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6413523 |
Pharmaceutical composition of escherichia coli heat-labile enterotoxin adjuvant and methods of use
Novel immunoregulatory utilities of Escherichi coli heat-labile enterotoxin (LT) are disclosed. This enterotoxin can be used in combination with an unrelated antigen to achieve a higher immune...
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6413943 |
Methods and reagents for inhibiting proliferation of smooth muscle cells
Disclosed are methods for using ΔE1/ΔE4 recombinant adenoviruses encoding cyclin dependent kinase inhibitors (CDKi's) as reagents for inhibiting smooth muscle cell proliferation. Also disclosed...
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6413517 |
Identification of broadly reactive DR restricted epitopes
The present invention is based on peptide binding specificities of HLA DR4w4, DR1 and DR7. Peptides binding to these DR molecules have a motif characterized by a large aromatic or hydrophobic...
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6410320 |
Method and compositions for isolation and growth of kidney tubule stem cells, in vitro kidney tubulogenesis and ex vivo construction of renal tubules
Methods, including culture media conditions, which provide for isolation and purification of renal tubule stem cells and for in vitro kidney tubulogenesis are disclosed. The methods rely on...
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6410041 |
Culturing cells in presence of amphipathic weak bases and/or cations and multiple drug resistance inhibitor containing reserpine
Methods are provided relating to the enhanced cytoplasmic accumulation of amphipathic weakly basic or amphipathic cationic molecules in prokaryotes and eukaryotes under conditions of high...
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6410297 |
Processes for preparation of Marek's disease virus using continuous avian cell lines
The present invention relates to avian cell lines which efficiently support the growth and productive infection of Marek's Disease Virus at high titers. The present invention also relates to avian...
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6410016 |
Method for administering viable microorganism composition for poultry
A method for administering viable microorganism compositions for poultry, comprising: administering a viable microorganism composition comprising viable lactic acid bacteria belonging to ...
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6410010 |
Recombinant P53 adenovirus compositions
Described are simplified and efficient methods for preparing recombinant adenovirus using liposome-mediated cotransfection and the direct observation of a cytopathic effect (CPE) in the transfected...
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6406861 |
Methods of enhancing effectiveness of therapeutic viral immunogenic agent administration
Methods of reducing pre-existing humoral immunity to a viral immunogenic therapeutic agent such as adenovirus, using immunoapheresis are disclosed. Antibodies specific for the viral immunogenic...
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6406689 |
Compositions and methods for treatment of tumors and metastatic diseases
Compositions and methods are provided which can be utilized in active immunization as a prophylactic treatment or a therapeutic treatment for tumors. The compositions are employed as injectable...
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6403100 |
Method of attenuating pathogenic mycobacteria and strains of mycobacteria so attenuated
This invention provides for novel attenuated strains of Mycobacterium tuberculosis and M. bovis. Attenuation is achieved by eliminating or by downregulating the expression of the α-crystallin...
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6403080 |
Methods of modulating an immune response to antigen, and cells for use in the method
Disclosed are methods and compositions wherein opsonin-enhanced cells, that is, cells which have been 1) modified so as to express an opsonin from a recombinant nucleic acid, 2) modified so as to...
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6403104 |
Hapten-conjugated mammalian cells and methods of making and using thereof
The present invention is directed to mammalian cells conjugated to a hapten and methods of making and using thereof. Conjugating hapten to mammalian cells is a useful way of preventing cells from...
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6403095 |
Treatment of primary and metastatic neoplastic diseases with HSP70-peptide complexes
The present invention relates to methods and compositions for eliciting an immune response and the prevention-and treatment of primary and metastatic neoplastic diseases and infectious diseases....
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6399070 |
Methods and compositions for eliciting an immune response with hsp90-peptide complexes
The present invention relates to methods and compositions for eliciting an immune response and the prevention and treatment of primary and metastatic neoplastic diseases and infectious diseases....
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6399385 |
Methods for rapid PEG-modification of viral vectors, compositions for enhanced gene transduction, compositions with enhanced physical stability, and uses therefor
A rapid method for modifying a viral capsid or envelope protein with a polyethylene glycol (PEG) is described. Also provided are methods of delivering a molecule using the PEG-modified viruses of...
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6399383 |
Human papilloma virus vectors
The invention provides human papillomavirus vectors useful in gene therapy. Such a vector contains E1 and E2 coding regions from a benign or low-risk human papillomavirus operably linked to a...
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6387367 |
Human mesenchymal stem cells
Human mesenchymal stem cells having the phenotype SH3+, CD45+ can be isolated. These precursor mesenchymal item cells are useful for treatment of patients in need of mensenchymal stem cell.
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6387368 |
Hybrid adenovirus-AAV virus and methods of use thereof
The present invention provides a hybrid vector construct which comprises a portion of an adenovirus, 5′ and 3′ ITR sequences from an AAV, and a selected transgene. Other hybrid vectors form a...
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6387366 |
Methods for reducing adverse side effects associated with cellular transplantation
The methods of the present invention are based on the discovery that adverse side effects (such as hemorrhage) can occur upon infusion of cells that express tissue factor. Accordingly, the methods...
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6383481 |
Method for transplantation of hemopoietic stem cells
This invention relates to a method of transplanting hemopoietic stem cells which Comprises subjecting a recipient to a radiation treatment using an effective exposure dose for hemopoietic stem cell...
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6384018 |
Polynucleotide tuberculosis vaccine
Genes encoding Mycobacterium tuberculosis ( M.tb ) proteins were cloned into eukaryotic expression vectors to express the encoded proteins in mammalian muscle cells in vivo. Animals were...
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6383494 |
Methods and composition for eliciting an immune response with gp96-peptide complexes
The present invention relates to methods and compositions for eliciting an immune response and the prevention and treatment of primary and metastatic neoplastic diseases and infectious diseases....
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6384202 |
Cell-specific active compounds regulated by the cell cycle
A DNA sequence is described for the gene therapy of diseases associated with the immune system. In its essential elements, the DNA sequence is composed of an activator sequence, a promoter module...
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6376185 |
DNA sequences of genes from fimbriae d'escherichia coli strain DSM 6601
The invention relates to DNA sequences from fimbrial gene clusters of Escherichia coli strain DSM 6601. This strain has two chromosomal fimbrial gene clusters, namely type I (fim) and FIC (foc)...
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6375929 |
Gene therapy for inhibition of angiogenesis
The present invention relates to methods of gene therapy for inhibiting angiogenesis associated with solid tumor growth, tumor metastasis, inflammation, psoriasis, rheumatoid arthritis,...
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6376228 |
Heterophil-adapted poultry vaccine
A method for vaccinating poultry to prevent salmonellosis and other microbial-related health problems in humans is described. The method involves isolation of a poultry heterophil-adapted strain of...
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6368852 |
Peptide capable of inducing immune response to human gastric cancer and agent for preventing or treating human gastric cancer, containing the peptide
A peptide that induces CTL against human gastric cancer cells is provided. A peptide having a specific amino-acid sequence and induces cytotoxic T cells that targets gastric cancer cells may be...
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6368600 |
Parasitic helminth cuticlin nucleic acid molecules and uses thereof
The present invention relates to: parasitic helminth cuticlin proteins; parasitic helminth cuticlin nucleic acid molecules, including those that encode such cuticlin proteins; antibodies raised...
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6368593 |
Enhanced immunogenic cell populations prepared using H2 receptor antagonists
This invention provides a method to enhance alloactivation in a mixed lymphocyte culture. Alloactivated cells are effective in treating tumors when implanted into a tumor site or coinjected with...
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6365153 |
Mechanically elongated neuronal cells and methods for producing and using these cells
Mechanically elongated neuronal cells and methods of mechanically producing elongated cells are provided. Also provided are methods for transplanting elongated neuronal cells into an animal for...
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6365148 |
Enteric coated microgranules for stabilizing lactic acid bacteria
The present invention relates to an enteric coated granule prepared by coating lactic acid bacteria-containing seed with a water-miscilble coating material and then, if desired, subjecting the...
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6365147 |
Methods for removing endotoxins from biological solutions using immobilized metal affinity chromatography
The present invention relates to methods for depleting endotoxin from biological solutions by exposure of solutions containing endotoxin to an immobilized metal affinity chromatography matrix...
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6362392 |
Nude mouse model for the growth and treatment of human neurally-derived tumors
A method for treating a neurofibrosarcoma tumor comprising administration of heparin and an angiostatic steroid is disclosed. Animal models for the growth of neurally-derived tumors and for testing...
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6361770 |
Method of enhancing expression of MHC class I molecules bearing endogenous peptides
A method of enhancing expression of MHC Class I molecules bearing endogenous peptides on the surface of a target cell expressing low or nondetectable levels of MHC Class I molecules and expressing...
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6358521 |
Fermented milk nutraceuticals
Fermented milk products produced by a culture comprising at least one strain of the group Er-2 with the strain N.V. Er 317/402 of Lactobacillus acidophilus and, optionally, a Lactobacillus...
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6355238 |
Specific immune system modulation
Methods and pharmaceutical compositions for modifying the immune response of a mammal to a specific antigen are provided. The methods include treating an antigen presenting cell to enhance...
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6342216 |
Therapy of cancer by insect cells containing recombinant baculovirus encoding genes
Provided are compositions and methods of use for insect cells comprising baculovirus encoding non-surface expressed proteins and peptides. The claimed invention particularly relates to compositions...
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6342386 |
Methods for removing undesired growth from a surface
Disclosed are compositions and/or paints containing hydrolytic enzyme(s), microorganism(s), or mixtures of the hydrolytic enzyme(s) and microorganism(s), wherein the microorganism or hydrolytic...
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6342390 |
Lipid vesicles containing adeno-associated virus rep protein for transgene integration and gene therapy
A composition for delivering at least one DNA sequence encoding a desired protein or polypeptide (such as a therapeutic agent) to a cell. The composition comprises an adeno-associated virus rep...
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6333028 |
Method of using haptenized ovarian carcinoma tumor cells
The present invention is directed to compositions and methods of treating cancer. The compositions of the present invention include a composition prepared from a tumor cell which is hapten modified...
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6333030 |
Chimeric retrovirus/adenovirus system
The present invention provides a chimeric viral vector system having a highly efficient in vivo gene delivery to cells after vascular administration and an intergrative capacity of heterologous...
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6333188 |
Lactic acid bacteria preparation having biopurification activity
Although the inventors previously found that the novel species designated Lactobacillus clearans was highly effective for health purposes, they noted in particular that this species lacked...
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6331284 |
P202 is a tumor suppressor
The present invention relates generally to the fields of cancer therapy and gene therapy. More particularly, the invention demonstrates methods for repressing or preventing transformation and...
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6328969 |
Method and compositions for stimulation of an immune response to a differentiation antigen stimulated by an altered differentiation antigen
Tolerance of the immune system for self differentiation antigens can be overcome and an immune response stimulated by administration of a therapeutic differentiation antigen. The therapeutic...
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6325999 |
Use of Fas ligand to suppress T-lymphocyte-mediated immune responses
A method for inhibiting T-lymphocyte-mediated immune responses, including those directed against autologous and/or heterologous tissues, e.g., by a recipient mammal of a transplanted tissue, said...
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6322782 |
Bacterium NRRL B-30043 for controlling algae
A method of reducing or eliminating off-flavor in water or fish by controlling cyanobacteria or algae in the water wherein cyanobacteria or algae produce agents that cause the off-flavor. The...
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6323024 |
Coxsackie virus vectors for delivery of nucleic acids encoding antigenic or therapeutic products
The present invention is drawn to the use of attenuated Coxsackievirus cardiotropic virus vectors as efficient gene transfer vectors to deliver immunomodulatory or other biologically active...
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6323321 |
Antibody 97A6
The present invention relates to a monoclonal antibody binding an antigen on the megakaryocytic cell line UT-7. The invention further relates to hybridoma cells producing such an antibody.
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6319905 |
Method of controlling L-Dopa production and of treating dopamine deficiency
The present invention provides an effective approach to achieve the tightly modulated production of L-DOPA and/or dopamine at a preselected target location in the brain of a mammal by combining...
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