|
Match
|
Document |
Document Title |
|
|
8158669 |
Method for treating neovascularization
The present invention describes an improved photodynamic treatment to treat subfoveal choroidal neovascularization (CNV).
|
|
|
8133482 |
Activatable photodynamic therapy agents
The present invention relates to the field of conjugates comprising a substrate which is attached to at least one photoactivatable killing agent and at least one first quencher, and methods for...
|
|
|
8097609 |
Swallowtail motifs for imparting water solubility to porphyrinic compounds
Porphyrinic compounds that contain solubilizing groups are described, along with methods of making and using the same and compositions comprising such compounds. Examples of such compounds include...
|
|
|
8029766 |
Intravascular imaging device and uses thereof
The invention is directed to a probe-type imaging device useful to visualize interior surfaces, e.g., the lumen of blood vessels. Specifically, the probe-type device is particularly useful for...
|
|
|
8030342 |
Dendritic polyamidoamine phthalocyanine derivative
The present invention is directed to a dendritic polyamidoamine phthalocyanine derivative which is useful as, for example, a fluorescent material or a photodynamic therapeutic drug for cancer. The...
|
|
|
7977474 |
Uses of porphyrin compounds
The invention provides the use of a compound of Formula (I), or metallated derivative thereof, in the preparation of a medicament for killing or attenuating the growth of microorganisms by a method...
|
|
|
7820143 |
Water soluble tetrapyrollic photosensitizers for photodynamic therapy
A tetrapyrollic photosensitizer compound having at least one pendant —CH2CH2CON(CH2CON(CH2COOH)2)2 or —N(CH2COOH)2 group or esters thereof said tetrapyrollic compound being a chlorin, bac...
|
|
|
7795219 |
Use of an agent that restores tissue perfusion and oxygenation
The presently disclosed subject matter provides methods for increasing perfusion in hypoxic regions of tissues in subjects. Also provided are methods for treating diseases and/or disorders...
|
|
|
7704489 |
Method of photocatalytic nanotagging
A nanotagged chemical structure comprising a chemical structure with an associated photocatalyst and a tagging nanoparticle (a nanotag) grown in proximity to the photocatalyst, and a method for...
|
|
|
7682603 |
Polymersomes incorporating highly emissive probes
The instant invention concerns compositions comprising polymersomes, visible or near infrared emissive agents, and optionally a targeting moiety associated with a surface of the polymersome. The...
|
|
|
7560110 |
Production and use of novel peptide-based agents with bispecific antibodies
The present invention relates to a bi-specific antibody or antibody fragment having at least one arm that specifically binds a targeted tissue and at least one other arm that specifically binds a...
|
|
|
7537751 |
Labeling reagents and labeled targets comprising nonmetallic porphyrins
This invention provides for labeling reagents, labeled targets and processes for preparing labeling reagents. The labeling reagents can take the form of cyanine dyes, xanthene dyes, porphyrin dyes,...
|
|
|
7371742 |
Porphyrin derivatives for photodynamic therapy
This invention relates to porphyrin compounds used to destroy or impair the functioning of a target biological material in photodynamic therapy, in particular against virus, tumoral cells,...
|
|
|
7348361 |
Solution for diagnosing or treating tissue pathologies
The invention concerns a 5-aminolevulinic acid ester (E-ALA) solution for producing a pharmaceutical preparation useful for diagnosing and/or treating tissue and/or cell pathologies by local...
|
|
|
7320786 |
Photodynamic therapy treatment for eye disease
This invention discloses methods, kits, and instructions to treat neovasculature diseases of the eye through the administration of a targeted photosensitizing agent and subsequent exposure to light...
|
|
|
7268155 |
Photosensitizer conjugates for pathogen targeting
Conjugate molecules which include photosensitizer compositions conjugated to non-antibody non-affinity pair targeting moieties and methods of making and using such conjugates are described.
|
|
|
7265100 |
Separation of regioisomers of metal phthalocyanines
The present invention refers to a process for the separation of regioisomeric mixtures of metal phthalocyanines of formula (I), to the regioisomers obtained by this process, and their use as...
|
|
|
7255851 |
Non-invasive localization of a light-emitting conjugate in a mammal
Methods and compositions for detecting and localizing light originating from a mammal are disclosed. Also disclosed are methods for targeting light emission to selected regions, as well as for...
|
|
|
7244841 |
Porphyrin derivatives and their use in photodynamic therapy
A compound of formula I: wherein X1, X2, X3, X4, Y1, Y2, Y3, Y4 and Z have meanings given in the description, and metallated forms of such compounds, which are useful in the treatment of medical...
|
|
|
7192650 |
Element having porphyrin polymer fixed on a substrate and method of preparing the same
A photo-functional molecule element having, on a substrate, a porphyrin polymer containing covalently-fixed porphyrin units, and the method of preparing the same. The photo-functional molecule...
|
|
|
7153956 |
Cyanine dye having multifunctional peripheral groups
The present invention provides an IR-absorbing dye of formula (I) or (II) wherein R10, R13, R20, R23, R30, R33, R40 and R43 are independently selected from a C1-12 alkyl group bearing a hydrophilic...
|
|
|
7148345 |
Synthetically expedient water-dispersible IR dyes having improved lightfastness
The present invention provides an IR-absorbing naphthalocyanine dye of formula (I): wherein M is selected from Ga(A1);A1 is an axial ligand selected from —OH, halogen (preferably Cl), —OR3, a hyd...
|
|
|
7147840 |
Oxo-bacteriopyropheophorbide-a carboxylic acid and esters thereof
A compound having the structural formula: where R is H or lower alkyl of 1 through 12 carbon atoms. In general, the compounds of the invention are 132-Oxo-bacteriopyropheophorbide—a carboxylic a...
|
|
|
7138103 |
Use of bi-specific antibodies for pre-targeting diagnosis and therapy
The present invention relates to targetable constructs which may be bound by a bi-specific antibody or antibody fragment having at least one arm that specifically binds construct. The targetable...
|
|
|
7138391 |
Hydrophilizable and hydrophilic cyanine dyes
The present invention provides an IR-absorbing dye of formula (I) or (II): wherein Q1, Q2, Q3 and Q4 are the same or different and are independently selected from a C3-20 heteroarylene group...
|
|
|
7125542 |
Methods and compositions for treating conditions of the eye
Provided are methods and compositions for the photodynamic therapy (PDT) of ocular conditions characterized by the presence of unwanted choroidal neovasculature, for example, neovascular...
|
|
|
7094866 |
Covalently fixed porphyrin polymer having porphyrin metal complex substituted with coordinating hetero aromatic ring as constituting unit thereof,and method of producing the same
A covalently linked linear porphyrin polymer represented by formula (1): wherein R represents an alkyl group or (wherein a, b and d independently represent H, an alkyl group or aryl group);X...
|
|
|
7087214 |
Water-soluble porphyrin platinum compounds with high tumor selectivity and their use for the treatment of benign and malignant tumor diseases
The invention relates to novel, water-soluble porphyrin platinum compounds of the tetraarylporphyrin platinum derivatives type or of the hematoporphyrin platinum derivatives type with high tumor...
|
|
|
7053210 |
Efficient synthesis of pyropheophorbide a and its derivatives
A process for the preparation of pyropheophorbide a and its derivatives, including 3-devinyl-3-(1′-hexyloxy)ethyl-pyropheophorbide-a, otherwise known as HPPH, is provided. The process involves t...
|
|
|
7045117 |
Method for tumor diagnosis comprising administering of palladium-substituted bacteriochlorophyll derivatives
Palladium-substituted Bacteriochlorophyll derivatives are administered to a subject suspected of having a tumor and the patient is then irradiated and the fluorescence of the suspected area is...
|
|
|
7030105 |
Method of synthesis of β-thiolato cobalamin compounds
The invention provides a method for preparing glutathionylcobalamin (GluSCbl) which involves running the reaction in an aqueous solvent with a relatively small excess of glutathione, i.e. GluSH,...
|
|
|
7026347 |
Porphyrin-polyamine conjugates for cancer therapy
Porphyrin-polyamine conjugate compounds are disclosed which have anticancer and antitumor effects. The porphyrin moiety selectively localizes in tumors, while the polyamine moiety serves as a...
|
|
|
7022840 |
Porphyrin array exhibiting large two photon absorption property and including, as structural unit, bis (imidazolylporphyrin metal complex) linked with acetylenic bond and the derivative thereof, and method of producing the same
A porphyrin array exhibiting a large two-photon absorption property, and being linked with an acetylenic bond(s), represented by the following formulas: wherein R1 represents an alkyl or aryl...
|
|
|
7019132 |
Porphyrin derivatives
The present invention is related to novel photopyrin compounds and the pharmaceutically acceptable salt thereof useful as an anticancer or photodynamic diagnostic agent by way of reproducing...
|
|
|
7014839 |
Light imaging contrast agents
The present invention relates to the use of particulate materials as contrast agents in in vivo light imaging.
|
|
|
7008742 |
Heat-induced formation of co-crystalline composition containing titanyl phthalocyanine and titanyl fluorophthalocyanine
A process for forming a cocrystalline mixture of titanyl phthalocyanine (TiOPc) and titanyl fluorophthalocyanine (TiOFPc) includes: dry milling a mixture of crude TiOPc and crude TiOFPc, thereby...
|
|
|
7008937 |
Porphyrins and metalloporphyrins for inhibiting heme iron uptake
The present invention provides a class of porphyrins and metal chelated porphyrins for use as inhibitors of heme iron uptake. The porphyrin/metal chelated porphyrin molecules of the invention are...
|
|
|
7005519 |
Tetraazaporphyrin compounds
This invention relates to a method of preparing a compound of formula (I): The method includes reacting one or more compounds of formula (II): in the presence of a base and a halogenating agent. In...
|
|
|
7005518 |
Phthalocyanine dyes
Fluorescent dyes are disclosed which are useful as reporter groups for labeling biomolecules. The silicon phthalocyanine dyes disclosed are preferably water soluble, isomericly pure, possess high...
|
|
|
7001588 |
Expanded porphyrin compositions for tumor inhibition
Expanded porphyrin comprising substitutions for at least two NH groups by S, Se or Te are non-photoactive and are selective for binding G-quadruplexes characteristic of the c-MYC control region....
|
|
|
6995260 |
Carboranylporphyrins and uses thereof
The present invention is directed to low toxicity boronated compounds and methods for their use in the treatment, visualization, and diagnosis of tumors. More specifically, the present invention is...
|
|
|
6982090 |
More easily visualized punctum plug configurations
An improved punctum plug is more easily visualized when positioned within a punctual canal of a recipient. The body of the plug features an outwardly exposed surface when properly positioned, and a...
|
|
|
6977075 |
Photosensitizer conjugates for targeting intracellular pathogens
The methods of the invention can be used to treat mycobacterial infections, or any disease or disorder that is caused by (or aggravated by) an intracellular pathogen. Accordingly, the invention...
|
|
|
6953570 |
Porphyrins with enhanced multi-photon absorption cross-sections for photodynamic therapy
A method of increasing the multi-photon absorption cross-section of a porphyrin-based photosensitizer by attaching at least one TPA-chromophore at the meso- or beta-positions of a porphyrin...
|
|
|
6849607 |
Galectin recognized photosensitizers for photodynamic therapy
Purpurin-carbohydrate conjugates and their method of preparation and use for treatment of cancer cells. The conjugates have the general formula: wherein R6 and R7 taken together are ═NR11 or are i...
|
|
|
6849249 |
Ocular diagnosis of Alzheimer's Disease
The invention features a method of diagnosing or providing a prognosis regarding the state of Alzheimer's Disease in a mammal by contacting an ocular tissue with a detectably-labeled compound,...
|
|
|
6849058 |
Photodynamic therapy in selective cell inactivation in blood and treating immune dysfunction diseases
Multiple sclerosis and rheumatoid arthritis can be treated effectively using photodynamic therapy. In this protocol, a photoactive compound is administered, allowed to distribute in the effected...
|
|
|
6827926 |
Metallotetrapyrrolic photosensitizing agents for use in photodynamic therapy
Metallotetrapyrrolic compounds having photherapeutic properties useful in photodetection and phototherapy of target issues, particularly porphyrins and azaporphyrins that including gallium in the...
|
|
|
6746663 |
Porphyrin compounds
The present invention provides the porphyrin compound which is used for photodynamic diagnosis and/or treatment for animals, and the photodynamic diagnostic and/or therapeutic agent for animals.
|
|
|
6710066 |
Photochemotherapeutic method using 5-aminolevulinic acid and other precursors of endogenous porphyrins
Methods of detecting and treating rapidly growing exogenous cells, such as Protista, or parasites, that preferentially accumulate a photoactivatable porphyrin in which 5-aminolevulinic acid or...
|