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7407672 |
Composition derived from biological materials and method of use and preparation
The invention provides a novel composition and methods of its preparation and uses. The composition comprises as main components serum and a gelling agent and is useful in various medical...
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7408096 |
Expression of Cry3B insecticidal protein in plants
The present invention discloses methods and compositions comprising a novel expression cassette providing significantly improved levels of accumulation of Coleopteran inhibitory Cry3B variant...
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7407661 |
Methods and reagents that generate a CD8 T cell immune response
New methods and reagents for vaccination are described which generate a CD8 T cell immune response against malarial and other antigens such as viral and tumour antigens. Novel vaccination regimes...
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7404950 |
Induced activation in dendritic cell
The present invention is directed to a composition and method which to treat diseases and to enhance a regulated immune response. More particularly, the present invention is drawn to compositions...
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7402427 |
Vectors with modified protease-dependent tropism
The present invention provides cell fusogenic vectors having replicative ability, whose protease-dependent tropism has been modified. M gene-deficient viral vectors encoding modified F proteins, in...
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7402429 |
Host cells comprising cDNA corresponding to the antigenome of nonsegmented negative strand RNA viruses, further encoding antigenically active proteins
The present invention relates, in general, to a methodology for the generation or nonsegmented negative-strand RNA viruses (Pringle, 1991) from cloned deoxyribonucleic acid (cDNA). Such rescued...
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7402307 |
Method for identifying and killing cancer cells
The invention provides a method for activating a T lymphocyte by contacting the T lymphocyte with a dendritic cell (DC) that presents a telomerase reverse transcriptase (TRT) peptide in the context...
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7399476 |
Nucleic acid free ghost preparations
The invention relates to preparations of bacterial ghosts which are substantially free of living bacterial cells and/or nucleic acids and their use in pharmaceutical preparations.
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7399750 |
Methods for cardiac gene transfer
Methods for the delivery of genes to improve cardiac function including the use of viral vectors, isolation of the heart from systemic circulation, and induction of hypothermia/cardiac arrest are...
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7396528 |
Corneal cells expressing active agents and methods of use thereof
The invention relates to methods of modifying cells of corneal tissue to express an active agent, to modified corneal tissue, to vectors utilised in such methods and to methods of xeno- and...
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7396821 |
Intravascular delivery of nucleic acid
Disclosed is a process for transfecting genetic material into a mammalian cell to alter endogenous properties of the cell. The process comprises designing a polynucleotide for transfection. Then...
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7396980 |
Defensin polynucleotides and methods of use
Methods and compositions for modulating development and defense responses are provided. Nucleotide sequences encoding defensin proteins are provided. The sequences can be used in expression...
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7393525 |
Method for introducing and expressing genes in animal cells, and live invasive bacterial vectors for use in the same
A method for introducing and expressing genes in animal cells is disclosed comprising infecting said the animal cells with live invasive bacteria, wherein bacteria contain a eukaryotic expression...
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7393526 |
Systemic gene delivery vehicles for the treatment of tumors
The present invention relates to the field of cellular and molecular therapy with modified (genetically or growth factor engineered) and unmodified stem cells (SCs). More particularly, the...
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7393677 |
Avidin-pseudotyped viral vectors and their use
The present invention pertains to an avidin-pseudotyped virus, and especially baculovirus, useful for delivery of foreign genes etc. The present invention also pertains to vectors comprising...
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7390482 |
Drug for auditory dysfunction
The present invention provides a pharmaceutical preparation for hearing impairment, which is suitable for gene therapy of hearing impairment, that is, a pharmaceutical preparation for hearing...
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7390483 |
Universal GM-CSF expressing bystander human K562 cell line
The present invention provides a universal immunomodulatory cytokine-expressing bystander cell line, a composition comprising such a cell line and a cancer antigen, a method of making such a cell...
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7387645 |
Cellular therapy to heal vascular tissue
The present invention encompasses methods and apparatus for minimizing the risks inherent in endovascular grafting for blood vessel therapy and repair. The invention involves delivering adult stem...
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7387894 |
Recombinant viral-based malaria vaccines
The present invention relates to novel vaccines against malaria infections, based on recombinant viral vectors, such as alpha viruses, adenoviruses or vaccinia viruses. The recombinant viral-based...
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7381710 |
Combined DNA vaccine and biological modifiers for cancer therapy
The present invention relates to the combination of a DNA vaccination strategy that makes use of a nucleic acid encoding an immunogenic polypeptide, with a non-immunosuppressive inducer of tumor...
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7378273 |
Expression vectors
The present invention provides novel regulatory elements and vectors for the expression of one or more proteins in a host cell. The present invention also provides methods for expressing one or...
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7378086 |
Retroviral vector having an ovalbumin promoter
Vectors and methods are provided for introducing genetic material into cells of a chicken or other avian species. More particularly, vectors and methods are provided for transferring a transgene to...
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7378569 |
Transgenic pigs carrying both hHO-1 and hDAF transgenes for xenotransplantation
The invention provides a transgenic animal carrying two transgenes, one encoding a human decay accelerating factor (hDAF) and the other encoding a human heme oxygenase-1 (hHO)-1, which are useful...
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7378087 |
Method of enhancing an immune response
A method of enhancing an immune response to an antigen is provided. The method involves augmenting the level of a TAP molecule in a target cell bearing the antigen. Preferably, the TAP molecules...
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7374752 |
Reovirus for the treatment of cellular proliferative disorders
Methods for treating proliferative disorders, by administering reovirus to a Ras-mediated proliferative disorder, are disclosed. The reovirus is administered so that it ultimately directly contacts...
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7371374 |
Neural transplantation using pluripotent neuroepithelial cells
The subject invention pertains to a novel method of correction of behavioral and/or psychological deficits made possible by the intracerebral transplantation of pluripotent neuroepithelial cells....
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7364727 |
Metastatic colon cancer specific promoter and uses thereof
Colon cancer specific promoter sequences and adenovirus vehicles are provided. By providing for transcriptional initiating regulation dependent upon transcription factors that are only active in...
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7364726 |
Pharmaceutical composition for cancer treatment containing cells that express a membrane cytokine
This invention comprises cellular vaccines and methods of using them in cancer immunotherapy, particularly in humans. The vaccines comprise a source of tumor-associated antigen, and a...
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7364728 |
Recombinant organisms producing insect toxins and methods for constructing same
This invention is a method for constructing recombinant organisms that produce proteins lethal to the larvae of insects. Nucleotide sequences were isolated from Bacillus popilliae that encode two...
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7364740 |
Molecular differences between species of the M. tuberculosis complex
Specific genetic deletion are identified in mycobacteria isolates, including variations in the M. tuberculosis genome sequence between isolates, and numerous deletion present in BCG as compared...
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7361354 |
Methods for treating malignancies expressing ICAM-1 using coxsackie a group viruses
There is disclosed a method of killing abnormal cells such as malignant cells including melanoma cells, using a virus recognizing at least one of a cell adhesion molecule and a complement...
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7355099 |
AXMI-004, a delta-endotoxin gene and methods for its use
Compositions and methods for conferring pesticidal activity to bacteria, plants, plant cells, tissues and seeds are provided. Compositions comprising a coding sequence for a delta-endotoxin...
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7351697 |
Tumor-specific vector for gene therapy
The invention relates to a vector for the gene therapeutic treatment of tumors, especially in connection with radiotherapy. Said vector is provided with a therapeutic gene in the DNA sequence...
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7351881 |
AXMI-008, a delta-endotoxin gene and methods for its use
Compositions and methods for conferring pesticidal activity to bacteria, plants, plant cells, tissues and seeds are provided. Compositions comprising a coding sequence for a delta-endotoxin and...
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7347998 |
Method of delivering therapeutic agents to site of tissue injury
A viral or non-viral vector particle having a modified viral surface protein wherein the viral surface protein is modified to include a targeting polypeptide including a binding region which binds...
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7344710 |
Combination bacteriolytic therapy for the treatment of tumors
Current chemotherapeutic approaches for cancer are in part limited by the inability of drugs to destroy neoplastic cells within poorly vascularized compartments of tumors. We have here...
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7344711 |
Use of adenoviruses mutated in the VA genes for cancer treatment
This invention refers to the use of an adenovirus for cancer treatment, being this adenovirus defective in its virus-associated (VA) RNAs. Said adenovirus has a mutation in the VAI or VAII gene...
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7344872 |
Method for rapid screening of bacterial transformants and novel simian adenovirus proteins
Chimpanzee serotype C68 proteins, peptides, and polypeptide are provided. Also provided are novel adenoviruses derived from these proteins, as well as compositions containing these proteins and...
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7342002 |
Molecular vaccine linking an endoplasmic chaperone polypeptide to an antigen
This invention provides compositions and methods for inducing and enhancing immune responses, such as antigen-specific cytotoxic T lymphocyte (CTL) responses, using chimeric molecules comprising...
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7341718 |
Neuronal gene transfer of adenovirus and herpes virus vectors
The present invention is related to compositions and methods for the delivery of nucleic acids to neurons in a mammal, and uses thereof. The present invention specifically discloses the use of...
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7338655 |
Gene therapy using TGF-β
The subject invention is related to a cell-mediated gene therapy treatment for orthopedic disease using a member belonging to the transforming growth factor-β (TGF-β) superfamily. TGF-β gene...
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7338656 |
Composition and method to alter lean body mass and bone properties in a subject
A method for decreasing the body fat proportion, increasing lean body mass, increasing bone density, or improving the rate of bone healing, or all, of a subject. Embodiments of the invention...
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7335505 |
Materials and methods relating to protein aggregation in neurodegenerative disease
The present invention provides methods of proteolytically converting a precursor protein (e.g. tau) to a product fragment (e.g., a 12 kd fragment) in a stable cell line, wherein the precursor...
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7332324 |
Attenuated vaccine useful for immunizations against Coccidioides spp. infections
A Coccidioides spp. fungus that is attenuated by the loss of endosporulation potential of the fungus wherein said fungus does not replicate when transformed into the parasitic phase.
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7332337 |
Viral vectors having tissue tropism for T-lymphocytes, B- and mast cells
The present invention relates to methods of introducing an expressible non-viral nucleic acid sequence into a T lymphocyte cell, a B-cell, or a mast cell, comprising contacting the cell with a...
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7329807 |
High-efficiency fusogenic vesicles, methods of producing them, and pharmaceutical compositions containing them
The present invention relates to novel fusogenic vesicles as highly efficient and versatile encapsulation systems for delivering a substance of choice, such as nucleic acids, proteins, peptides,...
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7326692 |
Induction of immunity using inhibitors of granzymes
The present invention provides methods for enhancing host immunity to a virus and/or a cancer and methods for enhancing the cytotoxic T-cell (CTL) mediated immune responses by providing granzyme B...
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7323165 |
Production of pancreatic islet cells and delivery of insulin
The present invention relates to the production of islet cells and insulin in a subject by providing for expression of an islet transcription factors in the pancreas of the subject, by for example,...
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7323623 |
RHIZOC3 nucleic acid molecules
The present invention is directed to nucleic acid molecules tat encode defensive polypeptides and methods of their use in enhancing disease resistance of a plant to a fungal pathogen. Vectors,...
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7320963 |
Methods and compositions for delivery of pharmaceutical agents
Methods and compositions for delivering pharmaceutical agents into cells, in particular urothelial cells of the bladder, are provided. In the methods and compositions of the invention, a...
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