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6495132 |
Method for producing polypeptides
There is provided a method for producing a polypeptide using a recombinant baculovirus according to the present invention, wherein said recombinant baculovirus is constructed by ligating the...
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6491924 |
Chlamydia pneumoniae antigenic polypeptide
Chlamydia pneumoniae antigenic polypeptides, which comprise polypeptide A containing a sequence of at least 5 consecutive amino acids in the polypeptide of SEQ ID NO: 1; DNAs encoding the...
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6491907 |
Recombinant parvovirus vectors and method of making
The present invention provides genetically-engineered parvovirus capsids and viruses designed to introduce a heterologous gene into a target cell. The parvoviruses of the invention provide a...
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6491910 |
Ovo administration of a competitive exclusion culture
An improved method of competitively excluding pathogens capable of intestinal colonization, such as Salmonella or Cambylobacter, from a digestive tract of a bird comprises administration in ovo to...
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6488926 |
Vaccine compositions
The invention provides a DNA construct comprising a DNA sequence encoding a fusion protein of the formula: TetC-(Z) a -Het, wherein: TetC is the C fragment of tetanus toxin, or a protein comprising...
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6485720 |
Transgene expression systems
The present invention relates to transgene expression systems, related compositions comprising the transgene expression systems, and methods of making and using them. Preferred systems employ an...
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6485722 |
Method for selective engraftment of drug-resistant hematopoietic stem cells
A method to increase the efficiency of hematopoietic stem cell engraftment in vivo is provided.
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6482406 |
Cell-based gene therapy for the pulmonary system
Cell-based gene transfer is effected by administering transfected cells containing an expressible transgene coding for an angiogenic factor or other therapeutic factor, into the pulmonary...
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6479281 |
Infectious pseudotyped lentiviral vectors lacking matrix protein and uses thereof
Vector systems that encode viral proteins that will assemble into an infectious lentivirus particle having a deletion of the lentiviral matrix are described. In one embodiment the vectors encode a...
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6479286 |
Methods and compositions for making dendritic cells from expanded populations of monocytes and for activating T cells
Methods of generating IL-3 expanded populations of monocytes and differentiating the cells into dendritic cells are provided. The methods include use of the dendritic cells to activate T-cells, in...
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6475503 |
Methods of using worm castings for insect repellency
The present invention describes a material and a method for repelling insects. The method consists of disposing a naturally formed chitinase about an area to be protected. The naturally formed...
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6475781 |
Trans-dominant suppressor genes for oligomeric proteins
The invention features two methods for making eucaryotic trans-dominant suppressor genes encoding polypeptide translation products capable of suppressing the activity of a growth factor that...
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6475770 |
Processes for preparation of Marek's Disease using continuous mammalian cell lines
The present invention relates to mammalian cell lines which efficiently support the growth and productive infection of Marek's Disease Virus at high titers. The present invention also relates to...
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6471966 |
Type 1 and type p fimbriae-adhesins isolated from novel e. coli strains, process for their preparation and uses thereof
Fimbriae adhesins have a molecular weight of 2×10 5 and 2×10 7 Da, and are comprised of 90-95% protein and 1-3% sugar. Type 1 fimbriae include five different protein fractions of 14-20 kDa,...
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6472374 |
Endometrial function
Disclosed is a method of altering one or more characteristics of at least some of the cells of the reproductive tract of a mammalian individual by the introduction into said cells of a nucleic...
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6472208 |
Method of producing human IFN-α using sendai virus-infected hematopoietic stem cells
The present invention relates to a novel method for producing human natural interferon-α using ex vivo expanded cord blood hematopoietic cells infected with sendaivirus, on a large scale.
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RE37890 |
Controlled delivery compositions and processes for treating organisms in a column of water or on land
Controlled release compositions of matter are disclosed comprising complexes for treating a population of one or more aquatic organisms in a column of water. The complexes comprise at least one...
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6468524 |
AAV4 vector and uses thereof
The present invention relates to AAV4 vectors for methods of delivering nucleic acids to cells. Specifically, the present invention provides methods of delivering nucleic acids to specific regions...
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6465007 |
Transgene expression in polarized cells
The well-differentiated airway epithelium is the principal target tissue for gene therapy for the treatment of CF. However, recent studies have shown that gene delivery vehicles, such as cationic...
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6464976 |
Methods and compositions for reducing immune response
The present invention provides an apparatus and method to diminish the pre-existing immune response to the administration of a therapeutic virus by the selective elimination of antiviral antibodies...
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6465249 |
Use of β-catenin in the expansion of stem and progenitor cells
Mammalian progenitor or stem cells are expanded in vitro by increasing the levels of β-catenin in the cell. The expanded cells substantially maintain their original phenotype including the ability...
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6465001 |
Treating medical conditions by polymerizing macromers to form polymeric materials
Water soluble macromers are modified by addition of free radical polymerizable groups, such as those containing a carbon-carbon double or triple bond, which can be polymerized under mild conditions...
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6465438 |
Nucleic acid vaccination for parvoviral infections
The general field of the invention is a method for nucleic acid vaccination for animals to protect them from parvoviral infection. This invention is more particularly related to the preparation and...
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6465254 |
Mutant loxP site and applications thereof
Highly efficient gene integration or gene replacement in the higher eucaryote including animal cells can be performed by using mutant loxP site having the following properties (a)-(c) in the...
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6461869 |
Purging leukemia cells from hematopoietic stem cells
A gene therapy system is disclosed that selectively kills leukemia cells in bone marrow, while leaving stem cells unaffected. All cells in a mixture of stem cells and leukemia cells are transfected...
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6458529 |
Assays for promoter operability in central nervous system cells
The invention concerns a recombinant DNA vector characterized in that it is capable of directing the expression an/or transcription of a selected nucleotide sequence in the cells of the central...
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6458766 |
Halovir, an antiviral marine natural product, and derivatives thereof
The present invention provides a compound having the structure: wherein R 1a and R 1b are independently selected from the group consisting of —H, alkyl, lower-alkyl, substituted alkyl and...
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6458322 |
Method for simplified shipping of clinical specimens and optional direct analysis
A method for shipping clinical specimens lawfully, safely, cheaply, and easily without regard to some or all of the laws, rules, and regulations regarding samples that may contain infectious and/or...
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6458368 |
Attenuated microorganism strains expressing HPV proteins
Attenuated strain of a prokaryotic microorganism, being an attenuated strain of Salmonella suitable for use in a live vaccine for administration to a human or animal, in which the microorganism is...
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6458586 |
Bovine cells expressing adenovirus essential functions for propagation of recombinant adenoviral vectors
The invention provides cell lines capable of supporting the replication of a defective recombinant virus vector. In one aspect, bovine cell lines expressing adenovirus E1 functions are provided....
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6455048 |
Prevention of primary and metastatic neoplastic diseases with hsp70-peptide complexes
The present invention relates to methods and compositions for eliciting an immune response and the prevention and treatment of primary and metastatic neoplastic diseases and infectious diseases....
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6455036 |
Granulated formulation and method for stabilizing biocontrol agents
A stabilized, granular, biocontrol agent formulation for agricultural pests relies upon a combination of a water absorbent material, a membrane stabilization agent, and a granulating agent to...
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6455681 |
DNA molecules encoding single strand gap response proteins involved in activation of a DNA repair/cell cycle checkpoint pathway
The present invention relates to isolated DNA molecules encoding mammalian single strand gap response proteins involved in activation of a DNA repair/cell cycle checkpoint pathway. Expression...
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6451580 |
Method of enriching organic contaminant-decomposing bacteria in porous material for treating soil
A porous material having a greater adsorptivity for adsorbing organic contaminants, such as agricultural chemicals, than a target soil, is fragmented. The fragmented porous material is mixed into a...
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6447767 |
Non-myeloablative tolerogenic treatment
The present invention features a method of inducing donor-specific tolerance in a host. Tolerogenic treatments of the present invention may be administered to a host prior to transplantation of...
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6448234 |
Compounds and methods for treatment and diagnosis of chlamydial infection
Compounds and methods for the diagnosis and treatment of Chlamydial infection are disclosed. The compounds provided include polypeptides that contain at least one antigenic portion of a Chlamydia...
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6444437 |
Process for the production of nutritional products with microorganisms using sequential solid substrate and liquid fermentation
Rural biomass and other cellulosic materials are converted to a protein-enriched animal feed supplement or to single-cell protein by a series of bio-reactions. A first stage bio-reaction is a solid...
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6440408 |
Method of treatment
A method of producing active immunity against a bacterial or protozoal disease in a subject comprises administering to the subject a vaccine conjugate comprising a live bacteria or protozoa and a...
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6436447 |
Evacuant
Disclosed is an evacuant possessing a sufficient evacuating effect in a small dose substantially without accompanying any irritation to bowel, irrespective of whether its preparations are in the...
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6432671 |
Tryparedoxin, expression plasmid, process of production, method of use, test kit, and pharmaceutical composition
The present invention provides novel enzymes, tryparedoxins, their isolation from Crithidia fasciculata, a method for the production thereof in genetically transformed bacteria, and their use as...
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6428789 |
Ringworm vaccine
A ringworm vaccine is disclosed comprising antigen isolated from at least one dermatophyte and a suitable carrier. The “antigen” can include a single antigen from a dermatophyte or a plurality...
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6423318 |
Hepatitis A virus vaccines
A live hepatitis A virus adapted to growth in MRC-5 cells, which HAV is preferably characterized by suitable attenuation for effective vaccine administration to humans and animals without...
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6422174 |
Drinking water additive for birds and method of administering the same
Disclosed is a poultry drinking water additive containing live bacteria of the genus Bacillus and monosaccharides, which can alleviate body weight loss of poultry for meat production after feed...
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6420136 |
Method of modulating p53 activity
This invention relates to a method for modulating the activity of the protein p53 in cells by the addition of a peptide or protein having p 33 ING1 biological activity or a nucleic acid coding for...
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6420345 |
Methods and reagents for inhibiting angiogenesis
Disclosed are methods for inhibiting angiogenesis using cyclin dependent kinase inhibitors (CDKi) and fusion proteins thereof, recombinant viruses comprising transgenes and nucleic acid sequences...
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6416976 |
TrpS
The invention provides trpS polypeptides and DNA (RNA) encoding trpS polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing trpS...
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6416764 |
Vaccine
A vaccine comprises a non-cytopathogenic strain of bovine viral diarrhea virus, grown in a bovine derived cell line such as MDBK and killed, for example with β-propiolactone. The adjuvant is Quil A.
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6413523 |
Pharmaceutical composition of escherichia coli heat-labile enterotoxin adjuvant and methods of use
Novel immunoregulatory utilities of Escherichi coli heat-labile enterotoxin (LT) are disclosed. This enterotoxin can be used in combination with an unrelated antigen to achieve a higher immune...
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6413943 |
Methods and reagents for inhibiting proliferation of smooth muscle cells
Disclosed are methods for using ΔE1/ΔE4 recombinant adenoviruses encoding cyclin dependent kinase inhibitors (CDKi's) as reagents for inhibiting smooth muscle cell proliferation. Also disclosed...
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6413517 |
Identification of broadly reactive DR restricted epitopes
The present invention is based on peptide binding specificities of HLA DR4w4, DR1 and DR7. Peptides binding to these DR molecules have a motif characterized by a large aromatic or hydrophobic...
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