|
Match
|
Document |
Document Title |
|
|
8177719 |
Contrast agent imaging with agent specific ultrasound detection
Highly specific measurements of flow in vessels, such as the coronary artery, can be obtained by processing cubic fundamental information. By showing flow in vessels with a high degree of...
|
|
|
RE43048 |
Ultrasonic diagnostic imaging with harmonic contrast agents
Apparatus and methods are disclosed for the detection and imaging of ultrasonic harmonic contrast agents. The harmonic echo effect is detected through alternate polarity acquisition of harmonic...
|
|
|
8084056 |
Preparation of a lipid blend and a phospholipid suspension containing the lipid blend
The present invention describes processes for the preparation of a lipid blend and a uniform filterable phospholipid suspension containing the lipid blend, such suspension being useful as an...
|
|
|
8078256 |
Integrated multi-rail imaging system
The imaging system can comprise a plurality of elongated rails, a scanhead assembly, and a small animal mount assembly. The scanhead assembly is selectively mounted onto a first rail and is...
|
|
|
8011826 |
Phantom
This invention provides an ultrasonic phantom that can respond to different ultrasonic intensities. Such ultrasonic phantom comprises a gel comprising a low-boiling compound in the form of droplets...
|
|
|
8012457 |
Ultrasound contrast agent dosage formulation
Clinical studies have been conducted and specific dosage formulations developed using polymeric microparticles having incorporated therein perfluorocarbon gases that provide significantly enhanced...
|
|
|
7985402 |
Targeting vector-phospholipid conjugates
Peptide vectors having high KDR binding affinity and processes for making such vectors are provided. The peptide vectors may be conjugated to phospholipids and included in ultrasound contrast agent...
|
|
|
7910088 |
Multivalent constructs for therapeutic and diagnostic applications
The invention provides compositions and methods for therapeutic and diagnostic applications.
|
|
|
7897141 |
Echogenic polymer microcapsules and nanocapsules and methods for production and use thereof
Methods for producing echogenic polymer microcapsules and nanocapsules for use in diagnostic imaging and delivery of bioactive compounds as well as targeted imaging and delivery to selected tissues...
|
|
|
7894880 |
Measurement of renal extraction fraction using contrast enhanced computed tomography
Renal extraction fraction (EF) is determined through use of computed tomography (CT) measurements of arterial blood before and after injection of a radiographic contrast agent into the blood and CT...
|
|
|
7892522 |
Contrast agents
Ultrasound contrast agents comprising microbubbles of biocompatible gas, e.g. a sulphur halide or a perfluorocarbon, stabilized by opsonisable amphiphilic material, e.g. a membrane-forming lipid...
|
|
|
7833359 |
Method for cleaning, employing a surfactant for fine-bubble formation
A method for cleaning articles using a surfactant which is effective in the formation of stable microbubbles is provided. The surfactant for microbubble formation contains a (poly)oxyalkylene...
|
|
|
7804595 |
Using optical scattering to measure properties of ultrasound contrast agent shells
A system and method for determining bubble shell properties using optical scattering. One or more ultrasound contrast agent (UCA) bubbles is placed in an imaging volume and illuminated with a...
|
|
|
7794693 |
Targeting vector-phospholipid conjugates
Peptide vectors having high KDR binding affinity and processes for making such vectors are provided. The peptide vectors may be conjugated to phospholipids and included in ultrasound contrast agent...
|
|
|
7753850 |
Method for ultrasound perfusion imaging
An ultrasound imaging system transmits a broad beam of ultrasound into tissues that are perfused with blood containing microbubbles. The ultrasound has an intensity that is sufficient to destroy...
|
|
|
7620442 |
Colonography on an unprepared colon
A method for generating colonography images for colorectal screening of a patient. The patient is administered an amount of radiopaque stool marker which will enable stool present in the patient's...
|
|
|
7597877 |
Administering a gravity segregation dispersion by continuous infusion
Method and apparatus for continuous infusion to a subject of dispersions in which the dispersed phase is susceptible to flotation or sedimentation. The dispersion is controllably delivered from an...
|
|
|
7588547 |
Methods and system for treating subcutaneous tissues
An apparatus and method for treating subcutaneous tissues using acoustic waves in the range of low acoustic pressure ultrasound waves is disclosed. The method includes injections of enhancing...
|
|
|
7560110 |
Production and use of novel peptide-based agents with bispecific antibodies
The present invention relates to a bi-specific antibody or antibody fragment having at least one arm that specifically binds a targeted tissue and at least one other arm that specifically binds a...
|
|
|
7452551 |
Targeted compositions for diagnostic and therapeutic use
Novel targeted compositions which may be used for diagnostic and therapeutic use. The compositions may comprise lipid, protein or polymer gas-filled vesicles which further comprise novel compounds...
|
|
|
7429249 |
Method for cavitation-induced tissue healing with low intensity ultrasound
A method and kit for therapeutically treating bone and tissue injuries using ultrasound. The method includes the steps of introducing an ultrasound contrast agent into the patient, preferably, the...
|
|
|
7422733 |
Linkable sialyl Lewis X analogs
Disclosed herein is a class of linkable tetrasaccharide compounds that includes the amino phenyl glycoside of sialyl Lewis X (SLeX) and related analogs. These compounds have conjugatable...
|
|
|
7374744 |
Harmonic ultrasound imaging with microbubbles
A method for ultrasonic harmonic imaging is disclosed, which uses microbubbles particularly selected for their properties of reradiating ultrasound energy at frequencies other than the exciting...
|
|
|
7374745 |
Ultrasound contrast agents
New ultrasound contrast agents that comprise microbubbles encapsulating a gas within a shell made from a blend of bipolar compounds having mixed carbon chain length. The compounds have hydrophobic...
|
|
|
7358226 |
Ultrasonic concentration of drug delivery capsules
Methods, compositions and apparatus for localized delivery of compounds are provided. In certain embodiments, radiation force is used to direct carriers to a target site, and additional radiation...
|
|
|
7344705 |
Composition comprising low density microspheres
Low density microspheres, methods for preparing same, and use of same as contrast agents are described. The microspheres have a void which contains a gas or the vapor of a volatile liquid selected...
|
|
|
7329402 |
Methods of imaging and treatment
Novel ultrasound methods comprising administering to a patient a targeted vesicle composition which comprises vesicles comprising a lipid, protein or polymer, encapsulating a gas, in combination...
|
|
|
7179449 |
Enhanced ultrasound detection with temperature-dependent contrast agents
Methods and devices for enhanced ultrasound detection based upon changing temperature and ultrasound reflectivity of a temperature-dependent contrast agent bound to an ultrasound target are...
|
|
|
7141235 |
Stabilized gas emulsion containing phospholipid for ultrasound contrast enhancement
A gas emulsion forming composition comprising a dry, hollow, particulate, approximately microspherical material permeated with a gas or gas mixture, which upon dissolution in aqueous liquid forms a...
|
|
|
7138103 |
Use of bi-specific antibodies for pre-targeting diagnosis and therapy
The present invention relates to targetable constructs which may be bound by a bi-specific antibody or antibody fragment having at least one arm that specifically binds construct. The targetable...
|
|
|
7115583 |
Microbubble compositions and methods for oligonucleotide delivery
The invention relates to a new and improved pharmaceutical composition and method for delivery of therapeutic agents. The methods and composition of the invention can be used with several...
|
|
|
7109167 |
Compounds for targeting endothelial cells, compositions containing the same and methods for their use
The present invention provides compounds for targeting endothelial cells, tumor cells or other cells that express the NP-1 receptor, compositions containing the same and methods for their use....
|
|
|
7105151 |
Oxygen delivery agents and uses for the same
The present invention describes, inter alia, oxygen delivery agents or blood substitutes comprising a fluorinated gas and a stabilizing material, uses for the oxygen delivery agents or blood...
|
|
|
7083778 |
Ultrasound contrast agents and methods of making and using them
Gas or air filled microbubble suspensions in aqueous phases usable as imaging contrast agents in ultrasonic echography. They contain surfactants and, optionally, hydrophilic stabilizers. The...
|
|
|
7078015 |
Ultrasound imaging and treatment
Methods of and apparatus for preparing temperature activated gaseous precursor-filled liposomes are described. Gaseous precursor-filled liposomes prepared by these methods are particularly usefull...
|
|
|
RE39146 |
Long-lasting aqueous dispersions or suspensions of pressure-resistant gas-filled microvesicles and methods for the preparation thereof
One can impart outstanding resistance against collapse under pressure to gas-filled microvesicle used as contrast agents in ultrasonic echography by using as fillers gases whose solubility in...
|
|
|
7041275 |
Irrigating fluid
A surgical irrigating fluid composition, especially for endoscopic surgery, is provided comprising a rinsing fluid and nitrous oxide added as a marker to the rinsing fluid in an amount which is...
|
|
|
7033574 |
Stable microbubbles suspensions injectable into living organisms
Gas or air filled microbubble suspensions in aqueous phases usable as imaging contrast agents in ultrasonic echography. They contain laminarized surfactants and, optionally, hydrophilic...
|
|
|
7022509 |
Gas vesicles of cells and methods of harvesting, isolating and modifying same
A method for removing a gas from a site comprising placing cells having gas vesicles under conditions that induce the cells to float to a surface of an aqueous medium, harvesting the cells from the...
|
|
|
7005120 |
Osmotically stabilized microbubble preparations
A microbubble preparation formed of a plurality of microbubbles comprising a first gas and a second gas surrounded by a membrane such as a surfactant, wherein the first gas and the second gas are...
|
|
|
7001589 |
Composite nanospheres and their conjugates with biomolecules
The invention concerns composite nanospheres having a diameter ranging between about 50 and 1000 nm plus or minus 5%, preferably between about 100 and 500 nm plus or minus 5% and advantageously...
|
|
|
6953569 |
Mixed gas microbubble compositions
A microbubble preparation formed of a plurality of microbubbles comprising a first gas and a second gas surrounded by a membrane such as a surfactant, wherein the first gas and the second gas are...
|
|
|
6939530 |
Preparation of further diagnostic agents
Microspheres are prepared by a process comprising (i) spray-drying a solution or dispersion of a wall-forming material in order to obtain intermediate microspheres and (ii) reducing the...
|
|
|
6939531 |
Ultrasonic imaging system utilizing a long-persistence contrast agent
A microbubble preparation formed of a plurality of microbubbles comprising a first gas and second gas surrounded by a membrane such as a surfactant, wherein the first gas and the second gas are...
|
|
|
6919068 |
Method of preparing gas-filled polymer matrix microparticles useful for echographic imaging
A method is provided to prepare gas-filled, porous microparticles having a polymer matrix interior which are useful as ultrasound echogenic contrast agents. An oil-in-water suspension is formed,...
|
|
|
6896875 |
Mixable combination for generating a suspension of stable microbubbles for ultrasonic imaging
Gas or air filled microbubble suspensions in aqueous phases usable as imaging contrast agents in ultrasonic echography. They contain laminarized surfactants and, optionally, hydrophilic...
|
|
|
6884407 |
Methods for diagnostic imaging involving the use of a contrast agent and a coronary vasodilator
Improved methods for providing an image of an internal region of a patient, especially the cardiovascular region. Embodiments of the invention involve the administration to the patient of a...
|
|
|
6875420 |
Method of ultrasound imaging
Disclosed herein are agents for enhancing the contrast in an ultrasound image. These agents are extremely small bubbles, or “microbubbles,” comprised of specially selected gases. The mic...
|
|
|
6811766 |
Ultrasound imaging with contrast agent targeted to microvasculature and a vasodilator drug
A combined preparation comprising: i) an ultrasound contrast agent capable of accumulation in tissue microvasculature; and ii) a pharamacologically effective amount of a vasodilator drug may be...
|
|
|
6808720 |
Charged lipids and uses for the same
The present invention is directed to charged lipids, compositions comprising charged lipids, and the use of these compositions in drug delivery, targeted drug delivery, therapeutic imaging and...
|