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8182804 |
Engineered enzymatically active bacteriophages and methods of uses thereof
The present invention provides engineered bacteriophages that express at least one biofilm degrading enzyme on their surface and uses thereof for degrading bacterial biofilms. The invention also...
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8173872 |
Bacillus thuringiensis insecticidal proteins
The invention pertains to novel insecticidal compounds derived from Bacillus thuringiensis strains. New proteins designated. Cry2Ae, Cry2Af, and Cry2Ag, and variants thereof are provided, as well...
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8168166 |
Live genetically attenuated malaria vaccine
Method for inoculating a vertebrate host against malaria, by administering to the host a live Plasmodium organism that is genetically engineered to disrupt a liver-stage-specific gene function.
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8168168 |
Infectivity-enhanced conditionally-replicative adenovirus and uses thereof
A modified adenovirus capable of overcoming the problem of low level of coxsackie-adenovirus receptor (CAR) expression on tumor cells and methods of using such adenovirus are provided. The fiber...
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8163292 |
Herpes simplex viruses and methods of viral replication
A herpes simplex virus is disclosed in which the herpes simplex virus genome comprises a nucleic acid sequence encoding an ING4 polypeptide.
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8158413 |
Lentiviral vector-based vaccine
Methods of eliciting humoral responses, methods of immunization, and methods of vaccination using lentiviral vector are disclosed. Additionally, immunogenic compositions and vaccines for West Nile...
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8158416 |
CDNA corresponding to the antigenome of nonsegmented negative strand RNA viruses, and process for the production of such viruses encoding additional antigenically active proteins
The present invention relates, in general, to a methodology for the generation of nonsegmented negative-strand RNA viruses (Pringle, 1991) from cloned deoxyribonucleic acid (cDNA). Such rescued...
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8153861 |
Genes for improving salt tolerance and drought tolerance of plant and the uses thereof
A gene comprising the nucleic acid sequence of SEQ ID NO:1 and another gene comprising the nucleic acid sequence of SEQ ID NO:2, the latter being artificially synthesized according to plant...
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8153116 |
Use of conditional plasmodium strains lacking an essential gene in malaria vaccination
The present invention relates to a malaria vaccine for administration to a host, comprising an attenuated malarial parasite with a gene that has been rendered non-functional, wherein the gene, when...
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8153115 |
Virus-like particles for treatment of viral infections
The invention provides virus-like particles for treatment of viral infections based on the virus causing the infection. The virus-like particles comprise the virus recombinant proteins that form a...
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8147823 |
Method of treating or retarding the development of blindness
A method for treating an ocular disorder characterized by the defect or absence of a normal gene in the ocular cells of a human or animal subject involves administering to the subject by subretinal...
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8147820 |
Attenuated vaccine against fish pathogen Francisella sp
An attenuated bacteria has been made by an insertion mutation in the iglC gene of Francisella asiatica, by allelic exchange. The attenuated strain proved to be an effective vaccine by providing...
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8148136 |
Diagnostics and vaccines for mycobacterial infections of animals and humans
This invention relates to the protein, Mycobacterium paratuberculosis acylase (mpa) and the gene encoding mpa, which we have identified in the pathogen Mycobacterium paratuberculosis Mptb (also...
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8142796 |
Monoparamunity inducers based on attenuated rabbit myxomaviruses
The present invention relates to monoparamunity inducers based on paramunizing viruses or viral components of a myxomavirus strain from rabbits with typically generalizing disease, to a method for...
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8142771 |
Use of coccidian
The present invention provides a novel use of coccidian, specifically relates to the use of coccidian as a vaccine live vector. The present invention further provides a live vaccine with coccidian...
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8142769 |
Preparation and xenotransplantation of porcine islets
The invention relates to developments in the treatment of diabetes in mammals. Particularly it relates to a method of preparing a xenotransplantable porcine islet preparation capable upon...
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8142770 |
Drug comprising as the active ingredient proliferative vector containing survivin promoter
It is intended to provide a drug to be used in gene therapy which specifically targets abnormal cells such as tumor cells and destroys the same for healing. Namely, a drug comprising, as the active...
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8137689 |
Transplant/implant device and method for its production
A transplant/implant device for delivering at least one predetermined biologically active compound to a human or animal host system or for another biological function in the host system is produced...
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8137947 |
Viral vectors whose replication and, optionally, passenger gene are controlled by a gene switch activated by heat in the presence or absence of a small-molecule regulator
The present invention relates to conditionally replicating viruses or pairs of viruses containing a gene switch that is activatable by transient heat or other proteotoxic stress in the presence or...
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8137664 |
Method and kit for repairing a defect in bone
Methods and devices are provided for the repair of bone defects. The bone defect repair may be accomplished by minimally invasive means. The bone defect repair may utilize a bone growth promoting...
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8137662 |
Proliferated cell lines and uses thereof
The subject invention pertains to tumor cell lines useful for increasing the proliferation potential of any human or animal cell in culture, thereby providing immortalized or continuous cell lines...
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8137962 |
Compositions for treating cystic fibrosis
The invention relates to compositions and methods of treating cystic fibrosis. More specifically, this invention relates to the use the AAV vectors and constructs to provide gene therapy to cystic...
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8129594 |
Bacillus thuringiensis gene with lepidopteran activity
The invention provides nucleic acids, and variants and fragments thereof, obtained from strains of Bacillus thuringiensis encoding polypeptides having pesticidal activity against insect pests,...
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8129593 |
Bacillus thuringiensis gene with lepidopteran activity
The invention provides nucleic acids, and variants and fragments thereof, obtained from strains of Bacillus thuringiensis encoding polypeptides having pesticidal activity against insect pests,...
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8128921 |
Use of conditional plasmodium strains lacking nutrient transporters in malaria vaccination
The present invention relates to a malaria vaccine for administration to a host comprising an attenuated malarial parasite with a gene which has been rendered non-functional, wherein the gene, when...
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8129185 |
Regulatory T cells and their use in immunotherapy and suppression of autoimmune responses
Based upon a strong correlation between regulator T cells (Treg cells) and suppressing or preventing a cytotoxic T cell response, provided are methods for the production of ex vivo activated and...
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8124592 |
Development of a preventive vaccine for filovirus infection in primates
The present invention relates generally to viral vaccines and, more specifically, to filovirus vaccines and methods of eliciting an immune response against a filovirus or disease caused by...
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8124068 |
Recombinant intracellular pathogen immunogenic compositions and methods of use
Immunogenic compositions comprising recombinant attenuated intracellular pathogens that have been transformed to express recombinant immunogenic antigens of the same or other intracellular...
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8119119 |
Non-integrative and non-replicative lentivirus, preparation and uses thereof
The invention concerns a non-integrative and non-replicative recombinant lentivirus as well as its uses, in particular for preparing a composition for transferring genes in vitro, ex vivo or in...
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8119117 |
Adenoviral expression vector comprising a CD40L fusion protein adapted to elicit cellular immunity
Provided are adenoviral vectors for generating an immune response to antigen. The vectors comprise a transcription unit encoding a secretable polypeptide, the polypeptide comprising a secretory...
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8119120 |
Marrow stem cell and pancreatic beta cell fusion cell useful for the treatment of diabetes
Methods disclosed include methods of treating T1DM, said method comprising delivering a therapeutic amount of β-MSC to a subject in need thereof. Further disclosed are fusion cells comprising and ...
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8119118 |
Helper virus-free herpesvirus amplicon particles and uses thereof
The invention features new helper virus-free methods for making herpesvirus amplicon particles that can be used in immunotherapies, including those for treating any number of infectious diseases...
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8115063 |
Bacillus thuringiensis gene with coleopteran activity
The invention provides nucleic acids, and variants and fragments thereof, obtained from strains of Bacillus thuringiensis encoding polypeptides having pesticidal activity against insect pests,...
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8114404 |
Method and composition for altering a B cell mediated pathology
The present invention provides a method for altering a B cell mediated pathology in a patient. This method comprises administering a composition comprising at least one and/or two chimeric...
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8114971 |
Nucleic acid molecules encoding proteins which impart the adhesion of Neisseria cells to human cells
Described are nucleic acid molecules encoding proteins mediating the adhesion of bacteria of the genus Neisseria to human cells. Also described are the proteins encoded by these nucleic acid...
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8110183 |
Method for sustained expression of an exogenous gene
A method for sustained expression of an exogenous gene forms a circular episomal plasmid to solve the problem of transient expression of baculovirus in the transduced mammalian cells caused by the...
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8105575 |
Expression vectors with improved safety
The present invention relates to the use of internal promoters in mammalian expression vectors including plasmid vectors and enhancer-deleted retroviral vectors. The retroviral vectors have...
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8106027 |
Development of a preventive vaccine for filovirus infection in primates
The present invention relates generally to viral vaccines and, more specifically, to filovirus vaccines and methods of eliciting an immune response against a filovirus or disease caused by...
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8105574 |
Simian adenovirus nucleic acid and amino acid sequences, vectors containing same, and methods of use
A recombinant vector comprises simian adenovirus sequences and a heterologous gene under the control of regulatory sequences. A cell line which expresses simian adenovirus gene(s) is also...
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8105806 |
Process for preparing optically active amino acids using a whole-cell catalyst
The present invention relates to a process for preparing, in particular, enantiomerically enriched L-α-amino acids, in particular those of the general formula (I). In this connection, the process ...
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8106026 |
Development of a preventive vaccine for filovirus infection in primates
The present invention relates generally to viral vaccines and, more specifically, to filovirus vaccines and methods of eliciting an immune response against a filovirus or disease caused by...
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8105592 |
Heavy chain and single domain antibodies
The present invention relates to heavy chain immunoglobulins or fragments thereof of the VHH or VNAR type, or domain antibodies (dAbs) of the heavy or light chains of immunoglobulins or fragments...
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8101826 |
Expression of Cry3B insecticidal protein in plants
The present invention discloses methods and compositions comprising a group of novel expression cassettes which provide significantly improved levels of accumulation of Coleopteran inhibitory Cry3B...
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8101169 |
Ocular gene therapy using avalanche-mediated transfection
The present invention provides a method of treating an ocular disease in a subject. In a first step, a nucleic acid is introduced into cells or a tissue. The nucleic acid is introduced by electron...
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8097260 |
Lipid a deficient mutants of Neisseria meningitidis
The invention provides lipid A deficient mutant Neisseria meningitidis cells, pharmaceutical compositions incorporating such cells, and methods of using such cells.
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8097453 |
Recombinant viral-based malaria vaccines
Described are vaccines against malarial infections, which are based on recombinant viral vectors, such as alpha viruses, adenoviruses, or vaccinia viruses. The recombinant viral-based vaccines can...
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8092791 |
Method of producing herpes simplex virus amplicons, resulting amplicons, and their use
The present invention relates to a method for producing herpes simplex virus (HSV) amplicon particles which includes co-transfecting a host cell with the following: (i) an amplicon vector...
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8093042 |
Lentiviral triplex DNA, and vectors and recombinant cells containing lentiviral triplex DNA
The present invention provides nucleic acid, vectors, viruses, and recombinant cells comprising triple-stranded structures, such as those resulting from central initiation and termination of HIV-1...
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8084041 |
Use of mycrobacterial vaccines in CD4+ or CD8+ lymphocyte-deficient mammals
Methods of treating a mammal that is deficient in CD4+ and/or CD8+ lymphocytes are provided. The methods comprise inoculating the mammal with an attenuated mycobacterium in the M. tuberculosis...
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8084024 |
Method for producing antibodies
The present invention relates to a method for producing antibodies and to antibodies produced by this method. In one embodiment the invention relates to a method for producing an antibody that...
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