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7208164 |
Ovo immunization against infectious bronchitis
The present invention is directed to processes and compositions for protecting host animals (e.g., chickens) from exposure to virulent infectious bronchitis virus. In ovo administration of live,...
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7204979 |
Generation of hematopoietic cells from multipotent neural stem cells
Multipotent neural stem cell (MNSC) progeny are induced to generate cells of the hematopoietic system by placing the MNSC progeny in a hematopoietic-inducing environment. The hematopoietic-inducing...
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7204989 |
HEV antigenic peptide and methods
A highly immunoreactive viral peptide, pE2, is disclosed which is derived from the carboxy-terminal end region of ORF2 region of the hepatitis E virus (HEV) genome. A unique feature of the novel...
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7204993 |
Streptococcus agalactiae vaccine
A composition prepared from intact killed cells of isolated β-hemolytic Streptococcus agalactiae and a concentrated extract of a culture of β-hemolytic Streptococcus agalactiae , is effective...
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7202080 |
Method for transdifferentiation of non-pancreatic stem cells to the pancreatic differentiation pathway
The subject invention comprises culture methods for transdifferentiation of non-pancreatic stem cells to the pancreatic differentiation pathway. It also concerns the endocrine hormones that can be...
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7198782 |
Method for the treatment of diabetes
A method for efficiently searching novel physiologically active substances under a certain predictability. This searching method comprises, among receptors of cells producing an antagonist to a...
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7198785 |
Systems and methods related to degradation of uremic toxins
The present invention generally relates to the treatment of uremic toxins in vivo using uremic toxin-treating enzymes, and/or cells capable of producing uremic toxin-treating enzymes or otherwise...
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7198797 |
Process for making larvicidal evaporation suppressant powder
A water-free process for converting initially non-larvicidal evaporation suppressant powder into a larvicidal variant possessing utility both for abatement of use by mosquitoes of an open water...
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7198783 |
Sensitization of neoplastic cells to radiation therapy with reovirus
The present invention relates to methods of sensitizing neoplastic cells to irradiation by using oncolytic viruses, particularly reoviruses. Also provided are methods of treating or ameliorating a...
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7198793 |
Bovine immunodeficiency virus (BIV) based vectors
This invention pertains to BIV constructs encompassing BIV combination vectors, BIV vectors and BIV packaging vectors and particularly the invention pertains to a three vector system comprising: a)...
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7195758 |
Methods of inducing a T cell mediated immune response by administering antigen presenting B cells
We teach a strategy to obtain large quantities of desired APCs, activated B cells, which are superior in their capacity to present tumor protein antigen in a multiadministration protocol. Human B...
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7196070 |
Prophylactic and therapeutic treatment of the ductal epithelium of a mammary gland for cancer
The present invention provides prophylactic and therapeutic methods of treating the ductal epithelium of an exocrine gland, in particular a mammary gland, for disease, in particular cancer. The...
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7192579 |
Methods of gene therapy using nucleic acid sequences for ATP-binding cassette transporter
The present invention provides nucleic acid and amino acid sequences of an ATP binding cassette transporter and mutated sequences thereof associated with macular degeneration. Methods of detecting...
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7192588 |
Vaccine composition and method of using the same
The present invention relates to a stable compacted, compressed or hard tableted injectable composition, including a vaccine composition comprising at least one freeze dried antigenic component and...
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7192580 |
Purging of cells using viruses
The subject invention relates to viruses that are able to purge (reduce or eliminate) undesirable cells in a mixture of cells. Undesirable cells can include neoplastic cells, cells mediating...
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7189390 |
Probiotics for pet food applications
The present invention relates to novel lactic acid bacterial micro-organisms that have been isolated and selected for their probiotic potential and their use for the preparation of petfood...
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7189557 |
Process for the intracellular over-production of streptokinase using genetically engineered strain of E. coli
An improved process for the production of streptokinase using a genetically engineered strain of Escherichia coli which overproduces streptokinase intracellularly and more particularly, the...
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7189391 |
Method of in vitro preconditioning healthy donor's myoblasts before transplantation thereof in compatible patients suffering of myopathies like muscular dystrophy, for improving transplantation success
Methods of pre-treating healthy donor's myoblast cultures with growth or trophic factors on transplantation into subjects suffering from myopathic conditions such as muscular dystrophy....
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7186408 |
Viral CD30 polypeptide
The present invention relates to the identification and characterisation of a viral homologue (vCD30) of mammalian CD30. The vCD30 polypeptide is shown to have immunomodulatory activity and has...
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7183105 |
Eubacterial minicells and their use as vectors for nucleic acid delivery and expression
Th invention provides compositions and methods for the production of achromosomal and anucleate cells useful for applications such as diagnositic and therapeutic uses, as well as research tools and...
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7182943 |
Method and system for modulation of microbial cell characteristics
A method and a system is disclosed for the modulation of various characteristics of probiotic cells and for the production of probiotics having altered characteristics. Such altered characteristics...
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RE39494 |
Inactivated mycoplasma hyopneumoniae and uses therefor
The invention relates to a method for making an inactivated vaccine of Mycoplasma hyopneumoniae by inactivating the bacteria with Thimerosal. The resulting bacterin is mixed with an adjuvant of...
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7179795 |
Nucleic acids encoding chimeric proteins comprising BMP-2 and a proteinase inhibitor
This invention relates to an agent for producing a pharmaceutical drug for postoperative use after removal of bone tumors produced from a nucleic acid by linking a known sequence for promoting bone...
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7179457 |
Modified nodavirus RNA for gene delivery
The invention provides a nodavirus RNA1 molecule modified to include a heterologous insertion which is downstream of its replicase ORF and, preferably, its B2 ORF. The insertion preferably...
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7179456 |
Use of parvovirus for brain tumor therapy
Treatment of brain tumors by a composition including parvovirus, e.g., parvovirus H1, LuIII, Mouse minute virus (MMV), Mouse parvovirus (MPV), Rat minute virus (RMV), Rat parvovirus (RPV), Rat...
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7175840 |
Compositions for gene therapy of rheumatoid arthritis including a gene encoding an anti-angiogenic protein or parts thereof
The present invention relates to the compositions for a gene therapy of rheumatoid arthritis including a gene encoding an anti-angiogenic protein or parts thereof. More specifically, the present...
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7175658 |
Artificial vascular grafts, their construction and use
The present invention relates to artificial vascular grafts, methods for manufacturing and uses for them. The grafts are coated on their lumen with UP50. The grafts comprise an inner surface on...
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7175843 |
Methods for selectively stimulating proliferation of T cells
Methods for inducing a population of T cells to proliferate by activating the population of T cells and stimulating an accessory molecule on the surface of the T cells with a ligand which binds the...
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7176186 |
Stimulation of cell-mediated immune responses by targeted particulate genetic immunization
The present invention relates to various methods of genetic immunization for the purpose of providing antigen-specific immunity in a mammalian host, including a human host. The invention is based...
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7175839 |
Cancer immunotherapy using allostimulated cells in a multiple sequential implantation strategy
This invention provides medicaments and methods for managing cancer using donor cells that are alloactivated in culture. Alloactivated cells are implanted into the bed of a solid tumor and initiate...
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7172893 |
Virus vectors and methods of making and administering the same
The present invention provides genetically-engineered parvovirus capsids and viruses designed to introduce a heterologous gene into a target cell. The parvoviruses of the invention provide a...
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7169394 |
Mycoplasma hyopneumoniae bacterin vaccine
The invention provides an improved Mycoplasma hyopneumoniae bacterin vaccine composition, which advantageously provides immunity from infection after a single administration. The composition...
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7169383 |
Attaching substances to micro-organisms
The invention relates to surface display of proteins on micro-organisms via the targeting and anchoring of heterologous proteins to the outer surface of cells such as yeast, fungi, mammalian and...
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7166277 |
Remyelination of neurons using multipotent neural stem cell progeny
The invention provides methods for producing myelin forming cells from multipotent self-renewing central nervous system neural stem cells as well as methods of using one or more cells from a...
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7166278 |
Modified organs and cells for xenotransplantation
It has been discovered that there are at least two significant antigens present on the cells of animal species such as pigs that elicit an immune or inflammatory response immediately upon...
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7166425 |
Method for detecting low concentrations of a target bacterium that uses phages to infect target bacterial cells
The invention is directed to a method for detecting low concentrations of bacteria in liquid solution that may or may not be complex liquid solutions. In one embodiment, immunomagnetic separation...
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7163678 |
Reovirus for the treatment of ral-mediated cellular proliferative disorders
Methods for treating proliferative disorders, by administering reovirus to a ral-mediated proliferative disorder, are disclosed. The reovirus is administered so that it ultimately directly contacts...
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7163806 |
Somatic cells with ablated PrP gene and methods of use
The present invention comprises a method for producing mammalian therapeutics free from prion contamination and cells for use in such methods. Such therapeutics are produced in somatic cells having...
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7163820 |
Escherichia coli strain for an oral vaccine against post-weaning diarrhea in pigs
The invention relates to a strain suitable for producing a live, orally applicable Escherichia coli vaccine for the prevention of post-weaning diarrhoea in pigs, and the procedure suitable for...
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7164000 |
RANTES mutants and therapeutic applications thereof
RANTES mutants characterised by the substitution or addition of amino acids at the N-terminal of RANTES wild-type sequence and in the N-loop and/or 40's loop regions of RANTES wild-type sequence,...
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7160539 |
Regulation of T cell-mediated immunity by tryptophan
A mechanism of macrophage-induced T cell suppression is the selective elimination of tryptophan and/or increase in one or more tryptophan metabolites within the local macrophage microenvironment...
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7153519 |
Implantable substrate coated with a macromer having free radical polymerizable substituents
Water soluble macromers are modified by addition of free radical polymerizable groups, such as those containing a carbon-carbon double or triple bond, which can be polymerized under mild conditions...
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7153500 |
Production of megakaryocytes by the use of human mesenchymal stem cells
The present invention is directed to hematopoietic progenitor cells isolated from a tissue specimen, such as marrow cells or peripheral blood, and to the method of co-culturing isolated...
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7153839 |
Method of protecting erythricytes, in particular for improvement of blood cytopenia
The present invention concerns a compound consisting of RNA, in particular RNA extracted from yeast, a pharmaceutical composition comprising such RNA and a method for the treatment of inflammatory...
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7155288 |
Method and system for myocardial infarction repair
An implantable system is provided that includes: a cell repopulation source comprising genetic material, undifferentiated and/or differentiated contractile cells, or a combination thereof capable...
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7148323 |
Major neutralization site of hepatitis E virus and use of this neutralization site in methods of vaccination and in methods of screening for neutralizing antibodies to hepatitis E virus
The invention describes the identification of a major neutralization site of hepatitis E virus (HEV) and the use of this neutralization site in methods of vaccination and in methods of screening...
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7147861 |
Human cytomegalovirus glycoprotein O as a new drug target and subunit vaccine candidate
A method of designing a new anti-CMV drug is disclosed. In one embodiment, the invention comprises (a) analyzing the binding of glycoprotein O to a glycoprotein O receptor and (b) designing a...
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7147848 |
Recombinant poliovirus for the treatment of cancer
The present invention is directed to non-pathogenic, oncolytic, recombinant polioviruses for the treatment of various forms of malignant tumors. The recombinant polioviruses of the invention are...
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7147846 |
Prosthetic grafts
An improved prosthetic graft for the bypass, replacement or repair of vessels and organs that are in contact with blood flow is disclosed. The prosthetic graft includes a porous prosthetic implant...
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7144729 |
Methods and compositions for tissue regeneration
The present invention provides the use and composition of matter of angiogenic or other growth/cytokine factors expressed by mixtures of allogeneic human cell strains or lines of various types and...
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