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7608255 |
Replication-competent anti-cancer vectors
Novel vectors which are replication competent in neoplastic cells and which overexpress an adenovirus death protein are disclosed. Some of the disclosed vectors are replication-restricted to...
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7601345 |
Lentivirus vectors for gene transfer to alveolar epithelial cells
The present invention demonstrates that VSV-G-pseudotyped lentivirus vectors efficiently transduce AEC in primary culture and in vivo with transduction favored by virus application from the apical...
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7601342 |
Cell fusions and methods of making and using the same
The invention is concerned with fusions of dendritic cells and antigen presenting cells. Also provided are methods of making and using these cell fusions, including methods of adoptive...
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7598078 |
Settings for recombinant adenoviral-based vaccines
The present invention provides new uses of recombinant adenoviral vectors in vaccination regimens, such as prime/boost set-ups and subsequent vaccinations and applications for gene therapy....
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7592149 |
Nucleic acid and corresponding protein entitled 184P1E2 useful in treatment and detection of cancer
A novel gene (designated 184P1E2) and its encoded protein, and variants thereof, are described wherein 184P1E2 exhibits tissue specific expression in normal adult tissue, and is aberrantly...
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7592013 |
Delivery of trefoil peptides
The present invention relates to a microorganism, preferably a bacterial strain, preferably a non-pathogenic strain, preferably a non-invasive strain, preferably a food grade strain, preferably a...
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7588757 |
Methods of treating Parkinson's disease using recombinant adeno-associated virus virions
Methods for treating Parkinson's disease (PD) are provided. Recombinant adeno-associated virus (rAAV) virions are used to deliver genes encoding dopamine-synthesizing enzymes to the central nervous...
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7588756 |
Treatment of cardiac power failure
The invention relates to medicaments for treating cardiac power failure. The medicaments contain a therapeutically effective quantity of one or more S100 protein(s) or one or more mutant or...
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7585657 |
Signal for packaging of influenza virus vector
The invention provides a packaging (incorporation) signal for influenza virus vectors, and methods of using the signal to transmit and maintain influenza viral and foreign nucleic acid in virus and...
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7585498 |
Regulation of adenovirus DNA packaging by IPTG
The present invention relates to recombinant Adenoviruses (Ad) which function as helper viruses to gutted Ad viruses lacking viral coding sequences. The recombinant Ad of the present invention...
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7585497 |
Induction of apoptosis and cell growth inhibition by protein 4.33
There is disclosed an isolated cDNA sequence (SEQ ID NO:1) encoding a P4.33 polypeptide and comprising a coding region (SEQ ID NO:2) of the sequence described in SEQ ID NO:1, or a sequence having...
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7582614 |
Use of myxoma virus for the therapeutic treatment of cancer and chronic viral infection
The present invention relates to therapeutic use of Myxoma virus. Myxoma virus can selectively infect cells that have a deficient innate anti-viral response, including cells that are not responsive...
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7582478 |
Cleaved serum response factor in cardiac diagnosis and therapy
The present invention is directed to the cleavage of serum response factor as it relates to cardiac disease. In specific embodiments, failing cardiac tissue is diagnosed in tissues comprising...
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7582290 |
Packaging cell line for diphtheria toxin expressing non-replicating adenovirus
The invention provides a packaging cell line for production of diphtheria toxin (DT) expressing, non-replicating adenovirus for use in suicide gene therapy of cancer cells, as well as production of...
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7579005 |
Process for recombinant expression and purification of antimicrobial peptides using periplasmic targeting signals as precipitable hydrophobic tags
A process was developed for expressing antimicrobial peptides in a recombinant host cell that eliminates host cell toxicity and antimicrobial peptide degradation, as well as providing a process for...
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7572438 |
Mutant having uracil phosphoribosyl transferase activity
The invention concerns a polypeptide having a uracil phosphoribosyl transferase (UPRTase) by mutation of one or several residues of the UPRTase. The invention also concerns a nucleotide sequence...
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7569552 |
DNA vaccines against tumor growth and methods of use therof
A DNA vaccine suitable for eliciting an immune response against cancer cells comprises a polynucleotide construct operably encoding an a Fra-1 protein, such as a polyubiquitinated human Fra-1...
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7569219 |
Recombinant double-stranded RNA phage, and use of the same
A recombinant double stranded RNA (dsRNA) phage expresses dsRNA-encoded genes in eukaryote cells. Recombinant dsRNA phage are useful for the expression of dsRNA expression cassettes encoding...
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7569218 |
Compositions for and methods of using herpes simplex virus glycoprotein D to suppress immune responses
Methods of delivering a desired polypeptide to an individual are disclosed. The methods comprise administering to the individual an immunogenic vector comprising a nucleic acid encoding the desired...
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7569217 |
Porcine adenovirus E1 and E4 regions
The present invention relates to the characterization of the porcine adenovirus E1 and E4 regions. The complete nucleotide sequence of the genome of porcine adenovirus type 3 (PAV-3), providing the...
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7566459 |
Modified mycobacterium tuberculosis strains and uses thereof
The present invention features modified Mycobacterium tuberculosis strains which lack a functional lspA gene, and vaccine formulations comprising the same. In many embodiments, a modified ...
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7563777 |
Method to induce neovascular formation and tissue regeneration
The present invention relates, e.g., to a method for inducing arteriogenesis, lymphangiogenesis, vasculogenesis, or cardiomyogenesis, and/or for inducing mitosis or proliferation of a smooth muscle...
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7563775 |
Insulin-responsive DNA binding protein-1 and methods to regulate insulin-responsive genes
The present invention relates to the novel protein Insulin-Responsive DNA Binding Protein-1 (IRDBP-1) and nucleotide sequences that encode it. IRDBP-1 binds to nucleic acid regions of genes that...
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7560613 |
Plant gene encoding trehalose metabolism enzymes
This invention relates to isolated nucleic acid fragments encoding trehalose metabolism enzymes, more specifically, alpha, alpha-trehalase, alpha, alpha-trehalose-phosphate synthase or...
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7560527 |
Modified adenovirus fibre and uses
The invention concerns an adenovirus fiber modified by mutation of one or several residues of the region included between residues 491 and 505 of SEQ ID NO: 1, the viral particles or...
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7556805 |
Compositions for treatment of melanoma and method of using same
Melanoma can be treated in a mammalian subject by administering to the subject an immunologically-effective amount of a xenogeneic melanoma-associated differentiation antigen. For example, genetic...
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7550148 |
Targeting of Herpes simplex virus to specific receptors
The invention relates to engineered Herpes simplex virus (HSV) particles that are targeted to one or more specific binding pair members, such as receptors. Also, recombinant vectors for producing...
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7550138 |
Plasmodium mutant and vaccines including the mutant
The invention relates to the production of new Plasmodium mutants which are defective in the expression of the protein P36p. These mutants are unable to cause malaria, yet they can be used as...
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7544669 |
Polynucleotide therapy
This invention provides a method of treating or preventing a disease in an animal associated with one or more self-protein(s), -polypeptide(s), or -peptide(s) that is present or involved in a...
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7541447 |
Process for the preparation of an improved Brucella strain plasmid to develop the strain and the vaccine comprising the said strain
A Brucella bacterium is modified by partial or complete deletion of the pgm gene, rendering the bacterium incapable of synthesizing a key enzyme in the metabolism of bacterial sugars. A live...
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7541179 |
Vector encoding human globin gene and use thereof in treatment of hemoglobinopathies
Recombinant lentiviral vectors having a region encoding a functional β-globin gene; and large portions of the β-globin locus control regions which include DNase I hypersensitive sites HS2, HS3...
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7541043 |
Vaccine for protection against Shigella sonnei disease
Compositions and methods for protecting a susceptable host against an infection of Shigella sonnei are disclosed. Such compositions and methods are useful for protecting the host against...
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7534613 |
Methods of treating parkinson's disease using viral vectors
Methods of delivering viral vectors, particularly recombinant AAV virions, to the CNS are provided. Also provided are methods of treating Parkinson's Disease.
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7534425 |
Animal model and cell-line expressing modified chlorine channel
The present invention relates to a test system for the identification and testing of active compounds which act on synapic transmission (active compounds for treatment of neuronal diseases), which...
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7531180 |
Chimeric alphavirus replicon particles
Chimeric alphaviruses and alphavirus replicon particles are provided including methods of making and using same. Specifically, alphavirus particles are provided having nucleic acid molecules...
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7531167 |
Herpes simplex virus vector
The invention provides a herpes simplex virus vector comprising deletions in ICP4, ICP27, and UL55.
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7524507 |
Recombinant microorganisms
A method of enhancing expression of a desired protein at mucosal effector sites, the method including placing the protein to be expressed under the control of a promoter having SEQ ID NO: 2, SEQ ID...
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7524493 |
Nucleic acid constructs cells transformed therewith and methods utilizing same for inducing liver regeneration and alleviation of portal hypertension
A method of inducing liver regeneration in a damaged liver tissue region of an individual is provided. The method including the step of providing at least two distinct growth factors to the damaged...
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7521043 |
Gene therapy for tumors using minus-strand RNA viral vectors encoding immunostimulatory cytokines
The present invention provides methods for treating tumors, which comprise the step of administering into tumor sites a minus-strand RNA viral vector encoding an immunostimulatory cytokine or cells...
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7517866 |
LIM mineralization protein splice variants
The present invention is directed to isolated nucleic acid molecules that encode LIM mineralization protein, or LMP. The invention further provides vectors comprising splice variants of nucleotide...
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7517669 |
Gene regulation therapy involving ferritin
A method is described for regulating gene expression related to iron metabolism to ameliorate diseases that include sickle cell disease, cancers, neurodegenerative diseases, Friedreich's ataxia and...
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7517520 |
Packaging of immunostimulatory oligonucleotides into virus-like particles: method of preparation and use
The invention relates to the finding that virus like particles (VLPs) can be loaded with immunostimulatory substances, in particular with DNA oligonucleotides containing non-methylated C and G...
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7510706 |
Pseudotype retroviral vectors containing membrane proteins having hemagglutinin activity
The present invention provides a retroviral vector containing a membrane protein having a hemagglutinin activity. The present inventors constructed a retroviral vector pseudotyped by the membrane...
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7504100 |
Method for delivering a biological compound using neural progenitor cells derived from whole bone marrow
A method is described for generating a clinically significant volume of neural progenitor cells from whole bone marrow. A mass of bone marrow cells may be grown in a culture supplemented with...
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7501126 |
Targeting of herpes simplex virus to specific receptors
The invention relates to engineered Herpes simplex virus (HSV) particles that are targeted to one or more specific receptors. Also, recombinant vectors for producing such HSV particles. By reducing...
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7498024 |
Compositions and methods for enhanced expression of immunoglobulins from a single vector using a peptide cleavage site
Single vector constructs for expression of an immunoglobulin molecule or fragment thereof and methods of making and using the same are described. The vectors comprise a self-processing cleavage...
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