|
Match
|
Document |
Document Title |
|
|
7560110 |
Production and use of novel peptide-based agents with bispecific antibodies
The present invention relates to a bi-specific antibody or antibody fragment having at least one arm that specifically binds a targeted tissue and at least one other arm that specifically binds a...
|
|
|
7537751 |
Labeling reagents and labeled targets comprising nonmetallic porphyrins
This invention provides for labeling reagents, labeled targets and processes for preparing labeling reagents. The labeling reagents can take the form of cyanine dyes, xanthene dyes, porphyrin dyes,...
|
|
|
7371742 |
Porphyrin derivatives for photodynamic therapy
This invention relates to porphyrin compounds used to destroy or impair the functioning of a target biological material in photodynamic therapy, in particular against virus, tumoral cells,...
|
|
|
7348361 |
Solution for diagnosing or treating tissue pathologies
The invention concerns a 5-aminolevulinic acid ester (E-ALA) solution for producing a pharmaceutical preparation useful for diagnosing and/or treating tissue and/or cell pathologies by local...
|
|
|
7320786 |
Photodynamic therapy treatment for eye disease
This invention discloses methods, kits, and instructions to treat neovasculature diseases of the eye through the administration of a targeted photosensitizing agent and subsequent exposure to light...
|
|
|
7268155 |
Photosensitizer conjugates for pathogen targeting
Conjugate molecules which include photosensitizer compositions conjugated to non-antibody non-affinity pair targeting moieties and methods of making and using such conjugates are described.
|
|
|
7265100 |
Separation of regioisomers of metal phthalocyanines
The present invention refers to a process for the separation of regioisomeric mixtures of metal phthalocyanines of formula (I), to the regioisomers obtained by this process, and their use as...
|
|
|
7255851 |
Non-invasive localization of a light-emitting conjugate in a mammal
Methods and compositions for detecting and localizing light originating from a mammal are disclosed. Also disclosed are methods for targeting light emission to selected regions, as well as for...
|
|
|
7244841 |
Porphyrin derivatives and their use in photodynamic therapy
A compound of formula I:
wherein X 1 , X 2 , X 3 , X 4 , Y 1 , Y 2 , Y 3 , Y 4 and Z have meanings given in the description, and metallated forms of such compounds, which are useful in the...
|
|
|
7192650 |
Element having porphyrin polymer fixed on a substrate and method of preparing the same
A photo-functional molecule element having, on a substrate, a porphyrin polymer containing covalently-fixed porphyrin units, and the method of preparing the same. The photo-functional molecule...
|
|
|
7153956 |
Cyanine dye having multifunctional peripheral groups
The present invention provides an IR-absorbing dye of formula (I) or (II)
wherein
R 10 , R 13 , R 20 , R 23 , R 30 , R 33 , R 40 and R 43 are independently selected from a C 1-12 alkyl...
|
|
|
7147840 |
Oxo-bacteriopyropheophorbide-a carboxylic acid and esters thereof
A compound having the structural formula:
where R is H or lower alkyl of 1 through 12 carbon atoms. In general, the compounds of the invention are 13 2 -Oxo-bacteriopyropheophorbide—a...
|
|
|
7148345 |
Synthetically expedient water-dispersible IR dyes having improved lightfastness
The present invention provides an IR-absorbing naphthalocyanine dye of formula (I):
wherein
M is selected from Ga(A 1 ); A 1 is an axial ligand selected from —OH, halogen (preferably Cl),...
|
|
|
7138391 |
Hydrophilizable and hydrophilic cyanine dyes
The present invention provides an IR-absorbing dye of formula (I) or (II):
wherein
Q 1 , Q 2 , Q 3 and Q 4 are the same or different and are independently selected from a C 3-20 ...
|
|
|
7138103 |
Use of bi-specific antibodies for pre-targeting diagnosis and therapy
The present invention relates to targetable constructs which may be bound by a bi-specific antibody or antibody fragment having at least one arm that specifically binds construct. The targetable...
|
|
|
7125542 |
Methods and compositions for treating conditions of the eye
Provided are methods and compositions for the photodynamic therapy (PDT) of ocular conditions characterized by the presence of unwanted choroidal neovasculature, for example, neovascular...
|
|
|
7122076 |
Synthetically expedient water-dispersible IR dyes
The present invention provides an IR-absorbing naphthalocyanine dye of formula (I):
wherein
M is selected from Si(A 1 )(A 2 ), Ge(A 1 )(A 2 ), Ga(A 1 ), Mg, Al(A 1 ), TiO, Ti(A 1 )(A 2...
|
|
|
7094866 |
Covalently fixed porphyrin polymer having porphyrin metal complex substituted with coordinating hetero aromatic ring as constituting unit thereof,and method of producing the same
A covalently linked linear porphyrin polymer represented by formula (1):
wherein
R represents an alkyl group or
(wherein a, b and d independently represent H, an alkyl...
|
|
|
7087214 |
Water-soluble porphyrin platinum compounds with high tumor selectivity and their use for the treatment of benign and malignant tumor diseases
The invention relates to novel, water-soluble porphyrin platinum compounds of the tetraarylporphyrin platinum derivatives type or of the hematoporphyrin platinum derivatives type with high tumor...
|
|
|
7053210 |
Efficient synthesis of pyropheophorbide a and its derivatives
A process for the preparation of pyropheophorbide a and its derivatives, including 3-devinyl-3-(1′-hexyloxy)ethyl-pyropheophorbide-a, otherwise known as HPPH, is provided. The process involves...
|
|
|
7045117 |
Method for tumor diagnosis comprising administering of palladium-substituted bacteriochlorophyll derivatives
Palladium-substituted Bacteriochlorophyll derivatives are administered to a subject suspected of having a tumor and the patient is then irradiated and the fluorescence of the suspected area is...
|
|
|
7030105 |
Method of synthesis of β-thiolato cobalamin compounds
The invention provides a method for preparing glutathionylcobalamin (GluSCbl) which involves running the reaction in an aqueous solvent with a relatively small excess of glutathione, i.e. GluSH,...
|
|
|
7026347 |
Porphyrin-polyamine conjugates for cancer therapy
Porphyrin-polyamine conjugate compounds are disclosed which have anticancer and antitumor effects. The porphyrin moiety selectively localizes in tumors, while the polyamine moiety serves as a...
|
|
|
7022840 |
Porphyrin array exhibiting large two photon absorption property and including, as structural unit, bis (imidazolylporphyrin metal complex) linked with acetylenic bond and the derivative thereof, and method of producing the same
A porphyrin array exhibiting a large two-photon absorption property, and being linked with an acetylenic bond(s), represented by the following formulas:
wherein R 1 represents an alkyl or aryl...
|
|
|
7019132 |
Porphyrin derivatives
The present invention is related to novel photopyrin compounds and the pharmaceutically acceptable salt thereof useful as an anticancer or photodynamic diagnostic agent by way of reproducing...
|
|
|
7014839 |
Light imaging contrast agents
The present invention relates to the use of particulate materials as contrast agents in in vivo light imaging.
|
|
|
7008742 |
Heat-induced formation of co-crystalline composition containing titanyl phthalocyanine and titanyl fluorophthalocyanine
A process for forming a cocrystalline mixture of titanyl phthalocyanine (TiOPc) and titanyl fluorophthalocyanine (TiOFPc) includes: dry milling a mixture of crude TiOPc and crude TiOFPc, thereby...
|
|
|
7008937 |
Porphyrins and metalloporphyrins for inhibiting heme iron uptake
The present invention provides a class of porphyrins and metal chelated porphyrins for use as inhibitors of heme iron uptake. The porphyrin/metal chelated porphyrin molecules of the invention are...
|
|
|
7005519 |
Tetraazaporphyrin compounds
This invention relates to a method of preparing a compound of formula (I):
The method includes reacting one or more compounds of formula (II):
in the presence of a base and a halogenating...
|
|
|
7005518 |
Phthalocyanine dyes
Fluorescent dyes are disclosed which are useful as reporter groups for labeling biomolecules. The silicon phthalocyanine dyes disclosed are preferably water soluble, isomericly pure, possess high...
|
|
|
7001588 |
Expanded porphyrin compositions for tumor inhibition
Expanded porphyrin comprising substitutions for at least two NH groups by S, Se or Te are non-photoactive and are selective for binding G-quadruplexes characteristic of the c-MYC control region....
|
|
|
6995260 |
Carboranylporphyrins and uses thereof
The present invention is directed to low toxicity boronated compounds and methods for their use in the treatment, visualization, and diagnosis of tumors. More specifically, the present invention is...
|
|
|
6982090 |
More easily visualized punctum plug configurations
An improved punctum plug is more easily visualized when positioned within a punctual canal of a recipient. The body of the plug features an outwardly exposed surface when properly positioned, and a...
|
|
|
6977075 |
Photosensitizer conjugates for targeting intracellular pathogens
The methods of the invention can be used to treat mycobacterial infections, or any disease or disorder that is caused by (or aggravated by) an intracellular pathogen. Accordingly, the invention...
|
|
|
6953570 |
Porphyrins with enhanced multi-photon absorption cross-sections for photodynamic therapy
A method of increasing the multi-photon absorption cross-section of a porphyrin-based photosensitizer by attaching at least one TPA-chromophore at the meso- or beta-positions of a porphyrin...
|
|
|
6849249 |
Ocular diagnosis of Alzheimer's Disease
The invention features a method of diagnosing or providing a prognosis regarding the state of Alzheimer's Disease in a mammal by contacting an ocular tissue with a detectably-labeled compound,...
|
|
|
6849058 |
Photodynamic therapy in selective cell inactivation in blood and treating immune dysfunction diseases
Multiple sclerosis and rheumatoid arthritis can be treated effectively using photodynamic therapy. In this protocol, a photoactive compound is administered, allowed to distribute in the effected...
|
|
|
6849607 |
Galectin recognized photosensitizers for photodynamic therapy
Purpurin-carbohydrate conjugates and their method of preparation and use for treatment of cancer cells. The conjugates have the general formula:
wherein R 6 and R 7 taken together are ═NR...
|
|
|
6827926 |
Metallotetrapyrrolic photosensitizing agents for use in photodynamic therapy
Metallotetrapyrrolic compounds having photherapeutic properties useful in photodetection and phototherapy of target issues, particularly porphyrins and azaporphyrins that including gallium in the...
|
|
|
6746663 |
Porphyrin compounds
The present invention provides the porphyrin compound which is used for photodynamic diagnosis and/or treatment for animals, and the photodynamic diagnostic and/or therapeutic agent for animals.
|
|
|
6710066 |
Photochemotherapeutic method using 5-aminolevulinic acid and other precursors of endogenous porphyrins
Methods of detecting and treating rapidly growing exogenous cells, such as Protista, or parasites, that preferentially accumulate a photoactivatable porphyrin in which 5-aminolevulinic acid or...
|
|
|
6706713 |
Conjugate for treating inflammatory infectious and/or skin diseases
This invention relates to the use of a conjugate comprising an active substance and a native protein which is not recognized as foreign protein for the production of a pharmaceutical preparation...
|
|
|
6696430 |
Use of vital dye for facilitating surgical procedures for vitreo-retinal surgery
A method for performing retinal membrane removal is disclosed using vital dyes which are applied to the membrane. Compositions including vital dyes which are useful in the retinal membrane removal...
|
|
|
6630128 |
Porphyrin derivatives their use in photodynamic therapy and medical devices containing them
There is provided a compound of formula (I), wherein R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 , R 9 , X, Y 1 , Y 2 , Y 3 , Z, M, A-B and C-D have meanings given in the description, which are...
|
|
|
6610298 |
Photosensitzer conjugates for targeting intracellular pathogens
The methods of the invention can be used to treat mycobacterial infections, or any disease or disorder that is caused by (or aggravated by) an intracellular pathogen. Accordingly, the invention...
|
|
|
6582930 |
Porphyrin compounds, their conjugates and assay methods based on the use of said conjugates
The preparation of phosphorescent metalloporphyrin labelling reagents and their use for preparation of phosphorescent conjugates with biomolecules. The labelling reagents obtainable are water...
|
|
|
6500800 |
Composition and method for causing photodynamic damage to target cells
The present invention is directed to a composition for causing photodynamic damage to target cells comprising a photosensitiser, a photosensitiser carrier component, a component which enables...
|
|
|
6500816 |
Remedies for photochemotherapy
Effective treatment of tumors, especially carcinomas, can be achieved by administering to man a photochemotherapeutic agent containing as an active ingredient a compound showing maximum absorption...
|
|
|
6444194 |
Indium photosensitizers for PDT
The invention disclosed herein involves a phototherapeutic pyrrolic core complexed with a non-radioactive Indium atom. Complexation of Indium by the pyrrolic core forms a metalopyrrolic compound...
|
|
|
6424857 |
Use of acousto-optical and sonoluminescene contrast agents
The invention relates inter alia to a method of generating information from an animate human or non-human animal body which method comprises: administering to said body a physiologically tolerable...
|