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9040059 Recombinant bacterium capable of eliciting a protective immune response against C. perfringens  
The present invention encompasses recombinant bacteria and immunogenic compositions comprising the bacteria. The immunogenic composition may be used to induce an immune response against C....
9034615 Glycolic acid production by fermentation from renewable resources  
The present invention provides a method for the biological production of glycolic acid from a fermentable carbon source in a microorganism. In one aspect of the present invention, a process for...
9034313 Nucleic acid molecules encoding rantes, and compositions comprising and methods of using the same  
Nucleic acid molecules comprising a nucleotide sequence encoding RANTES and fragments and variants thereof are disclosed. Additionally, nucleic acid molecules and compositions comprising the...
9028837 Methods and compositions for poxvirus A35R protein  
The present invention provides methods and compositions for modulating an immune response in a subject, comprising administering to the subject an effective amount of an A35R protein or active...
9017660 Compositions and methods for prevention of escape mutation in the treatment of Her2/neu over-expressing tumors  
This invention provides compositions and methods for treating and vaccinating against an Her2/neu antigen-expressing tumor and inducing an immune response against dominant in a non-human animal.
9017661 Cardiac repair by reprogramming of cardiac fibroblasts into cardiomyocytes  
The present invention involves the use of transcription factors including Tbx5, Mef2C, Hand2, myocardin and Gata4 to reprogram cardiac fibroblasts into cardiomyocytes, both in vitro and in vivo....
9017672 Hexon Tat-PTD modified adenovirus and uses thereof  
The invention provides a hexon Tat-PTD modified adenovirus, a gene delivery vector based on the modified adenovirus that enhances gene delivery efficiency, and an oncolytic agent based on the...
9017659 Pathotropic targeted gene delivery system for cancer and other disorders  
Systems for pathotropic (disease-seeking) targeted gene delivery are provided, including viral particles with extremely high titers. In particular, the viral particles are engineered to...
9006190 Compositions and methods for cancer diagnosis and therapy  
The miR15 and miR16 micro RNA genes are located at 13q14 within a 30 kb region of loss characteristic of cells from certain cancers, such as cells from chronic lymphocytic leukemia or prostate...
8987224 MicroRNA-198 as a tumor suppressor in pancreatic cancer  
A novel network of tumorigenic prognostic factors is identified that plays a critical role in advanced pancreatic cancer (PC) pathogenesis. This interactome is interconnected through a central...
8986708 Combinations of gene deletions for live attenuated Shigella vaccine strains  
Shigella vaccine strains whose primary attenuating feature is deletion of the virG(icsA) gene and additional two or more deletions in setAB(shET1), senA(shET2), senB(shET2-2), stxAB, and msbB2...
8986673 Replication stable and RNase resistant chimeras of pestivirus with insertion in 3′ nontranslated region (3′NTR)  
The invention relates to the field of nucleic acid amplification, particularly to quality control materials for use in viral RNA assays. It specifically relates to the construction of a...
8986672 Use of mutant Herpes Simplex Virus-2 for cancer therapy  
The present invention is directed to the composition and use of a modified Herpes Simplex Virus Type 2 (HSV-2) as a medicament in the treatment of cancer. The modified HSV-2 has fusogenic...
8986709 Vaccine for prophylaxis or treatment of an allergen-driven airway pathology  
The present invention relates to a life attenuated Bordetella pertussis vaccine which is deficient for tracheal cytotoxin (TCT), pertussis toxin (PTX), and dermonecrotic toxin (DNT) for...
8980634 Reverse genetics of negative-strand RNA viruses in yeast  
The present invention relates to a methodology for the generation of infectious ribonucleoparticles (RNPs) of negative-strand RNA viruses, and in particular of non-segmented negative-strand RNA...
8980246 Oncolytic vaccinia virus cancer therapy  
Embodiments of the invention are directed methods that include a thymidine kinase deficient vaccinia virus. The methods include administering the vaccinia virus at increased viral concentrations....
8974777 Adenovirus with mutations in the endoplasmic reticulum retention domain of the E3-19K protein and their use in cancer treatment  
The present invention relates to an adenovirus wherein said adenovirus replicates and it contains a mutation in the endoplasmic reticulum retention domain of E3-19K, and to the use of said mutant...
8968719 Live, oral vaccine for protection against Shigella dysenteriae serotype 1  
The invention relates to Salmonella typhi Ty21a comprising core-linked Shigella dysenteriae serotype 1 O-specific polysaccharide (O-Ps) and DNA encoding O antigen biosynthesis, said DNA selected...
8961951 Baculoviruses with enhanced virion production and a method for the production of baculoviruses  
The present invention provides a method for restoring budding capability to GP64null baculoviruses including gp64null AcMNPV by expressing therein a portion of the VSV G protein gene or a...
8961989 Methods for producing an immune response to tuberculosis  
Methods for producing an immune response to Mycobacterium tuberculosis (Mtb) are disclosed herein. In several examples, the immune response is a protective immune response. In additional...
8956606 Malignant tumor cell suppressor protein, malignant tumor cell suppressor gene, maligant tumor cell suppressive viral vector, and kit using the same  
A malignant tumor cell suppressor protein (a) or (b): (a) a protein comprising an amino acid sequence represented by SEQ ID No. 1; or(b) a protein comprising an amino acid sequence represented by...
8945530 DNA sequence, and recombinant preparation of the grass pollen allergen Lol p4  
The present invention relates to the provision of a DNA sequence of the major grass pollen allergen Lol p 4. The invention also encompasses fragments, new combinations of partial sequences and...
8945923 Antigen-specific clonal expansion of B cells  
The present invention provides recombinant proteins comprising the amino acid sequence of an intracellular segment of CD40 and an amino acid sequence mediating the association of the recombinant...
8945531 Recombinant herpes virus and pharmaceutical composition containing the same  
A recombinant herpes virus showing high antitumor activity is provided. In particular, a recombinant herpes simplex virus that expresses an ICP6 gene under control of a tumor-specific promoter or...
8945587 Synthetic lipid biology for combinatorial engineering of endotoxin  
The present disclosure generally relates to genetic engineering of bacteria. More particularly, the present disclosure relates to genetic engineering of Gram-negative bacteria expressing different...
8940290 Simian adenoviruses SAdV-43, -45, -46, -47, -48, -49, and -50 and uses thereof  
A recombinant vector comprises simian adenovirus 43, 45, 46, 47, 48, 49 or 50 sequences and a heterologous gene under the control of regulatory sequences. A cell line which expresses simian...
8936942 Polyethyleneglycol-modified lipid compounds and uses thereof  
The present invention provides compositions comprising polytheylyene-dialkyloxypropyl conjugates (PEG-DAA), liposomes, SNALP, and SPLP comprising such compositions, and methods of using such...
8932575 Compositions and methods for inducing migration by dendritic cells and an immune response  
Compositions and methods of activating dendritic cells with LMP1 and LMP1-activated dendritic cell based compositions and methods are effective for dendritic cell therapy and provide an adjuvant...
8932846 Unmarked recombinant intracellular pathogen immunogenic compositions expressing high levels of recombinant proteins  
Recombinant immunogenic compositions, and methods for the manufacture and use, are provided for the prevention and treatment of intracellular pathogen diseases in humans and animals. The...
8932604 Recombinant non-pathogenic marek's disease virus constructs encoding infectious laryngotracheitis virus and newcastle disease virus antigens  
Recombinant multivalent non-pathogenic Marek's Disease virus constructs that encode and express both Infectious Laryngotracheitis Virus and Newcastle Disease virus protein antigens, and methods of...
8932576 Robust expression of a bioactive mammalian protein in Chlamydomonas chloroplast  
Methods and compositions are disclosed to engineer chloroplast comprising heterologous mammalian genes via a direct replacement of chloroplast Photosystem II (PSII) reaction center protein coding...
8933298 Mutated eIF4E sequences from potato which impart resistance to potato virus Y  
The present invention relates to a nucleic acid molecule encoding a mutant form of wild-type translation initiation factor eIF4E, which has an amino acid sequence of SEQ ID NO: 1, wherein the...
8926958 Prevention and treatment of vascular disease with recombinant adeno-associated virus vectors encoding apolipoprotein A-I and apolipoprotein A-I milano  
Described herein is a gene therapeutic approach to the prevention and treatment of vascular disease and coronary heart disease; in particular, atherosclerosis. The inventive methods may be used in...
8927251 Targeting of herpes simplex virus to specific receptors  
The invention relates to engineered Herpes simplex virus (HSV) particles that are targeted to one or more specific binding pair members, such as receptors. Also, recombinant vectors for producing...
8911721 Method of constructing gene transport support  
An object of the present invention is to provide a method of efficiently constructing a gene delivery carrier having a favorable activity and expression efficiency of a protein expressed by a gene...
8911739 Methods of preventing rejection of transplanted tissue by administering anti-CD40L antibody and dendritic cells loaded with Hsp60sp peptide  
A method is provided for preventing rejection by an immune system of a recipient subject of a tissue transplanted from a donor subject into the recipient subject without the need for long-term...
8912315 Purkinje cell-tropic viral vector  
The present invention relates to a Purkinje cell-tropic viral vector in which a modified L7 promoter and a therapeutic gene are operably linked to a virus-based plasmid vector.
8906360 Light-activated cation channel and uses thereof  
The present invention provides compositions and methods for light-activated cation channel proteins and their uses within cell membranes and subcellular regions. The invention provides for...
8906359 Recombinant retrovirus pseudotyped with a E2 alphavirus glycoprotein  
Methods and compositions are provided for delivery of a polynucleotide encoding a gene of interest, typically an antigen, to a dendritic cell (DC). The virus envelope comprises a DC-SIGN specific...
8906387 In vivo transduction with a chimeric AAV capsid protein  
Recombinant adeno-associated viral (AAV) capsid proteins are provided. Methods for generating a library of recombinant adeno-associated viral capsid proteins are also provided.
8895303 Method of cell culture and method of treatment comprising a vEPO protein variant  
In one aspect the present invention is concerned with a method of cell culture, comprising the steps of (i) obtaining a stem or progenitor cell sample, (ii) culturing the stem or progenitor cell...
8895309 Myostatin inhibition for enhancing muscle and/or improving muscle function  
The present invention relates to methods for inhibiting myostatin, a regulator of muscle mass, for muscle enhancement (including inducing hypertrophy and/or hyperplasia) as well as improving...
8889121 Bacterium comprising a regulated rfaH nucleic acid  
The present invention encompasses a recombinant bacterium comprising a regulated rfaH nucleic acid, as well as a vaccine comprising said recombinant bacterium. Other embodiments of the present...
8884098 Expression cassettes for regulation of expression in monocotyledonous plants  
The present invention relates to expression cassettes comprising at least one transcription regulating nucleotide sequence obtainable from the group of genes of monocotyle-donous plants consisting...
8877209 Recombinant influenza vectors with tandem transcription units  
The invention provides a composition useful to prepare influenza viruses, e.g., in the absence of helper virus, using vectors which include tandem transcription cassettes containing PolI and/or...
8877176 Methods for promoting wound healing and muscle regeneration with the cell signaling protein Nell1  
The present invention provides methods for promoting wound healing and treating muscle atrophy in a mammal in need. The method comprises administering to the mammal a Nell1 protein or a Nell1...
8871193 Viral vectors and their use in therapeutic methods  
The invention provides viral vectors (e.g., herpes viral vectors) and methods of using these vectors to treat disease.
8871905 Modification of CXCR4 using engineered zinc finger proteins  
Disclosed herein are methods and compositions for modulating activity of CXCR4 genes, for example using zinc finger transcription factors (ZF-TFs) or zinc finger nucleases (ZFNs) comprising a zinc...
8865156 Compositions and methods for the maintenance of oral health  
The invention provides compositions comprising one or more isolated LDH-deficient mutans streptococcus strains and one or more isolated S. oralis strains and/or one or more isolated S. uberis...
8865445 Polypeptides having cellulolytic enhancing activity and polynucleotides encoding same  
The present invention relates to isolated polypeptides having cellulolytic enhancing activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid...