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8440177 |
Method of treating graft versus host disease using adipose derived mesenchymal stem cells
The present invention relates to the use of a particular type of adipose tissue derived mesenchymal stem cells (AD-MSCs), which exert immunosuppressive properties, in the manufacture of a...
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8440446 |
Bacteriophage strains for the treatment of bacterial infections, especially drug resistant strains of the genus Enterococcus
Novel bacteriophage strains are disclosed and their use in the production of preparations for use in the treatment of bacterial infections, particularly with drug resistant strains of bacteria of...
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8442772 |
Compositions and methods for defining cells
Disclosed are compositions and methods for classifying stem cells. The disclosure provides a way to define cells using a computational analysis.
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8435506 |
Attenuated FNR deficient enterobacteria
The invention provides an attenuated enterobacterium comprising an attenuating mutation in the fnr gene, and optionally further comprising a heterologous nucleic acid encoding a foreign antigen....
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8435788 |
Tissue matrices comprising placental stem cells
A method of manufacturing a tissue matrix for implantation into a patient is disclosed. The method sets forth collecting embryonic stem cells from a placenta which has been treated to remove...
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8431110 |
Compounds and method of identifying, synthesizing, optimizing and profiling protein modulators
This invention relates to methods of identifying, synthesizing, optimizing and profiling compounds that are inhibitors or activators of proteins, both naturally occurring endogenous proteins as...
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8431118 |
Anti-herpes simplex virus antibodies and methods of use thereof
The invention provides antibodies and polypeptides that specifically bind to the glycoprotein D of herpes simplex virus (HSV) and use of the antibodies and polypeptides for treating or diagnosing...
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8431116 |
Norovirus vaccine formulations
The present invention relates to antigenic and vaccine compositions comprising Norovirus antigens and adjuvants, in particular, mixtures of monovalent VLPs and mixtures of multivalent VLPs, and to...
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8431117 |
Sickled erythrocytes with anti-tumor agents induce tumor vaso-occlusion and tumoricidal effects
The present invention provides erythrocytes or nucleated erythrocyte precursors from animals or patients with at least one S hemoglobin allele which are capable of selectively localizing in tumor...
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8420612 |
Diabetes treatment methods and drug targets therefor
Provided are methods of treating insulin resistance or type II diabetes. Disrupting CAP in the macrophage can alter the inflammatory response associated with impaired insulin action and ultimately...
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8420391 |
RNA sequence-specific mediators of RNA interference
The present invention relates to a Drosophila in vitro system which was used to demonstrate that dsRNA is processed to RNA segments 21-23 nucleotides (nt) in length. Furthermore, when these 21-23...
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8415159 |
Tissue scaffolds derived from forestomach extracellular matrix
The present invention pertains to the development of Extracellular Matrix (ECM) scaffolds derived from the forestomach of a ruminant. Such scaffolds are useful in many clinical and therapeutic...
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8414879 |
Superporous hydrogel with cells encapsulated therein and method for producing the same
The present invention is a superporous hydrogel with cells encapsulated within the hydrogel matrix, and a method for producing the same.
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8414880 |
PDT treatment method for cellulites and cosmetic use
Photosensitizer mixtures and method of treating cellulites by light illumination are presented. Photosensitizer is combined with cellular products, e.g. adipose cells, collagen, previously removed...
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8414865 |
Use of Mycobacterium bovis BCG killed by extended freeze drying (EFD) for preventing or treating atherosclerosis
Use of Mycobacterium bovis BCG killed by Extended Freeze Drying (EFD) for preventing or treating atherosclerosis.
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8414884 |
Methods to increase transgene expression from bacterial-based delivery systems by co-expressing suppressors of the eukaryotic type I interferon response
Bacterial delivery systems with improved transgene expression are provided. The recombinant bacterial delivery systems deliver transgenes of interest and suppressors of the eukaryotic Type I...
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8414882 |
Leishmania challenge model
The present invention provides a method for effectively and reproducibly infecting canines with Leishmania infantum using sand flies to vector the parasite. The inventive method comprises several...
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8414886 |
Method of treating disease
This invention relates to compositions comprising a bacterium of the genus Dietzia that is useful for treating paratuberculosis in ruminants and to a method for culturing the bacterium. The...
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8414878 |
Irilis biopreparation based on bacillus-strain bacteria, bacillus subtilis and bacillus licheniformis contained therein
A bioengineering, in particular to develop novel probiotic preparations based on Bacillus-strain bacteria, which can be used for preventing and treating infectious diseases and disbiosis of a human...
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8414881 |
Method for enhancing stem cell trafficking
Consumption of blue-green algae, or extracts thereof, enhances trafficking or homing of stem cells in animals by inducing a transient increase in the population of stem cells present in the...
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8409563 |
Purine-derived substance-producing bacterium and a method for producing a purine-derived substance
A purine-derived substance is produced by culturing a bacterium belonging to the genus Bacillus which is able to produce purine-derived substance and has been modified so that enzymatic activity of...
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8404253 |
Modified live (JMSO strain) Haemophilus parasuis vaccine
The present invention is a culture of cells of Haemophilus parasuis exhibiting attenuated pathogenicity and capable of triggering a protective immune response when administered to pigs as a live...
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8388943 |
Multipotent stem cells from peripheral tissues and uses thereof
This invention relates to multipotent stem cells, purified from the peripheral tissue of mammals, and capable of differentiating into neural and non-neural cell types. These stem cells provide an...
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8388980 |
Yeast-based therapeutic for chronic hepatitis C infection
Disclosed are compositions, including vaccines, and methods for vaccinating an animal against hepatitis C virus (HCV) and for treating or preventing hepatitis C viral infection in an animal. The...
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8388944 |
Inactivating organisms using carbon dioxide at or near its supercritical pressure and temperature conditions
Whole organisms are inactivated by at least a factor of 106 using carbon dioxide at or near its supercritical pressure and temperature conditions.
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8383879 |
Non-human animal disease mode for hepatitis B virus-associated disease
A non-human animal disease model for hepatitis B virus-associated liver disease is disclosed. The animal disease model is transduced with a hepatitis B virus genome in the liver cells thereof and...
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8383095 |
Methods and compositions for enhancing engraftment of hematopoietic stem cells
The present disclosure relates to the field of hematopoietic stem cell transplantation. More specifically, methods, compositions and kits for improving engraftment of stem cell transplants by...
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8383098 |
Multipotent neural stem cells
An isolated multipotent neural stem cells has a phenotype identified by expression of the protein β-tubulin IV and Olig2 and the absence of the proteins NG2, PLP, and GFAP.
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8377430 |
Infant formula with probiotics
The invention relates to an infant formula comprising a source of protein in an amount of not more than 2.0 g/100 kcal, a source of lipids, a source of carbohydrate and a probiotic wherein the...
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8377688 |
Use of MVA to treat prostate cancer
The invention relates to compositions, kits, and methods for cancer prophylaxis and therapy using recombinant MVA viruses encoding tumor-associated antigens, such as PSA and PAP. The recombinant...
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8377450 |
Clone of Newcastle disease virus, its manufacture and its application in the medical treatment of cancer
A new clone of Newcastle disease virus which is interferon insensitive and has an ICPI between 1.2 and 2.0 and which may be used in the treatment of cancer and other diseases.
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8372390 |
Recombiant lentivirus comprising an E2 alphavirus glycoprotein that binds to DC-SIGN
Methods and compositions are provided for delivery of a polynucleotide encoding a gene of interest, typically an antigen, to a dendritic cell (DC). The virus envelope comprises a DC-SIGN specific...
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8367075 |
Synergistic combination and method thereof
A method for the treatment of myeloma and thymoma by administering a therapeutically effective dose of Mycobacterium indicus pranii with Cyclophosphamide. This disclosure generally relates to the...
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8361457 |
Duplexed parvovirus vectors
The present invention provides duplexed parvovirus vector genomes that are capable under appropriate conditions of forming a double-stranded molecule by intrastrand base-pairing. Also provided are...
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8361478 |
Recombinant viral-based malaria vaccines
Described are vaccines against malarial infections, which are based on recombinant viral vectors, such as alpha viruses, adenoviruses, or vaccinia viruses. The recombinant viral-based vaccines can...
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8361456 |
Method of inducing differentiation of bone marrow stromal cells to neural precursor cells, neural precursor cells, and uses thereof
There is provided a method of inducing differentiation of bone marrow stromal cells to neural cells or skeletal muscle cells by introduction of a Notch gene. Specifically, the invention provides a...
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8361482 |
Recombinant BCG tuberculosis vaccine designed to elicit immune responses to mycobacterium tuberculosis in all physiological stages of infection and disease
A vaccine against Mycobacteria tuberculosis (Mtb) is provided. The vaccine comprises a recombinant Bacille Calmette-Guerin (BCG) subunit-based vaccine in which one or more Mtb antigens and one or...
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8357373 |
Methods for stimulating an immune response using bacterial antigen delivery system
The invention relates to the use of the type III secretion system of bacteria to stimulate immune responses against tumor antigen(s) for treating antigen-loss variant tumors. Methods are provided...
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8354119 |
Resorbable extracellular matrix containing collagen I and collagen II for reconstruction of cartilage
A resorbable extracelluar matrix for reconstruction of cartilage tissue includes a mixture of collagen I and collagen II in a respective ratio of from about 1:19 to 19:1. The matrix can be utilized...
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8354100 |
Chondrocyte therapeutic delivery system
Systems and methods for modifying the environment of target cell using genetically altered chondrocytes are provided. The genetically engineered chondrocytes can be used to express a therapeutic...
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8350087 |
Biodegradable thermogelling polymer
There is provided a polymer comprising blocks of at least one polyethylene glycol) block, at least one poly(propylene glycol) block and at least one poly(hydroxybutyrate) block. Also provided is a...
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8343511 |
Methods and compositions for treating inflammatory bowel disease
The present disclosure provides improved compositions comprising rifabutin, clarithromycin, and clofazimine for use in the treatment of Inflammatory Bowel Diseases. In one instance, the...
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8343518 |
Preservation of bioactive materials by freeze dried foam
This invention provides methods and compositions to preserve bioactive materials in a dried foam matrix. Methods provide non-boiling foam generation and penetration of preservative agents at...
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8343480 |
Administration of stem or progenitor cells to a joint to enhance recovery from joint surgery
Disclosed are methods of enhancing recovery from joint surgery, comprising administering to the joint during surgery a composition comprising stem or progenitor cells in an amount effective to...
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8343478 |
Parapoxviruses in combination with other antiviral agents for the treatment of viral diseases
The present invention relates to the use of Parapoxviruses in combination with other agents for the treatment of viral diseases, and in particular HIV infections and AIDS. The invention also...
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8343479 |
Methods and compositions for the repair and/or regeneration of damaged myocardium
Methods, compositions, and kits for repairing damaged myocardium and/or myocardial cells including the administration of stem cells, such as adult stem cells, optionally with cytokines are...
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8337829 |
Conditioned medium and proliferated cell lines produced therefrom
The subject invention pertains to tumor cell lines useful for increasing the proliferation potential of any human or animal cell in culture, thereby providing immortalized or continuous cell lines...
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8337833 |
Methods of improving central nervous system functioning
Methods of causing an improvement in central nervous system function are provided. The methods include administering an aliquot of stem cells to the patient, the cells being derived from blood,...
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8337831 |
Live, oral vaccine for protection against Shigella dysenteriae serotype 1
The invention relates to Salmonella typhi Ty21a comprising core-linked Shigella dysenteriae serotype 1 O-specific polysaccharide (O-Ps) and DNA encoding O antigen biosynthesis, said DNA selected...
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8337828 |
Use of thymosin alpha 1, alone or in combination with PTX3 or ganciclovir, for the treatment of cytomegalovirus infection
It is described the use of thymosin alpha 1 in combination with long pentraxin PTX3 or Ganciclovir, for the preparation of a medicament for the prevention or treatment of viral diseases and/or for...
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