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7517669 |
Gene regulation therapy involving ferritin
A method is described for regulating gene expression related to iron metabolism to ameliorate diseases that include sickle cell disease, cancers, neurodegenerative diseases, Friedreich's ataxia and...
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7517520 |
Packaging of immunostimulatory oligonucleotides into virus-like particles: method of preparation and use
The invention relates to the finding that virus like particles (VLPs) can be loaded with immunostimulatory substances, in particular with DNA oligonucleotides containing non-methylated C and G...
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7510706 |
Pseudotype retroviral vectors containing membrane proteins having hemagglutinin activity
The present invention provides a retroviral vector containing a membrane protein having a hemagglutinin activity. The present inventors constructed a retroviral vector pseudotyped by the membrane...
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7504100 |
Method for delivering a biological compound using neural progenitor cells derived from whole bone marrow
A method is described for generating a clinically significant volume of neural progenitor cells from whole bone marrow. A mass of bone marrow cells may be grown in a culture supplemented with...
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7501126 |
Targeting of herpes simplex virus to specific receptors
The invention relates to engineered Herpes simplex virus (HSV) particles that are targeted to one or more specific receptors. Also, recombinant vectors for producing such HSV particles. By reducing...
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7498024 |
Compositions and methods for enhanced expression of immunoglobulins from a single vector using a peptide cleavage site
Single vector constructs for expression of an immunoglobulin molecule or fragment thereof and methods of making and using the same are described. The vectors comprise a self-processing cleavage...
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7491385 |
Nucleic acid constructs and cells, and methods utilizing same for modifying the electrophysiological function of excitable tissues
Polynucleotide expression constructs, populations of cells and methods of treating diseases caused by dysfunction in, or damage to, excitable tissues are provided.
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7491525 |
Specific proliferation in tumour cell which can express antioncogene with high efficiency and the use of it
The present invention provides a recombinant virus, which highly expresses a cancer therapeutic gene and specifically proliferates in tumor cells, and a method for the proliferation of the same. In...
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7488719 |
Wound and cutaneous injury healing with a nucleic acid encoding perlecan
A description of a biomolecule named Perlecan which is added internally or topically, or is expressed from exogenously added nucleic acids, as a whole or in part, to a healing wound to improve the...
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7485291 |
Compositions and methods for generating multiple polypeptides from a single vector using a virus derived peptide cleavage site, and uses thereof
Single vector constructs for expression of a functional antibody molecule are described. The vectors have a self-processing cleavage site between two heterologous DNA coding sequences allowing for...
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7485318 |
Biodegradable carrier and method for preparation thereof
A biodegradable carrier is produced for preservation and/or controlled delivery of biologically active agents where the biodegradable carrier is a silica xerogel which is made from water and silane...
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7479386 |
HXHV virus, nucleic material, peptide material and uses
Isolated HXHV virus having the following characteristics:
(i) a DNA genome which is at least partially single-stranded, (ii) the said genome comprises one reading frame (ORF) encoding one...
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7476382 |
Reovirus for the treatment of neoplasia
Methods for treating neoplasia, by administering reovirus to a Ras-mediated neoplasm, are disclosed. The reovirus is administered so that it ultimately directly contacts cells of the neoplasm....
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7476530 |
Mycobacterium avium subspecies paratuberculosis oral vaccine and methods
A method of using selective binding properties of killed and live isolates of Mycobacterium avium subspecies paratuberculosis (Map) to gastrointestinal tract mucosa is described which permits:
...
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7473418 |
Pan cancer oncolytic vectors and methods of use thereof
Replication-competent adenoviral vectors which selectively replicate in cancer cells are provided. The replication-competent viral vectors comprise an E2F responsive promoter and/or a telomerase...
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7470426 |
Treatment of neoplasms with viruses
The subject invention relates to viruses that are able to replicate and thereby kill neoplastic cells with a deficiency in the IFN-mediated antiviral response, and their use in treating neoplastic...
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7468181 |
Means and methods for the production of adenovirus vectors
The invention relates to methods and means for the production of adenoviral vectors on complementing cell lines, wherein the early region 4 open reading frame 6 (E4-orf6) encoding nucleic acid is...
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7468182 |
Lactobacillus acidophilus nucleic acids and uses thereof
Lactobacillus acidophilus NCFM nucleic acid molecules, polypeptides, fragments and variants thereof are provided in the current invention. In addition, fusion proteins, antigenic peptides, and...
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7465443 |
Acellular antibordetella vaccine
The invention relates to an immunogenic composition, characterized in that it comprises an adenyl cyclase-hemolysin (AC-Hly) protein, or an immunogenic portion of this AC-Hly, of a strain of ...
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7465454 |
Yeast-based vaccines as immunotherapy
Compositions and methods for treating and/or preventing a variety of diseases and conditions that are amenable to immunotherapy and, in one particular embodiment, compositions and methods for...
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7465442 |
Reduction of dermal scarring
Methods and compositions for reducing or inhibiting dermal scarring by expressing p21 WAF1/Cip1 in a wound site are provided.
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7465583 |
Duplexed parvovirus vectors
The present invention provides duplexed parvovirus vector genomes that are capable under appropriate conditions of forming a double-stranded molecule by intrastrand base-pairing. Also provided are...
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7462351 |
Nucleic acid delivery
The present invention provides formulations and methods to enhance the delivery of nucleic acids to cells. Formulations comprising dextrin polymers in combination with sugars provide enhanced...
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7459153 |
Viral vectors for gene therapy
Adenovirus types 11p and 4p show a higher binding affinity and infectivity than type 5 for endothelial and carcinoma cell lines. Adenovirus type 11p shows a stronger binding to cells for neural...
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7459161 |
Methods for eliciting an immune response using cytolysin and hemolysin fusion proteins
The disclosure below provides a protein export system for efficiently producing recombinant protein from a host cell. In a preferred embodiment, the protein export system utilizes protein export...
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7459154 |
Methods and reagents for the enhancement of virus transduction in the bladder epithelium
Agents and methods for enhancing recombinant virus transduction in the bladder epithelium are described. A first method involves contacting the luminal surface of the bladder with a composition...
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7459602 |
Mammalian cancer cell and transgenic mammal carrying human protooncogene and kit for diagnosing cancer using said protooncogene
The present invention provides a mammalian cell transfected with an expression vector comprising a human protooncogene which has the nucleotide sequence of SEQ ID NO: 1; a mammalian embryo carrying...
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7456008 |
Modified virus comprising one or more non-native polypeptides
A modified virus including one or more non-native polypeptides, and the use of such viruses in therapy, particularly in the treatment of tumours or other cancerous cells are disclosed. The...
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7456009 |
Adenovirus formulations
The invention relates to viral formulations and related pharmaceutical products for use in gene therapy and/or vaccine applications. Especially preferred viral formulations disclosed herein are...
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7452531 |
Compositions and methods for tumor-targeted delivery of effector molecules
The present application discloses the preparation and use of attenuated tumor-targeted bacteria vectors for the delivery of one or more primary effector molecule(s) to the site of a solid tumor....
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7452530 |
Reversal of viral-induced systemic shock and respiratory distress by blockade of the lymphotoxin beta pathway
This invention provides methods of inducing an antiviral response in an individual comprising administering to the individual an effective amount of a LT-B blocking agent and a pharmaceutically...
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7452529 |
Treatment of muscular dystrophy with cord blood cells
The invention features methods for treating a patient suffering from muscular dystrophy by administration of umbilical cord blood cells, e.g., by IV infusion.
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7449178 |
Attenuated gram negative bacteria
Disclosed and claimed are a mutant of a gram negative bacterium, wherein said bacterium has at least one mutation in a nucleotide sequence which codes for a polypeptide having an identity which is...
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7446099 |
Compositions and methods for biodegradable polymer-peptide mediated transfection
Complexes are disclosed which are a combination of a polynucleotide and a biodegradable polyacetal-peptide. The disclosed complexes are useful for cell transfection.
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7445929 |
Recombinant adenovirus vector having a reduced side effect
The present invention provides a novel adenovirus vector for which inflammation during the in vivo administration thereof is alleviated by inhibiting the induction of expression of an adenovirus...
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7442540 |
Polynucleotide encoding coleopteran-toxic polypeptide
Disclosed are novel insecticidal polypeptides, and compositions comprising these polypeptides, peptide fragments thereof, and antibodies specific therefor. Also disclosed are vectors, transformed...
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7438918 |
Lipid A deficient mutants of Neisseria meningitidis
The invention provides lipid A deficient mutant Neisseria meningitidis cells, pharmaceutical compositions incorporating such cells, and methods of using such cells.
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7435723 |
Process for delivery of polynucleotides to the prostate
Disclosed is a system for providing in vivo delivery of polynucleotides to mammalian prostate cells using an intravascular administration route. The polynucleotides are inserted in an injection...
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7435596 |
Modified cell line and method for expansion of NK cell
The present invention relates to novel methods for preferentially activating and expanding NK cells. The methods utilize the stimulatory effects of IL-15 and CD137 ligand to preferentially expand...
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7431922 |
Bioadhesive directed somatic cell therapy
The subject invention is related to a cell-mediated gene therapy treatment using a cell composition that includes bioadhesive material. The bioadhesive material allows targeted and localized...
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7427395 |
Chemotherapeutic agent-incorporated pharmaceutical preparation
An apparatus and a method of remote control which can enable real time operation of a device in home from a terminal device at remote location through a network are provided. A first server...
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7427396 |
AAV vectors for gene delivery to the lung
Methods of making and using recombinant AAV vectors and virions for gene delivery to the lung are described. The recombinant AAV virions are derived from caprine AAV and bovine AAV, both of which...
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7425443 |
Treatment of diabetes with synthetic beta cells
Disclosed is a method for obtaining glucose-regulated expression of active insulin in the cells of a mammalian subject. The method involves delivering into the subject a genetic construct...
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7419659 |
Expression control using variable intergenic sequences
The present invention relates to a method of production of antibodies wherein the heavy and light chains of a particular antibody molecule are encoded by the DNA present in a dicistronic message in...
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7419829 |
Vector system
The present invention provides a vector system comprising a mutated post-transcriptional regulatory element. In particular, the present invention relates to a mutated WPRE sequence that can...
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7419827 |
Cell lines
Genomic instability in T-antigen expressing cells can be overcome by modifying the gene expressing T-antigen so that it lacks Bub1 binding. Stable cell lines can be produced by incorporation of the...
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7414020 |
Human checkpoint kinase, hCDS1, compositions and methods
The invention provides for a novel human checkpoint kinase gene, hCDS1, comprising the nucleic acid sequence of residues 66-1694 of SEQ ID NO: 1, a protein expressed from the gene, fragments and...
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7414173 |
Isolated nucleic acid molecules encoding orally active androctonus amoreuxi pesticidal biopeptides
The present invention provides compositions and methods for isolated nucleic acid molecules encoding orally active Androctonus amoreuxi pesticidal polypeptides. Compositions include novel...
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7413733 |
Antigen transduced T cells used as a delivery system for antigens
A delivery system comprising a T cell comprising at least one antigen capable of loading antigen-presenting-cells with the antigen.
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7410644 |
Recombinant pox virus for immunization against tumor-associated antigens
Recombinant pox viruses capable of expressing cell-encoded, tumor-associated antigens are disclosed. The recombinant viruses are useful for evoking an immune response against the antigen.
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