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7384624 |
Oral contrast and method of producing the oral contrast
Oral contrast compositions are used as an aid for CAT scans and are ideally fast-flowing and good tasting for assisting in quick preparation of a patient in today's extremely active and busy...
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7378078 |
Compositions and methods for detecting proteolytic activity
The invention provides compositions and methods for non-invasive imaging of enzyme (e.g., protease) activity in cells, tissues and organs and entire bodies in vitro, in vivo and in situ. The...
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7374746 |
Non-isotopic detection of osteoblastic activity in vivo using modified bisphosphonates
The present invention is directed to a non-isotopic methods for the in vitro and in vivo detection of hydroxyapatite-positive cells and structures.
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7345150 |
Albumin-based colloid composition having at least one protected thiol region, methods of making, and methods of use
A composition comprising an albumin-based colloid composition having at least one protected thiol region, method of making the same, and method for use, including treating hypovolemic conditions...
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7335771 |
Quinacridone derivatives as labelling reagents for fluorescence detection of biological materials
Disclosed are new quinacridone dye derivatives having characteristic fluorescence lifetimes. Also disclosed are methods for labelling target biological materials employing the quinacridone dyes and...
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7320786 |
Photodynamic therapy treatment for eye disease
This invention discloses methods, kits, and instructions to treat neovasculature diseases of the eye through the administration of a targeted photosensitizing agent and subsequent exposure to light...
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7303741 |
Systems and methods for high-resolution in vivo imaging of biochemical activity in a living organism
This invention relates to bifunctional detection agents useful for providing high-resolution, in vivo imaging of biochemical activity in a living organism. Methods of using these bifunctional...
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7288244 |
Determining vulnerable plaque in blood vessels
The invention is based on the realisation that inflamed plaques in blood vessel walls, which are potentially vulnerable to rupture, can be detected at elevated temperatures which are lower than...
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7279588 |
Dinuclear metal complex and pyrophosphate assay using the same
A novel coordination complex formed by dinuclear metal complexation is provided. The complex is a dinuclear metal complex of a compound, wherein the compound comprises a conjugation ring system...
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7270801 |
Fluorogenic or fluorescent reporter molecules and their applications for whole-cell fluorescence screening assays for caspases and other enzymes and the use thereof
The present invention relates to novel fluorescent dyes, novel fluorogenic and fluorescent reporter molecules and new enzyme assay processes that can be used to detect the activity of caspases and...
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7268155 |
Photosensitizer conjugates for pathogen targeting
Conjugate molecules which include photosensitizer compositions conjugated to non-antibody non-affinity pair targeting moieties and methods of making and using such conjugates are described.
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7261876 |
Multivalent constructs for therapeutic and diagnostic applications
The invention provides compositions and methods for therapeutic and diagnostic applications.
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7252815 |
Pathological tissue detection and treatment employing targeted benzoindole optical agents
Novel tumor specific phototherapeutic and photodiagnostic agents are disclosed. The compounds consist of a carbocyanine dye for visualization, photosensitizer for photodynamic treatment, and tumor...
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7250154 |
Radio-opaque polymeric biomaterials
A radio-opaque dihydroxy compound substituted with at least one bromine or iodine atom. Radio-opaque medical implants and drug delivery devices and methods for therapeutic site-specific or systemic...
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7244413 |
Functionalized encapsulated fluorescent nanocrystals
Provided are a functionalized, encapsulated fluorescent nanocrystal comprising a liposome having encapsulated therein one or more fluorescent nanocrystals; use of the functionalized, encapsulated...
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7244232 |
Process for identifying cancerous and/or metastatic cells of a living organism
A process for identifying and treating cells in a living organism. The cells are labeled, circulated within the organism, detected with an implanted detector, and then either isolated or ablated.
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7235375 |
Organic anion transport proteins
The current invention discloses nucleic acid and amino acid sequences for novel organic anion transfer proteins (“OATPs”). The invention encompasses the OATPs described herein, together with...
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7235227 |
Paramagnetic particles that provide improved relaxivity
An improved contrast agent for magnetic resonance imaging comprises particles to each of which is coupled a multiplicity of chelating agents containing paramagnetic ions. In the improved agent, the...
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7198777 |
Optical contrast agents for optically modifying incident radiation
A method of enhancing the contrast of an image of a sample, comprises forming an image of a mixture, by exposing the mixture to electromagnetic radiation. The mixture comprises the sample and...
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7183313 |
Keto cannabinoids with therapeutic indications
Novel tricyclic cannabinoid compounds are presented. Some of these compounds exhibit fluorescence properties. The fluorescent cannabinoid compounds are typically endogenously fluorescent. Some of...
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7175953 |
Short-warp peptide-dye conjugate as contrast agent for optical diagnostic
The description herein includes cyanine dyes and analogs of the vaso-active intestinal peptide. These are useful to provide peptide-dye conjugates for use as contrast media in optical diagnoses.
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7175831 |
Light sensitive compounds for instant determination of organ function
Highly hydrophilic indole and benzoindole derivatives that absorb and fluoresce in the visible region of light are disclosed. These compounds are useful for physiological and organ function...
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7166719 |
Fluorinated photosensitizers related to chlorins and bacteriochlorins for photodynamic therapy
Provided herein are compounds for detection, diagnosis and treatment of target tissues or target compositions, including hyperproliferative tissues such as tumors, using photodynamic methods. In...
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7157566 |
Monomeric and dimeric fluorescent protein variants and methods for making same
The present invention relates generally to variant fluorescent proteins, and more specifically to monomeric and dimeric forms of Anthozoan fluorescent proteins. In one aspect, the present invention...
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7138103 |
Use of bi-specific antibodies for pre-targeting diagnosis and therapy
The present invention relates to targetable constructs which may be bound by a bi-specific antibody or antibody fragment having at least one arm that specifically binds construct. The targetable...
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7135162 |
Agent for diagnosing and treating malignant tumors
A composition of a compound or derivative thereof in which at least one carbon atom of 5-aminolevulinic acid is a carbon isotope and/or a nitrogen atom in its amino group is a nitrogen isotope, and...
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7128896 |
Pathological tissue detection and treatment employing targeted benzoindole optical agents
Novel tumor specific phototherapeutic and photodiagnostic agents are disclosed. The compounds consist of a carbocyanine dye for visualization, photosensitizer for photodynamic treatment, and tumor...
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7107092 |
Methods for diagnosing a neurodegenerative condition
A method of diagnosing, prognosing, staging, and/or monitoring a mammalian amyloidogenic disorder or a predisposition thereto by detecting a protein or polypeptide aggregate in the cortical and/or...
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7101533 |
Agent for inducing receptor potential
Disclosed is an agent for inducing receptor potential, which comprises an organic dye compound capable of inducing/evoking receptor potential in response to photostimulation in the optic nerve,...
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7094424 |
Cationic lipid compositions targeting angiogenic endothelial cells
Angiogenic endothelial cells are selectively targeted with lipid/DNA complexes or cationic liposomes containing a substance which affects the targeted cells by inhibiting or promoting their growth....
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7078406 |
Substituted diphenyloxazoles, the synthesis thereof, and the use thereof as fluorescence probes
The present invention is directed to a compound of Formula I:
wherein A, R 1 , and R 2 are defined herein. The present invention is also directed to compositions comprising compounds of...
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7056493 |
Radio-opaque polymer biomaterials
Iodinated and/or brominated derivatives of aromatic dihydroxy monomers are prepared and polymerized to form radio-opaque polymers. The monomers may also be copolymerized with other dihydroxy...
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7045117 |
Method for tumor diagnosis comprising administering of palladium-substituted bacteriochlorophyll derivatives
Palladium-substituted Bacteriochlorophyll derivatives are administered to a subject suspected of having a tumor and the patient is then irradiated and the fluorescence of the suspected area is...
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7034113 |
Bacteriocin-metal complexes in the detection of pathogens and other biological analytes
Complexes of bacteriocins and metals are provided that are useful in detecting bacteria, fungi and other biological analytes, and are particularly useful in detecting gram positive bacteria. The...
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7026166 |
Fluorogenic dyes
The present invention relates to the use of fluorogenic or chromogenic dyes as reporter molecules for detecting cell entry by a specific molecule.
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7025949 |
In-vivo diagnostic method by means of near infrared radiation
This invention relates to an in-vivo diagnostic method based on near infrared radiation (NIR radiation) that uses water-soluble dyes and their biomolecule adducts, each having specific...
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7014839 |
Light imaging contrast agents
The present invention relates to the use of particulate materials as contrast agents in in vivo light imaging.
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7011817 |
Hydrophilic cyanine dyes
Cyanine dye bioconjugates useful for diagnostic imaging and therapy are disclosed. The conjugates include several cyanine dyes with a variety of bis- and tetrakis (carboxylic acid) homologues. The...
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6986881 |
Identification of compounds that modify transcriptional responses to hypoxia
The invention provides methods for identifying compounds that can be used to modify transcriptional responses to hypoxia, and use of such compounds in therapeutic and diagnostic methods.
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6984374 |
Method for the evaluation of implantable materials
A method for the evaluation of a material to determine whether the material is susceptible to bacterial contamination or colonization comprising providing bacteria which are modified to produce a...
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6982090 |
More easily visualized punctum plug configurations
An improved punctum plug is more easily visualized when positioned within a punctual canal of a recipient. The body of the plug features an outwardly exposed surface when properly positioned, and a...
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6962690 |
Tissue specific fluorescent chelates possessing long wavelength UV excitation
Fluorescent chelates of lanthanide, terbium, europium and dysprosium with tetraazamacrocyclic compounds are discussed which can be used as fluorescent in vitro or in vivo diagnostic agents. These...
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6953570 |
Porphyrins with enhanced multi-photon absorption cross-sections for photodynamic therapy
A method of increasing the multi-photon absorption cross-section of a porphyrin-based photosensitizer by attaching at least one TPA-chromophore at the meso- or beta-positions of a porphyrin...
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6944493 |
Indocyanine green (ICG) compositions and related methods of use
Aqueous indocyanine green (ICG) composition exhibiting enhanced stability, as well as enhanced ICG concentration, as compared to presently available ICG products. The composition comprises an...
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6926884 |
GPIb-lipid bond construct and use thereof
The present invention provides a conjugate wherein GP (glycoprotein) Ib and a lipid are bonded via polyalkylene oxide. The present invention also provides a complex (GPIb lipid complex) containing...
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6913743 |
Near infrared imaging agent
This invention relates to an in-vivo diagnostic method based on near infrared radiation (NIR radiation) that uses water-soluble dyes and their biomolecule adducts, each having specific...
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6905671 |
Diagnostic agents and remedies for malignant tumors
An agent for diagnosing or photokinetically treating malignant tumors, comprising as an active ingredient a compound in which at least one carbon atom of 5-aminolevulinic acid is a carbon isotope...
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6900304 |
Emission ratiometric indicators of phosphorylation
A chimeric phosphorylation indicator is provided. A chimeric phosphorylation indicator can contain a donor molecule, a phosphorylatable domain, a phosphoaminoacid binding domain (PAABD), and an...
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6899864 |
Morpholino imaging and therapy
The present invention provides a kit and a method for targeting of a diagnostic or therapeutic agent to a target site in a mammal having a pathological condition. The kit comprises, in separate...
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6873716 |
Confocal-reflection streak lidar apparatus with strip-shaped photocathode, for applications at a wide range of scales
The system images the volume of a turbid medium and detects the contents. The medium can be water or air, or living tissue, or almost any other material which is at least partially...
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