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7625569 |
Yeast-based therapeutic for chronic hepatitis C infection
Disclosed are compositions, including vaccines, and methods for vaccinating an animal against hepatitis C virus (HCV) and for treating or preventing hepatitis C viral infection in an animal. The...
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7622271 |
Identification of aging genes through large-scale analysis
High throughput methods for screening genetic variants that are phenotypically distinguishable are provided. Methods for identifying “long-lived” genetic variants among a set of variants are...
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7622124 |
Mycoplasma hyopneumoniae bacterin vaccine
The invention provides an improved Mycoplasma hyopneumoniae bacterin vaccine composition, which advantageously provides immunity from infection after a single administration. The composition...
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7622108 |
Multi-lineage progenitor cells
Fetal blood multi-lineage progenitor cells that are capable of a wide spectrum of transdifferentiation are described.
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7622107 |
Recombinant intracellular pathogen immunogenic compositions and methods for use
Immunogenic compositions comprising recombinant attenuated intracellular pathogens that have been transformed to express recombinant immunogenic antigens of the same or other intracellular...
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7618623 |
Hybrid adeno-retroviral vector for the transfection of cells
An adenovirus, including adenoviral capsid proteins, and a replication-defective adenoviral vector that includes a 5′ retroviral LTR nucleic acid sequence, a 3′ retroviral LTR nucleic acid...
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7618622 |
Treatment of Parkinson's disease and related disorders using postpartum derived cells
Cells derived from postpartum tissue such as the umbilical cord and placenta, pharmaceutical compositions comprising such cells, and methods for using such cells and pharmaceutical compositions to...
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7618621 |
Mammalian multipotent neural stem cells and compositions, methods of preparation and methods of administration thereof
This invention relates to novel mammalian multipotent neural stem cells (MNSCs), compositions thereof, and methods of preparing and administering the cells to diseased, aged or damaged tissue such...
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7618452 |
Artificially produced, three-dimensional muscle tissue
The invention relates to a device for producing a three-dimensional circular muscle body from a carrier substance and from cell cultures incorporated therein comprising a cell culture dish ( 1 )...
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7615209 |
Compositions of NDV and methods of use thereof for treatment of cancer
The present invention discloses methods for inducing regression of a tumor in a subject by administering a pharmaceutical composition comprising a lentogenic strain of Newcastle disease virus...
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7608257 |
Sensitization of chemotherapeutic agent resistant neoplastic cells with a virus
The present invention relates to a method of increasing the sensitivity of neoplastic cells to chemotherapeutic agents by using a virus, a method of treating proliferative disorders with a virus...
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7608256 |
Methods to increase transgene expression from bacterial-based delivery systems by co-expressing suppressors of the eukaryotic type I interferon response
Bacterial delivery systems with improved transgene expression are provided. The recombinant bacterial delivery systems deliver transgenes of interest and suppressors of the eukaryotic Type I...
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7601530 |
Bacteria strain wenelen DSM 16786, use of said bacteria for leaching of ores or concentrates containing metallic sulfide mineral species and leaching processes based on the use of said bacteria or mixtures that contain said bacteria
The present invention is related to an isolated chemolithotrophic bacterial strain belonging to the specie Acidithiobacillus ferrooxidans, named “Wenelen” and deposited at the Deutsche...
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7601342 |
Cell fusions and methods of making and using the same
The invention is concerned with fusions of dendritic cells and antigen presenting cells. Also provided are methods of making and using these cell fusions, including methods of adoptive...
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7598228 |
Therapeutic methods and agents for diseases associated with decreased expression of AOP-1 gene or AOP-1
A prophylactic or therapeutic method for a disease associated with decreased expression of AOP-1 gene or AOP-1, comprising (1) transfecting a nucleic acid encoding AOP-1 or a nucleic acid encoding...
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7598225 |
Generation of immune response to prostate-specific antigen (PSA)
We have discovered that by using a recombinant viral vector, preferably a pox virus vector having at least one insertion site containing a DNA segment encoding prostate-specific antigen (PSA),...
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7595303 |
Genetic adjuvants for immunotherapy
The present invention pertains to methods and pharmaceutical compositions for modulating an immune response. The method of the present invention involves administration of an effective amount of...
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7595295 |
Use of pleiotrophin to promote neurogeneration
The invention provides methods for promoting neuron survival in patients by administering pleiotrophin, or nucleic acids encoding pleiotrophin. Uses of the invention include promoting neuron graft...
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7592321 |
Methods of treating lysosomal storage related diseases by gene therapy
Isolated nucleic acid-based vectors and lentivirus vectors, and methods of using those vectors to inhibit or prevent metabolic disorders in a mammal, are provided.
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7592003 |
Regulation of toll-like receptors on stem cells
The discovery of Toll-like receptors (TLRs) on the surface of hematopoietic cells provides new methods for the stimulation and differentiation of various classes of progenitor cells. TLR2 and TLR4...
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7589071 |
Large capacity viral amplicon using a minimal orilyt from human cytomegalovirus
A novel Human Cytomegalovirus vector system is provided. The vector system is characterized by an amplicon vector, having an HCMV derived origin and cleavage packaging signal, and a helper virus...
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7588771 |
Microorganisms for therapy
Therapeutic methods and microorganisms therefor are provided. The microorganisms are designed to accumulate in immunoprivileged tissues and cells, such as in tumors and other proliferating tissue...
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7588757 |
Methods of treating Parkinson's disease using recombinant adeno-associated virus virions
Methods for treating Parkinson's disease (PD) are provided. Recombinant adeno-associated virus (rAAV) virions are used to deliver genes encoding dopamine-synthesizing enzymes to the central nervous...
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7585849 |
Position dependent recognition of GNN nucleotide triplets by zinc fingers
The specificity of binding of a zinc finger to a triplet or quadruplet nucleotide target subsite depends upon the location of the zinc finger in a multifinger protein and, hence, upon the location...
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7582614 |
Use of myxoma virus for the therapeutic treatment of cancer and chronic viral infection
The present invention relates to therapeutic use of Myxoma virus. Myxoma virus can selectively infect cells that have a deficient innate anti-viral response, including cells that are not responsive...
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7582292 |
Adipose tissue derived stromal cells for the treatment of neurological disorders
The present invention relates to a treatment of neural injury and neurodegenerative diseases. Also included in the present invention is the use of adipose tissue derived stromal cells for the...
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7582289 |
Viruses for the treatment of cellular proliferative disorders
Methods for treating cell proliferative disorders by administering virus to proliferating cells having an activated Ras-pathway are disclosed. The virus is administered so that it ultimately...
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7579326 |
Gene switch systems employing regulators with decreased dimerization
Disclosed is a novel inducible expression system characterized by undetectable biological effect in the absence of an inducer, but which exhibits efficient inducibility in the presence of an inducer.
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7579009 |
Whole bacterial cells as immune modulator
An immune modulator composition and/or pharmaceutical composition comprising a whole cell of a bacterium from the genera Rhodococcus, Gordonia, Nocardia, Dietzia, Tsukamurella and Nocardioides ,...
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7572438 |
Mutant having uracil phosphoribosyl transferase activity
The invention concerns a polypeptide having a uracil phosphoribosyl transferase (UPRTase) by mutation of one or several residues of the UPRTase. The invention also concerns a nucleotide sequence...
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7569681 |
Caterpiller gene family
The present invention relates to a new family of structurally and functionally related nucleic acids and proteins, designed the CATERPILLER family, which is characterized by landmark structural...
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7569219 |
Recombinant double-stranded RNA phage, and use of the same
A recombinant double stranded RNA (dsRNA) phage expresses dsRNA-encoded genes in eukaryote cells. Recombinant dsRNA phage are useful for the expression of dsRNA expression cassettes encoding...
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7566459 |
Modified mycobacterium tuberculosis strains and uses thereof
The present invention features modified Mycobacterium tuberculosis strains which lack a functional lspA gene, and vaccine formulations comprising the same. In many embodiments, a modified ...
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7563777 |
Method to induce neovascular formation and tissue regeneration
The present invention relates, e.g., to a method for inducing arteriogenesis, lymphangiogenesis, vasculogenesis, or cardiomyogenesis, and/or for inducing mitosis or proliferation of a smooth muscle...
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7563776 |
Compositions comprising fusion polypeptides HIV-Nef and NGF, and methods of using the same
A conjugate comprising a first and second sequence, wherein the first sequence comprises at least part of the human low affinity Nerve Growth Factor receptor (LNGFR) or a polynucleotide coding for...
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7563278 |
Drug-eluting intravascular prostheses and methods of use
The present invention provides intravascular prostheses and methods of production and use. An implantable device for treating a vascular disease or disorder includes an intravascular prosthesis...
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7560280 |
Human cord blood derived unrestricted somatic stem cells (USSC)
A composition in human cord and placental blood which comprises unrestricted somatic stem cells is described here which can be amplified in vitro to large quantities sufficient for medical...
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7560102 |
Method for reducing neuronal degeneration so as to ameliorate the effects of injury or disease
Compositions and methods to promote nerve regeneration or to confer neuroprotection and prevent or inhibit neuronal degeneration within the nervous system, either the central nervous system or the...
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7556805 |
Compositions for treatment of melanoma and method of using same
Melanoma can be treated in a mammalian subject by administering to the subject an immunologically-effective amount of a xenogeneic melanoma-associated differentiation antigen. For example, genetic...
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7553663 |
Dedifferentiated, programmable stem cells of monocytic origin, and their production and use
The invention relates to the production of adult dedifferentiated, programmable stem cells from human monocytes by cultivation of monocytes in a culture medium which contains M-CSF and IL-3. The...
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7553657 |
Substrates containing a Trichoderma asperellum strain for biological control of Fusarium and Rhizoctonia
The strain of Trichoderma asperellum T34(2) CECT No. 20417 is useful for preparing substrates for biological control of vascular fusariose and death of plants caused by Rhizoctonia solani . The...
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7550138 |
Plasmodium mutant and vaccines including the mutant
The invention relates to the production of new Plasmodium mutants which are defective in the expression of the protein P36p. These mutants are unable to cause malaria, yet they can be used as...
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7547682 |
Tick galectin
A novel galectin, a polynucleotide encoding the same, a vector and a transformant comprising the polynucleotide, an antibody against the galectin, and a screening method for screening a substance...
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7544669 |
Polynucleotide therapy
This invention provides a method of treating or preventing a disease in an animal associated with one or more self-protein(s), -polypeptide(s), or -peptide(s) that is present or involved in a...
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7544509 |
Method for preparing stem cell preparations
This invention relates to multipotent stem cells, purified from the peripheral tissue of mammals, and capable of differentiating into neural and non-neural cell types. These stem cells provide an...
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7544355 |
Methods and compositions for allogeneic transplantation
The present invention relates, generally, to methods and compositions for allogeneic transplantation. More particularly, the invention relates to the use of alloreactive natural killer cells in...
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7541447 |
Process for the preparation of an improved Brucella strain plasmid to develop the strain and the vaccine comprising the said strain
A Brucella bacterium is modified by partial or complete deletion of the pgm gene, rendering the bacterium incapable of synthesizing a key enzyme in the metabolism of bacterial sugars. A live...
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7541343 |
Inhibiting cellular proliferation by expressing yin yang-1
The present invention provides a method of preventing or reducing cellular proliferation. The method involves administering to cells a composition which increases the level of YY1 protein, in...
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7537925 |
Mutated Lactococcus strain
A mutant of Lactococcus lactis spp. lactis , which produces lactate at high volumetric and specific productivity as well as high amounts of lactate dehydrogenase, as well as the use of said...
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7537756 |
Stem cells and their use in transplantation
Methods and compositions are described for the treatment of type I insulin-dependent diabetes mellitus and other conditions using newly identified stem cells that are capable of differentiation...
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