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7312324 Regulatory elements for delivery to the liver  
The invention is directed to novel combinations of liver specific enhancers and promoter elements for achieving persistent transgene expression in the liver. The liver specific enhancer elements...
7312077 Insulin-secreting immortalized liver cell line modified by glucose sensitivity  
The present invention provides a cell line which can be substituted for β cells in human mature pancreatic islets and express insulin in a glucose-concentration dependent manner, and enables the...
7312067 Lactic acid producing bacteria for use as probiotic organisms in the human vagina  
The present invention discloses novel isolated strains of lactic acid producing bacteria of the genera Lactobacillus and Pediococcus , and a method for isolation of such bacterial strains,...
7311907 Lentiviral packaging cells  
Novel packaging cell lines which produce recombinant retrovirus, free of detectable helper-virus are disclosed. Also disclosed are methods of making the cell lines and methods of producing...
7311906 Anti-viral activity of an anti-thymidine kinase monoclonal antibody  
Monoclonal antibodies to thymidine kinase 1 are disclosed which are useful in methods of detecting, diagnosing, and treating viral infection.
7311905 Embryonic-like stem cells derived from post-partum mammalian placenta, and uses and methods of treatment using said cells  
The present invention provides compositions and methods of using embryonic-like stem cells that originate from a post-partum placenta with conventional cord blood compositions or other stem or...
7311904 Tissue matrices comprising placental stem cells, and methods of making the same  
A method of manufacturing a tissue matrix for implantation into a patient is disclosed. The method sets forth collecting embryonic stem cells from a placenta which has been treated to remove...
7309694 Modified cytokines for use in cancer therapy  
Cytokine derivatives capable of homing the tumoral vessels and the antigen presenting cells and the use thereof as antitumoral agents.
7309505 Using mutations to improve Aspergillus phytases  
The present invention invention relates to an isolated nucleic acid molecule encoding a mutant phytase and the isolated mutant phytase itself. The present invention further relates to methods of...
7306927 Method of inducing immunity against stratum corneum chymotrytic enzyme  
The disclosed nucleic acid primer sets, used in combination with quantitative amplification (PCR) of tissue cDNA, can indicate the presence of specific proteases in a tissue sample. The detected...
7306902 Oncolytic viruses as phenotyping agents for neoplasms  
The present invention provides a method of diagnosing neoplasms having a particular phenotype by using oncolytic viruses that selectively replicate in neoplasms having the particular phenotype. For...
7306794 Methods and compositions for the treatment of defects in lipoprotein metabolism  
The invention provides a recombinant viral vector comprising the DNA of, or corresponding to, at least a portion of the genome of an adenovirus, which portion is capable of infecting a hepatic...
7306792 Tumor therapy with alphavirus-based and high affinity laminin receptor-targeted vectors  
The present invention relates to methods and compositions for treating tumors using vectors that preferentially target tumor cells. In particular, the invention relates to Sindbis virus vectors...
7300650 Reovirus for the treatment of neoplasia  
Methods for treating neoplasia, by administering reovirus to a Ras-mediated neoplasm, and use of reovirus for manufacture of a medicament for the treatment of neoplasia, are disclosed. The reovirus...
7297542 Adenovirus vector containing a heterologous peptide epitope in the hi loop of the fiber knob  
The present invention provides means to modify the tropism of recombinant adenoviral vectors using genetic methods to alter the adenoviral fiber cell-binding protein. The present invention...
7297540 Methods of generating tissue using devitalized, acellular scaffold matrices derived from micro-organs  
Methods of generating, and isolating adult stem cells and utilizing such cells and/or embryonic stem cells in generating tissue of a specific function and micro-architecture are provided.
7297329 Mammalian common lymphoid progenitor cell  
A substantially enriched mammalian hematopoietic cell subpopulation is provided, which is characterized by progenitor cell activity for lymphoid lineages, but lacking the potential to differentiate...
7294505 Stable episomal vectors  
The present invention provides a vector system which can be stably translocated from the cytoplasm of a cell to the nucleus where it is a stable nuclear episomal vector. A basic vector system...
7294337 Use of Lactobacillus farciminis for the prevention or treatment of digestive pathologies  
The invention relates to the use of lactic bacteria of the species Lactobacillus farciminis for the treatment or prevention of a pathology of the digestive tube, especially an acute or chronic...
7294334 Methods and compositions to treat myocardial conditions  
Methods, devices, kits and compositions to treat a myocardial infarction. In one embodiment, the method includes the prevention of remodeling of the infarct zone of the ventricle using a...
7294333 Nucleic acid constructs and cells, and methods utilizing same for modifying the electrophysiological function of excitable tissues  
A method of modifying the electrophysiological function of an excitable tissue region of an individual is provided. The method includes the step of implanting cells into the excitable tissue...
7291345 Formable and settable polymer bone composite and method of production thereof  
A composite osteoimplant. The osteoimplant includes a polymer and bone-derived particles. The composite is adapted and constructed to be formable during or immediately prior to implantation and to...
7291325 Method for producing target proteins by deleting or amplifying ibpA and/or ibpB gene coding for inclusion body-associated proteins  
A method for producing target proteins by deleting or amplifying ibpA and/or ibpB genes coding for inclusion body-associated proteins. Two methods for producing target proteins using ibpA and/or...
7285540 Medicament comprising HGF gene  
The present invention relates to a medicament comprising a HGF gene. The medicament of the present invention may be topically applied to the target organs so that the effects can be selectively...
7285538 Gene repair involving in vivo excision of targeting DNA  
Methods of modifying, repairing, attenuating and inactivating a gene or other chromosomal DNA in a cell are disclosed. Also disclosed are methods of treating or prophylaxis of a genetic disease in...
7285527 Tumor radiosensitization using gene therapy  
The invention provides a method of radiosensitizing a tumor in a subject by contacting the tumor with a cytokine or a nucleic acid molecule encoding a cytokine. The invention also provides a method...
7285414 Viruses targeted to hypoxic cells and tissues  
The present invention relates to compositions comprising a novel recombinant virus which replicates selectively in cells or tissues that are hypoxic or have an activated HIF pathway. The novel...
7282200 Mixed-cell gene therapy  
The subject invention is directed to a mixed cell composition to generate a therapeutic protein at a target site by providing a first population of mammalian cells transfected or transduced with a...
7282199 Adeno-associated virus (AAV) serotype 8 sequences, vectors containing same, and uses therefor  
Sequences of a serotype 8 adeno-associated virus and vectors and host cells containing these sequences are provided. Also described are methods of using such host cells and vectors in production of...
7282198 Immunotherapeutic methods targeted towards stratum corneum chymotryptic enzyme  
The present invention discloses the protease stratum corneum chymotrytic enzyme (SCCE) is specifically over-expressed in ovarian and other malignancies. A number of SCCE peptides can induce immune...
7279156 Apoptotic entities for use in treatment of endothelium dysfunction disorders  
Treatment and/or prophylaxis of endothelial dysfunction-related disorders in mammalian patients is effected by administering to the patient effective amounts of apoptotic bodies and/or apoptotic...
7276356 Recombinant negative strand RNA virus expression systems and vaccines  
Recombinant negative-strand viral RNA templates are described which may be used with purified RNA-directed RNA polymerase complex to express heterologous gene products in appropriate host cells...
7276234 Method of acquiring immunological tolerance  
The aim of the present invention is to provide a method of acquiring immunological tolerance to a foreign DNA or its expression product whereby the foreign DNA such as a vector carrying a foreign...
7273855 Use of prohibitin RNA in treatment of cancer  
It has now been found that the introduction of single stranded oligonucleotides of DNA or RNA, particularly RNA transcribed from portions of wild type prohibitin 3′UTR, into tumors leads to...
7270991 Expression system  
A recombinant microorganism comprises an asporogenic Bacillus subtilis strain in which a gene encoding a protease enzyme has been downregulated or inactivated. In particular sigma factorspoIIAC...
7270812 Pharmaceutical composition for treatment of cancers  
The present invention relates to a pharmaceutical composition for treatment of cancers containing Sindbis virus as an active ingredient, a method for treatment of cancers, which comprises...
7270810 Veto cells effective in preventing graft rejection and devoid of graft versus host potential  
A method of transplanting a transplant derived from a donor into a recipient is disclosed. The method comprises the steps of (a) transplanting the transplant into the recipient; and (b)...
7268120 Methods for treating cancer using cytokine-expressing polynucleotides  
The present invention provides a pharmaceutical composition, comprising a non-infectious, non-integrating polynucleotide construct comprising a polynucleotide encoding an interferon ω and one or...
7265095 Monoclonal antibody 3F1H10 neutralising VHSV (viral haemorrhagic septicaemia virus)  
The present invention relates to a non-infectious nucleic acid (RNA and DNA) construct constructed to express a recombinant antibody or antibody fragment in a host cell. The antibody molecule...
7264817 Immunogenic composition based on a truncated derivative of a membrane bound protein and process for making it  
Disclosed is an invention related to the preparation and use of vaccines against pathogenic organisms, such as herpes virus. The vaccines hereof are based upon the use of truncated, membrane-free...
7264798 Sensitization of chemotherapeutic agent resistant neoplastic cells with a virus  
The present invention relates to a method of increasing the sensitivity of neoplastic cells to chemotherapeutic agents by using a virus, a method of treating proliferative disorders with a virus...
7262174 Treatment for wounds  
It has been discovered that increasing telomerase activity in cells surrounding a wound has a variety of effects that enhance wound healing. Replication capacity is enhanced, and the mobility of...
7261887 Leishmania as carriers for the delivery of proteins and peptides  
Methods for delivering potentially therapeutic or prophylactic protein and peptide agents to mammalian cells are provided. The agents are delivered by mutant trypanosomatid protozoa that have been...
7261884 Live genetically attenuated malaria vaccine  
Method for inoculating a vertebrate host against malaria, by administering to the host a live Plasmodium organism that is genetically engineered to disrupt a liver-stage-specific gene function.
7261883 Vaccines containing ribavirin and methods of use thereof  
The present invention relates to compositions and methods for enhancing the effect of vaccines in animals, such as domestic, sport, or pet species, and humans. More particularly, the use of...
RE39789 Tumor therapy  
Neoplasia is treated by administering to a mammalian host a composition comprising ligands for the NKG2D receptor. In addition, other NKG2D ligands, proteins specific for the neoplastic cells and...
7258866 M. canis-containing ringworm vaccine  
A ringworm vaccine is disclosed comprising antigen isolated from at least one dermatophyte and a suitable carrier. The “antigen” can include a single antigen from a dermatophyte or a plurality...
7255879 Post-partum mammalian placenta, its use and placental stem cells therefrom  
The present invention provides a method of extracting and recovering embryonic-like stem cells, including, but not limited to pluripotent or multipotent stem cells, from an exsanguinated human...
7253151 Genes of IL-12P40 subunit mutated for improving the activity of IL-12 and use thereof for DNA vaccine adjuvant  
The present invention relates to the IL-12p40 subunit mutant gene which can produce IL-12(interleukin 12) of human and mouse origin with high activity, the expression vector including above mutant...
7252825 MAGE-3 peptides presented by HLA class II molecules  
The invention describes HLA class II binding peptides encoded by the MAGE-3 tumor associated gene, as well as nucleic acids encoding such peptides and antibodies relating thereto. The peptides...
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