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7074398 |
Retroviral vectors carrying senescent cell derived inhibitors 1 (SDI-1)or antisense SDI-1 nucleotide sequences
The present invention relates to retroviral vectors carrying DNA sequences encoding SDI-1, function analogues of SDI-1, or fragments thereof, or antisense SDI-1 DNA sequences, and especially...
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7074772 |
Design principle for the construction of expression constructs for gene therapy
The invention concerns an expressible nucleic acid construct, which contains only the sequence information necessary for expressing a gene for RNA or protein synthesis. Expression constructs of...
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7074552 |
Method of forming vascularized kidney tissue
A method for constructing a stable bioactive mammalian embryonic kidney is described herein. A kidney so constructed requires no artificial support, nor porous man made membranes or tubing to...
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7070771 |
Methods of expressing chimeric mouse and human CD40 ligand in human CD40+ cells
This invention relates to genes which encode accessory molecule ligands, such as the CD40 ligand and their use for immunomodulation, vaccination and treatments of various human diseases, including...
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7070992 |
Retroviral vectors with foreign-sequence insertion between retroviral primer binding site and retroviral splice donor
The subject of the invention is retroviral gene transfer vectors in which foreign sequences are introduced between the retroviral primer binding site (PBS) and the retroviral splice donor (SD). The...
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7070996 |
Production of cultured human mast cells and basophils for high throughput small molecule drug discovery
Provided are methods for producing and screening proliferated populations of CD34-negative progenitor cells, mucosal mast cells, connective tissue-type mast cells and basophil cells. The methods...
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7067120 |
Cytokine gene modified antigen-presenting cell/tumor cell conjugate, its preparation and use
The present invention provides an antigen-presenting cell(APC)/tumor cell conjugate, wherein the antigen-presenting cell (APC) is modified by a cytokine gene selected from the group consisting of...
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7063835 |
Virus strains
The present invention relates to non-laboratory virus strains, for example of herpes viruses such as HSV, with improved oncolytic and/or gene delivery capabilities as compared to laboratory virus...
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7060790 |
Peptides and nucleic acids derived from Eisenia foetida and the use thereof
The invention concerns Eisenia foetida polypeptides and peptides, particularly recombinant polypeptides, which are useful in tumour therapy, microbial infection, inflammation or immunology. The...
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7060688 |
Products and methods for controlling the suppression of the neoplastic phenotype
A method for gene therapy for cancers wherein chromosomal location of an inactive or defective cancer suppressing gene is established, a replacement gene which is preferably cloned is then used to...
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7060868 |
Autoimmune disease model animal
Pemphigus vulgaris (PV) is an autoimmune disease with a possible fatality of the skin and mucosae which is induced by an antibody against desmoglein 3 (Dsg3). Persistent production of anti-Dsg3...
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7060687 |
Live vaccines for allergy treatment
The invention relates to transformed bacteria of the genus Lactobacillus or Streptococcus, the bacteria having a DNA molecule that includes (1) a nucleotide sequence that encodes a protein...
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7056502 |
Recombinant aav vectors with AAV5 capsids and AAV5 vectors pseudotyped in heterologous capsids
A pseudotyped rAAV is described, which contains sequences derived from AAV5. A method for producing rAAV pseudotyped with AAV5 capsid is described in which the rep proteins of the serotype or any...
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7056699 |
Lentiviral LTR-deleted vector
A vector capable of transducing non-dividing and/or slowly dividing cells is provided, wherein the vector is a lentiviral LTR-deleted vector. Also provided is a method for producing a protein of...
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7056501 |
Recombinant neospora antigens and their uses
The present invention provides isolated bovine Neospora cultures. Also provided are recombinant immunodominant Neospora antigens. The cultures and antigens are used to develop diagnostic assays...
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7056492 |
Mycoplasma hyopneumoniae vaccine and methods for reducing Mycoplasma bovis pneumonia in cattle
The present invention relates to methods for treating or preventing a disease or disorder in an animal caused by infection by Mycoplasma bovis ( M. bovis ) by administering to the animal an...
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7052692 |
Role of tyrosine phosphorylation of a cellular protein in adeno-associated virus 2-mediated transgene expression
The present invention identifies a protein, designated the D-sequence-binding protein (D-BP), is phosphorylated at tyrosine residues and blocks AAV-mediated transgene expression in infected cells...
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7052904 |
Hybrid adeno-retroviral vector for the transfection of cells
An adenovirus, including adenoviral capsid proteins, and a replication-defective adenoviral vector that includes a 5′ retroviral LTR nucleic acid sequence, a 3′ retroviral LTR nucleic acid...
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7052829 |
Prevascularized constructs for implantation to provide blood perfusion
This application discloses methods and materials for preparing functional microvascular beds in the laboratory. These prevascularized constructs can be used to vascularize engineered tissue...
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7052694 |
Dendritic cell potentiation
A molecule capable of potentiating immune responses is described, as well as methods for using the molecule to enhance immune responses and enhance dendritic cell function. Also described are...
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7052703 |
T-cell receptorγ alternate reading frame protein, (TARP) and uses thereof
This invention provides nucleic acids containing sequences from a TCRγ transcript from prostate epithelial cells and many breast cancer cells and a T-cell receptor gamma Alternate Reading frame...
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7045122 |
Salmonella vaccine
The present invention relates to live attenuated Salmonella strains comprising a first attenuating mutation, that are not capable of making functional RecA. The invention also relates to these...
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7045306 |
Method for identifying compounds in vitro that modulate the dysregulation of transcription of transcription mediated by mutant huntingtin protein
The invention relates to methods and products for deregulating gene transcription in neurodegenerative disease associated with an expanded polyglutamine tract in mutant proteins. The invention is...
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7045294 |
Promoter sequences
The present invention relates an isolated human Site-1 Protease promoter region. The invention also relates to screening methods for agents decreasing the expression of Site-1 protease and thereby...
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7041283 |
Methods of using immunophilin binding drugs to improve integration and survival of neuronal cell transplants
A method of treatment of neurodegenerative diseases using neuronal cell transplants is provided. The growth, survival and integration of the transplanted neuronal cells is enhanced by a method of...
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7041653 |
Gene transcription and ionizing radiation: methods and compositions
The present invention provides a DNA molecule comprising a radiation responsive enhancer-promoter operatively linked to an encoding region that encodes at least one polypeptide. An encoding region...
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7041284 |
Recombinant adenoviral vector and method of use
This invention provides a recombinant adenovirus expression vector characterized by the partial or total deletion of the adenoviral protein IX DNA and having a gene encoding a foreign protein or a...
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7037508 |
Pestivirus mutants and vaccines containing the same
The present invention is directed to attenuated pestivirus mutants, which have a reduced ability to replicate as exhibited by a small plaque size. The mutations are in the 5′ nontranslated region...
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7033834 |
Methods and means for targeted gene delivery
A method for producing viral gene delivery vehicles which can be transferred to pre-selected cell types by using targeting conjugates. The gene delivery vehicles comprise: 1) the gene of interest;...
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7033585 |
Immunologically privileged cells and uses thereof
The invention is directed to immunologically privileged cells, e.g., autologous, allogeneic, and xenogeneic intermediate lobe pituitary cells, for delivering polypeptides, e.g., insulin, to a...
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7033586 |
Insecticidal Paecilomyces tenuipes strain FERM BP-7861
The present invention provides a Paecilomyces tenuipes T1 FERM BP-7861, insecticidal compositions, methods and uses. The insecticidal compositions comprise an insecticidally effective amount of ...
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7033584 |
Feeding Thraustochytriales to poultry for increasing omega-3 highly unsaturated fatty acids in eggs
A process is provided for growing microflora of the order Thraustochytriales such as Thraustochytrium, Schizochytrium, and mixtures thereof, in fermentation medium containing non-chloride...
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7030292 |
Method for producing a population of homozygous stem cells having a pre-selected immunotype and/or genotype, cells suitable for transplant derived therefrom, and materials and methods using same
A method of producing a homogenous population of homozygous stem (HS) cells pre-selected for immunotype and/or genotype from donor cells is described herein. The invention relates to methods of...
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7029665 |
Human suppressor tRNA oligonucleotides and methods for use for same
Novel synthetic suppressor tRNA have been provided which provide read-through of internal nonsense mutations, or which can site-specifically alter translation of transcribed sequences. Uses of the...
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7029838 |
Prevascularized contructs for implantation to provide blood perfusion
This application discloses methods and materials for preparing functional microvascular beds in the laboratory. These prevascularized constructs can be used to vascularize engineered tissue...
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7030096 |
Method of enhancing relaxation of penile smooth muscle by introduction of DNA encoding maxi-K potassium channel protein
The present invention is directed towards a method of regulating smooth muscle tone, comprising the introduction, into smooth muscle cells of a subject, of a DNA sequence encoding a protein...
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7030099 |
Tumor specific promoters of the midkine gene that allow for selective expression in P53-inactivated cells
A DNA comprising a 609 bp base sequence from −559 to +50 when the first base sequence of exon 1 of the midkine gene, a human retinoic acid-responsive growth/differentiation factor was set as +1,...
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7029668 |
Stimulation of angiogenesis via enhanced endothelial expression of syndecan-4 core proteins
The present invention provides tangible means and methods for stimulation of angiogenesis via enhanced endothelial expression of core proteins having a syndecan-4 cytoplasmic region...
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7029666 |
Uses for non-autologous mesenchymal stem cells
Methods and devices using non-autologous mesenchymal stem cells comprising treating a recipient in need thereof with an effective amount of non-autologous mesenchymal stem cells, including methods...
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7025998 |
Phytoestrogens and probiotic for women's health
A composition for the relief and/or prevention of climacteric and menopausal disorders affecting women in pre-, peri- or post-menopause, comprising Soy Isoflavones and viable lactic acid bacteria...
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7026113 |
EIA vaccine and diagnostic
The invention provides an equine infectious anemia (EIA) vaccine that provides immunity to mammals, especially equines, from infection with equine infectious anemia virus (EIAV) and which allows...
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7022319 |
Vectors carrying therapeutic genes encoding antimicrobial peptides for gene therapy
The present invention relates to recombinant vectors carrying sequences encoding naturally occurring antimicrobial peptides or derivatives thereof for the treatment of mammalian tumours and viral...
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7022321 |
Use of marrow-derived glial progenitor cells as gene delivery vehicles into the central nervous system
The present disclosure relates to a method for introducing a hematopoietic cell into the brain of a mammal, by administering bone marrow-derived progenitor cells into the body of the mammal by...
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7022830 |
Hepatitis C virus codon optimized non-structural NS3/4A fusion gene
Aspects of the present invention relate to the discovery of a novel hepatitis C virus (HCV) isolate. Embodiments include HCV peptides, nucleic acids encoding said HCV peptides, antibodies directed...
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7018627 |
Macrophage derived chemokine (MDC), MDC analogs, MDC inhibitor substances, and uses thereof
The present invention provides purified and isolated polynucleotide sequences encoding a novel macrophage-derived C—C chemokine designated “Macrophage Derived Chemokine” (MDC), and...
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7018640 |
In ovo vaccination against coccidiosis
The invention relates to a method of vaccinating a domesticated bird against coccidiosis comprising administering in ovo an effective immnunizing dose of live Eimeria sporozoites or merozoites,...
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7018835 |
Recombinant double-stranded RNA phage, and use of the same
A recombinant double stranded RNA (dsRNA) phage expresses dsRNA-encoded genes in eukaryote cells. Recombinant dsRNA phage are useful for the expression of dsRNA expression cassettes encoding...
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7018638 |
Mycoplasma hyopneumoniae bacterin vaccine
The invention provides an improved Mycoplasma hyopneumoniae bacterin vaccine composition, which advantageously provides immunity from infection after a single administration. The composition...
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7014847 |
Methods for preventing reovirus recognition for the treatment of cellular proliferative disorders
The present invention pertains to methods for preventing reovirus recognition in the treatment of cellular proliferative disorders, and particularly ras-mediated cellular proliferative disorders,...
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7015205 |
Melanoma vaccine and methods of making and using same
An immunotherapeutic vaccine providing antigen presenting cells that have been pulsed with a disrupted cell preparation which includes enucleated cytosol and cell membranes of cancer cells infected...
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