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Document Title |
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7620442 |
Colonography on an unprepared colon
A method for generating colonography images for colorectal screening of a patient. The patient is administered an amount of radiopaque stool marker which will enable stool present in the patient's...
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7560110 |
Production and use of novel peptide-based agents with bispecific antibodies
The present invention relates to a bi-specific antibody or antibody fragment having at least one arm that specifically binds a targeted tissue and at least one other arm that specifically binds a...
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7422733 |
Linkable sialyl Lewis X analogs
Disclosed herein is a class of linkable tetrasaccharide compounds that includes the amino phenyl glycoside of sialyl Lewis X (SLe X ) and related analogs. These compounds have conjugatable...
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7368129 |
Amphiphilic materials and liposome formulations thereof
Disclosed is a new structural class of amphiphilic molecules which incorporate a hydrophilic material or polymer attached, at spatially distinct sites, to at least two hydrophobic residues. Certain...
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7358226 |
Ultrasonic concentration of drug delivery capsules
Methods, compositions and apparatus for localized delivery of compounds are provided. In certain embodiments, radiation force is used to direct carriers to a target site, and additional radiation...
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7329402 |
Methods of imaging and treatment
Novel ultrasound methods comprising administering to a patient a targeted vesicle composition which comprises vesicles comprising a lipid, protein or polymer, encapsulating a gas, in combination...
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7285289 |
Nanoparticle vaccines
The present invention relates to nanoparticle vaccines comprised of a carrier, particularly polymerized lipids, having multiple copies of an antigen or combinations of different antigens displayed...
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7217427 |
Polymersomes and related encapsulating membranes
The present invention provides biocompatible vesicles comprising semi-permeable, thin-walled encapsulating membranes which are formed in an aqueous solution, and which comprise one or more...
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7186399 |
Methods for targeted drug delivery
A method for ligand-based binding of lipid encapsulated particles to molecular epitopes on a surface in vivo or in vitro comprises sequentially administering (a) a site specific ligand activated...
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7179449 |
Enhanced ultrasound detection with temperature-dependent contrast agents
Methods and devices for enhanced ultrasound detection based upon changing temperature and ultrasound reflectivity of a temperature-dependent contrast agent bound to an ultrasound target are...
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7166297 |
Lipid-based drug delivery systems against parasitic infections
The present invention is directed to a lipid-based delivery system for administration of an active drug substance selected from lysolipid derivatives which are particularly useful in the treatment...
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7141235 |
Stabilized gas emulsion containing phospholipid for ultrasound contrast enhancement
A gas emulsion forming composition comprising a dry, hollow, particulate, approximately microspherical material permeated with a gas or gas mixture, which upon dissolution in aqueous liquid forms a...
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7138136 |
Agglomerated particles for aerosol drug delivery
The invention provides a drug delivery vehicle for inhalation by a patient. The drug delivery vehicle comprises biocompatible particles between 0.1 and 1.0 microns in diameter, that are loaded with...
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7138103 |
Use of bi-specific antibodies for pre-targeting diagnosis and therapy
The present invention relates to targetable constructs which may be bound by a bi-specific antibody or antibody fragment having at least one arm that specifically binds construct. The targetable...
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7108863 |
Liposome composition for improved intracellular delivery of a therapeutic agent
A liposomal composition and a method of using the same for achieving intracellular delivery of a liposome-entrapped agent is described. The liposomes are composed of a pH sensitive lipid and...
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7105151 |
Oxygen delivery agents and uses for the same
The present invention describes, inter alia, oxygen delivery agents or blood substitutes comprising a fluorinated gas and a stabilizing material, uses for the oxygen delivery agents or blood...
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7094424 |
Cationic lipid compositions targeting angiogenic endothelial cells
Angiogenic endothelial cells are selectively targeted with lipid/DNA complexes or cationic liposomes containing a substance which affects the targeted cells by inhibiting or promoting their growth....
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7083572 |
Therapeutic delivery systems
Targeted therapeutic delivery systems comprising gas- or gaseous precursor-filled lipid microspheres comprising a therapeutic are described. Methods for employing such microspheres in therapeutic...
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7083778 |
Ultrasound contrast agents and methods of making and using them
Gas or air filled microbubble suspensions in aqueous phases usable as imaging contrast agents in ultrasonic echography. They contain surfactants and, optionally, hydrophilic stabilizers. The...
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7078015 |
Ultrasound imaging and treatment
Methods of and apparatus for preparing temperature activated gaseous precursor-filled liposomes are described. Gaseous precursor-filled liposomes prepared by these methods are particularly usefull...
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7070801 |
Sugar-modified liposome and products comprising the liposome
The present invention provides a sugar-modified liposome having a sugar chain bonded to its membrane surface, preferably through a linker protein, and having excellent absorption qualities,...
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RE39146 |
Long-lasting aqueous dispersions or suspensions of pressure-resistant gas-filled microvesicles and methods for the preparation thereof
One can impart outstanding resistance against collapse under pressure to gas-filled microvesicle used as contrast agents in ultrasonic echography by using as fillers gases whose solubility in...
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7060291 |
Modular targeted liposomal delivery system
A liposome including a fusogenic liposome, a linking moiety and a targeting moiety. The fusogenic liposome is a lipid bilayer encapsulating contents. The linking moiety is electrostatically bound...
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7035681 |
Colonography of an unprepared colon
A method for generating colonography images for colorectal screening of a patient. The patient is administered an amount of radiopaque stool marker which will enable stool present in the patient's...
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7033574 |
Stable microbubbles suspensions injectable into living organisms
Gas or air filled microbubble suspensions in aqueous phases usable as imaging contrast agents in ultrasonic echography. They contain laminarized surfactants and, optionally, hydrophilic...
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7005120 |
Osmotically stabilized microbubble preparations
A microbubble preparation formed of a plurality of microbubbles comprising a first gas and a second gas surrounded by a membrane such as a surfactant, wherein the first gas and the second gas are...
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7001589 |
Composite nanospheres and their conjugates with biomolecules
The invention concerns composite nanospheres having a diameter ranging between about 50 and 1000 nm plus or minus 5%, preferably between about 100 and 500 nm plus or minus 5% and advantageously...
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6998108 |
Antibodies to p30 polypeptides and methods making and using same
A novel ligand (p30) for herpes virus entry mediator, HVEM, is provided. p30 is useful for modulating immune responses and in inhibiting infection by herpes virus. Methods for treating subjects...
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6991805 |
Temperature sensitive control of liposome-cell adhesion
The present invention provides a liposomal composition for targeted delivery of drugs. The composition comprises poloxamer molecules and liposomes encapsulating one or more delivery agents. At...
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6989153 |
Radiation sensitive liposomes
The present invention relates to a radiation sensitive liposome, and the use of this liposome as carrier for therapeutic and diagnostic agent(s). In particular, the invention encompasses a...
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6986902 |
Polyanionic polymers which enhance fusogenicity
The present invention relates generally to the amphiphilic polyelectrolyte, poly(2-ethylacrylic acid) and covalently bonded lipids to generate Lipo-PEAA. These Lipo-PEAA are then used to make...
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6979460 |
Vinyl ether lipids with cleavable hydrophlic headgroups
A novel amphiphilic lipid compound having a cleavable, vinyl ether linked hydrophilic headgroup is described. Also described are liposomes containing the vinyl ether lipid compound, which may be...
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6974589 |
Neutral-cationic lipid for nucleic acid and drug delivery
A lipid represented by the formula:
wherein each of R 1 and R 2 is an alkyl or alkenyl chain having between about 8 to about 24 carbon atoms; n=0–20; L is selected from the group consisting...
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6958160 |
Self forming, thermodynamically stable liposomes and their applications
A liposome suspension forms spontaneously upon adding a lipid composition to an aqueous solution. The liposomes include diacylglycerol-PEG compounds. The melting point of the diacylglycerol-PEG is...
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6953569 |
Mixed gas microbubble compositions
A microbubble preparation formed of a plurality of microbubbles comprising a first gas and a second gas surrounded by a membrane such as a surfactant, wherein the first gas and the second gas are...
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6939531 |
Ultrasonic imaging system utilizing a long-persistence contrast agent
A microbubble preparation formed of a plurality of microbubbles comprising a first gas and second gas surrounded by a membrane such as a surfactant, wherein the first gas and the second gas are...
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6916488 |
Amphiphilic polymeric vesicles
Vesicles made from amphiphilic copolymers are disclosed. The amphiphilic copolymers can be ABA copolymers, where one of A and B is hydrophilic and the other is hydrophobic. AB copolymers can also...
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6896875 |
Mixable combination for generating a suspension of stable microbubbles for ultrasonic imaging
Gas or air filled microbubble suspensions in aqueous phases usable as imaging contrast agents in ultrasonic echography. They contain laminarized surfactants and, optionally, hydrophilic...
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6884407 |
Methods for diagnostic imaging involving the use of a contrast agent and a coronary vasodilator
Improved methods for providing an image of an internal region of a patient, especially the cardiovascular region. Embodiments of the invention involve the administration to the patient of a...
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6818227 |
Liposome composition and method for administration of a radiosensitizer
A method for administering a radiosensitizer to a tumor site in a subject is described. The method includes preparing liposomes composed of a vesicle-forming lipid and a lipid-derivatized...
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6808720 |
Charged lipids and uses for the same
The present invention is directed to charged lipids, compositions comprising charged lipids, and the use of these compositions in drug delivery, targeted drug delivery, therapeutic imaging and...
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6797257 |
Paramagnetic polymerized protein microspheres and methods of preparation thereof
The present invention relates to a composition that includes gadolinium particles encapsulated in microsphere shells. The composition is suitable for use as a contrast agent with a plurality of...
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6776761 |
Hollow microspheres with controlled fragility for medical use
A composition for ultrasonic imaging is described having a microbubble population of controlled fragility. The microbubbles comprise an outer shell and a hollow core. The ratio of shell thickness...
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6726925 |
Temperature-sensitive liposomal formulation
A liposome contains an active agent and has a gel-phase lipid bilayer membrane comprising phospholipid and a surface active agent. The phospholipids are the primary lipid source for the lipid...
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6716412 |
Methods of ultrasound treatment using gas or gaseous precursor-filled compositions
The present invention describes, among other things, the surprising discovery that gaseous precursor filled compositions are profoundly more effective as acoustically active contrast agents when...
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6676963 |
Ligand-targeted emulsions carrying bioactive agents
A composition for use in delivering a bioactive agent to targeted tissues or cells comprises: (a) a site-specific targeting ligand; (b) a lipid encapsulated oil in water emulsion; and (c) a...
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6627218 |
Cationic amphiphiles of cholesterol
A stable aqueous dispersion which comprises a cationic lipid which is a molecule which comprises a cholesterol-derived lipophilic group, a linker bond which is hydrolyzable by cellular enzymes and...
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6623722 |
Spray-drying microcapsules using an aqueous liquid containing a volatile liquid
A process for forming microcapsules comprising (i) providing a solution of a protein in an aqueous solvent and (ii) spraying the said solution into a gas such that the aqueous solvent evaporates,...
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6620404 |
Gaseous ultrasound contrast media and method for selecting gases for use as ultrasound contrast media
Disclosed herein are agents for enhancing the contrast in an ultrasound image. These agents are extremely small bubbles, or “microbubbles,” comprised of specially selected gases. The...
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6586001 |
Neutral lipopolymer and liposomal compositions containing same
Liposomes containing PEG-substituted neutral lipopolymers provide similar circulation times to liposomes incorporating conventional, negatively charged PEG-substituted phospholipids. Use of the...
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