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7144575 |
Methods for selectively stimulating proliferation of T cells
Methods for inducing a population of T cells to proliferate by activating the population of T cells and stimulating an accessory molecule on the surface of the T cells with a ligand which binds the...
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7138112 |
Plasmid maintenance system for antigen delivery
The present invention relates generally to a Plasmid Maintenance System for the stabilization of expression plasmids encoding foreign antigens, and methods for making and using the Plasmid...
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7138505 |
Factor VIII:C nucleic acid molecules
Methods and compositions are provided for recombinant DNA production of Factor VIIIC and truncated derivatives thereof. Based on amino acid sequences, probes are developed for isolating messenger...
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7135171 |
Endothelial precursor cells for enhancing and restoring vascular function
The invention provides methods of treating and preventing loss of tissue vascularization that can occur, for example, upon aging.
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7132102 |
Bacteriocins and novel bacterial strains
Novel bacteriocins and/or the novel lactic acid-producing strains are used for at least reducing the levels of colonization by at least one target bacteria in animals, especially poultry.
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7132285 |
Apoptotic entities for use in treatment of neurodegenerative and other neurological disorders
Treatment and/or prophylaxis, in mammalian patients, of neurodegenerative and other neurological medical disorders is effected by administering to the patient effective amounts of apoptotic bodies...
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7125858 |
Hyaluronic acid in the treatment of cancer
The present invention relates to a composition and method comprising purified HA, a second anti-neoplastic agent and a pharmaceutically acceptable carrier, wherein the purified HA and the second...
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7125717 |
Metabolically activated recombinant viral vectors and methods for their preparation and use
Recombinant viral vectors, especially parvovirus vectors such as adeno-associated virus (AAV) vectors, capable of enhanced expression of heterologous sequences, and methods for their construction...
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7125549 |
Methods and compositions for efficient gene transfer using transcomplementary vectors
The invention includes a viral vector method and composition comprising transcomplementary replication incompetent viral vectors, preferably adenoviral vectors, which are cotransformed to a...
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7122192 |
Porcine circoviruses, vaccines and diagnostic reagents
The invention relates to new porcine circovirus strains isolated from pulmonary or ganglionic samples obtained from farms affected by the post-weaning multisystemic wasting syndrome (PMWS). It...
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7122195 |
Mutant mycobacteria for use in therapy
This invention relates to recA mutant mycobacteria, particularly mutants of mycobacterial species which are members of the Mycobacterium tuberculosis complex, such as M. bovis BCG and M....
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7122181 |
Lentiviral vector-mediated gene transfer and uses thereof
The present invention provides lentiviral vectors that are useful in human gene therapy for inherited or acquired proliferative ocular disease. It furnishes methods to exploit the ability of...
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7122714 |
Mouse models of human prostate cancer
The present invention provides an immune deficient mouse having a human prostate xenograft of locally advanced or metastatic prostate cancer and uses thereof.
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7122179 |
Live genetically attenuated malaria vaccine
Method for inoculating a vertebrate host against malaria, by administering to the host a live Plasmodium organism that is genetically engineered to disrupt a gene whose expression is up-regulated...
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7122177 |
Preparation and xenotransplantation of porcine islets
The invention relates to developments in the treatment of diabetes in mammals. Particularly it relates to a method of preparing a xenotransplantable porcine islet preparation capable upon...
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7122178 |
Mesenchymal precursor cell
A method of enriching mesenchymal precursor sells including the step of enriching for cells based on at least two markers. The markers may be either i) the presence of markers specific for...
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7122623 |
Compounds and methods for modulating cell adhesion
Cyclic peptides comprising a cadherin cell adhesion recognition sequence HAV, and compositions comprising such cyclic peptides, are provided. Methods for using such peptides for modulating...
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7118740 |
Method for limiting the growth of cancer cells using an attenuated measles virus
A method for treating cancer cells is provided comprising directly or systemically administering a therapeutically effective dose of an attenuated measles virus. In one embodiment, the...
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7115258 |
Vesicular monoamine transporter gene therapy in parkinson's disease
The present invention provides methods and compositions for the therapeutic intervention of Parkinson's disease. More particularly, methods of making and sequestering dopamine are disclosed....
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7115256 |
Methods of treating schizophrenia
The invention provides methods for the treatment of abnormal psychiatric states, particularly the negative symptoms of schizophrenia and extrapyramidal side effects (EPS) of antipsychotic drugs....
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7112417 |
Foam composite for the repair or regeneration of tissue
The present patent describes a biocompatible composite made of a first fibrous layer attached to a three-dimensional inter-connected open cell porous foams that have a gradient in composition...
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7108855 |
Purified hepatitis C virus envelope proteins for diagnostic and therapeutic use
The present invention relates to a method for purifying recombinant HCV single or specific oligomeric envelope proteins selected from the group consisting of E1 and/or E2 and/or E1/E2,...
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7109029 |
Vector constructs
The present invention provides novel viral vectors and methods useful for the minimization of leaky gene expression, and, in particular, of nonspecific transcriptional read-through of genes. Such...
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7105156 |
Method of using an adenoviral vector encoding a retinoblastoma protein to treat hyperproliferating cells
Disclosed are methods of controlling cell cycle progression by introducing into a cell to be controlled a composition selected from the group consisting of p56 RB protein, a fragment of the p56 RB...
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7105494 |
Viral and non-viral vectors as vehicles for delivering transgenes for treating bone pathologies
The present invention relates to a method for treating bone pathologies comprising delivering a viral or non-viral delivery vehicle comprising genetic information (e.g. a transgene) encoding a...
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7105647 |
cDNAs and proteins involved in hypoxia, circadian and orphan signal transduction pathways, and methods of use
The present invention provides isolated nucleic acids and proteins that are new and distinct members of the bHLH-PAS superfamily of transcription regulators. These “MOPs” (members of PAS) are...
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7105157 |
Methods for treating cancers and pathogen infections using antigen-presenting cells loaded with RNA
The present invention relates to cells and methods for treating or preventing tumor formation or infections with pathogens in a patient. The cells of the invention are antigen-presenting cells...
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7105155 |
Method and activated lymphocyte preparations for preventing recurrence of carcinoma
Activated lymphocytes are administered to a cancer patient at least five or more times within eight months after performing surgical and chemotherapeutic treatment or radiotherapy for treating...
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7101543 |
Genetically modified cells expressing a TGFβ inhibitor, the cells being lung cancer cells
The present invention relates to compositions comprising a therapeutically effective amount of genetically modified cells containing a genetic construct expressing a TGFβ inhibitor effective to...
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7101708 |
Hematopoietic cell composition for use in transplantation
Cell compositions consisting essentially of mammalian hematopoietic CXCR4 + stem and progenitor capable to migrate in response to stromal-derived factor 1 (SDF-1) and/or capable to adhere to...
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7101542 |
Cell-mediated targeting of toxins to pathogenic cells
The invention features vectors encoding immunotoxic fusion proteins containing targeting domains and toxic domains, targeting cells transduced with the vectors, methods of making the targeting...
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7101541 |
Utilization of non-viral sequences for minus-strand DNA transfer and gene reconstitution
A retroviral vector for gene reconstitution is provided that includes a 3′ portion of a heterologous nucleic acid sequence 5′ of a first att site and a 5′ portion of the heterologous nucleic...
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7094419 |
Method of obtaining immune cells from an animal
The present invention is directed to an implantable immune modulation device that is useful for modulating an immune response in mammals, comprising a plurality of fibers, within a porous shell....
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7094410 |
DNA vaccine against proliferating endothelial cells and methods of use thereof
A DNA vaccine effective for inhibiting endothelial cell proliferation comprises a DNA construct operably encoding a vascular endothelial growth factor (VEGF) receptor protein. This invention...
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7094946 |
Animal model for allergic disorders
An animal suitable as a model for an allergic disorder, wherein the animal is an immuno-modulated animal which has been sensitized with an antigen under a specific pathogen free environment such...
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7090836 |
Vector for expressing α-L-iduronidase and method of treating MPS I by stereotactic injection into the brain of a mammal
A purified nucleic acid molecule capable of expressing a lysosomal enzyme, e.g., iduronidase or arylsulphatase, is provided. The molecule includes a promoter of the phosphoglycerate kinase gene to...
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7090840 |
Lactobacillus paracasei subsp. paracasei strain antibacterial against Helicobacter pylori and Escherichia coli 0157:h7
The present invention relates to novel lactic microorganism, method for preparation and uses thereof. Particularly, the present invention relates to novel Lactobacillus paracasei strain (...
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7090837 |
Compositions and methods for tissue specific targeting of lentivirus vectors
This disclosure provides lentiviral vectors containing an attachment incompetent fusogenic polypeptide and a heterologous targeting polypeptide. Also provided are lentiviral packaging constructs,...
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7087582 |
Combination for site-specifically transforming cells in vivo comprising a double-balloon catheter and nucleic acid comprising a gene encoding P21
The present invention provides a combination including a double-balloon catheter and a nucleic acid encoding the cyclin dependent kinase inhibitor p21. The nucleic acid may also encode HLA-B7, an...
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7087226 |
Lysin-deficient bacteriophages having reduced immunogenicity
The present invention features therapeutic bacteriophage deficient in the lysin protein (“Lys minus” phage). Lys minus bacteriophage are incapable of facilitating efficient lysis of the...
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7083794 |
Recombinant vaccines comprising immunogenic attenuated bacteria having RpoS positive phenotype
Attenuated immunogenic bacteria having an RpoS + phenotype, in particular, Salmonella enterica serotype Typhi having an RpoS + phenotype and methods therefor are disclosed. The Salmonella ...
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7078032 |
Delivery of therapeutic biologicals from implantable tissue matrices
Normal cells, such as fibroblasts or other tissue or organ cell types, are genetically engineered to express biologically active, therapeutic agents, such as proteins that are normally produced in...
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7078031 |
Pseudotyped lentiviral vectors and uses thereof
A vector system that will produce a pseudotyped lentiviral vector that can be used to deliver a desired gene is disclosed. The vector constructs that are described include a number of modifications...
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7078231 |
Human pancreatic epithelial progenitor cells and methods of isolation and use thereof
The invention discloses a substantially pure population of human pancreatic progenitor cells and methods of isolating and culturing the pancreatic progenitor cells. By carefully manipulating the...
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7074400 |
Regulatory constructs comprising intron 3 of prostate specific membrane antigen gene
The invention provides regulatory constructs comprising intron 3 of the prostate specific membrane antigen gene (PSMA). An isolated nucleic acid molecule encoding the partial sequence of intron 3...
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7074398 |
Retroviral vectors carrying senescent cell derived inhibitors 1 (SDI-1)or antisense SDI-1 nucleotide sequences
The present invention relates to retroviral vectors carrying DNA sequences encoding SDI-1, function analogues of SDI-1, or fragments thereof, or antisense SDI-1 DNA sequences, and especially...
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7074772 |
Design principle for the construction of expression constructs for gene therapy
The invention concerns an expressible nucleic acid construct, which contains only the sequence information necessary for expressing a gene for RNA or protein synthesis. Expression constructs of...
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7074552 |
Method of forming vascularized kidney tissue
A method for constructing a stable bioactive mammalian embryonic kidney is described herein. A kidney so constructed requires no artificial support, nor porous man made membranes or tubing to...
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7070771 |
Methods of expressing chimeric mouse and human CD40 ligand in human CD40+ cells
This invention relates to genes which encode accessory molecule ligands, such as the CD40 ligand and their use for immunomodulation, vaccination and treatments of various human diseases, including...
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7070992 |
Retroviral vectors with foreign-sequence insertion between retroviral primer binding site and retroviral splice donor
The subject of the invention is retroviral gene transfer vectors in which foreign sequences are introduced between the retroviral primer binding site (PBS) and the retroviral splice donor (SD). The...
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