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7438914 |
Composition and method for enhancing immune response
A composition and method for enhancing immune response in a living organism is disclosed. In particular, the present disclosure provides an adjuvant peptide for use in raising an immune response to...
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7431922 |
Bioadhesive directed somatic cell therapy
The subject invention is related to a cell-mediated gene therapy treatment using a cell composition that includes bioadhesive material. The bioadhesive material allows targeted and localized...
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7429375 |
Proteoglycan degrading mutants for the treatment of CNS
The present disclosure relates to the preparation and deletion mutants of chondroitinase proteins and their use in methods for promoting the diffusion of therapeutic composition into tissues and...
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7427602 |
Sustained DNA delivery from structural matrices
Disclosed are particular 3-dimensional structural matrices containing nucleic acids, various fabrication processes and methods for the prolonged release of nucleic acids in various biological...
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7427396 |
AAV vectors for gene delivery to the lung
Methods of making and using recombinant AAV vectors and virions for gene delivery to the lung are described. The recombinant AAV virions are derived from caprine AAV and bovine AAV, both of which...
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7425410 |
Methods for diagnosing a bipolar disorder and unipolar disorder
Changes that occur in Na+K+ ATPase regulation and therefore in the membrane potential in cells from bipolar individuals, as compared to cells from unaffected control individuals, are utilized to...
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7422746 |
Chemically programmable immunity
Methods and compositions for immediately immunizing an individual against any molecule or compound. The present invention comprises an immunity linker with at least two sites; (1) at least one...
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7422736 |
Somatic pluripotent cells
The present invention discloses a cultured somatic animal cell having a normal karyotype; the cell develops into an embryoid body when induced in vitro, or develops into a teratoma when introduced...
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7419661 |
Dermal sheath tissue in wound healing
The invention concerns the use of dermal sheath tissue and/or cells derived therefrom in wound healing systems. Specifically, the relevant features of this tissue type have been exploited to...
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7419829 |
Vector system
The present invention provides a vector system comprising a mutated post-transcriptional regulatory element. In particular, the present invention relates to a mutated WPRE sequence that can...
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7413732 |
Baculovirus expression system
The application relates for method for cloning the gene comprising the steps of: 1. Providing a replication-deficient baculovirus vector, 2. Providing a rescue vector comprising (a) nucleic acid...
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7413728 |
Immune modulator
Use of an immune modulator composition and/or pharmaceutical composition comprising a whole cell of a bacterium from the genera Rhodococcus, Gordonia, Nocardia, Dietzia, Tsukamurella and ...
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7413901 |
Method of forming vertebrate pancreas in vitro
The present invention provides a pancreas induced in vitro that is useful for developmental engineering and organ engineering, and a method wherein a pancreas induced in vitro which contributes to...
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7413733 |
Antigen transduced T cells used as a delivery system for antigens
A delivery system comprising a T cell comprising at least one antigen capable of loading antigen-presenting-cells with the antigen.
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7410637 |
Transgenic algae for delivering antigens to an animal
Delivery systems and methods are provided for delivering a biologically active protein to a host animal. The systems and methods provided include obtaining an algal cell transformed by an...
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7410787 |
Diagnosis of Whipple's disease
The invention relates to a method for in vitro seriological diagnosis of Whipple's disease, whereby the bacteria responsible for the disease are isolated and established in a culture and brought...
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7407805 |
Skin substitutes with improved barrier function
The present invention relates to in vitro cultured skin substitutes, and in particular to in vitro cultured skin substitutes that have improved barrier function. In some embodiments, improved...
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7404950 |
Induced activation in dendritic cell
The present invention is directed to a composition and method which to treat diseases and to enhance a regulated immune response. More particularly, the present invention is drawn to compositions...
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7405292 |
Cellular genes regulated by HIV-1 infection and methods of use thereof
This invention provides cellular gene products which have anti-apoptotic activity in HIV-1 infected cells and provides agents for the inhibition of the cellular gene products.
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7402306 |
Cancer immunotherapy with semi-allogeneic cells
The present invention relates to improved semi-allogeneic immunogenic cells which act to stimulate and induce an immunological response when administered to an individual. In particular, it relates...
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7402429 |
Host cells comprising cDNA corresponding to the antigenome of nonsegmented negative strand RNA viruses, further encoding antigenically active proteins
The present invention relates, in general, to a methodology for the generation or nonsegmented negative-strand RNA viruses (Pringle, 1991) from cloned deoxyribonucleic acid (cDNA). Such rescued...
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7399476 |
Nucleic acid free ghost preparations
The invention relates to preparations of bacterial ghosts which are substantially free of living bacterial cells and/or nucleic acids and their use in pharmaceutical preparations.
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7399750 |
Methods for cardiac gene transfer
Methods for the delivery of genes to improve cardiac function including the use of viral vectors, isolation of the heart from systemic circulation, and induction of hypothermia/cardiac arrest are...
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7396528 |
Corneal cells expressing active agents and methods of use thereof
The invention relates to methods of modifying cells of corneal tissue to express an active agent, to modified corneal tissue, to vectors utilised in such methods and to methods of xeno- and...
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7396537 |
Cell delivery patch for myocardial tissue engineering
A patch for cardiac tissue engineering includes a gel layer supported by an intermediate layer, which is attached to a reinforcement layer. These patches may be implanted in a heart to treat...
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7396822 |
Immunogenic minicells and methods of use
The disclosed invention relates to immunogenic minicells cells (anucleated) and their use to induce an immune response from a subject.
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7393525 |
Method for introducing and expressing genes in animal cells, and live invasive bacterial vectors for use in the same
A method for introducing and expressing genes in animal cells is disclosed comprising infecting said the animal cells with live invasive bacteria, wherein bacteria contain a eukaryotic expression...
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7393524 |
Baculovirus vectors comprising a capsid polypeptide fused to a GNRH polypeptide
The invention relates to a genetically engineered baculovirus wherein said virus is engineered to target therapeutic agents to cells, typically cancer cells, for example prostate cancer cells.
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7393526 |
Systemic gene delivery vehicles for the treatment of tumors
The present invention relates to the field of cellular and molecular therapy with modified (genetically or growth factor engineered) and unmodified stem cells (SCs). More particularly, the...
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7393527 |
Method for limiting the growth of cancer cells using an attenuated measles virus
A method for treating cancer cells is provided comprising directly or systemically administering a therapeutically effective dose of an attenuated measles virus. In one embodiment, the...
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7393541 |
Mycobacterial vaccine
Compositions and methods for enhancing the immunity of a subject or vaccinating a subject against mycobacterial infections are disclosed. The invention provides compositions comprising formalin...
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7390482 |
Drug for auditory dysfunction
The present invention provides a pharmaceutical preparation for hearing impairment, which is suitable for gene therapy of hearing impairment, that is, a pharmaceutical preparation for hearing...
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7390483 |
Universal GM-CSF expressing bystander human K562 cell line
The present invention provides a universal immunomodulatory cytokine-expressing bystander cell line, a composition comprising such a cell line and a cancer antigen, a method of making such a cell...
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7387894 |
Recombinant viral-based malaria vaccines
The present invention relates to novel vaccines against malaria infections, based on recombinant viral vectors, such as alpha viruses, adenoviruses or vaccinia viruses. The recombinant viral-based...
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7387773 |
Vaccine
The invention provides a vaccine comprising secreted protein derived from Mycobacterium avium subsp paratuberculosis ( M. ptb ) substantially free of whole organisms of that species either dead...
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7384627 |
Antitumor agents with the use of HSV
It is intended to provide highly safe antitumor agents which exhibit an antitumor effect on human remote tumors such as metastatic tumors too and by which an antitumor immune reaction enabling an...
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7378078 |
Compositions and methods for detecting proteolytic activity
The invention provides compositions and methods for non-invasive imaging of enzyme (e.g., protease) activity in cells, tissues and organs and entire bodies in vitro, in vivo and in situ. The...
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7374753 |
Probiotic lactic acid bacterium to treat bacterial infections associated with SIDS
Compositions including a non-pathogenic lactic acid-producing bacteria, such as a Bacillus species, spores or an extracellular product of B. coagulans , formulated for oral administration to the...
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7374752 |
Reovirus for the treatment of cellular proliferative disorders
Methods for treating proliferative disorders, by administering reovirus to a Ras-mediated proliferative disorder, are disclosed. The reovirus is administered so that it ultimately directly contacts...
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7364725 |
Endothelial cells engineered to express or overexpress fibulin-5 and a growth factor
The present invention relates to endothelial and smooth muscle cells genetically altered to express or over-express one or more cell adhesion factors. The invention further relates to cells...
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7364740 |
Molecular differences between species of the M. tuberculosis complex
Specific genetic deletion are identified in mycobacteria isolates, including variations in the M. tuberculosis genome sequence between isolates, and numerous deletion present in BCG as compared...
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7361354 |
Methods for treating malignancies expressing ICAM-1 using coxsackie a group viruses
There is disclosed a method of killing abnormal cells such as malignant cells including melanoma cells, using a virus recognizing at least one of a cell adhesion molecule and a complement...
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7361359 |
Neospora caninum isolate
The present invention relates to a novel Neospora caninum isolate from Nowra and extracts thereof. The strain is useful in the development of diagnostic assays for the detection of parasites in...
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7361332 |
Treating tumors using implants comprising combinations of allogeneic cells
This invention provides methods and compositions for treating tumors. The cell population is made up of alloactivated lymphocytes from the patient or from one or more third-party donors that are...
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7361334 |
Method of treatment of diabetes through induction of immunological tolerance
A method of creating tolerance to transplanted cells, tissue, or organs without the need for continuous immunosuppression. A tolerizing dose of a cell or tissue within a membrane structure is...
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7361639 |
Gene therapy agent for Haemophilia B and its preparation method
The invention relates to site-specific integrating expression vectors for therapy Hemophilia B and to methods of preparing them. A vector of the invention contains a human Factor IX gene in a...
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7361497 |
Probiotic bacteria
Strains of probiotic bacteria, their isolation, characteristics and methods of use to prevent or treat carriage by a food production animal of Salmonella that causes human salmonellosis are...
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7361333 |
Prevention of diabetes through induction of immunological tolerance
A method of creating tolerance to transplanted cells, tissue, or organs without the need for continuous immunosuppression. A tolerizing dose of a cell or tissue within a membrane structure is...
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7354749 |
Decellularisation of matrices
A method of preparing matrices or tissue engineered biomaterials for implantation, and in particular to a method of improving decellularisation of matrices or tissue engineered biomaterials prior...
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7347997 |
Method of using a feedstuff additive
Microorganism of the genus Eubacterium , and its obtainment and use, which is suitable in pure culture, DSM 11798, and/or mixed culture with the strain Enterococcus casseliflavus , DSM 11799, or...
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